ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE
Objective: To assess pressurised metered dose inhaler technique of the nursing staff in different... more Objective: To assess pressurised metered dose inhaler technique of the nursing staff in different government hospitals of Karachi. Methods: A cross-sectional study was carried out in four randomly chosen government hospitals of Karachi. After checking for study criteria and obtaining written informed consent, a total of 120 nurses were interviewed and then given a placebo inhaler to demonstrate their inhaler technique. The reference for assessment was the 12-step inhalation technique suggested by the American College of Chest Physicians. Results: The study results revealed that out of the 12 steps of the inhaler technique, only 3 steps were followed by a majority of the study participants i.e. taking the cap off (64.2%), putting the metered dose inhaler in mouth with lips sealed (59.2%) and breathing in slowly by pressing down the metered dose inhaler (62.5%). The mean inhaler technique score of the study participants was 3.18 ± 2.34 out of 12 and only 1 (0...
ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE
Objective: To assess the postoperative outcomes of laparoscopic appendectomy in terms of compli-... more Objective: To assess the postoperative outcomes of laparoscopic appendectomy in terms of compli- cations and to compare them on gender basis. Methods: This was the prospective observational study conducted at department of General Surgery Chandka Medical College Hospital Larkana with non-probability convenient sampling technique. The duration of study was one year from January 2013 till December 2013. 150 patients were selected that were diagnosed with acute appendicitis. Patients were followed up for 2 weeks and their compli- cations were observed. All data was entered and analysed on SPSS version 20. Inferential analysis was performed using chi-square test whereas the significance level was set at 0.05. Results: The study results showed that 14 male (18.7%) and 16 female (21.4%) patients developed complications (p=0.094). 5 male (6.6%) and 8 female (10.6%) patients developed paralytic ileus (p=0.384). 5 male (6.6%) and 3 female (4%) patients develop...
The people with less Vitamin D have enlarged probability for acute respiratory tract infections. ... more The people with less Vitamin D have enlarged probability for acute respiratory tract infections. There is substantial uncertainty about the link between “25(OH)D” ratio and the prevalence of “COVID-19”. With the major endpoints of death, duration of staying in hospital, cannulation and rate of recurrence of COV-19 indicators, this study was done to evaluate the quantity of Vit-D in Corona patients in Jinnah post graduate medical Centre Krachi, Pakistan, and to link “vitamin D” insufficiency and shortage with these events. Eighty patients in total had their “25(OH)D” status assessed throughout the duration of their COVID-19 disease. Deficient (9 nanogram/milliliter), inadequate (5-35 ng/mL), or appropriate (> 25 ng/mL) 25-hydroxyvitamin D levels were determined. Patients in ICU (P = 0.035), protruding oxygen supply (P = 0.03), tenacious eosinophilic pneumonia, and decease were all substantially correlated with “Vit-D” insufficiency in univariate Cox regression. After adjusting fo...
It is commonly known that the Pakistani population has inadequate vitamin D levels, but its effec... more It is commonly known that the Pakistani population has inadequate vitamin D levels, but its effects on bone health and the level of N-terminal peptide of procollagen (PINP) have not yet determined. The aim of the research work was to check the vitamin D grade of exercisers and non-exercisers and examine how it related to P1NP concentration, a biochemical marker of bone production, and bone mineral density. A random sampling technique was used to select males and females who were staying in neighborhood. They were between the ages of 18 and 35 years. 92 people of Pakistani ancestry made up the total population. With 46 people, Group A was a non-exercising control group. Group B has 46 individuals in it. Both of these groups were gathered for the data analysis. BMD, procollagen type-1 amino-terminal pro-peptide, calciferol, and other biological indicator of bone remodeling were measured in serum. (P1NP). Using broadband ultrasound attenuation, the quality of the bones was evaluated. B...
Objectives: Ischemia modified albumin (IMA) may aid in the early detection and management of diab... more Objectives: Ischemia modified albumin (IMA) may aid in the early detection and management of diabetic retinopathy (DR). In this study, we examined the relationship between IMA and DR, and the effect of intravitreal anti-vascular endothelial growth factor (anti-VEGF) on IMA levels in patients with DR. Methods: This Quasi-experimental study was conducted from March-December 2018 at a Al-Ibrahim Eye Hospital in Karachi, Pakistan. Adult patients (age ≥ 18 year) with Type-2 diabetes mellitus (T2DM) presenting to the Diabetic Clinic were categorized as control (Group-A n=30: DM without DR) or case (Group-B n=59: DM with DR). Patients in Group-B received an intravitreal injection of bevacizumab (anti-VEGF). Visual acuity, retinoscopy and serum IMA were recorded at baseline and at a 30-day follow-up for both groups. Results: A significant drop in IMA levels was seen one month after bevacizumab (IMA baseline: 1590.82±121.22 and follow up: 940.8±91.26; p<0.01) in Group-B subjects. Visual a...
Objective: The objective of this study is to evaluate the correlation of radiologically diagnosed... more Objective: The objective of this study is to evaluate the correlation of radiologically diagnosed non-alcoholic fatty liver disease (NAFLD) with serum uric acid (SUA) levels.Methods: It is a case control study conducted in private sector tertiary care hospital. A total of 200 subjects were involved in this study after calculation of sample size. The study participants were recruited from the medicine ward while the healthy controls were taken from the general population. Non probability consecutive sampling technique was employed. Inclusion criteria was patients who were diagnosed with fatty liver through abdominal ultrasonography. Exclusion criteria was patients suffering from any other chronic illness that can lead to an echogenic liver on ultrasound (viral hepatitisand diabetes) and history of alcohol consumption. Ethical approval for the study was taken from IRB. Data were entered and analysed using IBM SPSS version 23.0. Mean with standard deviation for age, BMI, SBP, DBP and S...
Objective: To assess the role of Insulin growth factor-I (IGF-I) in females selected for assisted... more Objective: To assess the role of Insulin growth factor-I (IGF-I) in females selected for assisted reproductive technique (ART).Methods: In this cross-sectional study 133 infertile females were recruited for Intracytoplasmic sperm injection (ICSI). The antral follicle count (AFC), pre-ovulatory follicle count (PFC), total doses of follicle stimulating hormone (FSH) were estimated. IGF was measured. Successful pregnancy conception afterICSI was confirmed by an intrauterine gestational sac with cardiac activity after embryo transfer. Receiver Operating Curve (ROC) analysis was also done to find out the area under the curve for clinically pregnant samples using IGF-I. Binary logistic regression analysis was done to estimate the odds ratio with 95% confidence interval for clinical pregnancy using IGF-I; all p-values less than 0.05 were considered significant.Results: Study results revealed that IGF-I gave positive association with clinical pregnancy outcome, and is a more reliable predic...
Objective: This study was conducted to investigate and compare the analgesic activity of methanol... more Objective: This study was conducted to investigate and compare the analgesic activity of methanolic extracts of seeds of Cuminum Cyminum (L) and Centratherum anthelminticum (L)in mice. Methods: This study was conducted in the department of Pharmacology University of Karachi; 30 healthy mice were selected from animal house of Pharmacology department of University of Karachi for the study. All animals were divided into three groups, each group of 10 mice. Mice of Group 1 were given DMSO (Dimethyl sulphoxide) an organic solvent, mice of group 2 were given Methanolic extract of Cuminum Cyminum (L) and mice of group 3 were given Methanolic extract of Centratherum anthelminticum (L). The analgesic activity was investigated by tail flick test, heat is used to stimulate pain and observe analgesic activity, after a week of oral dosing of Methanolic extracts of seeds of Cuminum Cyminum (L) and Centratherum anthelminticum (L) in mice. Methanolic extracts of Cuminum Cyminum (L) and Centratherum...
Background: Hepcidin is the only iron regulating hormone in human body. The foetus begins to synt... more Background: Hepcidin is the only iron regulating hormone in human body. The foetus begins to synthesize Hepcidin from the 1st trimester of gestation to control unidirectional iron transfer from mother to foetus. The objective of the present study was to determine the correlation of cord Hepcidin with iron status markers of mothers, neonates and neonatal morphometrics. Method: Twenty-five healthy pregnant women and their neonates were included in the study. Haemoglobin, Iron status markers and Hepcidin were analyzed in maternal and cord blood. Neonatal anthropometric variables were measured. Pearson/Spearman correlation was used for association of different variables of mother-neonate pairs. Results: Maternal Hepcidin showed positive correlation with maternal Iron, Ferritin and Transferrin Saturation (TS) (r=0.455 and p=0.022, r=0.511 and p=0.009, r=0.440 and p=0.025 respectively). Cord Hepcidin was positively correlated with cord iron, Ferritin and Transferrin saturation (r=0.593 an...
Objectives: The purpose of the current study was to compare the serum Apelin level in patients wi... more Objectives: The purpose of the current study was to compare the serum Apelin level in patients with and without polycystic ovarian syndrome to assess this as a diagnostic marker for PCOS. In a case-control study 60 polycystic ovarian syndrome patients diagnosed according to Rotterdam criteria and 20 healthy controls of reproductive age group were recruited. Study Design: Case Control study. Setting: Jinnah Postgraduate Medical Center in Collaboration with Aga Khan University, Karachi. Period: August 2017 and February 2019. Material & Methods: Blood samples were collected after 12 hours fasting and was used to test serum Apelin, insulin, cortisol and fasting blood glucose levels. Results: Seventy percent PCO subjects had irregular menstrual cycle and 68% suffered from hirsutism; while all PCO subjects had more than 10 antral follicle seen on ultrasound in either one or both ovaries in comparison of 15% controls (p<0.05). Higher Apelin and Testosterone levels in PCO group was repor...
ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE
Objective: To assess pressurised metered dose inhaler technique of the nursing staff in different... more Objective: To assess pressurised metered dose inhaler technique of the nursing staff in different government hospitals of Karachi. Methods: A cross-sectional study was carried out in four randomly chosen government hospitals of Karachi. After checking for study criteria and obtaining written informed consent, a total of 120 nurses were interviewed and then given a placebo inhaler to demonstrate their inhaler technique. The reference for assessment was the 12-step inhalation technique suggested by the American College of Chest Physicians. Results: The study results revealed that out of the 12 steps of the inhaler technique, only 3 steps were followed by a majority of the study participants i.e. taking the cap off (64.2%), putting the metered dose inhaler in mouth with lips sealed (59.2%) and breathing in slowly by pressing down the metered dose inhaler (62.5%). The mean inhaler technique score of the study participants was 3.18 ± 2.34 out of 12 and only 1 (0...
ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE
Objective: To assess the postoperative outcomes of laparoscopic appendectomy in terms of compli-... more Objective: To assess the postoperative outcomes of laparoscopic appendectomy in terms of compli- cations and to compare them on gender basis. Methods: This was the prospective observational study conducted at department of General Surgery Chandka Medical College Hospital Larkana with non-probability convenient sampling technique. The duration of study was one year from January 2013 till December 2013. 150 patients were selected that were diagnosed with acute appendicitis. Patients were followed up for 2 weeks and their compli- cations were observed. All data was entered and analysed on SPSS version 20. Inferential analysis was performed using chi-square test whereas the significance level was set at 0.05. Results: The study results showed that 14 male (18.7%) and 16 female (21.4%) patients developed complications (p=0.094). 5 male (6.6%) and 8 female (10.6%) patients developed paralytic ileus (p=0.384). 5 male (6.6%) and 3 female (4%) patients develop...
The people with less Vitamin D have enlarged probability for acute respiratory tract infections. ... more The people with less Vitamin D have enlarged probability for acute respiratory tract infections. There is substantial uncertainty about the link between “25(OH)D” ratio and the prevalence of “COVID-19”. With the major endpoints of death, duration of staying in hospital, cannulation and rate of recurrence of COV-19 indicators, this study was done to evaluate the quantity of Vit-D in Corona patients in Jinnah post graduate medical Centre Krachi, Pakistan, and to link “vitamin D” insufficiency and shortage with these events. Eighty patients in total had their “25(OH)D” status assessed throughout the duration of their COVID-19 disease. Deficient (9 nanogram/milliliter), inadequate (5-35 ng/mL), or appropriate (> 25 ng/mL) 25-hydroxyvitamin D levels were determined. Patients in ICU (P = 0.035), protruding oxygen supply (P = 0.03), tenacious eosinophilic pneumonia, and decease were all substantially correlated with “Vit-D” insufficiency in univariate Cox regression. After adjusting fo...
It is commonly known that the Pakistani population has inadequate vitamin D levels, but its effec... more It is commonly known that the Pakistani population has inadequate vitamin D levels, but its effects on bone health and the level of N-terminal peptide of procollagen (PINP) have not yet determined. The aim of the research work was to check the vitamin D grade of exercisers and non-exercisers and examine how it related to P1NP concentration, a biochemical marker of bone production, and bone mineral density. A random sampling technique was used to select males and females who were staying in neighborhood. They were between the ages of 18 and 35 years. 92 people of Pakistani ancestry made up the total population. With 46 people, Group A was a non-exercising control group. Group B has 46 individuals in it. Both of these groups were gathered for the data analysis. BMD, procollagen type-1 amino-terminal pro-peptide, calciferol, and other biological indicator of bone remodeling were measured in serum. (P1NP). Using broadband ultrasound attenuation, the quality of the bones was evaluated. B...
Objectives: Ischemia modified albumin (IMA) may aid in the early detection and management of diab... more Objectives: Ischemia modified albumin (IMA) may aid in the early detection and management of diabetic retinopathy (DR). In this study, we examined the relationship between IMA and DR, and the effect of intravitreal anti-vascular endothelial growth factor (anti-VEGF) on IMA levels in patients with DR. Methods: This Quasi-experimental study was conducted from March-December 2018 at a Al-Ibrahim Eye Hospital in Karachi, Pakistan. Adult patients (age ≥ 18 year) with Type-2 diabetes mellitus (T2DM) presenting to the Diabetic Clinic were categorized as control (Group-A n=30: DM without DR) or case (Group-B n=59: DM with DR). Patients in Group-B received an intravitreal injection of bevacizumab (anti-VEGF). Visual acuity, retinoscopy and serum IMA were recorded at baseline and at a 30-day follow-up for both groups. Results: A significant drop in IMA levels was seen one month after bevacizumab (IMA baseline: 1590.82±121.22 and follow up: 940.8±91.26; p<0.01) in Group-B subjects. Visual a...
Objective: The objective of this study is to evaluate the correlation of radiologically diagnosed... more Objective: The objective of this study is to evaluate the correlation of radiologically diagnosed non-alcoholic fatty liver disease (NAFLD) with serum uric acid (SUA) levels.Methods: It is a case control study conducted in private sector tertiary care hospital. A total of 200 subjects were involved in this study after calculation of sample size. The study participants were recruited from the medicine ward while the healthy controls were taken from the general population. Non probability consecutive sampling technique was employed. Inclusion criteria was patients who were diagnosed with fatty liver through abdominal ultrasonography. Exclusion criteria was patients suffering from any other chronic illness that can lead to an echogenic liver on ultrasound (viral hepatitisand diabetes) and history of alcohol consumption. Ethical approval for the study was taken from IRB. Data were entered and analysed using IBM SPSS version 23.0. Mean with standard deviation for age, BMI, SBP, DBP and S...
Objective: To assess the role of Insulin growth factor-I (IGF-I) in females selected for assisted... more Objective: To assess the role of Insulin growth factor-I (IGF-I) in females selected for assisted reproductive technique (ART).Methods: In this cross-sectional study 133 infertile females were recruited for Intracytoplasmic sperm injection (ICSI). The antral follicle count (AFC), pre-ovulatory follicle count (PFC), total doses of follicle stimulating hormone (FSH) were estimated. IGF was measured. Successful pregnancy conception afterICSI was confirmed by an intrauterine gestational sac with cardiac activity after embryo transfer. Receiver Operating Curve (ROC) analysis was also done to find out the area under the curve for clinically pregnant samples using IGF-I. Binary logistic regression analysis was done to estimate the odds ratio with 95% confidence interval for clinical pregnancy using IGF-I; all p-values less than 0.05 were considered significant.Results: Study results revealed that IGF-I gave positive association with clinical pregnancy outcome, and is a more reliable predic...
Objective: This study was conducted to investigate and compare the analgesic activity of methanol... more Objective: This study was conducted to investigate and compare the analgesic activity of methanolic extracts of seeds of Cuminum Cyminum (L) and Centratherum anthelminticum (L)in mice. Methods: This study was conducted in the department of Pharmacology University of Karachi; 30 healthy mice were selected from animal house of Pharmacology department of University of Karachi for the study. All animals were divided into three groups, each group of 10 mice. Mice of Group 1 were given DMSO (Dimethyl sulphoxide) an organic solvent, mice of group 2 were given Methanolic extract of Cuminum Cyminum (L) and mice of group 3 were given Methanolic extract of Centratherum anthelminticum (L). The analgesic activity was investigated by tail flick test, heat is used to stimulate pain and observe analgesic activity, after a week of oral dosing of Methanolic extracts of seeds of Cuminum Cyminum (L) and Centratherum anthelminticum (L) in mice. Methanolic extracts of Cuminum Cyminum (L) and Centratherum...
Background: Hepcidin is the only iron regulating hormone in human body. The foetus begins to synt... more Background: Hepcidin is the only iron regulating hormone in human body. The foetus begins to synthesize Hepcidin from the 1st trimester of gestation to control unidirectional iron transfer from mother to foetus. The objective of the present study was to determine the correlation of cord Hepcidin with iron status markers of mothers, neonates and neonatal morphometrics. Method: Twenty-five healthy pregnant women and their neonates were included in the study. Haemoglobin, Iron status markers and Hepcidin were analyzed in maternal and cord blood. Neonatal anthropometric variables were measured. Pearson/Spearman correlation was used for association of different variables of mother-neonate pairs. Results: Maternal Hepcidin showed positive correlation with maternal Iron, Ferritin and Transferrin Saturation (TS) (r=0.455 and p=0.022, r=0.511 and p=0.009, r=0.440 and p=0.025 respectively). Cord Hepcidin was positively correlated with cord iron, Ferritin and Transferrin saturation (r=0.593 an...
Objectives: The purpose of the current study was to compare the serum Apelin level in patients wi... more Objectives: The purpose of the current study was to compare the serum Apelin level in patients with and without polycystic ovarian syndrome to assess this as a diagnostic marker for PCOS. In a case-control study 60 polycystic ovarian syndrome patients diagnosed according to Rotterdam criteria and 20 healthy controls of reproductive age group were recruited. Study Design: Case Control study. Setting: Jinnah Postgraduate Medical Center in Collaboration with Aga Khan University, Karachi. Period: August 2017 and February 2019. Material & Methods: Blood samples were collected after 12 hours fasting and was used to test serum Apelin, insulin, cortisol and fasting blood glucose levels. Results: Seventy percent PCO subjects had irregular menstrual cycle and 68% suffered from hirsutism; while all PCO subjects had more than 10 antral follicle seen on ultrasound in either one or both ovaries in comparison of 15% controls (p<0.05). Higher Apelin and Testosterone levels in PCO group was repor...
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