Independent academic researcher on clinical practice of pharmacology, medical treatment counseling, rational prescribing, antibiotic resistance and arsenicosis.Professor of Pharmacology, HFRCMCManaging Editor, JMSRSecretary, IERCMedical Counselor, FHMC
Background Ensuring an appropriate continuum of care in maternal, newborn, and child health, as w... more Background Ensuring an appropriate continuum of care in maternal, newborn, and child health, as well as providing nutrition care, is challenging in remote areas. To make care accessible for mothers and infants, we developed a telehealth care system called Portable Health Clinic for Maternal, Newborn, and Child Health. Objective Our study will examine the telehealth care system’s effectiveness in improving women’s and infants’ care uptake and detecting their health problems. Methods A quasi-experimental study will be conducted in rural Bangladesh. Villages will be allocated to the intervention and control areas. Pregnant women (≥16 gestational weeks) will participate together with their infants and will be followed up 1 year after delivery or birth. The intervention will include regular health checkups via the Portable Health Clinic telehealth care system, which is equipped with a series of sensors and an information system that can triage participants’ health levels based on the res...
Background:Antibiotic resistance is a global crisis posing a considerable threat, especially, to ... more Background:Antibiotic resistance is a global crisis posing a considerable threat, especially, to developing countries and can cause 10 million deaths by 2050. Medical students as future doctors play an essential role in promoting the rational use of antibiotics. The objectives of this study were to evaluate the respondents’ knowledge, attitude and practice (KAP) regarding antibiotic use, antibiotic self-medication, and antibiotic resistance and compare the KAP among different subgroups of respondents at KIST Medical College, Lalitpur, Nepal. Methods: A cross-sectional study was done among final year medical students and interns from September to October 2019. A structured questionnaire with 22 statements for assessing knowledge, 13 statements for attitude and 12 statements for practice was used as a data collection tool. Differences in the KAP scores among different subgroups were studied using appropriate statistical tests. Results: A total of 131 respondents participated, and ...
Background: The objective was to perceive the demographic characteristics, clinical symptoms, com... more Background: The objective was to perceive the demographic characteristics, clinical symptoms, comorbidities, and biomarkers (hematological, inflammatory, hepatic, renal, and metabolic) of Intensive Care Unit admitted survivors and deceased patients with coronavirus and link with ABO system admitted to a tertiary level hospital in Dhaka, Bangladesh. Methods: It was a retrospective cohort, conducted in Holy Family Red Crescent Medical College Hospital, dedicated to COVID-19 at Dhaka, Bangladesh from 15th May to 9th September 2020. All 112 patients admitted to ICU diagnosed as COVID-19 cases (RT-PCR of the nasopharyngeal swab) were included in the study. Demographic data, prognostic biomarkers of 76 ICU patients were available and found from hospital records (non-electronic) and treatment sheets, and compared between the survived and deceased patients.
Background: Pneumonia acquired outside the hospital by an immune-competent individual is defined ... more Background: Pneumonia acquired outside the hospital by an immune-competent individual is defined as community acquired pneumonia (CAP). It is to be distinguished, on the basis of a wider spectrum of pathogens, from nosocomial pneumonia from pneumonia in an immune-compromised host. Community-acquired pneumonia is associated with a significant mortality and morbidity. Etiology of CAP varies geographically and the understanding of local epidemiology plays an important role in decision making for empirical treatment before test results are available. Primary decisions about empirical antimicrobial treatment required knowledge of predominant microbial patterns and their sensitivities. Objectives: The aim of this study was to identify the bacterial etiology of CAP, their sensitivity towards empirical therapy and to observe the clinical course as well as short term outcome in hospitalized adult patients. Methodology: It was one year-long observational prospective study on 87 patients diagn...
Background: In COVID-19 pandemic increasing the frequency of hand washing and disinfection is the... more Background: In COVID-19 pandemic increasing the frequency of hand washing and disinfection is the most important preventive measure of this disease which is causing in deleterious impact on skin among general population. So the aim of the study was to evaluate whether these measures are associated with development of skin damage. Methods: This was a descriptive type of cross-sectional, observational study conducted over a period of six months from April 2021 to September 2021 including 1166 patients coming to some private clinics in Gazipur with skin manifestations. Skin diseases were diagnosed by dermatologist on basis of clinical morphology with appropriate investigations. Data were collected by structured questionnaire and analyzed using SPSS. Results: Out of 1166 patients, 35.68% reported skin changes or symptoms over hands (ScH), and 13.98% reported skin changes on their face (ScF). Around 87.39% and 86.53% of the participants reported a change in hand washing habits and saniti...
Healthcare professionals are the crucial and influencing source of information for vaccines and t... more Healthcare professionals are the crucial and influencing source of information for vaccines and their communication among patients and communities that can accelerate successful vaccination in a country. This cross-sectional study was one of the first and foremost ones in Bangladesh to observe the basic perception and attitudes towards vaccination against COVID-19 among the healthcare workers (HCWs) - doctors, interns, nurses, ward boys, cleaners, and medical technologists of major COVID-dedicated hospitals. The cross-sectional questionnaire-based study was conducted in February 2021 among 550 HCWs to assess the perception and attitude towards vaccination against COVID-19. The study participants were targeted as the priority group for COVID-19 vaccination, working in two major COVID-dedicated hospitals, Holy Family Red Crescent Medical College Hospital (HF-center), and Sheikh Russel National Gastro-liver Institute and Hospital (SR-center) in Dhaka, Bangladesh during the pandemic. Th...
The rapid progression of corona virus disease in 2019 (COVID-19) pandemic has become an unprecede... more The rapid progression of corona virus disease in 2019 (COVID-19) pandemic has become an unprecedented global concern. This systemic review aimed at evaluating the available evidence on efficacy, safety to identify any promising role for compassionate use of remdesivir in patient suffered for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as re-purposeful use. We searched PubMed, EMBASE, Cochrane Library for randomized controlled trials (RCTs), prospective case series studies and case reports that evaluated use of remdesivir in COVID-19. The outcomes were mortality, recovery rate, length of hospital stay and clinical outcome. Though the drug remdesivir (RDV) is not approved by the FDA, still the "Emergency Use Authorization" (EUA) for compassionate use in severe cases is endorsed. After vigorous searching, screening and sorting of completed and published scientific evidences in electronic database, there were only 2 randomized control trial (RCT), 2 uncontroll...
Stroke is one of the commonest causes of mortality among the world. Hemorrhagic stroke accounts n... more Stroke is one of the commonest causes of mortality among the world. Hemorrhagic stroke accounts nearly 15% of all the strokes. Different risk factors have been identified, of them hypertension, anti-coagulation therapy and previous history of ischemic strokes are significant. Regarding the genetic causes of intracerebral hemorrhage (ICH) monogenic causes play a small role. It was found that Apolipoprotein E (APOE) gene has a strong association with ICH. This is a 299 amino acids long protein located in chromosome 19. APOE has three alleles, they are epsilon 2, 3 and 4. Total 10 meta-analysis were reviewed in this article which involved 52,705 participants. When looking for the association, ∈2 and ∈4 showed positive and ∈3 showed negative association with ICH. Association of ∈4 (OR mean 1.77) was stronger than that of ∈2 (OR mean 1.71).
<jats:p>Irrational use of medicine is a major problem worldwide. Phartnaceutical drug promo... more <jats:p>Irrational use of medicine is a major problem worldwide. Phartnaceutical drug promotion is a means of informing health professionals about new drugs. The approach is often unethical and inappropriate and may promote irrational prescribing. Sources of drug information are one of the important indicators of irrational drug use by the practitioners in developing countries. A randomized cross sectional study was done to evaluate and empire the knowledge about drug information and indicators of rational drug use among the practitioners in Dhaka city. 183 practitioners were randomly selected and interviewed in Iwo groups. Ninety of them were selected from Holy Family Red Crescent Medical College (HFRCMC) an autonomous teaching hospital in Dhaka city. Ninety three practitioners front non-teaching hospitals of Dhaka city were also interviewed by tatijOrm structured questionnaire comprising the sources of drug information and rational drug use indicators by WHO and buentational Network for Rational Use of Drug (1NRUD) criteria.. The interviews were taken during February 2010 to July 2010 by the mulergrachtate medical students of third year am! fourth year. 71% doctors of HFRCMC considered the interned and 73% doctors front other group considered the company literature as the source of drug information. Use of medical journal and BDNF was very low in both the groups. The overall awareness and strength of rational prescribing practice was found poor in comparison to 11FRCMC. Most of the practitioners (84% and 71%).were found concerned and informed about the prices of drug that indicates the strength of rational practice of pharmaco economics.</jats:p>
The sudden outbreak of a novel coronavirus in 2019 in Wuhan, China, that rapidly provoked a globa... more The sudden outbreak of a novel coronavirus in 2019 in Wuhan, China, that rapidly provoked a global concern, marked as the third attack of corona virus in the human society that affected the global healthcare system as well as the global economy. Until and unless an effective vaccine is discovered against the virus, the pharmacological intervention by different antivirals is in the run for remedy. The aim of this systematic review was to evaluate the role of favipiravir along with its safety and efficacy for the patients who are suffering from severe acute respiratory distress syndrome due to CoronaVirus-2 (SARS-CoV-2) as re-purposeful use. We searched PubMed, EMBASE for randomized controlled trials (RCTs), cilicaltrial.com for registered on going trails to evaluate the pros and cons of using favipiravir in COVID-19. After vigorous searching, screening and sorting of 314 articles for completed and published scientific evidences in electronic database, there were only 2 completed and published randomized control trials (RCT) and 17 ongoing or unpublished trials found until June 2020. The main outcome measures were viral clearance, clinical improvement and adverse events reported and published on 147 patients infected with SARS-CoV2. The 2 completed RCTs showed significantly better treatment effects on disease progression, viral clearance, improved the latency to relief for pyrexia and cough on favipiravir treated patients. Adverse effects caused Favipiravir are mild and manageable. Although 9 more RCTs and cohort studies are supposed to be completed by this time that may unveil some evidence for use of anti-RNA-viral drug favipiravir against influenza or Ebola to re-purposing against COVID-19 as adopted in different treatment guidelines.
International Journal Of Community Medicine And Public Health
In recent days rare but aggressive fungal disease in the form of mucormycosis has emerged and bec... more In recent days rare but aggressive fungal disease in the form of mucormycosis has emerged and become a health concern mostly for the patients suffering from severe COVID-19 infection, poorly controlled diabetes mellitus, and patients who receive immunosuppressive therapies for diseases like malignancies. Many studies have demonstrated the relationship between COVID-19, immunosuppressive therapies, diabetes mellitus, and mucormycosis. In diabetes mellitus, poor glycemic control allows the fungi to produce pathogenesis. On the other hand, immunosuppression causes compromised neutrophil function that inhibits phagocytosis and the fusion of phagolysosome. Epidemiological data has proved that the incidence of mucormycosis from a global perspective has been on the rise and it has an association with an increasing number of diabetic cases in the world. In countries like India, Nepal, and Bangladesh where the number of diabetic and cancer patients has been growing constantly, mucormycosis c...
Pneumonia is a worldwide, serious threat to health and an enormous socio-economic burden for heal... more Pneumonia is a worldwide, serious threat to health and an enormous socio-economic burden for health care system. Community-acquired pneumonia (CAP) is associated with a significant mortality and morbidity. Knowledge of predominant microbial patterns in CAP constitutes the basis for initial decisions about empirical antimicrobial treatment. The aim of this study was to identify the bacterial etiology of CAP in adult hospitalized patients and to see their antibiotic sensitivity pattern as well as to observe their clinical profile and short term outcome. It was a hospital based prospective observational study. A total of 87 hospitalized patients diagnosed with CAP were enrolled consecutively from the medicine ward of Chittagong Medical College Hospital (CMCH). Sputum for Gram staining, Z N staining, culture sensitivity, blood culture and sensitivity and PCR for Legionella pneumophila, Mycoplasma pneumoniae, Chlamydophila pneumonia and Streptococcus pneumonia were done. Patients were fo...
Antigamente conhecida como Lepra, a Hanseníase possui como agente etiológico o Micobacterium lepr... more Antigamente conhecida como Lepra, a Hanseníase possui como agente etiológico o Micobacterium leprae, sendo caracterizada pela OMS, como uma Doença Tropical Negligenciada. Com base na gravidade da doença e no problema de saúde pública que ela representa, esta pesquisa objetivou analisar o perfil epidemiológico dos casos de hanseníase no município de Cascavel-PR, no período de 2013 a 2018, através de dados do Sistema de Informação de Agravos de Notificação-SINAN. Trata-se de um estudo observacional, transversal, de abordagem quantitativa e de natureza descritiva, realizado mediante análise de fichas de notificação do SINAN. Pode-se observar, no período estudado, a predominância de casos no sexo masculino em relação ao sexo feminino. A faixa etária que teve um número maior de casos, prevaleceu entre 35 a >60 anos; a classificação mais significativa foi a multibacilar e a forma clinica mais encontrada a dimorfa, com maior predomínio de casos na periferia do município. Diante das inf...
Since the first detection of a cluster of COVID-19 patients in China in late 2019, it becomes a g... more Since the first detection of a cluster of COVID-19 patients in China in late 2019, it becomes a global concern due to its transmissibility and ability to progress patients in severe respiratory failure and acute respiratory distress syndrome, which need intensive care unit support for a long time. We observed the repurposing use of remdesivir and favipiravir whether considered as a therapeutic option or not through survival rate and changes in biomarker during 10-day treatment stay in ICU. The retrospective observational study in a tertiary care hospital dedicated to COVID-19 at Dhaka, Bangladesh was done at the peak of COVID-19 pandemic in Bangladesh. The mortality rate, length of ICU stays and eight prognostic biomarkers of patients treated with remdesivir and favipiravir was observed as one of the first ever reported experience in Bangladesh. Among the critically ill patients in ICU, 26 (44.8%) died and 32 (55.2%) were cured during the study period and highest mean duration of st...
The study was designed to compare the hypoglycemic effects of coconut water extract of Picralima ... more The study was designed to compare the hypoglycemic effects of coconut water extract of Picralima nitida seeds to that of Daonil in alloxan-induced diabetic albino rats. Twenty five albino rats weighing between 170 - 200 g were randomly divided into five groups after allowing the rats to acclimatize for seven days and were made diabetic by intraperitoneal administration of 150 mg/kg of alloxan. The rats were giving different volumes of the extract and Daonil as per their groupings. All the substances were given for five days by oro-gastric tube. The blood glucose level were measured daily in the rats. There was an initial inactivity in the rats following administration of the extract mixture and their appetite was low except for the control group. The blood glucose levels (in mmols/dL) of the rats at the start and end of the experiment for the groups were: control (9.6 ± 0.1 to 9.2 ± 0.1), coconut water only (11.5 ± 0.3 to 6.2 ± 0.1), aqueous extract of P. nitida seeds (12.4 ± 0.1 to...
Background: Dengue is a mosquito-borne viral disease worldwide. The number of new cases and morta... more Background: Dengue is a mosquito-borne viral disease worldwide. The number of new cases and mortality in Bangladesh increased in recent years. This study aims to observe the difference between demographic data, warning signs, high-risk co-morbidity, treatment pattern, and laboratory investigations in two different types of dengue fever during the pick tropical season. Method: This retrospective observational study was done in Holy Family Red Crescent Medical College from May to October 2019 from hospital records of a total of 102 dengue NS1 positive patients. The classical dengue fever (CDF) group consists of 72 patients and the dengue hemorrhagic fever (DHF) group consists of 30 patients. Demographic data, high-risk co-morbidity (pregnancy, old age, DM, HTN), ‘warning sign’ (abdominal tenderness, mucosal bleeding, lethargy, restlessness, persistent vomiting, clinical fluid accumulation, liver enlargement > 2cm, increase HCT, decrease Platelet), treatment pattern, and laboratory ...
Objective: With the rapid increase in the rate of infection, repurposing use of many drugs like a... more Objective: With the rapid increase in the rate of infection, repurposing use of many drugs like antivirals, antibiotics, LMWH, steroid, oxygen therapy were considered as an option to find promising anti-COVID therapeutics. In this study, we aim to observe the extent and variety of drugs used in different clinical categories of COVID-19 patients admitted to hospital in Bangladesh. To observe the requirement of oxygen therapy according to severity was also a prime objective to reveal the overall trend, frequency, and pattern of pharmacotherapy in a COVID-dedicated hospital. Materials and method: A total of 1348 patients were admitted, of whom 473 were included in this single-center retrospective study. The critical group consists of 99 ICU patients, the severe group has 38, moderate was 82 and mild group 254 cases, admitted in the general ward. Hospital records of each patient were screened and information about drug and supportive therapy were collected manually by the researchers in...
Background Ensuring an appropriate continuum of care in maternal, newborn, and child health, as w... more Background Ensuring an appropriate continuum of care in maternal, newborn, and child health, as well as providing nutrition care, is challenging in remote areas. To make care accessible for mothers and infants, we developed a telehealth care system called Portable Health Clinic for Maternal, Newborn, and Child Health. Objective Our study will examine the telehealth care system’s effectiveness in improving women’s and infants’ care uptake and detecting their health problems. Methods A quasi-experimental study will be conducted in rural Bangladesh. Villages will be allocated to the intervention and control areas. Pregnant women (≥16 gestational weeks) will participate together with their infants and will be followed up 1 year after delivery or birth. The intervention will include regular health checkups via the Portable Health Clinic telehealth care system, which is equipped with a series of sensors and an information system that can triage participants’ health levels based on the res...
Background:Antibiotic resistance is a global crisis posing a considerable threat, especially, to ... more Background:Antibiotic resistance is a global crisis posing a considerable threat, especially, to developing countries and can cause 10 million deaths by 2050. Medical students as future doctors play an essential role in promoting the rational use of antibiotics. The objectives of this study were to evaluate the respondents’ knowledge, attitude and practice (KAP) regarding antibiotic use, antibiotic self-medication, and antibiotic resistance and compare the KAP among different subgroups of respondents at KIST Medical College, Lalitpur, Nepal. Methods: A cross-sectional study was done among final year medical students and interns from September to October 2019. A structured questionnaire with 22 statements for assessing knowledge, 13 statements for attitude and 12 statements for practice was used as a data collection tool. Differences in the KAP scores among different subgroups were studied using appropriate statistical tests. Results: A total of 131 respondents participated, and ...
Background: The objective was to perceive the demographic characteristics, clinical symptoms, com... more Background: The objective was to perceive the demographic characteristics, clinical symptoms, comorbidities, and biomarkers (hematological, inflammatory, hepatic, renal, and metabolic) of Intensive Care Unit admitted survivors and deceased patients with coronavirus and link with ABO system admitted to a tertiary level hospital in Dhaka, Bangladesh. Methods: It was a retrospective cohort, conducted in Holy Family Red Crescent Medical College Hospital, dedicated to COVID-19 at Dhaka, Bangladesh from 15th May to 9th September 2020. All 112 patients admitted to ICU diagnosed as COVID-19 cases (RT-PCR of the nasopharyngeal swab) were included in the study. Demographic data, prognostic biomarkers of 76 ICU patients were available and found from hospital records (non-electronic) and treatment sheets, and compared between the survived and deceased patients.
Background: Pneumonia acquired outside the hospital by an immune-competent individual is defined ... more Background: Pneumonia acquired outside the hospital by an immune-competent individual is defined as community acquired pneumonia (CAP). It is to be distinguished, on the basis of a wider spectrum of pathogens, from nosocomial pneumonia from pneumonia in an immune-compromised host. Community-acquired pneumonia is associated with a significant mortality and morbidity. Etiology of CAP varies geographically and the understanding of local epidemiology plays an important role in decision making for empirical treatment before test results are available. Primary decisions about empirical antimicrobial treatment required knowledge of predominant microbial patterns and their sensitivities. Objectives: The aim of this study was to identify the bacterial etiology of CAP, their sensitivity towards empirical therapy and to observe the clinical course as well as short term outcome in hospitalized adult patients. Methodology: It was one year-long observational prospective study on 87 patients diagn...
Background: In COVID-19 pandemic increasing the frequency of hand washing and disinfection is the... more Background: In COVID-19 pandemic increasing the frequency of hand washing and disinfection is the most important preventive measure of this disease which is causing in deleterious impact on skin among general population. So the aim of the study was to evaluate whether these measures are associated with development of skin damage. Methods: This was a descriptive type of cross-sectional, observational study conducted over a period of six months from April 2021 to September 2021 including 1166 patients coming to some private clinics in Gazipur with skin manifestations. Skin diseases were diagnosed by dermatologist on basis of clinical morphology with appropriate investigations. Data were collected by structured questionnaire and analyzed using SPSS. Results: Out of 1166 patients, 35.68% reported skin changes or symptoms over hands (ScH), and 13.98% reported skin changes on their face (ScF). Around 87.39% and 86.53% of the participants reported a change in hand washing habits and saniti...
Healthcare professionals are the crucial and influencing source of information for vaccines and t... more Healthcare professionals are the crucial and influencing source of information for vaccines and their communication among patients and communities that can accelerate successful vaccination in a country. This cross-sectional study was one of the first and foremost ones in Bangladesh to observe the basic perception and attitudes towards vaccination against COVID-19 among the healthcare workers (HCWs) - doctors, interns, nurses, ward boys, cleaners, and medical technologists of major COVID-dedicated hospitals. The cross-sectional questionnaire-based study was conducted in February 2021 among 550 HCWs to assess the perception and attitude towards vaccination against COVID-19. The study participants were targeted as the priority group for COVID-19 vaccination, working in two major COVID-dedicated hospitals, Holy Family Red Crescent Medical College Hospital (HF-center), and Sheikh Russel National Gastro-liver Institute and Hospital (SR-center) in Dhaka, Bangladesh during the pandemic. Th...
The rapid progression of corona virus disease in 2019 (COVID-19) pandemic has become an unprecede... more The rapid progression of corona virus disease in 2019 (COVID-19) pandemic has become an unprecedented global concern. This systemic review aimed at evaluating the available evidence on efficacy, safety to identify any promising role for compassionate use of remdesivir in patient suffered for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as re-purposeful use. We searched PubMed, EMBASE, Cochrane Library for randomized controlled trials (RCTs), prospective case series studies and case reports that evaluated use of remdesivir in COVID-19. The outcomes were mortality, recovery rate, length of hospital stay and clinical outcome. Though the drug remdesivir (RDV) is not approved by the FDA, still the "Emergency Use Authorization" (EUA) for compassionate use in severe cases is endorsed. After vigorous searching, screening and sorting of completed and published scientific evidences in electronic database, there were only 2 randomized control trial (RCT), 2 uncontroll...
Stroke is one of the commonest causes of mortality among the world. Hemorrhagic stroke accounts n... more Stroke is one of the commonest causes of mortality among the world. Hemorrhagic stroke accounts nearly 15% of all the strokes. Different risk factors have been identified, of them hypertension, anti-coagulation therapy and previous history of ischemic strokes are significant. Regarding the genetic causes of intracerebral hemorrhage (ICH) monogenic causes play a small role. It was found that Apolipoprotein E (APOE) gene has a strong association with ICH. This is a 299 amino acids long protein located in chromosome 19. APOE has three alleles, they are epsilon 2, 3 and 4. Total 10 meta-analysis were reviewed in this article which involved 52,705 participants. When looking for the association, ∈2 and ∈4 showed positive and ∈3 showed negative association with ICH. Association of ∈4 (OR mean 1.77) was stronger than that of ∈2 (OR mean 1.71).
<jats:p>Irrational use of medicine is a major problem worldwide. Phartnaceutical drug promo... more <jats:p>Irrational use of medicine is a major problem worldwide. Phartnaceutical drug promotion is a means of informing health professionals about new drugs. The approach is often unethical and inappropriate and may promote irrational prescribing. Sources of drug information are one of the important indicators of irrational drug use by the practitioners in developing countries. A randomized cross sectional study was done to evaluate and empire the knowledge about drug information and indicators of rational drug use among the practitioners in Dhaka city. 183 practitioners were randomly selected and interviewed in Iwo groups. Ninety of them were selected from Holy Family Red Crescent Medical College (HFRCMC) an autonomous teaching hospital in Dhaka city. Ninety three practitioners front non-teaching hospitals of Dhaka city were also interviewed by tatijOrm structured questionnaire comprising the sources of drug information and rational drug use indicators by WHO and buentational Network for Rational Use of Drug (1NRUD) criteria.. The interviews were taken during February 2010 to July 2010 by the mulergrachtate medical students of third year am! fourth year. 71% doctors of HFRCMC considered the interned and 73% doctors front other group considered the company literature as the source of drug information. Use of medical journal and BDNF was very low in both the groups. The overall awareness and strength of rational prescribing practice was found poor in comparison to 11FRCMC. Most of the practitioners (84% and 71%).were found concerned and informed about the prices of drug that indicates the strength of rational practice of pharmaco economics.</jats:p>
The sudden outbreak of a novel coronavirus in 2019 in Wuhan, China, that rapidly provoked a globa... more The sudden outbreak of a novel coronavirus in 2019 in Wuhan, China, that rapidly provoked a global concern, marked as the third attack of corona virus in the human society that affected the global healthcare system as well as the global economy. Until and unless an effective vaccine is discovered against the virus, the pharmacological intervention by different antivirals is in the run for remedy. The aim of this systematic review was to evaluate the role of favipiravir along with its safety and efficacy for the patients who are suffering from severe acute respiratory distress syndrome due to CoronaVirus-2 (SARS-CoV-2) as re-purposeful use. We searched PubMed, EMBASE for randomized controlled trials (RCTs), cilicaltrial.com for registered on going trails to evaluate the pros and cons of using favipiravir in COVID-19. After vigorous searching, screening and sorting of 314 articles for completed and published scientific evidences in electronic database, there were only 2 completed and published randomized control trials (RCT) and 17 ongoing or unpublished trials found until June 2020. The main outcome measures were viral clearance, clinical improvement and adverse events reported and published on 147 patients infected with SARS-CoV2. The 2 completed RCTs showed significantly better treatment effects on disease progression, viral clearance, improved the latency to relief for pyrexia and cough on favipiravir treated patients. Adverse effects caused Favipiravir are mild and manageable. Although 9 more RCTs and cohort studies are supposed to be completed by this time that may unveil some evidence for use of anti-RNA-viral drug favipiravir against influenza or Ebola to re-purposing against COVID-19 as adopted in different treatment guidelines.
International Journal Of Community Medicine And Public Health
In recent days rare but aggressive fungal disease in the form of mucormycosis has emerged and bec... more In recent days rare but aggressive fungal disease in the form of mucormycosis has emerged and become a health concern mostly for the patients suffering from severe COVID-19 infection, poorly controlled diabetes mellitus, and patients who receive immunosuppressive therapies for diseases like malignancies. Many studies have demonstrated the relationship between COVID-19, immunosuppressive therapies, diabetes mellitus, and mucormycosis. In diabetes mellitus, poor glycemic control allows the fungi to produce pathogenesis. On the other hand, immunosuppression causes compromised neutrophil function that inhibits phagocytosis and the fusion of phagolysosome. Epidemiological data has proved that the incidence of mucormycosis from a global perspective has been on the rise and it has an association with an increasing number of diabetic cases in the world. In countries like India, Nepal, and Bangladesh where the number of diabetic and cancer patients has been growing constantly, mucormycosis c...
Pneumonia is a worldwide, serious threat to health and an enormous socio-economic burden for heal... more Pneumonia is a worldwide, serious threat to health and an enormous socio-economic burden for health care system. Community-acquired pneumonia (CAP) is associated with a significant mortality and morbidity. Knowledge of predominant microbial patterns in CAP constitutes the basis for initial decisions about empirical antimicrobial treatment. The aim of this study was to identify the bacterial etiology of CAP in adult hospitalized patients and to see their antibiotic sensitivity pattern as well as to observe their clinical profile and short term outcome. It was a hospital based prospective observational study. A total of 87 hospitalized patients diagnosed with CAP were enrolled consecutively from the medicine ward of Chittagong Medical College Hospital (CMCH). Sputum for Gram staining, Z N staining, culture sensitivity, blood culture and sensitivity and PCR for Legionella pneumophila, Mycoplasma pneumoniae, Chlamydophila pneumonia and Streptococcus pneumonia were done. Patients were fo...
Antigamente conhecida como Lepra, a Hanseníase possui como agente etiológico o Micobacterium lepr... more Antigamente conhecida como Lepra, a Hanseníase possui como agente etiológico o Micobacterium leprae, sendo caracterizada pela OMS, como uma Doença Tropical Negligenciada. Com base na gravidade da doença e no problema de saúde pública que ela representa, esta pesquisa objetivou analisar o perfil epidemiológico dos casos de hanseníase no município de Cascavel-PR, no período de 2013 a 2018, através de dados do Sistema de Informação de Agravos de Notificação-SINAN. Trata-se de um estudo observacional, transversal, de abordagem quantitativa e de natureza descritiva, realizado mediante análise de fichas de notificação do SINAN. Pode-se observar, no período estudado, a predominância de casos no sexo masculino em relação ao sexo feminino. A faixa etária que teve um número maior de casos, prevaleceu entre 35 a >60 anos; a classificação mais significativa foi a multibacilar e a forma clinica mais encontrada a dimorfa, com maior predomínio de casos na periferia do município. Diante das inf...
Since the first detection of a cluster of COVID-19 patients in China in late 2019, it becomes a g... more Since the first detection of a cluster of COVID-19 patients in China in late 2019, it becomes a global concern due to its transmissibility and ability to progress patients in severe respiratory failure and acute respiratory distress syndrome, which need intensive care unit support for a long time. We observed the repurposing use of remdesivir and favipiravir whether considered as a therapeutic option or not through survival rate and changes in biomarker during 10-day treatment stay in ICU. The retrospective observational study in a tertiary care hospital dedicated to COVID-19 at Dhaka, Bangladesh was done at the peak of COVID-19 pandemic in Bangladesh. The mortality rate, length of ICU stays and eight prognostic biomarkers of patients treated with remdesivir and favipiravir was observed as one of the first ever reported experience in Bangladesh. Among the critically ill patients in ICU, 26 (44.8%) died and 32 (55.2%) were cured during the study period and highest mean duration of st...
The study was designed to compare the hypoglycemic effects of coconut water extract of Picralima ... more The study was designed to compare the hypoglycemic effects of coconut water extract of Picralima nitida seeds to that of Daonil in alloxan-induced diabetic albino rats. Twenty five albino rats weighing between 170 - 200 g were randomly divided into five groups after allowing the rats to acclimatize for seven days and were made diabetic by intraperitoneal administration of 150 mg/kg of alloxan. The rats were giving different volumes of the extract and Daonil as per their groupings. All the substances were given for five days by oro-gastric tube. The blood glucose level were measured daily in the rats. There was an initial inactivity in the rats following administration of the extract mixture and their appetite was low except for the control group. The blood glucose levels (in mmols/dL) of the rats at the start and end of the experiment for the groups were: control (9.6 ± 0.1 to 9.2 ± 0.1), coconut water only (11.5 ± 0.3 to 6.2 ± 0.1), aqueous extract of P. nitida seeds (12.4 ± 0.1 to...
Background: Dengue is a mosquito-borne viral disease worldwide. The number of new cases and morta... more Background: Dengue is a mosquito-borne viral disease worldwide. The number of new cases and mortality in Bangladesh increased in recent years. This study aims to observe the difference between demographic data, warning signs, high-risk co-morbidity, treatment pattern, and laboratory investigations in two different types of dengue fever during the pick tropical season. Method: This retrospective observational study was done in Holy Family Red Crescent Medical College from May to October 2019 from hospital records of a total of 102 dengue NS1 positive patients. The classical dengue fever (CDF) group consists of 72 patients and the dengue hemorrhagic fever (DHF) group consists of 30 patients. Demographic data, high-risk co-morbidity (pregnancy, old age, DM, HTN), ‘warning sign’ (abdominal tenderness, mucosal bleeding, lethargy, restlessness, persistent vomiting, clinical fluid accumulation, liver enlargement > 2cm, increase HCT, decrease Platelet), treatment pattern, and laboratory ...
Objective: With the rapid increase in the rate of infection, repurposing use of many drugs like a... more Objective: With the rapid increase in the rate of infection, repurposing use of many drugs like antivirals, antibiotics, LMWH, steroid, oxygen therapy were considered as an option to find promising anti-COVID therapeutics. In this study, we aim to observe the extent and variety of drugs used in different clinical categories of COVID-19 patients admitted to hospital in Bangladesh. To observe the requirement of oxygen therapy according to severity was also a prime objective to reveal the overall trend, frequency, and pattern of pharmacotherapy in a COVID-dedicated hospital. Materials and method: A total of 1348 patients were admitted, of whom 473 were included in this single-center retrospective study. The critical group consists of 99 ICU patients, the severe group has 38, moderate was 82 and mild group 254 cases, admitted in the general ward. Hospital records of each patient were screened and information about drug and supportive therapy were collected manually by the researchers in...
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Papers by Morshed Nasir