Parenteral ketorolac is as effective as parenteral morphine for short-term pain relief in patient... more Parenteral ketorolac is as effective as parenteral morphine for short-term pain relief in patients with long bone fractures, and it results in fewer adverse effects.
We determined whether the effect of apolipoprotein E ()-ε4 genotype on Alzheimer's disease (A... more We determined whether the effect of apolipoprotein E ()-ε4 genotype on Alzheimer's disease (AD) markers differs in men and women across AD stages. Among normal control (NC) participants (N = 702) and participants with mild cognitive impairment (N = 576) and AD (N = 305), we examined the associations of sex and -ε4 carrier status with cortical amyloid-β (Aβ) burden, hippocampal volume ratio (HpVR; hippocampal volume/intracranial volume × 10), brain glucose metabolism, and verbal memory. In NC, -ε4 related to greater Aβ burden and poorer verbal memory across sex but to smaller HpVR and hypometabolism in men only. In mild cognitive impairment, -ε4 related to smaller HpVR, hypometabolism, greater Aβ burden, and poorer verbal memory across sex. In AD, -ε4 related to greater Aβ burden in men only and smaller HpVR across sex and showed no association with hypometabolism or verbal memory. Sex differences in the association between -ε4 and AD markers vary by disease stage.
Journal of Alzheimer's disease : JAD, Jan 16, 2018
The APOE ɛ4 allele and increased vascular risk have both been independently linked to cognitive i... more The APOE ɛ4 allele and increased vascular risk have both been independently linked to cognitive impairment and dementia. Since few studies have characterized how these risk factors affect everyday functioning, we investigated the relationship between APOE ɛ4 genotype and elevated pulse pressure (PP) on functional change in cognitively normal participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI). 738 normally aging participants underwent APOE genotyping, and baseline PP was calculated from blood pressure indices. The Functional Activities Questionnaire (FAQ) was completed by participants' informant at baseline and 6, 12, 24, 36, and 48-month follow-up visits. Multiple linear regression and multilevel modeling were used to examine the effects of PP and APOE ɛ4 genotype on cross-sectional and longitudinal FAQ scores, respectively. Adjusting for demographic and clinical covariates, results showed that both APOE ɛ4 status and elevated PP predicted greater funct...
Given the demand for developing objective methods for characterizing traumatic brain injury (TBI)... more Given the demand for developing objective methods for characterizing traumatic brain injury (TBI), research dedicated to evaluating putative biomarkers has burgeoned over the past decade. Since it is critical to elucidate the underlying pathological processes that underlie the higher diverse outcomes that follow neurotrauma, considerable efforts have been aimed at identifying biomarkers of both the acute- and chronic-phase TBI. Such information is not only critical for helping to elucidate the pathological changes that lead to poor long-term outcomes following TBI but it may also assist in the identification of possible prevention and interventions for individuals who sustain head trauma. In the current review, we discuss the potential role of vascular dysfunction and chronic inflammation in both acute- and chronic-phase TBI, and we also highlight existing studies that have investigated inflammation biomarkers associated with poorer injury outcome.
Lowering groundwater table is one of the main concerns in water resources management in many area... more Lowering groundwater table is one of the main concerns in water resources management in many areas. Artificial groundwater recharge might be a suitable solution for this issue and its efficiency was widely proven in several countries such as Israel, Netherland, USA, Australia, etc. However, clogging is one of the factors affecting the success of an artificial groundwater recharge system. Investigations by many authors concluded that, clogging might be caused by biological, physical, chemical or mechanical processes. Many studies used laboratory columns to understand and predict clogging issues when applying artificial groundwater recharge before field trials proceeded. The columns tests described in this thesis are used to study clogging processes resulting from injection of municipal sewage water into different sandy soils matrix with special regard to biological and physical processes. The focus of the work is thus the simulation of artificial groundwater recharge operation in the laboratory scale to understand the interrelationships among clogging processes, effects of reclaimed water quality and process-related aspects. Two main experiments were run continuously to 1) investigate the clogging process with sandy soil typically from Dresden, Germany, by active and inactive columns in order to understand the interrelationships between clogging processes and effects of water quality on clogging rate, and 2) investigate the clogging process with sandy soil simulating soil in Long Bien district, Hanoi, to understand effects of municipal sewage water on different type of soils.
Reposition and revitalize your organization by teaching staff members to use data for identifying... more Reposition and revitalize your organization by teaching staff members to use data for identifying, setting, and directing performance goals.
The Vietnamese community in the United States today has unique and special needs. If Vietnamese y... more The Vietnamese community in the United States today has unique and special needs. If Vietnamese young sters are to succeed in school, princi pals must learn to meet these needs.
Parenteral ketorolac is as effective as parenteral morphine for short-term pain relief in patient... more Parenteral ketorolac is as effective as parenteral morphine for short-term pain relief in patients with long bone fractures, and it results in fewer adverse effects.
We determined whether the effect of apolipoprotein E ()-ε4 genotype on Alzheimer's disease (A... more We determined whether the effect of apolipoprotein E ()-ε4 genotype on Alzheimer's disease (AD) markers differs in men and women across AD stages. Among normal control (NC) participants (N = 702) and participants with mild cognitive impairment (N = 576) and AD (N = 305), we examined the associations of sex and -ε4 carrier status with cortical amyloid-β (Aβ) burden, hippocampal volume ratio (HpVR; hippocampal volume/intracranial volume × 10), brain glucose metabolism, and verbal memory. In NC, -ε4 related to greater Aβ burden and poorer verbal memory across sex but to smaller HpVR and hypometabolism in men only. In mild cognitive impairment, -ε4 related to smaller HpVR, hypometabolism, greater Aβ burden, and poorer verbal memory across sex. In AD, -ε4 related to greater Aβ burden in men only and smaller HpVR across sex and showed no association with hypometabolism or verbal memory. Sex differences in the association between -ε4 and AD markers vary by disease stage.
Journal of Alzheimer's disease : JAD, Jan 16, 2018
The APOE ɛ4 allele and increased vascular risk have both been independently linked to cognitive i... more The APOE ɛ4 allele and increased vascular risk have both been independently linked to cognitive impairment and dementia. Since few studies have characterized how these risk factors affect everyday functioning, we investigated the relationship between APOE ɛ4 genotype and elevated pulse pressure (PP) on functional change in cognitively normal participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI). 738 normally aging participants underwent APOE genotyping, and baseline PP was calculated from blood pressure indices. The Functional Activities Questionnaire (FAQ) was completed by participants' informant at baseline and 6, 12, 24, 36, and 48-month follow-up visits. Multiple linear regression and multilevel modeling were used to examine the effects of PP and APOE ɛ4 genotype on cross-sectional and longitudinal FAQ scores, respectively. Adjusting for demographic and clinical covariates, results showed that both APOE ɛ4 status and elevated PP predicted greater funct...
Given the demand for developing objective methods for characterizing traumatic brain injury (TBI)... more Given the demand for developing objective methods for characterizing traumatic brain injury (TBI), research dedicated to evaluating putative biomarkers has burgeoned over the past decade. Since it is critical to elucidate the underlying pathological processes that underlie the higher diverse outcomes that follow neurotrauma, considerable efforts have been aimed at identifying biomarkers of both the acute- and chronic-phase TBI. Such information is not only critical for helping to elucidate the pathological changes that lead to poor long-term outcomes following TBI but it may also assist in the identification of possible prevention and interventions for individuals who sustain head trauma. In the current review, we discuss the potential role of vascular dysfunction and chronic inflammation in both acute- and chronic-phase TBI, and we also highlight existing studies that have investigated inflammation biomarkers associated with poorer injury outcome.
Lowering groundwater table is one of the main concerns in water resources management in many area... more Lowering groundwater table is one of the main concerns in water resources management in many areas. Artificial groundwater recharge might be a suitable solution for this issue and its efficiency was widely proven in several countries such as Israel, Netherland, USA, Australia, etc. However, clogging is one of the factors affecting the success of an artificial groundwater recharge system. Investigations by many authors concluded that, clogging might be caused by biological, physical, chemical or mechanical processes. Many studies used laboratory columns to understand and predict clogging issues when applying artificial groundwater recharge before field trials proceeded. The columns tests described in this thesis are used to study clogging processes resulting from injection of municipal sewage water into different sandy soils matrix with special regard to biological and physical processes. The focus of the work is thus the simulation of artificial groundwater recharge operation in the laboratory scale to understand the interrelationships among clogging processes, effects of reclaimed water quality and process-related aspects. Two main experiments were run continuously to 1) investigate the clogging process with sandy soil typically from Dresden, Germany, by active and inactive columns in order to understand the interrelationships between clogging processes and effects of water quality on clogging rate, and 2) investigate the clogging process with sandy soil simulating soil in Long Bien district, Hanoi, to understand effects of municipal sewage water on different type of soils.
Reposition and revitalize your organization by teaching staff members to use data for identifying... more Reposition and revitalize your organization by teaching staff members to use data for identifying, setting, and directing performance goals.
The Vietnamese community in the United States today has unique and special needs. If Vietnamese y... more The Vietnamese community in the United States today has unique and special needs. If Vietnamese young sters are to succeed in school, princi pals must learn to meet these needs.
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