International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 2000
In Brazil, there is little information about the clinical and epidemiological characteristics of ... more In Brazil, there is little information about the clinical and epidemiological characteristics of paucibacillary, single skin lesion leprosy patients (SSL-PB). Only recently has the official notification system distinguished leprosy patients with a single lesion as a clinical entity, for whom the single-dose ROM (rifampin, ofloxacin and minocycline) regimen has been recommended. In this paper, we describe the baseline clinical features and the immunological background of a multicenter cohort of SSL-PB leprosy cases enrolled between December 1997-1998. Patients were recruited at health centers located in the following regions: Southeast = Rio de Janeiro; North = Amazon and Rondônia states and Center-West = Goiás state. Eligible cases were newly detected, untreated single-lesion leprosy patients without thickened nerve involvement, and were assessed by clinical, bacilloscopic and histopathological exams. The Mitsuda skin test and anti-PGL-I serology (ELISA) were also performed. Of the ...
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 2001
This paper aims to describe the histomorphologic features of skin biopsies of single lesion lepro... more This paper aims to describe the histomorphologic features of skin biopsies of single lesion leprosy patients recruited at outpatient clinics in four Brazilian states in the Northeast (Amazonas and Rondonia), Southeast (Rio de Janeiro) and Center-West (Goiás) between October 1997 and December 1998. Patients clinically diagnosed as single skin lesion paucibacillary (SSL-PB) leprosy had a standard 4-mm punch biopsy taken from the lesion before rifampin, ofloxacin, minocycline (ROM) therapy. The features of the cellular inflammatory infiltrates, the presence of nerve involvement and acid-fast bacilli (AFB) were used to categorize SSL-PB biopsies into different histopathological groups. Two-hundred-seventy-eight (93.0%) out of 299 patients had a skin biopsy available. Seven single lesion patients were diagnosed as BL or LL leprosy types (MB) by the histopathological exams and 12 cases were excluded due to other skin diseases. Therefore, 259 patients had skin lesions with histomorphologic...
Introdução: Introdução: vem sendo detectado casos de recidiva e/ou reinfecções em pacientes multi... more Introdução: Introdução: vem sendo detectado casos de recidiva e/ou reinfecções em pacientes multibacilares (MB) na nossa região, foi realizado um estudo para dimensionar a magnitude do problema, uma vez que esses casos seriam um foco de disseminação de hanseníase devido a alta carga bacilar. Objetivos: Objetivo: avaliar a ocorrência de casos de recidivas e/ou reinfecções e resistência aos medicamentos anti-hansênicas em pacientes MB em Rondônia. Materiais e Métodos: Materiais e Métodos: consulta aos registros e prontuários dos centros de referência, aos registros do SINAN com entrada como "recidiva" e também às "outras entradas". Sendo excluídos casos que não eram MB e os casos reacionais. Sendo incluídos os casos em que a baciloscopia (BAAR) fossem positivos com presença de bacilos íntegros, ou pelo histopatógico demonstrando sinais de atividade com bacilos íntegros. Foi observado, também casos que foram realizados Reação em Cadeia de Polimerase (PCR). Resultado...
Base de dados : LILACS. Pesquisa : 529797 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 529797 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. Martelli, Celina M. T. Texto completo. ...
The American journal of tropical medicine and hygiene, 2007
Leprosy affects skin and peripheral nerves, and acute inflammatory type 1 reactions (reversal rea... more Leprosy affects skin and peripheral nerves, and acute inflammatory type 1 reactions (reversal reaction) can cause neurologic impairment and disabilities. Single skin lesion paucibacillary leprosy volunteers (N = 135) recruited in three Brazilian endemic regions, treated with single-dose rifampin, ofloxacin, and minocycline (ROM), were monitored for 3 years. Poor outcome was defined as type 1 reactions with or without neuritis. IgM anti-phenolic glycolipid I, histopathology, Mitsuda test, and Mycobacterium leprae DNA polymerase chain reaction (ML-PCR) were performed at baseline. chi(2) test, Kaplan-Meir curves, and Cox proportional hazards were applied. The majority of volunteers were adults with a mean age of 30.5 +/- 15.4 years; 44.4% were ML-PCR positive. During follow-up, 14.8% of the patients had a poor clinical outcome, classified as a type 1 reaction. Older age (> or = 40 years), ML-PCR positivity, and lesion size > 5 cm were associated with increased risk. In multivaria...
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 2000
In Brazil, there is little information about the clinical and epidemiological characteristics of ... more In Brazil, there is little information about the clinical and epidemiological characteristics of paucibacillary, single skin lesion leprosy patients (SSL-PB). Only recently has the official notification system distinguished leprosy patients with a single lesion as a clinical entity, for whom the single-dose ROM (rifampin, ofloxacin and minocycline) regimen has been recommended. In this paper, we describe the baseline clinical features and the immunological background of a multicenter cohort of SSL-PB leprosy cases enrolled between December 1997-1998. Patients were recruited at health centers located in the following regions: Southeast = Rio de Janeiro; North = Amazon and Rondônia states and Center-West = Goiás state. Eligible cases were newly detected, untreated single-lesion leprosy patients without thickened nerve involvement, and were assessed by clinical, bacilloscopic and histopathological exams. The Mitsuda skin test and anti-PGL-I serology (ELISA) were also performed. Of the ...
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 2001
This paper aims to describe the histomorphologic features of skin biopsies of single lesion lepro... more This paper aims to describe the histomorphologic features of skin biopsies of single lesion leprosy patients recruited at outpatient clinics in four Brazilian states in the Northeast (Amazonas and Rondonia), Southeast (Rio de Janeiro) and Center-West (Goiás) between October 1997 and December 1998. Patients clinically diagnosed as single skin lesion paucibacillary (SSL-PB) leprosy had a standard 4-mm punch biopsy taken from the lesion before rifampin, ofloxacin, minocycline (ROM) therapy. The features of the cellular inflammatory infiltrates, the presence of nerve involvement and acid-fast bacilli (AFB) were used to categorize SSL-PB biopsies into different histopathological groups. Two-hundred-seventy-eight (93.0%) out of 299 patients had a skin biopsy available. Seven single lesion patients were diagnosed as BL or LL leprosy types (MB) by the histopathological exams and 12 cases were excluded due to other skin diseases. Therefore, 259 patients had skin lesions with histomorphologic...
Introdução: Introdução: vem sendo detectado casos de recidiva e/ou reinfecções em pacientes multi... more Introdução: Introdução: vem sendo detectado casos de recidiva e/ou reinfecções em pacientes multibacilares (MB) na nossa região, foi realizado um estudo para dimensionar a magnitude do problema, uma vez que esses casos seriam um foco de disseminação de hanseníase devido a alta carga bacilar. Objetivos: Objetivo: avaliar a ocorrência de casos de recidivas e/ou reinfecções e resistência aos medicamentos anti-hansênicas em pacientes MB em Rondônia. Materiais e Métodos: Materiais e Métodos: consulta aos registros e prontuários dos centros de referência, aos registros do SINAN com entrada como "recidiva" e também às "outras entradas". Sendo excluídos casos que não eram MB e os casos reacionais. Sendo incluídos os casos em que a baciloscopia (BAAR) fossem positivos com presença de bacilos íntegros, ou pelo histopatógico demonstrando sinais de atividade com bacilos íntegros. Foi observado, também casos que foram realizados Reação em Cadeia de Polimerase (PCR). Resultado...
Base de dados : LILACS. Pesquisa : 529797 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 529797 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. Martelli, Celina M. T. Texto completo. ...
The American journal of tropical medicine and hygiene, 2007
Leprosy affects skin and peripheral nerves, and acute inflammatory type 1 reactions (reversal rea... more Leprosy affects skin and peripheral nerves, and acute inflammatory type 1 reactions (reversal reaction) can cause neurologic impairment and disabilities. Single skin lesion paucibacillary leprosy volunteers (N = 135) recruited in three Brazilian endemic regions, treated with single-dose rifampin, ofloxacin, and minocycline (ROM), were monitored for 3 years. Poor outcome was defined as type 1 reactions with or without neuritis. IgM anti-phenolic glycolipid I, histopathology, Mitsuda test, and Mycobacterium leprae DNA polymerase chain reaction (ML-PCR) were performed at baseline. chi(2) test, Kaplan-Meir curves, and Cox proportional hazards were applied. The majority of volunteers were adults with a mean age of 30.5 +/- 15.4 years; 44.4% were ML-PCR positive. During follow-up, 14.8% of the patients had a poor clinical outcome, classified as a type 1 reaction. Older age (> or = 40 years), ML-PCR positivity, and lesion size > 5 cm were associated with increased risk. In multivaria...
Uploads
Papers by Kazue Narahashi