Summary. Background: Glycoprotein (GP)VI is the major signaling receptor for collagen on platelets and signals via the associated FcRc-chain, which has an immunoreceptor tyrosine- containing activation motif (ITAM). Objective: To... more
Summary. Background: Glycoprotein (GP)VI is the major signaling receptor for collagen on platelets and signals via the associated FcRc-chain, which has an immunoreceptor tyrosine- containing activation motif (ITAM). Objective: To determine why GPVI-FcRc signals poorly, or not at all, in response to collagen in hematopoietic cell lines, despite robust responses to the GPVI-reactive snake venom toxin convulxin. Methods and results:
