A 4 year-old nulliparous mongrel dog with a history of pseudopregnancy was presented for examinat... more A 4 year-old nulliparous mongrel dog with a history of pseudopregnancy was presented for examination. The dog presented erythema, tenderness and enlargement of the right inguinal and left caudal abdominal mammary glands with bloody discharges. Hematological and biochemical evaluation revealed leukocytosis with a shift to the left and increased glucose, cholesterol and triglyceride levels. Based on history, the animal was suspected of having diabetes mellitus. Cytological evaluation of milk showed numerous white blood cells with predominant cell type of degenerate neutrophils containing rod and coccoid bacteria. The pH of bloody milk was 8 and bacteriological culture revealed Staphylococcus intermedius, Bacillus cereus and Pseudomonas auroginosa infection. In spite of cabergolin and antibiotic therapy with ceftriaxone and control of diabetes, no clinical improvement was observed. Ceftazidime was given based on an antibiogram result but after 2 weeks due to slow clinical improvement, ...
Case Description- A six-month-old Doberman Pinscher male with sever laceration in the mucosa of t... more Case Description- A six-month-old Doberman Pinscher male with sever laceration in the mucosa of the lip, nose and nostrils as well as the shoulder area was referred to Veterinary Hospital of Shahid Bahonar University of Kerman. Clinical Findings- The animal showed anorexia, depression, and sialorrhea. There was also a deep laceration over the right shoulder. Treatment and Outcome- Surgery was performed under general anesthesia. Submocusa and mocusa were sutured in separate layer using simple interrupted pattern of absorbable suture material, and the skin of the nostril was reconstructed with the same pattern and non-absorbable suture material. Clinical Relevance- Injuries of the oral cavity in dogs happen in a variety of conditions. This report describes surgical reconstruction of lip and muzzle laceration in a Doberman pinscher
Conjoined twinning has been reported in most domestic animal species. It occurs extremely rarely ... more Conjoined twinning has been reported in most domestic animal species. It occurs extremely rarely in horses, occasionally in dogs and cats and more commonly in cattle than in the other ruminants. A pregnant ewe was referred to the Veterinary Clinic of Shahid Bahonar University of Kerman for dystocia, and a male dicephalic lamb was delivered, which survived for 8 hours. It was a co-twin to another male lamb which was clinically normal. After macroscopic and C.T. examination the lamb was carefully dissected and histopathologic slices from the testis, lymph nodes, spleen, liver, kidneys, lung, fore stomachs and abomasum were taken, prepared routinely and stained with hematoxylin and eosin. In this study the anomalies which were seen can be categorized to complete and incomplete duplication, lack of fusion and axial deviation. Key words: lamb, diprosopus, spina bifida, kyphoscoliosis
Today, on the contrary of the last ten decades, the necessity of teaching hygienic issues, and ca... more Today, on the contrary of the last ten decades, the necessity of teaching hygienic issues, and caring the children's health, is pretty obvious. Avicenna (10 AC), the famous Iranian physician and philosopher, scrutinized the health and hygiene with a deep insight to the matter. He considered the wellness not only as the recovery from the disease, but emphasized the maintenance of health by suggesting special points and instructions. In Islamic education, paying attention to cleanliness, health and physical strength is very important and considered as the intermediate goals for the achievement of "pure life", which is the ultimate goal. Avicenna paid special attention to physical purity, health and wellness, and devoted the major parts of his book to them. The present article analyzes the Avicenna's educational opinions, specially his viewpoints regarding hygiene and health in three stages of childhood, teenage years, and youth.
Objective- In the present study the role of essential oil of Salvia rhtidia (SR), in ameliorating... more Objective- In the present study the role of essential oil of Salvia rhtidia (SR), in ameliorating renal ischemia reperfusion (IR) injuries is evaluated. Design- Experimental in vivo study. Animals- 48 male healthy Wistar rats between 250-300 grams. Procedures- The animals were randomly divided into eight groups of six rats. In ischemic groups (groups A-D), under general anesthesia both renal pedicles were approach from ventral midline and occluded for 40 min by Rumel tourniquet. Groups A and B received SR essential oil 48, 24 and 1 h before operation, whereas group C and D received the same volume of normal saline (NS). In Sham groups (E-H) all the procedures were like groups A-D, except occluding the renal pedicles. The period of reperfusion in
Objective- To evaluate the effects of venesection and vitamin C on systemic renal and hepatic les... more Objective- To evaluate the effects of venesection and vitamin C on systemic renal and hepatic lesions after limb ischemia-reperfusion in rabbit. Design- Experimental study. Animals- 20 male white New Zealand rabbits between 2.5-3 kg, randomly assigned in 5 equal groups. Procedures- After general anesthesia right femoral artery and vein were approached from inguinal region. In treatment and control groups the ischemia was induced by occlusion of both vessels for six hours, using a Rumel tourniquet. The same procedures were performed for sham groups, except the occluding of the vessels. In treatment1 and sham1 groups, 500 mg/kg vitamin C was injected intramuscularly during 30 min before occluding of the vessels and before the end of the operation, respectively. The same volume of normal saline was injected in control and sham 2 groups. For animals in the treatment 2 group, at the end of the ischemic period, the arterial tourniquet was released to allow arterial inflow before commencem...
BackgroundEugenol (EG) is an effective factor in disbudding by clove essential oil. Therefore, th... more BackgroundEugenol (EG) is an effective factor in disbudding by clove essential oil. Therefore, this study was conducted to investigate the hematological and clinical effects of disbudding using EG in goat kids. The aim of this study was to compered the stress level, blood biochemical parameters, and some vital organ enzymes in goat kids following disbudding by eugenol and cautery. The 25 Raieni (Cashmere) goat kids (5-day-old) were randomly assigned to five equal groups (n=5).ResultsThe cortisol serum level immediately after disbudding in group 2 was 7.94±0.7 µg/dL, vs. group 4, 6.34±0.55 (mean ± SE), immediately after disbudding respiratory rate in group 3 was 77±16.97 vs. group 1, 108±28.28, also pulse rate in group 3 was 239.4±28.26 vs. group 1, 284±38.36; and rectal temperature showed no significant difference (P<0.05).ConclusionAccording to the results disbudding by EG induced less stress and pain compared to disbudding by cautery in goat kids (P<0.05). Analysis of specif...
Objective- To evaluate the role of autogenous bone marrow (BM), in the healing of experimentally... more Objective- To evaluate the role of autogenous bone marrow (BM), in the healing of experimentally induced burn wound in rats. Design- Experimental in-vivo study. Animals- 20 adult male white New Zealand rabbits. Procedures- Two burn wounds were created under general anesthesia using a 100 W electric soldering iron, heated to the point of redness (about 800° C) on each side of the back, 4 cm apart. 2 mg/kg morphine was injected intramuscularly twice daily for four days to control pain. The scab was removed from the wound 48 hours after the wound creation, when daily rinsing the wounds with normal saline began and continued until the end of the study. 48 hours after the wound creation, 1 ml BM was aspirated from left tibial plateau and injected around the wounds of the treatment group at four points, (0.2 ml at each site). The same amount of normal saline was injected around the wounds of the control group. Half of the animals were sacrificed on day 7 and the rest, on day 14 for b...
Objective- To evaluate the effects of venesection and vitamin C on systemic renal and hepatic les... more Objective- To evaluate the effects of venesection and vitamin C on systemic renal and hepatic lesions after limb ischemia-reperfusion in rabbit. Design- Experimental study. Animals- 20 male white New Zealand rabbits between 2.5-3 kg, randomly assigned in 5 equal groups. Procedures- After general anesthesia right femoral artery and vein were approached from inguinal region. In treatment and control groups the ischemia was induced by occlusion of both vessels for six hours, using a Rumel tourniquet. The same procedures were performed for sham groups, except the occluding of the vessels. In treatment1 and sham1 groups, 500 mg/kg vitamin C was injected intramuscularly during 30 min before occluding of the vessels and before the end of the operation, respectively. The same volume of normal saline was injected in control and sham 2 groups. For animals in the treatment 2 group, at the end of the ischemic period, the arterial tourniquet was released to allow arterial inflow before commencem...
Liquorice root extract (LE) has been used from long ago as an effective medication, especially in... more Liquorice root extract (LE) has been used from long ago as an effective medication, especially in gastric ulcer. In this study, the healing potential of aqueous LE on dermal wounds was evaluated. The study was carried out on 45 male Spragne-Dawly rats. Two uniform 7mm- diameter skin defects were created on the back of each animal by 7mm skin punch (total of 90 wounds). LE was applied once daily on half of the wounds for 7 days, after which the animals were sacrificed for histopathological, biochemical (hydroxyproline content) and biomechanical studies. The ultimate surface area of the wounds was also measured. LE caused a significant increase in the number of fibroblasts and capillary buds, collagen contents and tensile strength of the wounds. The wound surface area in the treatment group was also significantly less than the control group. It can be concluded that LE is an effective herbal remedy in wound healing.
Case Description- An Arabian 10-mounth-old filly with a large mass on the left lateral side of th... more Case Description- An Arabian 10-mounth-old filly with a large mass on the left lateral side of the neck was referred to the Department of Surgery, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Shahid Bahnoar University of Kerman. Clinical Findings- In clinical examination a large, ulcerated mass (12×10×4cm diameter) was detected on left lateral side of the neck, covered with some serosangeneous discharge. Vital parameters (heart rate, respiratory rate, body temperature) were within normal range. Treatment and Outcome-The surgery was performed under general inhalation anesthesia and the mass was removed en bloc. Histopathological examination of the mass showed a large number of eosinophils infiltrated within the dermis and superficial hypodermis, which was diagnosed as eosinophilic granuloma. Clinical Relevance- This benign tumor is relatively common in horse which is caused mostly due to hypersensitivity reaction to some unknown allergens and chemicals and most of th...
The present study was designed to evaluate the effects of platelet growth factors and periosteal ... more The present study was designed to evaluate the effects of platelet growth factors and periosteal mesenchymal stem cells on bone healing process, radiographically. Forty male White New Zealand rabbits in five equal groups were used in this study. A 2 mm full thickness bone defect was made in left radial bone of each animal. In group A (control) the defect was left with no medical intervention. In group B the defect was covered by a fibrin membrane. In group C the defect was covered by a fibrin membrane plus platelet growth factors. In group D the defect was covered by a fibrin membrane plus periosteal mesenchymal stem cells, and in group E the defect was covered by a fibrin membrane enriched with platelet growth factors and periosteal mesenchymal stem cells. Radiological evaluation was done immediately after surgery (week 0) and then at the 1st, 2nd, 4th, 6th and 8th weeks after operation. At the end of the eighth week, bone samples were taken to evaluate the histopathology. The radi...
Objective- To evaluate the healing potential of oleaster leave water soluble extract on skin woun... more Objective- To evaluate the healing potential of oleaster leave water soluble extract on skin wounds. Design- Experimental study. Animals- 30 male Sprague-Dawley rats, randomly assigned in two equal groups. Procedures- Under general anesthesia, and following surgical preparation, two uniform skin defects were made by 7mm skin punch. The water soluble extract was then applied on half of the wounds for 7 days. The animals were sacrificed on day 8 and histopathological and biomechanical samples were taken. Wound planimetry was also performed. Results- All the evaluated parameters in histopathological and biomechanical studies were significantly superior in treatment group in comparison with the control one. The surface area of the treatment wounds were also significantly less than the control wounds. Conclusion and Clinical Relevance- This study showed that oleaster leave extract has a pro-healing effect on the experimental skin wounds and it can be considered as an available herbal pr...
Objective- To evaluate the effects of Artemisia sieberi extract on experimental dermal wounds hea... more Objective- To evaluate the effects of Artemisia sieberi extract on experimental dermal wounds healing. Design- Experimental study.Animals- 30 male Spragne-Dawly rats. Procedures- Two uniform 7 mm diameter skin defect were created on the back of each animal by skinpunch (total of 60 wounds). Then, the extract of the plant was applied once daily on half of the wounds forhistopathological and biomechanical examinations. Results- Artemisia sieberi extract caused a significant increase in the number of fibroblasts and capillarybuds and also significant decrease in the epithelial gap which showed the better formation of healing tissuein treatment group. On the other hand, the improvement of biomechanical indices in treatment group revealed a significant increase in tensile strength of the wounds. Conclusion and Clinical Relevance- It can be concluded that Artemisia sieberi is an effective herbalremedy in wound healing.
The present study described chorangioma in a sheep with clinical signs of dystocia. During surger... more The present study described chorangioma in a sheep with clinical signs of dystocia. During surgery, foetus was not found and both of the uterine horns were distended with a lot of liquid. Multiple welldemarcated nodules of firm consistency, yellow-tan colour and 2.5–4 cm diameter were projected from the cotyledons into the lumens. Histopathologically, the nodules showed expanded chorionic villi composed of proliferated blood vessels in a variable amount of loose perivascular stroma. Syncytial trophoblast cells with hyperchromatic nucleus were dispersed in the tumour’s parenchyma. Based on pathologic characteristics and according to the abundant vascular proliferation and nodular form, a neoplastic lesion named chorangioma was diagnosed. To the author’s knowledge, it is the first report of chorangioma in sheep.
Objective-In the present study the role of essential oil of Salvia rhtidia (SR), in ameliorating ... more Objective-In the present study the role of essential oil of Salvia rhtidia (SR), in ameliorating renal ischemia reperfusion (IR) injuries is evaluated. Design-Experimental in vivo study. Animals-48 male healthy Wistar rats between 250-300 grams. Procedures-The animals were randomly divided into eight groups of six rats. In ischemic groups (groups A-D), under general anesthesia both renal pedicles were approach from ventral midline and occluded for 40 min by Rumel tourniquet. Groups A and B received SR essential oil 48, 24 and 1 h before operation, whereas group C and D received the same volume of normal saline (NS). In Sham groups (E-H) all the procedures were like groups A-D, except occluding the renal pedicles. The period of reperfusion in groups A, C, E, and G was 1hour, whereas in groups B, D, F, and H was 24 hours, when blood samples were taken to evaluate blood urea nitrogen (BUN) and creatinine followed by sacrificing the animals for histopathological and ultrastructural stud...
Objective-To evaluate the effects of venesection and vitamin C on systemic renal and hepatic lesi... more Objective-To evaluate the effects of venesection and vitamin C on systemic renal and hepatic lesions after limb ischemia-reperfusion in rabbit. Design-Experimental study. Animals-20 male white New Zealand rabbits between 2.5-3 kg, randomly assigned in 5 equal groups. Procedures-After general anesthesia right femoral artery and vein were approached from inguinal region. In treatment and control groups the ischemia was induced by occlusion of both vessels for six hours, using a Rumel tourniquet. The same procedures were performed for sham groups, except the occluding of the vessels. In treatment1 and sham1 groups, 500 mg/kg vitamin C was injected intramuscularly during 30 min before occluding of the vessels and before the end of the operation, respectively. The same volume of normal saline was injected in control and sham 2 groups. For animals in the treatment 2 group, at the end of the ischemic period, the arterial tourniquet was released to allow arterial inflow before commencement ...
A 4 year-old nulliparous mongrel dog with a history of pseudopregnancy was presented for examinat... more A 4 year-old nulliparous mongrel dog with a history of pseudopregnancy was presented for examination. The dog presented erythema, tenderness and enlargement of the right inguinal and left caudal abdominal mammary glands with bloody discharges. Hematological and biochemical evaluation revealed leukocytosis with a shift to the left and increased glucose, cholesterol and triglyceride levels. Based on history, the animal was suspected of having diabetes mellitus. Cytological evaluation of milk showed numerous white blood cells with predominant cell type of degenerate neutrophils containing rod and coccoid bacteria. The pH of bloody milk was 8 and bacteriological culture revealed Staphylococcus intermedius, Bacillus cereus and Pseudomonas auroginosa infection. In spite of cabergolin and antibiotic therapy with ceftriaxone and control of diabetes, no clinical improvement was observed. Ceftazidime was given based on an antibiogram result but after 2 weeks due to slow clinical improvement, ...
Case Description- A six-month-old Doberman Pinscher male with sever laceration in the mucosa of t... more Case Description- A six-month-old Doberman Pinscher male with sever laceration in the mucosa of the lip, nose and nostrils as well as the shoulder area was referred to Veterinary Hospital of Shahid Bahonar University of Kerman. Clinical Findings- The animal showed anorexia, depression, and sialorrhea. There was also a deep laceration over the right shoulder. Treatment and Outcome- Surgery was performed under general anesthesia. Submocusa and mocusa were sutured in separate layer using simple interrupted pattern of absorbable suture material, and the skin of the nostril was reconstructed with the same pattern and non-absorbable suture material. Clinical Relevance- Injuries of the oral cavity in dogs happen in a variety of conditions. This report describes surgical reconstruction of lip and muzzle laceration in a Doberman pinscher
Conjoined twinning has been reported in most domestic animal species. It occurs extremely rarely ... more Conjoined twinning has been reported in most domestic animal species. It occurs extremely rarely in horses, occasionally in dogs and cats and more commonly in cattle than in the other ruminants. A pregnant ewe was referred to the Veterinary Clinic of Shahid Bahonar University of Kerman for dystocia, and a male dicephalic lamb was delivered, which survived for 8 hours. It was a co-twin to another male lamb which was clinically normal. After macroscopic and C.T. examination the lamb was carefully dissected and histopathologic slices from the testis, lymph nodes, spleen, liver, kidneys, lung, fore stomachs and abomasum were taken, prepared routinely and stained with hematoxylin and eosin. In this study the anomalies which were seen can be categorized to complete and incomplete duplication, lack of fusion and axial deviation. Key words: lamb, diprosopus, spina bifida, kyphoscoliosis
Today, on the contrary of the last ten decades, the necessity of teaching hygienic issues, and ca... more Today, on the contrary of the last ten decades, the necessity of teaching hygienic issues, and caring the children's health, is pretty obvious. Avicenna (10 AC), the famous Iranian physician and philosopher, scrutinized the health and hygiene with a deep insight to the matter. He considered the wellness not only as the recovery from the disease, but emphasized the maintenance of health by suggesting special points and instructions. In Islamic education, paying attention to cleanliness, health and physical strength is very important and considered as the intermediate goals for the achievement of "pure life", which is the ultimate goal. Avicenna paid special attention to physical purity, health and wellness, and devoted the major parts of his book to them. The present article analyzes the Avicenna's educational opinions, specially his viewpoints regarding hygiene and health in three stages of childhood, teenage years, and youth.
Objective- In the present study the role of essential oil of Salvia rhtidia (SR), in ameliorating... more Objective- In the present study the role of essential oil of Salvia rhtidia (SR), in ameliorating renal ischemia reperfusion (IR) injuries is evaluated. Design- Experimental in vivo study. Animals- 48 male healthy Wistar rats between 250-300 grams. Procedures- The animals were randomly divided into eight groups of six rats. In ischemic groups (groups A-D), under general anesthesia both renal pedicles were approach from ventral midline and occluded for 40 min by Rumel tourniquet. Groups A and B received SR essential oil 48, 24 and 1 h before operation, whereas group C and D received the same volume of normal saline (NS). In Sham groups (E-H) all the procedures were like groups A-D, except occluding the renal pedicles. The period of reperfusion in
Objective- To evaluate the effects of venesection and vitamin C on systemic renal and hepatic les... more Objective- To evaluate the effects of venesection and vitamin C on systemic renal and hepatic lesions after limb ischemia-reperfusion in rabbit. Design- Experimental study. Animals- 20 male white New Zealand rabbits between 2.5-3 kg, randomly assigned in 5 equal groups. Procedures- After general anesthesia right femoral artery and vein were approached from inguinal region. In treatment and control groups the ischemia was induced by occlusion of both vessels for six hours, using a Rumel tourniquet. The same procedures were performed for sham groups, except the occluding of the vessels. In treatment1 and sham1 groups, 500 mg/kg vitamin C was injected intramuscularly during 30 min before occluding of the vessels and before the end of the operation, respectively. The same volume of normal saline was injected in control and sham 2 groups. For animals in the treatment 2 group, at the end of the ischemic period, the arterial tourniquet was released to allow arterial inflow before commencem...
BackgroundEugenol (EG) is an effective factor in disbudding by clove essential oil. Therefore, th... more BackgroundEugenol (EG) is an effective factor in disbudding by clove essential oil. Therefore, this study was conducted to investigate the hematological and clinical effects of disbudding using EG in goat kids. The aim of this study was to compered the stress level, blood biochemical parameters, and some vital organ enzymes in goat kids following disbudding by eugenol and cautery. The 25 Raieni (Cashmere) goat kids (5-day-old) were randomly assigned to five equal groups (n=5).ResultsThe cortisol serum level immediately after disbudding in group 2 was 7.94±0.7 µg/dL, vs. group 4, 6.34±0.55 (mean ± SE), immediately after disbudding respiratory rate in group 3 was 77±16.97 vs. group 1, 108±28.28, also pulse rate in group 3 was 239.4±28.26 vs. group 1, 284±38.36; and rectal temperature showed no significant difference (P<0.05).ConclusionAccording to the results disbudding by EG induced less stress and pain compared to disbudding by cautery in goat kids (P<0.05). Analysis of specif...
Objective- To evaluate the role of autogenous bone marrow (BM), in the healing of experimentally... more Objective- To evaluate the role of autogenous bone marrow (BM), in the healing of experimentally induced burn wound in rats. Design- Experimental in-vivo study. Animals- 20 adult male white New Zealand rabbits. Procedures- Two burn wounds were created under general anesthesia using a 100 W electric soldering iron, heated to the point of redness (about 800° C) on each side of the back, 4 cm apart. 2 mg/kg morphine was injected intramuscularly twice daily for four days to control pain. The scab was removed from the wound 48 hours after the wound creation, when daily rinsing the wounds with normal saline began and continued until the end of the study. 48 hours after the wound creation, 1 ml BM was aspirated from left tibial plateau and injected around the wounds of the treatment group at four points, (0.2 ml at each site). The same amount of normal saline was injected around the wounds of the control group. Half of the animals were sacrificed on day 7 and the rest, on day 14 for b...
Objective- To evaluate the effects of venesection and vitamin C on systemic renal and hepatic les... more Objective- To evaluate the effects of venesection and vitamin C on systemic renal and hepatic lesions after limb ischemia-reperfusion in rabbit. Design- Experimental study. Animals- 20 male white New Zealand rabbits between 2.5-3 kg, randomly assigned in 5 equal groups. Procedures- After general anesthesia right femoral artery and vein were approached from inguinal region. In treatment and control groups the ischemia was induced by occlusion of both vessels for six hours, using a Rumel tourniquet. The same procedures were performed for sham groups, except the occluding of the vessels. In treatment1 and sham1 groups, 500 mg/kg vitamin C was injected intramuscularly during 30 min before occluding of the vessels and before the end of the operation, respectively. The same volume of normal saline was injected in control and sham 2 groups. For animals in the treatment 2 group, at the end of the ischemic period, the arterial tourniquet was released to allow arterial inflow before commencem...
Liquorice root extract (LE) has been used from long ago as an effective medication, especially in... more Liquorice root extract (LE) has been used from long ago as an effective medication, especially in gastric ulcer. In this study, the healing potential of aqueous LE on dermal wounds was evaluated. The study was carried out on 45 male Spragne-Dawly rats. Two uniform 7mm- diameter skin defects were created on the back of each animal by 7mm skin punch (total of 90 wounds). LE was applied once daily on half of the wounds for 7 days, after which the animals were sacrificed for histopathological, biochemical (hydroxyproline content) and biomechanical studies. The ultimate surface area of the wounds was also measured. LE caused a significant increase in the number of fibroblasts and capillary buds, collagen contents and tensile strength of the wounds. The wound surface area in the treatment group was also significantly less than the control group. It can be concluded that LE is an effective herbal remedy in wound healing.
Case Description- An Arabian 10-mounth-old filly with a large mass on the left lateral side of th... more Case Description- An Arabian 10-mounth-old filly with a large mass on the left lateral side of the neck was referred to the Department of Surgery, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Shahid Bahnoar University of Kerman. Clinical Findings- In clinical examination a large, ulcerated mass (12×10×4cm diameter) was detected on left lateral side of the neck, covered with some serosangeneous discharge. Vital parameters (heart rate, respiratory rate, body temperature) were within normal range. Treatment and Outcome-The surgery was performed under general inhalation anesthesia and the mass was removed en bloc. Histopathological examination of the mass showed a large number of eosinophils infiltrated within the dermis and superficial hypodermis, which was diagnosed as eosinophilic granuloma. Clinical Relevance- This benign tumor is relatively common in horse which is caused mostly due to hypersensitivity reaction to some unknown allergens and chemicals and most of th...
The present study was designed to evaluate the effects of platelet growth factors and periosteal ... more The present study was designed to evaluate the effects of platelet growth factors and periosteal mesenchymal stem cells on bone healing process, radiographically. Forty male White New Zealand rabbits in five equal groups were used in this study. A 2 mm full thickness bone defect was made in left radial bone of each animal. In group A (control) the defect was left with no medical intervention. In group B the defect was covered by a fibrin membrane. In group C the defect was covered by a fibrin membrane plus platelet growth factors. In group D the defect was covered by a fibrin membrane plus periosteal mesenchymal stem cells, and in group E the defect was covered by a fibrin membrane enriched with platelet growth factors and periosteal mesenchymal stem cells. Radiological evaluation was done immediately after surgery (week 0) and then at the 1st, 2nd, 4th, 6th and 8th weeks after operation. At the end of the eighth week, bone samples were taken to evaluate the histopathology. The radi...
Objective- To evaluate the healing potential of oleaster leave water soluble extract on skin woun... more Objective- To evaluate the healing potential of oleaster leave water soluble extract on skin wounds. Design- Experimental study. Animals- 30 male Sprague-Dawley rats, randomly assigned in two equal groups. Procedures- Under general anesthesia, and following surgical preparation, two uniform skin defects were made by 7mm skin punch. The water soluble extract was then applied on half of the wounds for 7 days. The animals were sacrificed on day 8 and histopathological and biomechanical samples were taken. Wound planimetry was also performed. Results- All the evaluated parameters in histopathological and biomechanical studies were significantly superior in treatment group in comparison with the control one. The surface area of the treatment wounds were also significantly less than the control wounds. Conclusion and Clinical Relevance- This study showed that oleaster leave extract has a pro-healing effect on the experimental skin wounds and it can be considered as an available herbal pr...
Objective- To evaluate the effects of Artemisia sieberi extract on experimental dermal wounds hea... more Objective- To evaluate the effects of Artemisia sieberi extract on experimental dermal wounds healing. Design- Experimental study.Animals- 30 male Spragne-Dawly rats. Procedures- Two uniform 7 mm diameter skin defect were created on the back of each animal by skinpunch (total of 60 wounds). Then, the extract of the plant was applied once daily on half of the wounds forhistopathological and biomechanical examinations. Results- Artemisia sieberi extract caused a significant increase in the number of fibroblasts and capillarybuds and also significant decrease in the epithelial gap which showed the better formation of healing tissuein treatment group. On the other hand, the improvement of biomechanical indices in treatment group revealed a significant increase in tensile strength of the wounds. Conclusion and Clinical Relevance- It can be concluded that Artemisia sieberi is an effective herbalremedy in wound healing.
The present study described chorangioma in a sheep with clinical signs of dystocia. During surger... more The present study described chorangioma in a sheep with clinical signs of dystocia. During surgery, foetus was not found and both of the uterine horns were distended with a lot of liquid. Multiple welldemarcated nodules of firm consistency, yellow-tan colour and 2.5–4 cm diameter were projected from the cotyledons into the lumens. Histopathologically, the nodules showed expanded chorionic villi composed of proliferated blood vessels in a variable amount of loose perivascular stroma. Syncytial trophoblast cells with hyperchromatic nucleus were dispersed in the tumour’s parenchyma. Based on pathologic characteristics and according to the abundant vascular proliferation and nodular form, a neoplastic lesion named chorangioma was diagnosed. To the author’s knowledge, it is the first report of chorangioma in sheep.
Objective-In the present study the role of essential oil of Salvia rhtidia (SR), in ameliorating ... more Objective-In the present study the role of essential oil of Salvia rhtidia (SR), in ameliorating renal ischemia reperfusion (IR) injuries is evaluated. Design-Experimental in vivo study. Animals-48 male healthy Wistar rats between 250-300 grams. Procedures-The animals were randomly divided into eight groups of six rats. In ischemic groups (groups A-D), under general anesthesia both renal pedicles were approach from ventral midline and occluded for 40 min by Rumel tourniquet. Groups A and B received SR essential oil 48, 24 and 1 h before operation, whereas group C and D received the same volume of normal saline (NS). In Sham groups (E-H) all the procedures were like groups A-D, except occluding the renal pedicles. The period of reperfusion in groups A, C, E, and G was 1hour, whereas in groups B, D, F, and H was 24 hours, when blood samples were taken to evaluate blood urea nitrogen (BUN) and creatinine followed by sacrificing the animals for histopathological and ultrastructural stud...
Objective-To evaluate the effects of venesection and vitamin C on systemic renal and hepatic lesi... more Objective-To evaluate the effects of venesection and vitamin C on systemic renal and hepatic lesions after limb ischemia-reperfusion in rabbit. Design-Experimental study. Animals-20 male white New Zealand rabbits between 2.5-3 kg, randomly assigned in 5 equal groups. Procedures-After general anesthesia right femoral artery and vein were approached from inguinal region. In treatment and control groups the ischemia was induced by occlusion of both vessels for six hours, using a Rumel tourniquet. The same procedures were performed for sham groups, except the occluding of the vessels. In treatment1 and sham1 groups, 500 mg/kg vitamin C was injected intramuscularly during 30 min before occluding of the vessels and before the end of the operation, respectively. The same volume of normal saline was injected in control and sham 2 groups. For animals in the treatment 2 group, at the end of the ischemic period, the arterial tourniquet was released to allow arterial inflow before commencement ...
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