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Malaria is one of the major health problems in the world. It remains an important cause of very high human morbidity and mortality, especially, among children and pregnant women. It results from the infection of parasites belonging to the... more
Malaria is one of the major health problems in the world. It remains an important cause of very high human morbidity and mortality, especially, among children and pregnant women. It results from the infection of parasites belonging to the genus Plasmodium. Plasmodium falciparum and Plasmodium vivax are the major pathogens responsible for causing human malaria. Approximately 75% of cases are caused by P. falciparum and associated with the mortality rate of approximately 0.5 to 1.0%. Both P. falciparum and P. vivax induce anemia during their erythrocytic stages of infection. Most of the malarial infections are related to some degree of anemia, the severity of which depends upon patient-specific characteristics (e.g., age, innate and acquired resistance, comorbid features, etc.) as well as parasite-specific characteristics (e.g., species, adhesive, and drug-resistant phenotype, etc.). Malarial anemia encompasses reduced production of erythrocytes as well as increased removal of circula...
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Quantum dots (QDs) are among the most likely items in the nano nanocrystal fluorophores have several potential medical applications including nanodiagnostics, imaging, targeted drug delivery, and approach for cancer detection is urgent,... more
Quantum dots (QDs) are among the most likely items in the nano nanocrystal fluorophores have several potential medical applications including nanodiagnostics, imaging, targeted drug delivery, and approach for cancer detection is urgent, and real underlying biological mechanisms. With the optical and chemical advantages of quantum dots (QDs), QD cancer behavior study. This review in cancer cell imaging and tumor remaining issues and future perspectives.
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Solid dispersions have engrossed substantial attention as an effectual means of refining the dissolution rate and hence the bioavailability of a variety of hydrophobic drugs. In this review, it is intended to discuss the future prospects... more
Solid dispersions have engrossed substantial attention as an effectual means of refining the dissolution rate and hence the bioavailability of a variety of hydrophobic drugs. In this review, it is intended to discuss the future prospects related to the area of solid dispersion manufacturing. Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Therefore, increase in dissolution of poorly soluble drugs by solid dispersion technique presents a challenge to the formulation scientists. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by reducing drug particle size, improving wettability and forming amorphous particles. This review article discusses the various preparation techniques and characterization for solid dispersion and compiles some of the recent technology transfers in the form of patents.