Synthesis of natural products has speeded up drug discovery process by minimizing the time for th... more Synthesis of natural products has speeded up drug discovery process by minimizing the time for their purification from natural source. Several diseases like Alzheimer's disease (AD) demand exploring multi targeted drug candidates, and for the first time we report the multi AD target inhibitory potential of synthesized dihydroactinidiolide (DA). Though the activity of DA in several solvent extracts have been proved to possess free radical scavenging, anti bacterial and anti cancer activities, its neuroprotective efficacy has not been evidenced yet. Hence DA was successfully synthesized from β-ionone using facile two-step oxidation method. It showed potent acetylcholinesterase (AChE) inhibition with half maximal inhibitory concentration (IC) 34.03 nM, which was further supported by molecular docking results showing strong H bonding with some of the active site residues such as GLY117, GLY119 and SER200 of AChE. Further it displayed DPPH and (.NO) scavenging activity with IC value ...
... 200811. Manisankar , P. , PL Abirama Sundari , R. Sasikumar , and D. Jestin Roy . 2008 . ... ... more ... 200811. Manisankar , P. , PL Abirama Sundari , R. Sasikumar , and D. Jestin Roy . 2008 . ... 2005 . Int. J. Environ. Anal. Chem. 85 ( 6 ): 409 422 . [Taylor & Francis Online], [Web of Science ®] View all references; 200615. Manisankar , P. , G. Selvanathan , and C. Vedhi . 2006 . ...
Http Dx Doi Org 10 1080 00397910903457373, Nov 3, 2010
... Lee , WS ; Park , IH ; Yoona , YJ N,N-Dimethylamination of acid chlorides with DMF . Synth. .... more ... Lee , WS ; Park , IH ; Yoona , YJ N,N-Dimethylamination of acid chlorides with DMF . Synth. ... 1985 , 89 , 2286 2291 ; (c) Parmeter , JE ; Weinberg , WH The interaction of formamide with hydrogen-presaturated Ru (001): Conversion of .eta.1 (O)-NH 2 CHO to .eta.2(C, O)-bonded ...
... Santhosh P, Manesh KM, Gopalan A, Lee KP (2007) Sens Actuators B 125:92 15. ... Patil SH, Ban... more ... Santhosh P, Manesh KM, Gopalan A, Lee KP (2007) Sens Actuators B 125:92 15. ... Patil SH, Banerjee K, Dasgupta S, Oulkar DP, Patil SB, Jadhav MR, Savant RH, Adsule PG, Deshmukh MB (2009) J Chroma-togr A 1216:2307 37. Li HP, Lin CH, Jen JF (2009) Talanta 79:466 38. ...
ABSTRACT This contribution reports the first synthesis of conducting polymers (CPs), specifically... more ABSTRACT This contribution reports the first synthesis of conducting polymers (CPs), specifically, polyaniline (PAn) and polypyrrole (PPy), in supercritical carbon dioxide (scCO2). CPs synthesized electrochemically in scCO2 were characterized with cyclic voltammetry (CV), four-point probe conductivity, scanning electron microscopy (SEM), and UV-vis spectroscopy. Preliminary data indicate that CPs synthesized by this method exhibit novel morphology and high conductivity comparable to that synthesized by traditional methods.
Journal of Nanoscience and Nanotechnology, Aug 1, 2010
This is the first report on the preparation of nanobelts/nanodiscs of poly(1,5-diamino naphthalen... more This is the first report on the preparation of nanobelts/nanodiscs of poly(1,5-diamino naphthalene) (PDAN-P) in bulk quantities through a "hard-soft combined templates" approach. PDAN was nanostructured within the channels of MCM-41 (hard template) in the presence of beta-napthalene sulfonic acid (beta-NSA) (soft template) and further used as the seed for the bulk preparation of pure PDAN nanobelts/nanodiscs of PDAN (PDAN-P). Field emision scanning electron microscope image reveals that a typical nanobelt has a length of approximately 3 microm, with a uniform breadth of approximately 150 nm and a thickness of approximately 50 nm. UV-Visible spectrum reveals that the electronic features of PDAN-P are different from PDAN prepared by conventional method (PDAN-C). The electrochemical and interfacial characteristics of PDAN-P were evaluated by cyclic voltammetry and impedance spectroscopy and compared with PDAN-C. The current density characteristics of ITO/PDAN-P and ITO/PDAN-C were also compared. The potential for the onset of current and the current densities beyond the onset potentials were higher at ITO/PDAN-P than for ITO/PDAN-C. Results from electrochemical imedance spectroscopy informed that the ac conductivity of PDAN-P is higher than PDAN-C. Thus, PDAN-P exhibits distinctly different electronic and electrochemical characteristics as compared to PDAN-C.
LiNiO2 and substituted nickel oxides, LiNi0·8M0·2O2 and LiCo0·8M0·2O2 (M = Mg2+, Ca2+, Ba2+), hav... more LiNiO2 and substituted nickel oxides, LiNi0·8M0·2O2 and LiCo0·8M0·2O2 (M = Mg2+, Ca2+, Ba2+), have been synthesized using simple solid state technique and used as cathode active materials for lithium rechargeable cells. Physical properties of the synthesized products are discussed in the structural (XRD, TEM, SEM with EDAX) and spectroscopic (FTIR) measurements. XRD results show that the compounds are similar to
International Journal of Environmental Analytical Chemistry, Sep 17, 2010
Electroanalysis of endosulfan, an important organochlorine pesticide and o -chlorophenol, a toxic... more Electroanalysis of endosulfan, an important organochlorine pesticide and o -chlorophenol, a toxic pollutant was carried out with polypyrrole coated glassy carbon electrode. Pyrrole was electropolymerised on glassy carbon electrode potentiostatically at 0.9 V. Cyclic voltammogram, square wave voltammogram, differential pulse stripping voltammogram and square wave stripping voltammogram under their optimum experimental conditions were obtained for the determination of both compounds. On polypyrrole coated electrode, higher peak current response was observed with differential pulse and squarewave stripping techniques. Comparatively better analytical signal was noticed with square waveform than the differential pulse form. Optimum stripping voltammetric conditions were arrived and the calibration plot was made. The determination limit is 2.457 2 10 3 and 23.346 mM for endosulfan and 7.779 2 10 and 26.916 mM for o-chlorophenol.
... 709–711. Article | PDF (470 K) | View Record in Scopus | Cited By in Scopus (11). [14] C. Zha... more ... 709–711. Article | PDF (470 K) | View Record in Scopus | Cited By in Scopus (11). [14] C. Zhang,G. Li and H. Peng, Mater Lett 63 (2009), pp. 592–594. ... [19] S. Manigandan, S. Majumder, S. Ganguly and K. Kargupta, Mater Lett 6–15 (2008), pp. 2535–2538.
Synthesis of natural products has speeded up drug discovery process by minimizing the time for th... more Synthesis of natural products has speeded up drug discovery process by minimizing the time for their purification from natural source. Several diseases like Alzheimer's disease (AD) demand exploring multi targeted drug candidates, and for the first time we report the multi AD target inhibitory potential of synthesized dihydroactinidiolide (DA). Though the activity of DA in several solvent extracts have been proved to possess free radical scavenging, anti bacterial and anti cancer activities, its neuroprotective efficacy has not been evidenced yet. Hence DA was successfully synthesized from β-ionone using facile two-step oxidation method. It showed potent acetylcholinesterase (AChE) inhibition with half maximal inhibitory concentration (IC) 34.03 nM, which was further supported by molecular docking results showing strong H bonding with some of the active site residues such as GLY117, GLY119 and SER200 of AChE. Further it displayed DPPH and (.NO) scavenging activity with IC value ...
... 200811. Manisankar , P. , PL Abirama Sundari , R. Sasikumar , and D. Jestin Roy . 2008 . ... ... more ... 200811. Manisankar , P. , PL Abirama Sundari , R. Sasikumar , and D. Jestin Roy . 2008 . ... 2005 . Int. J. Environ. Anal. Chem. 85 ( 6 ): 409 422 . [Taylor & Francis Online], [Web of Science ®] View all references; 200615. Manisankar , P. , G. Selvanathan , and C. Vedhi . 2006 . ...
Http Dx Doi Org 10 1080 00397910903457373, Nov 3, 2010
... Lee , WS ; Park , IH ; Yoona , YJ N,N-Dimethylamination of acid chlorides with DMF . Synth. .... more ... Lee , WS ; Park , IH ; Yoona , YJ N,N-Dimethylamination of acid chlorides with DMF . Synth. ... 1985 , 89 , 2286 2291 ; (c) Parmeter , JE ; Weinberg , WH The interaction of formamide with hydrogen-presaturated Ru (001): Conversion of .eta.1 (O)-NH 2 CHO to .eta.2(C, O)-bonded ...
... Santhosh P, Manesh KM, Gopalan A, Lee KP (2007) Sens Actuators B 125:92 15. ... Patil SH, Ban... more ... Santhosh P, Manesh KM, Gopalan A, Lee KP (2007) Sens Actuators B 125:92 15. ... Patil SH, Banerjee K, Dasgupta S, Oulkar DP, Patil SB, Jadhav MR, Savant RH, Adsule PG, Deshmukh MB (2009) J Chroma-togr A 1216:2307 37. Li HP, Lin CH, Jen JF (2009) Talanta 79:466 38. ...
ABSTRACT This contribution reports the first synthesis of conducting polymers (CPs), specifically... more ABSTRACT This contribution reports the first synthesis of conducting polymers (CPs), specifically, polyaniline (PAn) and polypyrrole (PPy), in supercritical carbon dioxide (scCO2). CPs synthesized electrochemically in scCO2 were characterized with cyclic voltammetry (CV), four-point probe conductivity, scanning electron microscopy (SEM), and UV-vis spectroscopy. Preliminary data indicate that CPs synthesized by this method exhibit novel morphology and high conductivity comparable to that synthesized by traditional methods.
Journal of Nanoscience and Nanotechnology, Aug 1, 2010
This is the first report on the preparation of nanobelts/nanodiscs of poly(1,5-diamino naphthalen... more This is the first report on the preparation of nanobelts/nanodiscs of poly(1,5-diamino naphthalene) (PDAN-P) in bulk quantities through a "hard-soft combined templates" approach. PDAN was nanostructured within the channels of MCM-41 (hard template) in the presence of beta-napthalene sulfonic acid (beta-NSA) (soft template) and further used as the seed for the bulk preparation of pure PDAN nanobelts/nanodiscs of PDAN (PDAN-P). Field emision scanning electron microscope image reveals that a typical nanobelt has a length of approximately 3 microm, with a uniform breadth of approximately 150 nm and a thickness of approximately 50 nm. UV-Visible spectrum reveals that the electronic features of PDAN-P are different from PDAN prepared by conventional method (PDAN-C). The electrochemical and interfacial characteristics of PDAN-P were evaluated by cyclic voltammetry and impedance spectroscopy and compared with PDAN-C. The current density characteristics of ITO/PDAN-P and ITO/PDAN-C were also compared. The potential for the onset of current and the current densities beyond the onset potentials were higher at ITO/PDAN-P than for ITO/PDAN-C. Results from electrochemical imedance spectroscopy informed that the ac conductivity of PDAN-P is higher than PDAN-C. Thus, PDAN-P exhibits distinctly different electronic and electrochemical characteristics as compared to PDAN-C.
LiNiO2 and substituted nickel oxides, LiNi0·8M0·2O2 and LiCo0·8M0·2O2 (M = Mg2+, Ca2+, Ba2+), hav... more LiNiO2 and substituted nickel oxides, LiNi0·8M0·2O2 and LiCo0·8M0·2O2 (M = Mg2+, Ca2+, Ba2+), have been synthesized using simple solid state technique and used as cathode active materials for lithium rechargeable cells. Physical properties of the synthesized products are discussed in the structural (XRD, TEM, SEM with EDAX) and spectroscopic (FTIR) measurements. XRD results show that the compounds are similar to
International Journal of Environmental Analytical Chemistry, Sep 17, 2010
Electroanalysis of endosulfan, an important organochlorine pesticide and o -chlorophenol, a toxic... more Electroanalysis of endosulfan, an important organochlorine pesticide and o -chlorophenol, a toxic pollutant was carried out with polypyrrole coated glassy carbon electrode. Pyrrole was electropolymerised on glassy carbon electrode potentiostatically at 0.9 V. Cyclic voltammogram, square wave voltammogram, differential pulse stripping voltammogram and square wave stripping voltammogram under their optimum experimental conditions were obtained for the determination of both compounds. On polypyrrole coated electrode, higher peak current response was observed with differential pulse and squarewave stripping techniques. Comparatively better analytical signal was noticed with square waveform than the differential pulse form. Optimum stripping voltammetric conditions were arrived and the calibration plot was made. The determination limit is 2.457 2 10 3 and 23.346 mM for endosulfan and 7.779 2 10 and 26.916 mM for o-chlorophenol.
... 709–711. Article | PDF (470 K) | View Record in Scopus | Cited By in Scopus (11). [14] C. Zha... more ... 709–711. Article | PDF (470 K) | View Record in Scopus | Cited By in Scopus (11). [14] C. Zhang,G. Li and H. Peng, Mater Lett 63 (2009), pp. 592–594. ... [19] S. Manigandan, S. Majumder, S. Ganguly and K. Kargupta, Mater Lett 6–15 (2008), pp. 2535–2538.
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