Graduate at Surgery from Universidade Federal do Paraná (1996), master's at Medicine from Faculdade Evangélica do Paraná (2000) and PhD at Surgery from Universidade Federal do Paraná (2003) and at Biothermodymanics from Universidade Federal do Paraná (2008). Post-doctoral at Faculdade de Medicina do Hospital de Clinicas da Universidade de Sao Paulo, Neurology Department. Has experience in Surgery, Legal Medicine and Clinical Thermology (infrared imaging, thermography), acting on the following subjects: pain managment, breast cancer, angiology and surgery.
OBJETIVO: Determinar se a termografia infravermelha é capaz de detectar com precisão a perda de p... more OBJETIVO: Determinar se a termografia infravermelha é capaz de detectar com precisão a perda de perfusão tecidual em áreas de parênquima esplênico. MÉTODOS: Cinco porcos Landrace pesando entre 12 a 15 kg, após medicação pré-anestésica intramuscular e anestesia por infusão endovenosa, foram submetidos a quatro etapas de ligaduras sequenciais, dos vasos arteriais para o pólo inferior do baço: 1-vasos do ligamento esplênico; 2-ramo da artéria esplênica para o pólo inferior; 3-ramo arterial para o pólo inferior na face visceral do órgão; 4-parênquima esplênico dividindo o órgão. As imagens foram captadas por câmera Therma CAM SC500 instalada a 50 centímetros da superfície do órgão. As temperaturas foram medidas na região proximal (vascularizada) e na região distal (isquêmica), em três áreas circulares distintas de cada região através do software SAT Report, antes e após cada etapa de ligaduras, constituindo cinco grupos de medidas: tempo 0 = antes da etapa 1; tempo 1 = após etapa 1; tem...
ABSTRACT Digital Thermal Monitoring (DTM) is a non-invasive provocative assessment of vascular re... more ABSTRACT Digital Thermal Monitoring (DTM) is a non-invasive provocative assessment of vascular reactivity, as a potential indicator of endothelial dysfunction and cardiovascular disease risk. This test is based on temperature changes of the fingertips, after brachial artery decompression. In this work we studied the thermal response employing infrared (IR) thermography images of the upper extremities. For this it was applied brachial pneumatic compression and decompression. Two subjects, with and without high cardiovascular risk, were studied. Initially, they remained seated for two minutes and the IR images of the fingertips started to be registered. Then, the right arm brachial artery was compressed by inflating the blood pressure device for five minutes. Next, the brachial artery was decompressed and thermal images were acquired for more five minutes. Thermal pattern curves responses were obtained during compression and decompression periods.
A termografia e metodo diagnostico inocuo e sem radiacao ionica, capaz de quantificar objetivamen... more A termografia e metodo diagnostico inocuo e sem radiacao ionica, capaz de quantificar objetivamente, por imagem, as reacoes inflamatorias locais do sistema musculoesqueletico, sendo util no registro da atividade inflamatoria e na avaliacao terapeutica. Associacao Brasileira de Termologia Faculdade de Medicina da Universidade de Sao Paulo – Brasil Hospital Vila Franca de Xira Grupo de Estudo Medico Legal da SPOT
The goal of the MAIS system is to provide support for flexible and adaptive execution of applicat... more The goal of the MAIS system is to provide support for flexible and adaptive execution of applications in a distributed, multichannel, mobile information system. In such a system, a fundamental requirement is an ability to describe the continuously evolving execution environment and user characteristics. Service requests are therefore satisfied by considering both the request itself and its provisioning environment.
Medial prefrontal cortex (mPFC) has been implicated in the reward process and the development of ... more Medial prefrontal cortex (mPFC) has been implicated in the reward process and the development of cocaine addiction. In the current study, we used a proteomics-based approach, combining two-dimensional gel electrophoresis (2-DE) with mass spectrometry (MS), to analyze protein expression profiles of rat mPFC after repeated cocaine exposure. Conditioned place preference (CPP) assay was used here to evaluate cocaine-induced reward effect in rats. We detected about 3100 protein spots in rat mPFC. After repeated cocaine exposure, 125 spots were changed by more than 1.1-fold of control levels. Among them, 71 spots with 1.5-fold or greater changes in protein expression over control levels have been identified, including 50 spots that were up-regulated and 21 spots that were down-regulated by repeated cocaine exposure. These identified proteins that showed significant changes in expression in mPFC after repeated cocaine exposure may be useful biomarkers for assessing cocaine abuse and potential new targets for investigating the mechanism of cocaine abuse.
IntroductionPeriprosthetic joint infection (PJI) is considered one of the most feared causes of i... more IntroductionPeriprosthetic joint infection (PJI) is considered one of the most feared causes of implant failure, due to the difficulty in formulating a proper and timely diagnosis. In the diagnostic workup are often used test with a low specificity, such as the dosage of ESR and CRP, or sensitivity, such as cultures or the leukocyte count of the synovial fluid. Radiological investigations are expensive and unreliable to play a direct role in the diagnosis of PJI. The alpha-defensin is an antimicrobial peptide released by neutrophils in response to pathogens and it is an ideal biomarker for the diagnosis of PJI. It is now possible to verify the presence of alpha-defensin in periprosthetic synovial fluid with an ELISA (Synovasure® PJI, Zimmer) that provides results in 10 minutes, with a sensitivity of 97% and a specificity of 96%, without being affected by systemic inflammatory diseases or by the assumption of antibiotics. The purpose of this study is to assess the applicability and r...
Chronic paroxysmal hemicrania (CPH) is an unusual cause of headache, affecting predominantly wome... more Chronic paroxysmal hemicrania (CPH) is an unusual cause of headache, affecting predominantly women in the third to fourth decade. It is characterized by multiple attacks of unilateral pain, mostly located in fronto-orbito-temporal region, often associated with autonomic symptoms, such as lacrymation, conjunc-tival hyperaemia and nasal obstruction or rhinor-rhea. Each attack usually lasts from 2 to 45 min and as diagnostic criteria it should be absolutely respon-sive to indomethacin in varying doses (1). Since the first description and definition of diag-nostic criteria, few cases of CPH have been described in children. We report a 10 years-old girl with symp-toms beginning since early childhood. Case report
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology, 2003
AIM This study was aimed at assessing the clinical performances of a NaI(Tl) crystal 3D PET scann... more AIM This study was aimed at assessing the clinical performances of a NaI(Tl) crystal 3D PET scanner, C-PET (ADAC-UGM), using a multi-ring 2D BGO PET scanner (multi-ring PET), as a reference. METHODS Thirty-seven oncological patients were studied in sequence with multi-ring PET and C-PET, within 30 days of a CT study. In order to assess the behaviour of C-PET in relation to acquisition count rate, patients were divided into 3 groups according to the count rate at the time of the C-PET scan acquisition. Group A (n=21): 3000-5000 kcounts/sec (recommended count rate range); Group B (n=8): <3000 Kcounts/sec and Group C (n=8): >5000 Kcounts/sec. RESULTS The number of lesions detected by multi-ring PET and C-PET, classified according to size, was compared. For Group A and Group B there was a good agreement between C-PET and multi-ring PET in terms of lesion detectability (relative sensitivity: 99.9% and 96.0%, respectively), while for Group C the relative sensitivity of C-PET was 61....
The engineering development and outcomes of distal humeral hemiarthroplasty (DHH) have gained inc... more The engineering development and outcomes of distal humeral hemiarthroplasty (DHH) have gained increasing interest for the utilization of these implants in a new large horizon of clinical scenario. This chapter will focus on the spectrum of the surgical indications and the expected results of DHH.
OBJETIVO: Determinar se a termografia infravermelha é capaz de detectar com precisão a perda de p... more OBJETIVO: Determinar se a termografia infravermelha é capaz de detectar com precisão a perda de perfusão tecidual em áreas de parênquima esplênico. MÉTODOS: Cinco porcos Landrace pesando entre 12 a 15 kg, após medicação pré-anestésica intramuscular e anestesia por infusão endovenosa, foram submetidos a quatro etapas de ligaduras sequenciais, dos vasos arteriais para o pólo inferior do baço: 1-vasos do ligamento esplênico; 2-ramo da artéria esplênica para o pólo inferior; 3-ramo arterial para o pólo inferior na face visceral do órgão; 4-parênquima esplênico dividindo o órgão. As imagens foram captadas por câmera Therma CAM SC500 instalada a 50 centímetros da superfície do órgão. As temperaturas foram medidas na região proximal (vascularizada) e na região distal (isquêmica), em três áreas circulares distintas de cada região através do software SAT Report, antes e após cada etapa de ligaduras, constituindo cinco grupos de medidas: tempo 0 = antes da etapa 1; tempo 1 = após etapa 1; tem...
ABSTRACT Digital Thermal Monitoring (DTM) is a non-invasive provocative assessment of vascular re... more ABSTRACT Digital Thermal Monitoring (DTM) is a non-invasive provocative assessment of vascular reactivity, as a potential indicator of endothelial dysfunction and cardiovascular disease risk. This test is based on temperature changes of the fingertips, after brachial artery decompression. In this work we studied the thermal response employing infrared (IR) thermography images of the upper extremities. For this it was applied brachial pneumatic compression and decompression. Two subjects, with and without high cardiovascular risk, were studied. Initially, they remained seated for two minutes and the IR images of the fingertips started to be registered. Then, the right arm brachial artery was compressed by inflating the blood pressure device for five minutes. Next, the brachial artery was decompressed and thermal images were acquired for more five minutes. Thermal pattern curves responses were obtained during compression and decompression periods.
A termografia e metodo diagnostico inocuo e sem radiacao ionica, capaz de quantificar objetivamen... more A termografia e metodo diagnostico inocuo e sem radiacao ionica, capaz de quantificar objetivamente, por imagem, as reacoes inflamatorias locais do sistema musculoesqueletico, sendo util no registro da atividade inflamatoria e na avaliacao terapeutica. Associacao Brasileira de Termologia Faculdade de Medicina da Universidade de Sao Paulo – Brasil Hospital Vila Franca de Xira Grupo de Estudo Medico Legal da SPOT
The goal of the MAIS system is to provide support for flexible and adaptive execution of applicat... more The goal of the MAIS system is to provide support for flexible and adaptive execution of applications in a distributed, multichannel, mobile information system. In such a system, a fundamental requirement is an ability to describe the continuously evolving execution environment and user characteristics. Service requests are therefore satisfied by considering both the request itself and its provisioning environment.
Medial prefrontal cortex (mPFC) has been implicated in the reward process and the development of ... more Medial prefrontal cortex (mPFC) has been implicated in the reward process and the development of cocaine addiction. In the current study, we used a proteomics-based approach, combining two-dimensional gel electrophoresis (2-DE) with mass spectrometry (MS), to analyze protein expression profiles of rat mPFC after repeated cocaine exposure. Conditioned place preference (CPP) assay was used here to evaluate cocaine-induced reward effect in rats. We detected about 3100 protein spots in rat mPFC. After repeated cocaine exposure, 125 spots were changed by more than 1.1-fold of control levels. Among them, 71 spots with 1.5-fold or greater changes in protein expression over control levels have been identified, including 50 spots that were up-regulated and 21 spots that were down-regulated by repeated cocaine exposure. These identified proteins that showed significant changes in expression in mPFC after repeated cocaine exposure may be useful biomarkers for assessing cocaine abuse and potential new targets for investigating the mechanism of cocaine abuse.
IntroductionPeriprosthetic joint infection (PJI) is considered one of the most feared causes of i... more IntroductionPeriprosthetic joint infection (PJI) is considered one of the most feared causes of implant failure, due to the difficulty in formulating a proper and timely diagnosis. In the diagnostic workup are often used test with a low specificity, such as the dosage of ESR and CRP, or sensitivity, such as cultures or the leukocyte count of the synovial fluid. Radiological investigations are expensive and unreliable to play a direct role in the diagnosis of PJI. The alpha-defensin is an antimicrobial peptide released by neutrophils in response to pathogens and it is an ideal biomarker for the diagnosis of PJI. It is now possible to verify the presence of alpha-defensin in periprosthetic synovial fluid with an ELISA (Synovasure® PJI, Zimmer) that provides results in 10 minutes, with a sensitivity of 97% and a specificity of 96%, without being affected by systemic inflammatory diseases or by the assumption of antibiotics. The purpose of this study is to assess the applicability and r...
Chronic paroxysmal hemicrania (CPH) is an unusual cause of headache, affecting predominantly wome... more Chronic paroxysmal hemicrania (CPH) is an unusual cause of headache, affecting predominantly women in the third to fourth decade. It is characterized by multiple attacks of unilateral pain, mostly located in fronto-orbito-temporal region, often associated with autonomic symptoms, such as lacrymation, conjunc-tival hyperaemia and nasal obstruction or rhinor-rhea. Each attack usually lasts from 2 to 45 min and as diagnostic criteria it should be absolutely respon-sive to indomethacin in varying doses (1). Since the first description and definition of diag-nostic criteria, few cases of CPH have been described in children. We report a 10 years-old girl with symp-toms beginning since early childhood. Case report
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology, 2003
AIM This study was aimed at assessing the clinical performances of a NaI(Tl) crystal 3D PET scann... more AIM This study was aimed at assessing the clinical performances of a NaI(Tl) crystal 3D PET scanner, C-PET (ADAC-UGM), using a multi-ring 2D BGO PET scanner (multi-ring PET), as a reference. METHODS Thirty-seven oncological patients were studied in sequence with multi-ring PET and C-PET, within 30 days of a CT study. In order to assess the behaviour of C-PET in relation to acquisition count rate, patients were divided into 3 groups according to the count rate at the time of the C-PET scan acquisition. Group A (n=21): 3000-5000 kcounts/sec (recommended count rate range); Group B (n=8): <3000 Kcounts/sec and Group C (n=8): >5000 Kcounts/sec. RESULTS The number of lesions detected by multi-ring PET and C-PET, classified according to size, was compared. For Group A and Group B there was a good agreement between C-PET and multi-ring PET in terms of lesion detectability (relative sensitivity: 99.9% and 96.0%, respectively), while for Group C the relative sensitivity of C-PET was 61....
The engineering development and outcomes of distal humeral hemiarthroplasty (DHH) have gained inc... more The engineering development and outcomes of distal humeral hemiarthroplasty (DHH) have gained increasing interest for the utilization of these implants in a new large horizon of clinical scenario. This chapter will focus on the spectrum of the surgical indications and the expected results of DHH.
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