An innovative form of administration of amphotericin B deoxycholate (namely, continuous infusion)... more An innovative form of administration of amphotericin B deoxycholate (namely, continuous infusion) was proposed to reduce the toxicity of the drug while maintaining good antifungal efficacy. Continuous infusion of amphotericin B deoxycholate has been studied for the ...
The combination of amphotericin B and sodium deoxycholate is the formulation most used in clinica... more The combination of amphotericin B and sodium deoxycholate is the formulation most used in clinical practice. The development of new agents such as amphotericin with lipid formulations, caspofungin, voriconazole and other azolic derivatives, promoted alternatives to amphotericin B deoxycholate. However, because of the high cost of these new drugs, their use is difficult in a scenario of limited resources. A few strategies have been devised to make the use of amphotericin B deoxycholate less toxic. In this review, we seek to describe the accumulated knowledge about this molecule, with focus on its use in continuous infusion, which appears to be an alternative to reduce toxicity, while maintaining its clinical efficacy.
An innovative form of administration of amphotericin B deoxycholate (namely, continuous infusion)... more An innovative form of administration of amphotericin B deoxycholate (namely, continuous infusion) was proposed to reduce the toxicity of the drug while maintaining good antifungal efficacy. Continuous infusion of amphotericin B deoxycholate has been studied for the ...
The combination of amphotericin B and sodium deoxycholate is the formulation most used in clinica... more The combination of amphotericin B and sodium deoxycholate is the formulation most used in clinical practice. The development of new agents such as amphotericin with lipid formulations, caspofungin, voriconazole and other azolic derivatives, promoted alternatives to amphotericin B deoxycholate. However, because of the high cost of these new drugs, their use is difficult in a scenario of limited resources. A few strategies have been devised to make the use of amphotericin B deoxycholate less toxic. In this review, we seek to describe the accumulated knowledge about this molecule, with focus on its use in continuous infusion, which appears to be an alternative to reduce toxicity, while maintaining its clinical efficacy.
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