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Generation of tumor-infiltrating lymphocytes from pancreatic cancer lesions for cellular therapymore
by Thomas Poiret and Liu Zhenjiang
Publication Date: 2014
Publication Name: Journal for ImmunoTherapy of Cancer
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by Thomas Poiret and Liu Zhenjiang
Publication Date: 2014
Publication Name: Journal for ImmunoTherapy of Cancer
Research Interests:
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by Thomas Poiret and Liu Zhenjiang
Publication Date: 2014
Publication Name: Journal for ImmunoTherapy of Cancer
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Publication Date: 2014
Publication Name: Journal for ImmunoTherapy of Cancer
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The emergence of drug-resistant tuberculosis is challenging tuberculosis control worldwide. In the absence of an effective vaccine to prevent primary infection with Mycobacterium tuberculosis and tuberculosis disease, host-directed... more
The emergence of drug-resistant tuberculosis is challenging tuberculosis control worldwide. In the absence of an effective vaccine to prevent primary infection with Mycobacterium tuberculosis and tuberculosis disease, host-directed therapies may offer therapeutic options, particularly for patients with multidrug-resistant and extensively drug-resistant tuberculosis where prognosis is often limited. CD8(+) and CD4(+) T cells mediate antigen-specific adaptive cellular immune responses. Their use in precision immunotherapy in clinical conditions, especially in treating cancer as well as for prevention of life-threatening viral infections in allogeneic transplant recipients, demonstrated safety and clinical efficacy. We review key achievements in T-cell therapy, including the use of recombinant immune recognition molecules (eg, T-cell receptors and CD19 chimeric antigen receptors), and discuss its potential in the clinical management of patients with drug-resistant and refractory tuberc...