Background: Euclea divinorum, belonging to the family Ebeneceae, has extensive traditional medici... more Background: Euclea divinorum, belonging to the family Ebeneceae, has extensive traditional medicinal use in Africa. However, it lacks sufficient published data on its pharmacognostic, physicochemical, and phytochemical properties. Aims and Objectives: Thus, this study aimed at comprehensively evaluating the pharmacognostic, physicochemical, and phytochemical properties of E. divinorum using established techniques. Materials and Methods: The evaluation included assessing organoleptic properties, macroscopy, and microscopy of leaves, stems, and roots. Various physicochemical parameters, such as loss on drying and extractive values via hot and cold maceration, were determined. Phytochemical screening was also conducted on root aqueous extracts. Results and Conclusion: Results revealed specific characteristics of E. divinorum leaves, including light green coloration, distinct odor, and bitterness. Macroscopic examination highlighted opposite phyllotaxy, simple leaf types with lamina length range of 71.09-93.89 mm and a width range of 6.05-17.59 mm, obtuse leaf apexes, cuneate leaf bases, entire leaf margins, and smooth leaf surfaces. Venation displayed a reticulate pattern, with the midrib prominently visible on the lower surface. Microscopic analysis of the lower leaf epidermis showed an average of stomatal density of 3.75±0.67, epidermal density of 35.75±2.16 and stomatal index of 10.47±1.11. Microscopic examination of the leaf lamina across the midrib revealed cortical parenchymal cells containing calcium oxalate crystals, lignified xylem, and non-lignified phloem. Stem cross-sections displayed single-layered cells comprising the epidermis, secondary phloem, secondary xylem, and pith. Similar structures were observed in root cross-sections. The plant's moisture content was found to be 44.8±1.962%, with water and alcohol-soluble extractive values of 7.27±0.17 and 1.13±0.05 g/100g, respectively, through cold maceration, and 14.77±0.28 and 11.43±0.39 g/100g, respectively through hot maceration. The total ash content was measured at 3.03± 0.103%. Phytochemical screening detected various compounds, with anthraquinone glycosides, coumarine glycosides, saponin glycosides, flavonoids, proteins, and tannins being abundant. Alkaloids, cardiac glycosides, and steroids were absent. This research contributes to standardizing E. divinorum, aiding in its identification, preventing adulteration, and ensuring therapeutic efficacy.
Quality assurance, shelf life, stability studies of ASU herbal, medicinal plants-Syzygium aromati... more Quality assurance, shelf life, stability studies of ASU herbal, medicinal plants-Syzygium aromaticum (Linn.) Merr LM Perry and W. fruticosa (Linn.) Kurz Abstract Introduction: QA, Shelf life, Stability Studies of ASU. herbal products remains a challenging task. The Coarse powder of SA and WF are specially designed for oral consumption and contains herbal ingredients known for their specific medicinal benefits. Storage conditions can significantly affect the shelf life of ASU. herbal Coarse powders, therefore, it is essential to assess the stability of these Coarse powders. According to ICH / WHO guidelines, which is used to treat various human ailments. This study aims to evaluate the QA, SL, SS investigated, analyzed parameters of coarse powders of flowers buds and flowers parts of the plant drugs SA and WF. Methods: The QA, SL, SS investigated studies with the accelerated stability studies at 40 °C and a relative humidity (RH) of 75% ±5 over a period of 6 months, with assessments conducted at the 0, 2nd, 4th, and 6th months. Various parameters, including Organoleptic characteristics, Pharmacognosy, HPTLC. identification, physico-chemical properties, Toxicological studies having investigated HM, AT, PR and MB load, were monitored during these intervals of SA and WF were carried out and performed using standard methods. The accelerated testing conditions are at least 10 °C Temp. higher than the long-term study conditions and are intended to increase the rate at which degradation reactions take place thus revealing quality changes at an early stage globally climatic zones are divided into max. 6 months intervals time period for shelf life, stability studies and the storage conditions. Results: The results of these studies were taken into consideration when estimating the QA, SL, SS of SA and WF Course powder drugs. The extended shelf life estimate was determined by applying an accelerated deterioration rate of 10% for physico-chemical parameters. Conclusions: The QA, SL, SS findings were revealed that the test drugs batches were stability is confirmed, no max. significance changes occurred in tested samples and shown stable potent of undeteriorate condition. As a result, it was established that the SA and WF course powder have an estimated shelf life Max. 1 years and eight months and 2 Year. The Studies revealed data's can be provide referential supports and essential in the future for QA, Product Acceptability, Pharmaco-vigilance aspects.
Introduction: Biodiversity, Phramacognostical, Pharmacological, Toxicological research studies of... more Introduction: Biodiversity, Phramacognostical, Pharmacological, Toxicological research studies of ASU herbal products remains a big challenging task. There needs to be more than the advance investigation research studies and screening parameters to validation, authenticate and differentiate adulterants in ASU medicinal plants. Peucedanum grande C.B. Clarke is one of the herbs used to treat various health wellness and therapeutic illness of public mankind. This study aims to evaluate the Biodiversity, Phramacognostical, Pharmacological, Toxicological research studies of the seed part of plant of P G. Methods: The Botanical identification, Pharmacognosy and Toxicological quality control research analysis of the seed part of plant of P G. powder were carried out using standard methods. The Quality, safety and toxicity effects of the tested drug samples were also investigated. Results: The Botanical identification, Pharmacognosy, Toxicological QC. Properties of P G. have shown that all the parameters were within the permissible limits. The tested drug samples showed significant Quality, safety and toxicity studies against certain pathogens organisms and promising anti-pathogenic activity. Conclusions: In the investigated review studies of Pharmacognosy, Toxicological DSR, QC. research findings revealed that the revalidated test drug was free from adulterations. This investigated herb's research data confirmed to drug standardization and therapeutically may treat that the drug is safe for internal use and cures in Anti-lithiatic, Carminative, Demulcent, Diaphoretic, Anti-Inflammatory,Anti-dote, Stimulant, Expectorant, Deobstruent, Lithotriptic, Emmenagogue disorder. Keywords: Duqu, Peucedanum grande C.B. Clarke, DSR, QC. and QA, Biodiversity ,Pharmacognosy and Toxicological, Pharmacological Quality, Safety and Toxicity studies.
World Journal of Pharmacy and Pharmaceutical Sciences, 2024
Standardization and product acceptability is used to describe all measures under taken during the... more Standardization and product acceptability is used to describe all measures under taken during the manufacturing process and quality control and quality assurance of drug leading to its reproducible quality. Therefore we need to develop standard validation techniques to standardize and validate of the herbal products and formulations using QC. QA Screening Studies. The drug Woodfordia fruticosa (Linn.) Kurz) is therapeutically useful in the treatment of Anti-pyretic, Anti-pills, Anti-inflammatory, Anti-ulcer, Anti-diarrheal, Anti-Sinus, Anti-Diabetes, Anti-Leukorrhea, Anti-Leprosy, Anti-hyperglycemic activity, Anti-depressant activity, Anti-cancer activity, Antioxidant activity. The single drug WF was Standardization, Quality Control Screening studied in three different batches as per the guidelines of WHO/ AYUSH Protocols basis. Present research study is aimed to evaluate the Standardization and product quality acceptability using physico-chemical parameters; HPTLC fingerprinting as per WHO guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain Foreign matter, w/w- (0.08 %,0.07%,0.08%), LOD/ Moisture, w/w- (6.054%,6.010% 6.320%), Total ash, w/w-(5.79%,5.82%,6.93%), Acid in-soluble ash, w/w-(0.776%,0.770%,0.778%), Alcohol and water soluble extractive matter, w/v- (12.80%,12.46%, 12.38%) & (24.40%, 4.46%,24.50%), pH(10% solution) (4.8,4.9,4.8), the HPTLC finger prints showed various spots at 254nm, 366nm Iodine vapours and visible light (M-S reagent). The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. The QC. findings revealed that the test drug was free from adulterations. The evaluated validated quality standards will be very useful for referential support, validation of the standards of WF, pharmaco-vigilance and providing the quality raw medicine to deprived human being.
KEYWORDS: (Woodfordia fruticosa (Linn) Kurz), Physico-chemical quality QC and QA HPTLC fingerprinting and Unani Compound drug.
World Journal of Pharmacy and Pharmaceutical Sciences, 2024
Introduction: DSR, QC, and QA. of herbal products remains a challenging task. There needs to be m... more Introduction: DSR, QC, and QA. of herbal products remains a challenging task. There needs to be more than investigated screening parameters to validation, in order to authenticate and differentiate adulterants in medicinal plants. Tagetes erecta L. is one of the herbaceous plant which is used to treat various human ailments. This study aims to evaluate the DSR, QC, HPTLC, and GC-MS fingerprint profiles of the flower part of plant drug and extracts of T E. Methods: The QC and DSR with the Toxicology studies as heavy metal, aflatoxins, pesticide residues analysis, HPTLC and GC-MS analysis of the chloroform and ethanolic extract of T E. were carried out and performed using standard methods. The antibacterial potential, antimicrobial & antitoxicity effects of the tested drug samples of different microbes, hazardous and toxins were also investigated. Results: The DSR, QC. properties of T E. have shown that all the parameters were within the permissible limits. The HPTLC fingerprint profile of the chloroform and ethanolic extract exhibited various peaks under UV 254 nm, under UV 366 nm and V-S reagent, visible light region. The GC-MS analysis confirmed and illustrated the presence of various BAC. in the test sample. The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. Conclusions: The QC. findings revealed that the test drug was free from adulterations. Shown Antibacterial immense potential. The physicochemical constants, HPTLC, and GC-MS profiles of T E. can be essential data in the future. This herb's extracts may treat and cures in Scabies, Fever, Skin diseases.
KEYWORDS: Tagetes erecta L., DSR, QC., and QA., HPTLC, and GC-MS profiles, Toxicology studies.
International Level Double Blind Peer Reviewed,Refereed,Indexed Research Journal, 2024
सार संक्षेप: उस्तुखुद्दुस (लेवेनन्डुला स्टोकस एल, Lavandula stoechas L.) लेमिएसी परिवार का सबसे म... more सार संक्षेप: उस्तुखुद्दुस (लेवेनन्डुला स्टोकस एल, Lavandula stoechas L.) लेमिएसी परिवार का सबसे महत्वपूर्ण सुगंधित पौधा है। यह यूनानी चिकित्सा प्रणाली में जरूब-ए-दिमाग के रूप मे जाना जाता है। क्योकि इसके सफाई के गुण के कारण यह दिमाग से अस्वस्थ पदार्थों को निकालने की क्षमता रखता है। जो न्यूरोलॉजिकल विकारों जैसे कि अनिद्रा, स्म्र्तिलोप, मेलंकॉलिया, आदि का कारण बन सकते है। यह औषधि के रूप में प्राचीन समय से प्र्योग की जाती रही है। और प्राचीन समय मे पहली शताब्दी ईसा पूर्व में इसके विभिन्न फार्माकोलोजिकल गुणों के लिए डीओस्कोरिडेस (Dioscorides) द्वारा इसका उल्लेख किया गया था। इसके फार्माकोलोजिकल गुणों / प्रभावों पर विभिन्न अध्ययनों की जाँच की गई है जो इसमे मौजूद उसके बायोएक्टिव संघटकों का श्रेय दे सकते है,जैसे ग्लाइकोसाइड, फेनोल, स्टोराइड्स, ट्र्पीन आदि। वर्तमान शोध पत्र में उस्तुखुद्दुस के मैक्रोस्कोपी, पाउडर माइक्रोस्कोपी एवं पौधे के औषधीय गुणों की व्याख्या की गयी है। यह अध्ययन औषधि के सही पहचान और मूल्यक्षमता के लिए उपयोगी होगा।
Advance International Journal of Multidisciplinary Research , 2024
Woodfordia fruticosa (L.) Kurz commonly known as Dhawa or Dhataki, is an important medicinal plan... more Woodfordia fruticosa (L.) Kurz commonly known as Dhawa or Dhataki, is an important medicinal plant that has been traditionally used in various systems of medicine for its therapeutic properties such asdysentery, leprosy, leucorrhoea, menorrhagia, toothache. It has been used as astringent to treat dysentery and also for the treatment of bowl complaint and rheumatism. Pharmacognostical studies encompass the macroscopic and microscopic evolution of the plant material, including its botanical description, organoleptic properties and anatomical features, which aid in the identification and authentication of the plant. Physicochemical studies involve the determination of various physicochemical parameters such as foreign matter, ash values, extractive values. These parameters provide valuable information regarding the chemical composition and quality standards of Woodfordia fruticosa, facilitating its standardization and quality control in herbal drug. Overall, the Pharmacognostical and Physicochemical studies outlined in this study serve as a comprehensive reference for researchers and organizations engaged in further exploration of medicinal potential of Woodfordia fruticosa, paving the way for the development of therapeutic agents and herbal drugs.
Abstract / अमूर्त : मानकीकरण और उत्पाद स्वीकार्यता का उपयोग विनिर्माण प्रक्रिया और गुणवत्ता नियंत... more Abstract / अमूर्त : मानकीकरण और उत्पाद स्वीकार्यता का उपयोग विनिर्माण प्रक्रिया और गुणवत्ता नियंत्रण और दवा की गुणवत्ता आश्वासन के दौरान किए गए, सभी उपायों का वर्णन करने के लिए किया जाता है, जिससे इसकी प्रतिलिपि प्रस्तुत करने योग्य गुणवत्ता प्राप्त होती है। इसलिए हमें गुणवत्ता नियंत्रण का उपयोग करके हर्बल फॉर्मूलेशन के मानकीकरण और सत्यापन के लिए मानक सत्यापन तकनीक विकसित करने की आवश्यकता है। गुणवत्ता आश्वासन स्क्रीनिंग अध्ययन। दवा धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन.) कुर्ज़) एंटी-पायरेटिक, एंटी-पिल्स, एंटी-इंफ्लेमेटरी, एंटी-अल्सर, एंटी-डायरिया, एंटी-साइनस, एंटीएंटरोवायरल, एंटी-हाइपरग्लाइसेमिक के उपचार में चिकित्सीय रूप से उपयोगी है। , मधुमेह रोधी, ल्यूकोरिया रोधी, कुष्ठ रोग रोधी, स्त्री रोग, अधिक रक्तस्राव, प्लीहा, दांत निकलने संबंधी आदि विभिन्न समस्याओं को नियंत्रित और सुरक्षित रखता है। एकल दवा डब्ल्यूएफ का मानकीकरण, गुणवत्ता नियंत्रण स्क्रीनिंग का डब्ल्यूएचओ/आयुष प्रोटोकॉल के आधार पर दिशानिर्देशों के अनुसार तीन अलग-अलग बैचों में अध्ययन किया गया। वर्तमान शोध अध्ययन का उद्देश्य भौतिक-रासायनिक मापदंडों का उपयोग करके मानकीकरण और उत्पाद गुणवत्ता स्वीकार्यता का मूल्यांकन करना है; विश्लेषण किए गए मापदंडों के डब्ल्यूएचओ दिशानिर्देशों के अनुसार एचपीटीएलसी फिंगरप्रिंटिंग। परीक्षण नमूनों के प्रत्येक III बैच के भौतिक-रासायनिक औसत रीडिंग डेटा से पता चला कि दवा में विदेशी पदार्थ, w/w-(0.08%, 0.07%, 0.08%), LOD / नमी, w/w- (5.79%,5.82,6.93 % शामिल हैं ), कुल राख, w/w- (5.79%,5.82%, एवं 6.93, %), एसिड में घुलनशील राख, w/w-(0.776%,0.770%, एवं 0.778,%), अल्कोहल और पानी में घुलनशील अर्क पदार्थ, w/v- (12.80%, 12.46%, 12.38%) और (24.40%, 24.46%, 24.50%), पीएच (10% समाधान) (4.8 ,4.9, 4.8), एचपीटीएलसी फिंगर प्रिंट्स ने 254 एनएम, 366 एनएम आयोडीन वाष्प और दृश्य प्रकाश (एम-एस अभिकर्मक) पर विभिन्न धब्बे दिखाए। गुणवत्ता नियंत्रण अध्ययनों के सत्यापन से माइक्रोबियल लोड, एफ्लाटॉक्सिन, भारी धातु और कीटनाशक अवशेषों की अनुपस्थिति का पता चला, मूल्यांकन किया गया मान्य गुणवत्ता मानक संदर्भात्मक समर्थन, डब्ल्यूएफ के मानकों के सत्यापन, फार्माको-सतर्कता और वंचित मानव को गुणवत्तापूर्ण कच्ची दवा प्रदान करने के लिए बहुत उपयोगी होंगे।
Keywords / मूलशब्द : धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन) कुर्ज़), भौतिक-रासायनिक गुणवत्ता, गुणवत्ता नियंत्रण और आश्वासन पैरामीटर, टीएलसी / एचपीटीएलसी फिंगरप्रिंटिंग और यूनानी यौगिक दवा।
Abstract / अमूर्त परिचय: हर्बल उत्पादों की गुणवत्ता नियंत्रण एक बड़ा चुनौतीपूर्ण कार्य बना हुआ है... more Abstract / अमूर्त परिचय: हर्बल उत्पादों की गुणवत्ता नियंत्रण एक बड़ा चुनौतीपूर्ण कार्य बना हुआ है। औषधीय पौधों में मिलावटों के सत्यापन, प्रमाणीकरण और अंतर के लिए फार्माकोग्नॉसी, भौतिक रसायन और स्क्रीनिंग मापदंडों से कहीं अधिक की आवश्यकता है। गुल-ए-साद बार्ग (मेरिगोल्ड), टैगेट्स इरेक्टा एल. सार्वजनिक मानव जाति के विभिन्न स्वास्थ्य कल्याण और चिकित्सीय बीमारियों के इलाज के लिए उपयोग की जाने वाली जड़ी-बूटियों में से एक है। इस अध्ययन का उद्देश्य मैरीगोल्ड के पौधे के फूल भाग के क्यूसी, वानस्पतिक पहचान, फार्माकोग्नॉसी, भौतिक रासायनिक अध्ययन का मूल्यांकन करना है। विधियाँ: टी ई. मोटे पाउडर के पौधे के फूल भाग की वानस्पतिक पहचान, फार्माकोग्नॉसी भौतिक रसायन और गुणवत्ता नियंत्रण अनुसंधान विश्लेषण मानक विधियों का उपयोग करके किया गया। परीक्षण किए गए दवा नमूनों की गुणवत्ता, सुरक्षा और विषाक्तता प्रभाव की भी जांच की गई। परिणाम: वानस्पतिक पहचान, फार्माकोग्नॉसी, भौतिक रसायन और क्यूसी। टी ई के गुणों से पता चला है कि सभी पैरामीटर अनुमेय सीमा के भीतर थे। परीक्षण किए गए दवा के नमूनों ने कुछ रोगजनक जीवों के खिलाफ महत्वपूर्ण गुणवत्ता, सुरक्षा और विषाक्तता अध्ययन दिखाया और रोग-रोधी गतिविधि का वादा किया। निष्कर्ष: वानस्पतिक पहचान, फार्माकोग्नॉसी, गुणवत्ता नियंत्रण अनुसंधान निष्कर्षों से पता चला कि परीक्षण दवा के सभी नमूने मिलावट से मुक्त थे। इस जांचे गए जड़ी-बूटी के शोध डेटा से पता चला है कि दवा मानकीकरण और चिकित्सीय रूप से खुजली, बुखार, त्वचा रोगों और आंखों के रोगों का इलाज और इलाज कर सकती है।
Keywords / मूलशब्द (कीवर्ड): गुल-ए-साद बार्ग, टैगेट्स इरेक्टा एल. (मेरिगोल्ड), ड्रग मानकीकरण अनुसंधान, क्यूसी., और क्यूए, एचपीटीएलसी फिंगरप्रिंट, और जीसी-एमएस प्रोफाइल, गुणवत्ता, सुरक्षा और विषाक्तता अध्ययन।
International Journal of Recent Scientific Research, 2024
Beninca hispida (Thunb.)-Petha is a very important processed, dynamic commercial product found of... more Beninca hispida (Thunb.)-Petha is a very important processed, dynamic commercial product found of North India. It is processed largely in North India-Uttar Pradesh, Uttarakhand plan area and Bihar States from wax gourd or ash gourd. Petha sweet is having geographical indication (GI) tag from Agra, U.P. State in India. BH. used as amazing therapeutic potentials as a Antioxidant, Antidiabetic, Hypoglycemic and Hypolipidemic, Anti-inflammatory, Alzheimer's disease, Anti-compulsive effect, Allergic inflammation, Antibiotic, Anti-microbial, Anti-Ulcer, Anti-Acidic, Anti-asthmatic, Cytotoxic and Anticancer, Anti-obesity, Antidepressant and Anxiolytic, Analgesic and Antipyretic, Antihypertensive, Anti ageing of Skin, Gastro protective from since ancient time. Three fresh samples of BH. taken into these studies from North India Region U.P., U.K. and Bihar State which 3 samples were freshly collected P1,P2 and P3. and developed from applied SOP. on the basis of authenticated classical texts and literature of standard methods. The quality control & quality assurance studies were conducted in accordance to the WHO., AOAC., IPC. and UPC., approved guidelines. The physicochemical data showed that the drug samples contain, Average values as Foreign Matter, w/w,(%)-Nil, LOD/ moisture (3.85%), Total Ash, w/w,(%)-(6.21%), Acid Insoluble , w/w,(%)-(0.32%), Alcohol and Water Soluble Extractive Matter, w/v, (%)-(2.50%) & (5.56%), pH(1% solution) (5.92), pH(10% solution) (5.35), and various bioactive phytochemical screening examined were assessed in BH., HPTLC. studies of chloroform and alcohol extracts of different samples P1.P2 and P3 of Petha BH. Classical formulation showed various spots at examine under 254nm and under 366nm (UV. region), found no major spots is observed, under exposed to Vinyl-Sulfuric acid reagent. derivatized obtained with equate, best separation using selected suitable solvent system of mobile phase. The quality control studies results revealed the absence of hazardous and toxic contamination from the drug samples of BH. Moreover the obtained research studies data and comparative screening will provide the referential supportive information in the development of Pharmacopeial standard monographs, identification of classical formulation, reinvestigation, quality assurance and pharmaco-vigilance and validation of the Quality standard of BH. classical sweet food providing the quality food used as a medicine to Health & Wellness of needful public mass of the world.
International Journal of Pharmacy and Pharmaceutical Science ; https://www.pharmacyjournal.org/, 2024
Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for heal... more Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for health, wellness and cures to mankind and it is used in all cultures all over history The primeval and tribal's, hillers persons learned by trial and error basis to identified valuable potent medicinal plants. In modern scenario more demand increasing towards herbal medicinal ASU products because ASU and TAM herbal products having low hazardness and toxicity as compare to other medicine and there is increasing awareness and general acceptability of herbal drugs in today's medical practice on global demand basis. In present, It is however a known fact that over 80% of the world population used herbal medicines and product for healthy living. As well as globally demand of herbal products increases the need of herbal quality assurance for customer satisfaction also increases. For the prevention of drug substitution, adulteration and developed abuse herbal products, WHO have been released guidelines on global requirement and public domain to all herbal industries. The identification of this highly active moiety is an important requirement for Quality assurance, quality control and dose determination of plant related dugs. Standardization research of ASU. Herbal drugs means confirmation or validation of its identity, purity, quality and efficacy. It is mandatory for every ASU herbal industry. It must need for collection, handling, processing and production of ASU herbal medicine as well as employ such parameters in ensuring the quality, safety, efficacy and compulsory need for the global ASU. TAM. Herbal market. In this overview all guidelines which are required for development of ASU and TAM herbal products at global scale.
International Journal of Pharmacy and Pharmaceutical Science; www.pharmacyjournal.org , 2022
Introduction: Quality control of herbal products remains a big challenging task. There needs to b... more Introduction: Quality control of herbal products remains a big challenging task. There needs to be more than the Pharmacognosy, physicochemical and screening parameters to validation, authenticate and differentiate adulterants in medicinal plants. Genda phool / Gul-e-Sad Barg (Marigold), Tagetes erecta L. is one of the herbs used to treat various health wellness and therapeutic illness of public mankind. This study aims to evaluate the QC, Botanical identification, Pharmacognosy, physicochemical studies of the flower part of plant of Marigold. Methods: The Botanical identification, Pharmacognosy physicochemical and quality control research analysis of the flower part of plant of T E. coarse powder were carried out using standard methods. The Quality, safety and toxicity effects of the tested drug samples were also investigated. Results: The Botanical identification, Pharmacognosy, physicochemical and QC. Properties of T E. have shown that all the parameters were within the permissible limits. The tested drug samples showed significant Quality, safety and toxicity studies against certain pathogens organisms and promising antipathogenic activity. Conclusions: The Botanical identification, Pharmacognosy, quality control research findings revealed that the test drug was free from adulterations. This investigated herb's research data confirmed to drug standardization and therapeutically may treat that the drug is safe for internal use and cures in Scabies, Fever, Skin diseases and eyes diseases.
The people worldwide are adopting herbal medicines as alternative health care system. Their reli... more The people worldwide are adopting herbal medicines as alternative health care system. Their reliance on herbal medicines has led to remarkable growth of tradition system of medicine. The preparation of herbal formulation is usually based on traditional methods in accordance with the procedure described in classical literature which sometimes lacks scientific validation. It is utmost important to scientifically standardize the method of preparation and physicochemical parameters to ensure their authenticity and therapeutic effects. Therefore, a herbal Unani formulation Qurs-e-Isqeel widely known for its action as diuretic and antidote and therapeutically used in poisoning, fracture, ascites and dysuria. The drug was studied through various standardization parameters such as organoleptic evaluation (colour, Odor and taste), physico-chemical evaluations (moisture content, total ash, acid insoluble ash, pH values, water and ethanol soluble extractive, volatile oil) and microscopy. The evaluations of WHO parameters such as heavy metals, aflatoxins, pesticide residue and microbial contamination were also carried out to ascertain the quality of drug. The data revealed the present work will help in developing pharmacopoeial standards for maintaining the quality and batch to batch consistency of Qurse-Isqeel.
International Journal of Natural Product Science , 2013
Diabetes mellitus (DM), or Diabetes (Madhumeha) chronic degenerative disease is one of the common... more Diabetes mellitus (DM), or Diabetes (Madhumeha) chronic degenerative disease is one of the common metabolic disorder acquiring around above 3.0% of the world"s population and is anticipated to cross more than 4 to 5% by the year 2025. Since ancient times herbal medicines have been used as a traditional, folk, Ayurvedic & Unani medicines, the source of anti-diabetic medicines. In view of the above aspects, the present review discusses various medicinal plants with their anti-diabetic activity Which include Meshashringi or Gurmar leaves (Gymmema Sylvestre), Jamun Guthli(Syzygium cuimini), Beeja saar or Vijay saar bark (Pterocarpus marsupium),
International Journal of Natural Product Science, 2013
Many herbal remedies individually or in combination have been recommended in various medical expo... more Many herbal remedies individually or in combination have been recommended in various medical expositions for the cure of different disease. The Pongamia pinnata (Vent) commonly known"s "Karanj" has been recognized in different system of traditional medicines for the treatment of different diseases and ailments of human beings. It contains several phyto-chemical like carbohydrates, alkaloids, flavonoids, glycosides, steroids, tannins and sponins. It is found that the plants contain a number of secondary metabolites and have the pharmacological actions. Hyro-alcoholic extract of Pongamia pinnata (Vent) were studied for its anti oxidant, cardio protective activities. Reduction in DPPH colour indicated presence of strong antioxidant activity.
International Journal of Pharmaceutical Science and Research , 2014
Endangered Indian medicinal plants have used as traditional and alternative Indian system of medi... more Endangered Indian medicinal plants have used as traditional and alternative Indian system of medicine (ISM.) from last several ancient time. In 20th and 21th centaury generation are becoming aware of the side effect and adverse reaction of synthetic drugs and so there is an increasing interest, Scope of innovate in herbal medicinal plants based Ayurvedic, Sidha, Unani (ASU.) medicinal products. In the continuously using of Adulteration and Substitution, Spurious drugs on the place of original Indian endangered and costly ASU. Herbal medicinal plants hence today generate the major task of Indian drug regularity affaire, drug controlling approach as well as herbal industries face burning problem. Resulted growing high altitude region many endangered and rare costly original medicinal species such as these are Vatsnabh, (Aconitum Chasmanthumstapfex. Haimes), Ativishaor Atis, (Aconitumheterophylum Wall. Ex. Royal), Kutki, (Picrorhiza kurroa royleex), Kuth or Kustha, (Saussurea lappa C.B.CL.), Puskarmool, (Inularacemosa Hook.F.), Riddhi, (Hobenariainte media D. Don), Vriddhi, (Habenariaedge worthii Hook.f.ex.Collett), Kakoli, (Roseea purpurrea Smith), Kshirakakoli, (Fritillariar oylei Hook) and (Lilium polyphyllum D. Don), Jeevak, (Crepipiuma cumina tum D.Don.) Szlach.), Meda, (Polygonatum verticillatum Linn.)Allioni), Mahameda, (Polygonatum cirrhifolium (wall.) Royal) and (Polygonatum Vertecillatum Alloi), Rakta Chandana , Sandal Surkh,(Pterocarpus santalinus Linn.), Sveta Chandana, Sandal Safed ,(Santalum album Linn.), Kesar, Keshar or Kum Kum, Zafran ,(Crocus sativus Linn.) etc. completely endangered and incorrect identification of their intestinally or unintentionally, Finally they become effectively adulterated and substituted in condition. The present communication investigate research review has reported their drug regularity affaire and drug controlling, pharmacovigilance approach of Adulteration and Substitution, Spurious drugs with active phytochemical constituents, extensive taxonomical and ethnobotanical authentication, medicinal properties of these several endangered and costly medicinal plants.
International Journal of Traditional and Complimentary Medicine , 2020
Cancer is one of the harmful leading causes of death worldwide. Several synthetic agents have bee... more Cancer is one of the harmful leading causes of death worldwide. Several synthetic agents have been used to cure the disease but they have their adverse side effects, low-hilling potential and toxicity.Present Article reviewed three important medicinal plants i.e.-Taxus baccata L. Or Taxus baccata Thunb., Catharanthus roseus(L.
International Journal of Multidisciplinary and Education Research, 2021
In the present life style scenario of human being, Cancer and noval strain of Corona Covid-19 vir... more In the present life style scenario of human being, Cancer and noval strain of Corona Covid-19 virus are one of the danger leading causes of death all over the world. Several synthetic agents have been used to cure the disease but they have their adverse side effects, low-hilling potential and toxicity. Present article reviewed three important asian medicinal plants, (Curcuma Domestica valeton or Curcuma longa L., Tinospora cordifolia (Willd.) Miers, and Ocimum sanctum L., Ocimum tanuiflorum L. which traditionally used ancient time as an ASU. medicines in Asian countries for the treatment and prevention of Cancer, Tumor and bacterial, virus infections in Asian and Sothern, North east and Himalayan region of India.These plants contain several anti-cancerous, anti-tumorous and anti-oxidant, immuno-modubulator bioactives constituents, secondary metabolites such as strong alkaloids-Curcuminoids and Curcumin, Phenols, ascorbic acid in Curcuma Domestica valeton or Curcuma longa L., Alkaloids-Berberine, Choline, Titembetarine, Magno florine, Tinosporin, Palmetine, Isocolumbin, Aporphine, Jatrorrhizine ,Tetrahydropalmatine, βsitosterol, β-sitosteryl glycosides etc. present in Tinospora cordifolia (Willd.) Miers and strong alkaloids such as Apigenin and Taxol, Phenolic compound, Ursolic acid, Caffeic acid and Citral, Eugenol, Orintin, Vicenin present in Ocimum sanctum L., Ocimum tanuiflorum L. various as well as several flavonoids, polyphenols, saponins and tannins etc. reported and investigated in these meditional potent plants. This investigated revealed research data's the ethno-botanically and pharmagnosticaly,biological activities of active principles of these plants that will help noval drug discovery of anti-cancer, anti-tumor and immuno-modubulator formulations and development of pharmacopial standards.
International Journal of Ayurveda Pharma Chemistry , 2020
Standardization is used to describe all measures under taken during the manufacturing process and... more Standardization is used to describe all measures under taken during the manufacturing process and quality control as well as quality assurance of drug leading to its reproducible quality. Most of the traditional and classical preparation of compound medicine are effective but still they lack in its standardization. Therefore, we need to develop standard techniques to standardize and validate herbal formulations. The drug Itrifal Haamaan is therapeutically used as Blood purifier, Anti-Vitiligo, Anti-Pityriasis, Prevents premature graying of hairs and Phlegmatic diseases. The drug Itrifal Haamaan was prepared in three different batches as per the guidelines of National Formulary of Unani Medicine(Part-IV). Present study is aimed to evaluate the pharmacopoeial standards using physico-chemical parameters; HPTLC fingerprinting, quality control and assurance parameters using WHO guidelines to ascertain the quality of drug. The physico-chemical data showed that the drug contain LOD/ Moisture (9.51%), Total Ash (1.65%), Acid insoluble Ash(0.60%), Alcohol and Water soluble extractive matters (51.07%) & (71.04%), pH(1% solution) (4.77), pH(10% solution) (4.26), Bulk Density (1.5415 gm/ml),Reducing Sugar and Non-Reducing Sugar (58.54%) & (7.79%) and the TLC/HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent).The quality control study revealed the absence of microbial load, aflatoxins, heavy metals and pesticide residues, and can be considered safe for internal use and for curing for treated patients. The evaluated standards will be very useful for laying the phamacopoeial standards and as be supporting reference of Itrifal Haamaan and also in providing the quality medicine to needful human being.
Background: Euclea divinorum, belonging to the family Ebeneceae, has extensive traditional medici... more Background: Euclea divinorum, belonging to the family Ebeneceae, has extensive traditional medicinal use in Africa. However, it lacks sufficient published data on its pharmacognostic, physicochemical, and phytochemical properties. Aims and Objectives: Thus, this study aimed at comprehensively evaluating the pharmacognostic, physicochemical, and phytochemical properties of E. divinorum using established techniques. Materials and Methods: The evaluation included assessing organoleptic properties, macroscopy, and microscopy of leaves, stems, and roots. Various physicochemical parameters, such as loss on drying and extractive values via hot and cold maceration, were determined. Phytochemical screening was also conducted on root aqueous extracts. Results and Conclusion: Results revealed specific characteristics of E. divinorum leaves, including light green coloration, distinct odor, and bitterness. Macroscopic examination highlighted opposite phyllotaxy, simple leaf types with lamina length range of 71.09-93.89 mm and a width range of 6.05-17.59 mm, obtuse leaf apexes, cuneate leaf bases, entire leaf margins, and smooth leaf surfaces. Venation displayed a reticulate pattern, with the midrib prominently visible on the lower surface. Microscopic analysis of the lower leaf epidermis showed an average of stomatal density of 3.75±0.67, epidermal density of 35.75±2.16 and stomatal index of 10.47±1.11. Microscopic examination of the leaf lamina across the midrib revealed cortical parenchymal cells containing calcium oxalate crystals, lignified xylem, and non-lignified phloem. Stem cross-sections displayed single-layered cells comprising the epidermis, secondary phloem, secondary xylem, and pith. Similar structures were observed in root cross-sections. The plant's moisture content was found to be 44.8±1.962%, with water and alcohol-soluble extractive values of 7.27±0.17 and 1.13±0.05 g/100g, respectively, through cold maceration, and 14.77±0.28 and 11.43±0.39 g/100g, respectively through hot maceration. The total ash content was measured at 3.03± 0.103%. Phytochemical screening detected various compounds, with anthraquinone glycosides, coumarine glycosides, saponin glycosides, flavonoids, proteins, and tannins being abundant. Alkaloids, cardiac glycosides, and steroids were absent. This research contributes to standardizing E. divinorum, aiding in its identification, preventing adulteration, and ensuring therapeutic efficacy.
Quality assurance, shelf life, stability studies of ASU herbal, medicinal plants-Syzygium aromati... more Quality assurance, shelf life, stability studies of ASU herbal, medicinal plants-Syzygium aromaticum (Linn.) Merr LM Perry and W. fruticosa (Linn.) Kurz Abstract Introduction: QA, Shelf life, Stability Studies of ASU. herbal products remains a challenging task. The Coarse powder of SA and WF are specially designed for oral consumption and contains herbal ingredients known for their specific medicinal benefits. Storage conditions can significantly affect the shelf life of ASU. herbal Coarse powders, therefore, it is essential to assess the stability of these Coarse powders. According to ICH / WHO guidelines, which is used to treat various human ailments. This study aims to evaluate the QA, SL, SS investigated, analyzed parameters of coarse powders of flowers buds and flowers parts of the plant drugs SA and WF. Methods: The QA, SL, SS investigated studies with the accelerated stability studies at 40 °C and a relative humidity (RH) of 75% ±5 over a period of 6 months, with assessments conducted at the 0, 2nd, 4th, and 6th months. Various parameters, including Organoleptic characteristics, Pharmacognosy, HPTLC. identification, physico-chemical properties, Toxicological studies having investigated HM, AT, PR and MB load, were monitored during these intervals of SA and WF were carried out and performed using standard methods. The accelerated testing conditions are at least 10 °C Temp. higher than the long-term study conditions and are intended to increase the rate at which degradation reactions take place thus revealing quality changes at an early stage globally climatic zones are divided into max. 6 months intervals time period for shelf life, stability studies and the storage conditions. Results: The results of these studies were taken into consideration when estimating the QA, SL, SS of SA and WF Course powder drugs. The extended shelf life estimate was determined by applying an accelerated deterioration rate of 10% for physico-chemical parameters. Conclusions: The QA, SL, SS findings were revealed that the test drugs batches were stability is confirmed, no max. significance changes occurred in tested samples and shown stable potent of undeteriorate condition. As a result, it was established that the SA and WF course powder have an estimated shelf life Max. 1 years and eight months and 2 Year. The Studies revealed data's can be provide referential supports and essential in the future for QA, Product Acceptability, Pharmaco-vigilance aspects.
Introduction: Biodiversity, Phramacognostical, Pharmacological, Toxicological research studies of... more Introduction: Biodiversity, Phramacognostical, Pharmacological, Toxicological research studies of ASU herbal products remains a big challenging task. There needs to be more than the advance investigation research studies and screening parameters to validation, authenticate and differentiate adulterants in ASU medicinal plants. Peucedanum grande C.B. Clarke is one of the herbs used to treat various health wellness and therapeutic illness of public mankind. This study aims to evaluate the Biodiversity, Phramacognostical, Pharmacological, Toxicological research studies of the seed part of plant of P G. Methods: The Botanical identification, Pharmacognosy and Toxicological quality control research analysis of the seed part of plant of P G. powder were carried out using standard methods. The Quality, safety and toxicity effects of the tested drug samples were also investigated. Results: The Botanical identification, Pharmacognosy, Toxicological QC. Properties of P G. have shown that all the parameters were within the permissible limits. The tested drug samples showed significant Quality, safety and toxicity studies against certain pathogens organisms and promising anti-pathogenic activity. Conclusions: In the investigated review studies of Pharmacognosy, Toxicological DSR, QC. research findings revealed that the revalidated test drug was free from adulterations. This investigated herb's research data confirmed to drug standardization and therapeutically may treat that the drug is safe for internal use and cures in Anti-lithiatic, Carminative, Demulcent, Diaphoretic, Anti-Inflammatory,Anti-dote, Stimulant, Expectorant, Deobstruent, Lithotriptic, Emmenagogue disorder. Keywords: Duqu, Peucedanum grande C.B. Clarke, DSR, QC. and QA, Biodiversity ,Pharmacognosy and Toxicological, Pharmacological Quality, Safety and Toxicity studies.
World Journal of Pharmacy and Pharmaceutical Sciences, 2024
Standardization and product acceptability is used to describe all measures under taken during the... more Standardization and product acceptability is used to describe all measures under taken during the manufacturing process and quality control and quality assurance of drug leading to its reproducible quality. Therefore we need to develop standard validation techniques to standardize and validate of the herbal products and formulations using QC. QA Screening Studies. The drug Woodfordia fruticosa (Linn.) Kurz) is therapeutically useful in the treatment of Anti-pyretic, Anti-pills, Anti-inflammatory, Anti-ulcer, Anti-diarrheal, Anti-Sinus, Anti-Diabetes, Anti-Leukorrhea, Anti-Leprosy, Anti-hyperglycemic activity, Anti-depressant activity, Anti-cancer activity, Antioxidant activity. The single drug WF was Standardization, Quality Control Screening studied in three different batches as per the guidelines of WHO/ AYUSH Protocols basis. Present research study is aimed to evaluate the Standardization and product quality acceptability using physico-chemical parameters; HPTLC fingerprinting as per WHO guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain Foreign matter, w/w- (0.08 %,0.07%,0.08%), LOD/ Moisture, w/w- (6.054%,6.010% 6.320%), Total ash, w/w-(5.79%,5.82%,6.93%), Acid in-soluble ash, w/w-(0.776%,0.770%,0.778%), Alcohol and water soluble extractive matter, w/v- (12.80%,12.46%, 12.38%) & (24.40%, 4.46%,24.50%), pH(10% solution) (4.8,4.9,4.8), the HPTLC finger prints showed various spots at 254nm, 366nm Iodine vapours and visible light (M-S reagent). The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. The QC. findings revealed that the test drug was free from adulterations. The evaluated validated quality standards will be very useful for referential support, validation of the standards of WF, pharmaco-vigilance and providing the quality raw medicine to deprived human being.
KEYWORDS: (Woodfordia fruticosa (Linn) Kurz), Physico-chemical quality QC and QA HPTLC fingerprinting and Unani Compound drug.
World Journal of Pharmacy and Pharmaceutical Sciences, 2024
Introduction: DSR, QC, and QA. of herbal products remains a challenging task. There needs to be m... more Introduction: DSR, QC, and QA. of herbal products remains a challenging task. There needs to be more than investigated screening parameters to validation, in order to authenticate and differentiate adulterants in medicinal plants. Tagetes erecta L. is one of the herbaceous plant which is used to treat various human ailments. This study aims to evaluate the DSR, QC, HPTLC, and GC-MS fingerprint profiles of the flower part of plant drug and extracts of T E. Methods: The QC and DSR with the Toxicology studies as heavy metal, aflatoxins, pesticide residues analysis, HPTLC and GC-MS analysis of the chloroform and ethanolic extract of T E. were carried out and performed using standard methods. The antibacterial potential, antimicrobial & antitoxicity effects of the tested drug samples of different microbes, hazardous and toxins were also investigated. Results: The DSR, QC. properties of T E. have shown that all the parameters were within the permissible limits. The HPTLC fingerprint profile of the chloroform and ethanolic extract exhibited various peaks under UV 254 nm, under UV 366 nm and V-S reagent, visible light region. The GC-MS analysis confirmed and illustrated the presence of various BAC. in the test sample. The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. Conclusions: The QC. findings revealed that the test drug was free from adulterations. Shown Antibacterial immense potential. The physicochemical constants, HPTLC, and GC-MS profiles of T E. can be essential data in the future. This herb's extracts may treat and cures in Scabies, Fever, Skin diseases.
KEYWORDS: Tagetes erecta L., DSR, QC., and QA., HPTLC, and GC-MS profiles, Toxicology studies.
International Level Double Blind Peer Reviewed,Refereed,Indexed Research Journal, 2024
सार संक्षेप: उस्तुखुद्दुस (लेवेनन्डुला स्टोकस एल, Lavandula stoechas L.) लेमिएसी परिवार का सबसे म... more सार संक्षेप: उस्तुखुद्दुस (लेवेनन्डुला स्टोकस एल, Lavandula stoechas L.) लेमिएसी परिवार का सबसे महत्वपूर्ण सुगंधित पौधा है। यह यूनानी चिकित्सा प्रणाली में जरूब-ए-दिमाग के रूप मे जाना जाता है। क्योकि इसके सफाई के गुण के कारण यह दिमाग से अस्वस्थ पदार्थों को निकालने की क्षमता रखता है। जो न्यूरोलॉजिकल विकारों जैसे कि अनिद्रा, स्म्र्तिलोप, मेलंकॉलिया, आदि का कारण बन सकते है। यह औषधि के रूप में प्राचीन समय से प्र्योग की जाती रही है। और प्राचीन समय मे पहली शताब्दी ईसा पूर्व में इसके विभिन्न फार्माकोलोजिकल गुणों के लिए डीओस्कोरिडेस (Dioscorides) द्वारा इसका उल्लेख किया गया था। इसके फार्माकोलोजिकल गुणों / प्रभावों पर विभिन्न अध्ययनों की जाँच की गई है जो इसमे मौजूद उसके बायोएक्टिव संघटकों का श्रेय दे सकते है,जैसे ग्लाइकोसाइड, फेनोल, स्टोराइड्स, ट्र्पीन आदि। वर्तमान शोध पत्र में उस्तुखुद्दुस के मैक्रोस्कोपी, पाउडर माइक्रोस्कोपी एवं पौधे के औषधीय गुणों की व्याख्या की गयी है। यह अध्ययन औषधि के सही पहचान और मूल्यक्षमता के लिए उपयोगी होगा।
Advance International Journal of Multidisciplinary Research , 2024
Woodfordia fruticosa (L.) Kurz commonly known as Dhawa or Dhataki, is an important medicinal plan... more Woodfordia fruticosa (L.) Kurz commonly known as Dhawa or Dhataki, is an important medicinal plant that has been traditionally used in various systems of medicine for its therapeutic properties such asdysentery, leprosy, leucorrhoea, menorrhagia, toothache. It has been used as astringent to treat dysentery and also for the treatment of bowl complaint and rheumatism. Pharmacognostical studies encompass the macroscopic and microscopic evolution of the plant material, including its botanical description, organoleptic properties and anatomical features, which aid in the identification and authentication of the plant. Physicochemical studies involve the determination of various physicochemical parameters such as foreign matter, ash values, extractive values. These parameters provide valuable information regarding the chemical composition and quality standards of Woodfordia fruticosa, facilitating its standardization and quality control in herbal drug. Overall, the Pharmacognostical and Physicochemical studies outlined in this study serve as a comprehensive reference for researchers and organizations engaged in further exploration of medicinal potential of Woodfordia fruticosa, paving the way for the development of therapeutic agents and herbal drugs.
Abstract / अमूर्त : मानकीकरण और उत्पाद स्वीकार्यता का उपयोग विनिर्माण प्रक्रिया और गुणवत्ता नियंत... more Abstract / अमूर्त : मानकीकरण और उत्पाद स्वीकार्यता का उपयोग विनिर्माण प्रक्रिया और गुणवत्ता नियंत्रण और दवा की गुणवत्ता आश्वासन के दौरान किए गए, सभी उपायों का वर्णन करने के लिए किया जाता है, जिससे इसकी प्रतिलिपि प्रस्तुत करने योग्य गुणवत्ता प्राप्त होती है। इसलिए हमें गुणवत्ता नियंत्रण का उपयोग करके हर्बल फॉर्मूलेशन के मानकीकरण और सत्यापन के लिए मानक सत्यापन तकनीक विकसित करने की आवश्यकता है। गुणवत्ता आश्वासन स्क्रीनिंग अध्ययन। दवा धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन.) कुर्ज़) एंटी-पायरेटिक, एंटी-पिल्स, एंटी-इंफ्लेमेटरी, एंटी-अल्सर, एंटी-डायरिया, एंटी-साइनस, एंटीएंटरोवायरल, एंटी-हाइपरग्लाइसेमिक के उपचार में चिकित्सीय रूप से उपयोगी है। , मधुमेह रोधी, ल्यूकोरिया रोधी, कुष्ठ रोग रोधी, स्त्री रोग, अधिक रक्तस्राव, प्लीहा, दांत निकलने संबंधी आदि विभिन्न समस्याओं को नियंत्रित और सुरक्षित रखता है। एकल दवा डब्ल्यूएफ का मानकीकरण, गुणवत्ता नियंत्रण स्क्रीनिंग का डब्ल्यूएचओ/आयुष प्रोटोकॉल के आधार पर दिशानिर्देशों के अनुसार तीन अलग-अलग बैचों में अध्ययन किया गया। वर्तमान शोध अध्ययन का उद्देश्य भौतिक-रासायनिक मापदंडों का उपयोग करके मानकीकरण और उत्पाद गुणवत्ता स्वीकार्यता का मूल्यांकन करना है; विश्लेषण किए गए मापदंडों के डब्ल्यूएचओ दिशानिर्देशों के अनुसार एचपीटीएलसी फिंगरप्रिंटिंग। परीक्षण नमूनों के प्रत्येक III बैच के भौतिक-रासायनिक औसत रीडिंग डेटा से पता चला कि दवा में विदेशी पदार्थ, w/w-(0.08%, 0.07%, 0.08%), LOD / नमी, w/w- (5.79%,5.82,6.93 % शामिल हैं ), कुल राख, w/w- (5.79%,5.82%, एवं 6.93, %), एसिड में घुलनशील राख, w/w-(0.776%,0.770%, एवं 0.778,%), अल्कोहल और पानी में घुलनशील अर्क पदार्थ, w/v- (12.80%, 12.46%, 12.38%) और (24.40%, 24.46%, 24.50%), पीएच (10% समाधान) (4.8 ,4.9, 4.8), एचपीटीएलसी फिंगर प्रिंट्स ने 254 एनएम, 366 एनएम आयोडीन वाष्प और दृश्य प्रकाश (एम-एस अभिकर्मक) पर विभिन्न धब्बे दिखाए। गुणवत्ता नियंत्रण अध्ययनों के सत्यापन से माइक्रोबियल लोड, एफ्लाटॉक्सिन, भारी धातु और कीटनाशक अवशेषों की अनुपस्थिति का पता चला, मूल्यांकन किया गया मान्य गुणवत्ता मानक संदर्भात्मक समर्थन, डब्ल्यूएफ के मानकों के सत्यापन, फार्माको-सतर्कता और वंचित मानव को गुणवत्तापूर्ण कच्ची दवा प्रदान करने के लिए बहुत उपयोगी होंगे।
Keywords / मूलशब्द : धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन) कुर्ज़), भौतिक-रासायनिक गुणवत्ता, गुणवत्ता नियंत्रण और आश्वासन पैरामीटर, टीएलसी / एचपीटीएलसी फिंगरप्रिंटिंग और यूनानी यौगिक दवा।
Abstract / अमूर्त परिचय: हर्बल उत्पादों की गुणवत्ता नियंत्रण एक बड़ा चुनौतीपूर्ण कार्य बना हुआ है... more Abstract / अमूर्त परिचय: हर्बल उत्पादों की गुणवत्ता नियंत्रण एक बड़ा चुनौतीपूर्ण कार्य बना हुआ है। औषधीय पौधों में मिलावटों के सत्यापन, प्रमाणीकरण और अंतर के लिए फार्माकोग्नॉसी, भौतिक रसायन और स्क्रीनिंग मापदंडों से कहीं अधिक की आवश्यकता है। गुल-ए-साद बार्ग (मेरिगोल्ड), टैगेट्स इरेक्टा एल. सार्वजनिक मानव जाति के विभिन्न स्वास्थ्य कल्याण और चिकित्सीय बीमारियों के इलाज के लिए उपयोग की जाने वाली जड़ी-बूटियों में से एक है। इस अध्ययन का उद्देश्य मैरीगोल्ड के पौधे के फूल भाग के क्यूसी, वानस्पतिक पहचान, फार्माकोग्नॉसी, भौतिक रासायनिक अध्ययन का मूल्यांकन करना है। विधियाँ: टी ई. मोटे पाउडर के पौधे के फूल भाग की वानस्पतिक पहचान, फार्माकोग्नॉसी भौतिक रसायन और गुणवत्ता नियंत्रण अनुसंधान विश्लेषण मानक विधियों का उपयोग करके किया गया। परीक्षण किए गए दवा नमूनों की गुणवत्ता, सुरक्षा और विषाक्तता प्रभाव की भी जांच की गई। परिणाम: वानस्पतिक पहचान, फार्माकोग्नॉसी, भौतिक रसायन और क्यूसी। टी ई के गुणों से पता चला है कि सभी पैरामीटर अनुमेय सीमा के भीतर थे। परीक्षण किए गए दवा के नमूनों ने कुछ रोगजनक जीवों के खिलाफ महत्वपूर्ण गुणवत्ता, सुरक्षा और विषाक्तता अध्ययन दिखाया और रोग-रोधी गतिविधि का वादा किया। निष्कर्ष: वानस्पतिक पहचान, फार्माकोग्नॉसी, गुणवत्ता नियंत्रण अनुसंधान निष्कर्षों से पता चला कि परीक्षण दवा के सभी नमूने मिलावट से मुक्त थे। इस जांचे गए जड़ी-बूटी के शोध डेटा से पता चला है कि दवा मानकीकरण और चिकित्सीय रूप से खुजली, बुखार, त्वचा रोगों और आंखों के रोगों का इलाज और इलाज कर सकती है।
Keywords / मूलशब्द (कीवर्ड): गुल-ए-साद बार्ग, टैगेट्स इरेक्टा एल. (मेरिगोल्ड), ड्रग मानकीकरण अनुसंधान, क्यूसी., और क्यूए, एचपीटीएलसी फिंगरप्रिंट, और जीसी-एमएस प्रोफाइल, गुणवत्ता, सुरक्षा और विषाक्तता अध्ययन।
International Journal of Recent Scientific Research, 2024
Beninca hispida (Thunb.)-Petha is a very important processed, dynamic commercial product found of... more Beninca hispida (Thunb.)-Petha is a very important processed, dynamic commercial product found of North India. It is processed largely in North India-Uttar Pradesh, Uttarakhand plan area and Bihar States from wax gourd or ash gourd. Petha sweet is having geographical indication (GI) tag from Agra, U.P. State in India. BH. used as amazing therapeutic potentials as a Antioxidant, Antidiabetic, Hypoglycemic and Hypolipidemic, Anti-inflammatory, Alzheimer's disease, Anti-compulsive effect, Allergic inflammation, Antibiotic, Anti-microbial, Anti-Ulcer, Anti-Acidic, Anti-asthmatic, Cytotoxic and Anticancer, Anti-obesity, Antidepressant and Anxiolytic, Analgesic and Antipyretic, Antihypertensive, Anti ageing of Skin, Gastro protective from since ancient time. Three fresh samples of BH. taken into these studies from North India Region U.P., U.K. and Bihar State which 3 samples were freshly collected P1,P2 and P3. and developed from applied SOP. on the basis of authenticated classical texts and literature of standard methods. The quality control & quality assurance studies were conducted in accordance to the WHO., AOAC., IPC. and UPC., approved guidelines. The physicochemical data showed that the drug samples contain, Average values as Foreign Matter, w/w,(%)-Nil, LOD/ moisture (3.85%), Total Ash, w/w,(%)-(6.21%), Acid Insoluble , w/w,(%)-(0.32%), Alcohol and Water Soluble Extractive Matter, w/v, (%)-(2.50%) & (5.56%), pH(1% solution) (5.92), pH(10% solution) (5.35), and various bioactive phytochemical screening examined were assessed in BH., HPTLC. studies of chloroform and alcohol extracts of different samples P1.P2 and P3 of Petha BH. Classical formulation showed various spots at examine under 254nm and under 366nm (UV. region), found no major spots is observed, under exposed to Vinyl-Sulfuric acid reagent. derivatized obtained with equate, best separation using selected suitable solvent system of mobile phase. The quality control studies results revealed the absence of hazardous and toxic contamination from the drug samples of BH. Moreover the obtained research studies data and comparative screening will provide the referential supportive information in the development of Pharmacopeial standard monographs, identification of classical formulation, reinvestigation, quality assurance and pharmaco-vigilance and validation of the Quality standard of BH. classical sweet food providing the quality food used as a medicine to Health & Wellness of needful public mass of the world.
International Journal of Pharmacy and Pharmaceutical Science ; https://www.pharmacyjournal.org/, 2024
Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for heal... more Traditionally utilization of ASU herbal drugs as medicine used is the since ancient time for health, wellness and cures to mankind and it is used in all cultures all over history The primeval and tribal's, hillers persons learned by trial and error basis to identified valuable potent medicinal plants. In modern scenario more demand increasing towards herbal medicinal ASU products because ASU and TAM herbal products having low hazardness and toxicity as compare to other medicine and there is increasing awareness and general acceptability of herbal drugs in today's medical practice on global demand basis. In present, It is however a known fact that over 80% of the world population used herbal medicines and product for healthy living. As well as globally demand of herbal products increases the need of herbal quality assurance for customer satisfaction also increases. For the prevention of drug substitution, adulteration and developed abuse herbal products, WHO have been released guidelines on global requirement and public domain to all herbal industries. The identification of this highly active moiety is an important requirement for Quality assurance, quality control and dose determination of plant related dugs. Standardization research of ASU. Herbal drugs means confirmation or validation of its identity, purity, quality and efficacy. It is mandatory for every ASU herbal industry. It must need for collection, handling, processing and production of ASU herbal medicine as well as employ such parameters in ensuring the quality, safety, efficacy and compulsory need for the global ASU. TAM. Herbal market. In this overview all guidelines which are required for development of ASU and TAM herbal products at global scale.
International Journal of Pharmacy and Pharmaceutical Science; www.pharmacyjournal.org , 2022
Introduction: Quality control of herbal products remains a big challenging task. There needs to b... more Introduction: Quality control of herbal products remains a big challenging task. There needs to be more than the Pharmacognosy, physicochemical and screening parameters to validation, authenticate and differentiate adulterants in medicinal plants. Genda phool / Gul-e-Sad Barg (Marigold), Tagetes erecta L. is one of the herbs used to treat various health wellness and therapeutic illness of public mankind. This study aims to evaluate the QC, Botanical identification, Pharmacognosy, physicochemical studies of the flower part of plant of Marigold. Methods: The Botanical identification, Pharmacognosy physicochemical and quality control research analysis of the flower part of plant of T E. coarse powder were carried out using standard methods. The Quality, safety and toxicity effects of the tested drug samples were also investigated. Results: The Botanical identification, Pharmacognosy, physicochemical and QC. Properties of T E. have shown that all the parameters were within the permissible limits. The tested drug samples showed significant Quality, safety and toxicity studies against certain pathogens organisms and promising antipathogenic activity. Conclusions: The Botanical identification, Pharmacognosy, quality control research findings revealed that the test drug was free from adulterations. This investigated herb's research data confirmed to drug standardization and therapeutically may treat that the drug is safe for internal use and cures in Scabies, Fever, Skin diseases and eyes diseases.
The people worldwide are adopting herbal medicines as alternative health care system. Their reli... more The people worldwide are adopting herbal medicines as alternative health care system. Their reliance on herbal medicines has led to remarkable growth of tradition system of medicine. The preparation of herbal formulation is usually based on traditional methods in accordance with the procedure described in classical literature which sometimes lacks scientific validation. It is utmost important to scientifically standardize the method of preparation and physicochemical parameters to ensure their authenticity and therapeutic effects. Therefore, a herbal Unani formulation Qurs-e-Isqeel widely known for its action as diuretic and antidote and therapeutically used in poisoning, fracture, ascites and dysuria. The drug was studied through various standardization parameters such as organoleptic evaluation (colour, Odor and taste), physico-chemical evaluations (moisture content, total ash, acid insoluble ash, pH values, water and ethanol soluble extractive, volatile oil) and microscopy. The evaluations of WHO parameters such as heavy metals, aflatoxins, pesticide residue and microbial contamination were also carried out to ascertain the quality of drug. The data revealed the present work will help in developing pharmacopoeial standards for maintaining the quality and batch to batch consistency of Qurse-Isqeel.
International Journal of Natural Product Science , 2013
Diabetes mellitus (DM), or Diabetes (Madhumeha) chronic degenerative disease is one of the common... more Diabetes mellitus (DM), or Diabetes (Madhumeha) chronic degenerative disease is one of the common metabolic disorder acquiring around above 3.0% of the world"s population and is anticipated to cross more than 4 to 5% by the year 2025. Since ancient times herbal medicines have been used as a traditional, folk, Ayurvedic & Unani medicines, the source of anti-diabetic medicines. In view of the above aspects, the present review discusses various medicinal plants with their anti-diabetic activity Which include Meshashringi or Gurmar leaves (Gymmema Sylvestre), Jamun Guthli(Syzygium cuimini), Beeja saar or Vijay saar bark (Pterocarpus marsupium),
International Journal of Natural Product Science, 2013
Many herbal remedies individually or in combination have been recommended in various medical expo... more Many herbal remedies individually or in combination have been recommended in various medical expositions for the cure of different disease. The Pongamia pinnata (Vent) commonly known"s "Karanj" has been recognized in different system of traditional medicines for the treatment of different diseases and ailments of human beings. It contains several phyto-chemical like carbohydrates, alkaloids, flavonoids, glycosides, steroids, tannins and sponins. It is found that the plants contain a number of secondary metabolites and have the pharmacological actions. Hyro-alcoholic extract of Pongamia pinnata (Vent) were studied for its anti oxidant, cardio protective activities. Reduction in DPPH colour indicated presence of strong antioxidant activity.
International Journal of Pharmaceutical Science and Research , 2014
Endangered Indian medicinal plants have used as traditional and alternative Indian system of medi... more Endangered Indian medicinal plants have used as traditional and alternative Indian system of medicine (ISM.) from last several ancient time. In 20th and 21th centaury generation are becoming aware of the side effect and adverse reaction of synthetic drugs and so there is an increasing interest, Scope of innovate in herbal medicinal plants based Ayurvedic, Sidha, Unani (ASU.) medicinal products. In the continuously using of Adulteration and Substitution, Spurious drugs on the place of original Indian endangered and costly ASU. Herbal medicinal plants hence today generate the major task of Indian drug regularity affaire, drug controlling approach as well as herbal industries face burning problem. Resulted growing high altitude region many endangered and rare costly original medicinal species such as these are Vatsnabh, (Aconitum Chasmanthumstapfex. Haimes), Ativishaor Atis, (Aconitumheterophylum Wall. Ex. Royal), Kutki, (Picrorhiza kurroa royleex), Kuth or Kustha, (Saussurea lappa C.B.CL.), Puskarmool, (Inularacemosa Hook.F.), Riddhi, (Hobenariainte media D. Don), Vriddhi, (Habenariaedge worthii Hook.f.ex.Collett), Kakoli, (Roseea purpurrea Smith), Kshirakakoli, (Fritillariar oylei Hook) and (Lilium polyphyllum D. Don), Jeevak, (Crepipiuma cumina tum D.Don.) Szlach.), Meda, (Polygonatum verticillatum Linn.)Allioni), Mahameda, (Polygonatum cirrhifolium (wall.) Royal) and (Polygonatum Vertecillatum Alloi), Rakta Chandana , Sandal Surkh,(Pterocarpus santalinus Linn.), Sveta Chandana, Sandal Safed ,(Santalum album Linn.), Kesar, Keshar or Kum Kum, Zafran ,(Crocus sativus Linn.) etc. completely endangered and incorrect identification of their intestinally or unintentionally, Finally they become effectively adulterated and substituted in condition. The present communication investigate research review has reported their drug regularity affaire and drug controlling, pharmacovigilance approach of Adulteration and Substitution, Spurious drugs with active phytochemical constituents, extensive taxonomical and ethnobotanical authentication, medicinal properties of these several endangered and costly medicinal plants.
International Journal of Traditional and Complimentary Medicine , 2020
Cancer is one of the harmful leading causes of death worldwide. Several synthetic agents have bee... more Cancer is one of the harmful leading causes of death worldwide. Several synthetic agents have been used to cure the disease but they have their adverse side effects, low-hilling potential and toxicity.Present Article reviewed three important medicinal plants i.e.-Taxus baccata L. Or Taxus baccata Thunb., Catharanthus roseus(L.
International Journal of Multidisciplinary and Education Research, 2021
In the present life style scenario of human being, Cancer and noval strain of Corona Covid-19 vir... more In the present life style scenario of human being, Cancer and noval strain of Corona Covid-19 virus are one of the danger leading causes of death all over the world. Several synthetic agents have been used to cure the disease but they have their adverse side effects, low-hilling potential and toxicity. Present article reviewed three important asian medicinal plants, (Curcuma Domestica valeton or Curcuma longa L., Tinospora cordifolia (Willd.) Miers, and Ocimum sanctum L., Ocimum tanuiflorum L. which traditionally used ancient time as an ASU. medicines in Asian countries for the treatment and prevention of Cancer, Tumor and bacterial, virus infections in Asian and Sothern, North east and Himalayan region of India.These plants contain several anti-cancerous, anti-tumorous and anti-oxidant, immuno-modubulator bioactives constituents, secondary metabolites such as strong alkaloids-Curcuminoids and Curcumin, Phenols, ascorbic acid in Curcuma Domestica valeton or Curcuma longa L., Alkaloids-Berberine, Choline, Titembetarine, Magno florine, Tinosporin, Palmetine, Isocolumbin, Aporphine, Jatrorrhizine ,Tetrahydropalmatine, βsitosterol, β-sitosteryl glycosides etc. present in Tinospora cordifolia (Willd.) Miers and strong alkaloids such as Apigenin and Taxol, Phenolic compound, Ursolic acid, Caffeic acid and Citral, Eugenol, Orintin, Vicenin present in Ocimum sanctum L., Ocimum tanuiflorum L. various as well as several flavonoids, polyphenols, saponins and tannins etc. reported and investigated in these meditional potent plants. This investigated revealed research data's the ethno-botanically and pharmagnosticaly,biological activities of active principles of these plants that will help noval drug discovery of anti-cancer, anti-tumor and immuno-modubulator formulations and development of pharmacopial standards.
International Journal of Ayurveda Pharma Chemistry , 2020
Standardization is used to describe all measures under taken during the manufacturing process and... more Standardization is used to describe all measures under taken during the manufacturing process and quality control as well as quality assurance of drug leading to its reproducible quality. Most of the traditional and classical preparation of compound medicine are effective but still they lack in its standardization. Therefore, we need to develop standard techniques to standardize and validate herbal formulations. The drug Itrifal Haamaan is therapeutically used as Blood purifier, Anti-Vitiligo, Anti-Pityriasis, Prevents premature graying of hairs and Phlegmatic diseases. The drug Itrifal Haamaan was prepared in three different batches as per the guidelines of National Formulary of Unani Medicine(Part-IV). Present study is aimed to evaluate the pharmacopoeial standards using physico-chemical parameters; HPTLC fingerprinting, quality control and assurance parameters using WHO guidelines to ascertain the quality of drug. The physico-chemical data showed that the drug contain LOD/ Moisture (9.51%), Total Ash (1.65%), Acid insoluble Ash(0.60%), Alcohol and Water soluble extractive matters (51.07%) & (71.04%), pH(1% solution) (4.77), pH(10% solution) (4.26), Bulk Density (1.5415 gm/ml),Reducing Sugar and Non-Reducing Sugar (58.54%) & (7.79%) and the TLC/HPTLC finger prints showed various spots at 254nm, 366nm and visible light (V-S reagent).The quality control study revealed the absence of microbial load, aflatoxins, heavy metals and pesticide residues, and can be considered safe for internal use and for curing for treated patients. The evaluated standards will be very useful for laying the phamacopoeial standards and as be supporting reference of Itrifal Haamaan and also in providing the quality medicine to needful human being.
ABSTRACT
Introduction: DSR, QC., and QA. of herbal products remains a challenging task. There nee... more ABSTRACT Introduction: DSR, QC., and QA. of herbal products remains a challenging task. There needs to be more than investigated screening parameters to validation, in order to authenticate and differentiate adulterants in medicinal plants. Tagetes erecta L. is one of the herbaceous plant which is used to treat various human ailments. This study aims to evaluate the DSR, QC, HPTLC, and GC-MS fingerprint profiles of the flower part of plant drug and extracts of T E. Methods: The QC and DSR with the toxicity studies as heavy metal, aflatoxins, pesticide residues analysis, HPTLC and GC-MS analysis of the chloroform and ethanolic extract of T E. were carried out and performed using standard methods. The antibacterial potential, antimicrobial & antitoxicity effects of the tested drug samples of different microbes, hazardous and toxins were also investigated. Results: The DSR, QC. properties of T E. have shown that all the parameters were within the permissible limits. The HPTLC fingerprint profile of the chloroform and ethanolic extract exhibited various peaks under UV 254 nm, under UV 366 nm and V-S reagent, visible light region. The GC-MS analysis confirmed and illustrated the presence of various BAC. in the test sample. The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. Conclusions: The QC. findings revealed that the test drug was free from adulterations. Shown Antibacterial immense potential. The physicochemical constants, HPTLC, and GC-MS profiles of T E. can be essential data in the future. This herb's extracts may treat and cures in Scabies, Fever, Skin diseases. Keywords: Tagetes erecta L., DSR, QC., and QA., HPTLC, and GC-MS profiles, Toxicology studies
ABSTRACT
Standardization and product acceptability is used to describe all measures under taken ... more ABSTRACT Standardization and product acceptability is used to describe all measures under taken during the manufacturing process and quality control and quality assurance of drug leading to its reproducible quality. Therefore we need to develop standard validation techniques to standardize and validate of the herbal formulations using QC. QA Screening Studies. The drug Woodfordia fruticosa (Linn.) Kurz) is therapeutically useful in the treatment of Anti-pyretic, Anti-pills, Anti-inflammatory, Anti-ulcer, Anti-diarrheal, Anti-Sinus, Anti-Diabetes, Anti-Leukorrhea, Anti-Leprosy, Anti-hyperglycemic activity, Anti-depressant activity, Anti-cancer activity, Antioxidant activity. The single drug WF was Standardization, Quality Control Screening studied in three different batches as per the guidelines of WHO/ AYUSH Protocols basis. Present research study is aimed to evaluate the Standardization and product quality acceptability using physico-chemical parameters; HPTLC fingerprinting as per WHO guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain Foreign matter, w/w- (0.08 %,0.07%,0.08%), LOD/ Moisture ,w/w- (6.054%,6.010% 6.320%), Total ash, w/w- (5.79%,5.82%,6.93%), Acid in-soluble ash, w/w-(0.776%,0.770%,0.778%), Alcohol and water soluble extractive matter, w/v- (12.80%,12.46%, 12.38%) & (24.40%,24.46%, 24.50%), pH(10% solution) (4.8,4.9,4.8), the HPTLC finger prints showed various spots at 254nm, 366nm Iodine vapours and visible light (M-S reagent). The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. The QC. findings revealed that the test drug was free from adulterations. The evaluated validated quality standards will be very useful for referential support, validation of the standards of WF, pharmaco-vigilance and providing the quality raw medicine to deprived human being. Keywords: (Woodfordia fruticosa (Linn) Kurz), Physico-chemical quality QC and QA HPTLC fingerprinting and Unani Compound drug.
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Papers by Pawan Kr. Sagar
control and quality assurance of drug leading to its reproducible
quality. Therefore we need to develop standard validation techniques
to standardize and validate of the herbal products and formulations
using QC. QA Screening Studies. The drug Woodfordia fruticosa
(Linn.) Kurz) is therapeutically useful in the treatment of Anti-pyretic,
Anti-pills, Anti-inflammatory, Anti-ulcer, Anti-diarrheal, Anti-Sinus,
Anti-Diabetes, Anti-Leukorrhea, Anti-Leprosy, Anti-hyperglycemic
activity, Anti-depressant activity, Anti-cancer activity, Antioxidant
activity. The single drug WF was Standardization, Quality Control
Screening studied in three different batches as per the guidelines of
WHO/ AYUSH Protocols basis. Present research study is aimed to
evaluate the Standardization and product quality acceptability using
physico-chemical parameters; HPTLC fingerprinting as per WHO
guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain Foreign matter, w/w- (0.08 %,0.07%,0.08%), LOD/ Moisture, w/w- (6.054%,6.010% 6.320%), Total ash, w/w-(5.79%,5.82%,6.93%), Acid in-soluble ash, w/w-(0.776%,0.770%,0.778%), Alcohol and water soluble extractive matter, w/v- (12.80%,12.46%, 12.38%) & (24.40%, 4.46%,24.50%), pH(10% solution) (4.8,4.9,4.8), the HPTLC finger prints showed various spots at 254nm, 366nm Iodine vapours and visible light (M-S reagent). The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. The QC. findings revealed that the test drug was free
from adulterations. The evaluated validated quality standards will be very useful for referential support, validation of the standards of WF, pharmaco-vigilance and providing the quality raw medicine to deprived human being.
KEYWORDS: (Woodfordia fruticosa (Linn) Kurz), Physico-chemical quality QC and QA HPTLC fingerprinting and Unani Compound drug.
KEYWORDS: Tagetes erecta L., DSR, QC., and QA., HPTLC, and GC-MS profiles, Toxicology studies.
मूल्य बिन्दु: उस्तुखुद्दुस (लेवेनन्डुला स्टोकस एल,),अनिद्रा, स्म्र्तिलोप, ग्लाइकोसाइड, फेनोल, स्टोराइड्स, ट्र्पीन ।
Keywords / मूलशब्द : धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन) कुर्ज़), भौतिक-रासायनिक गुणवत्ता, गुणवत्ता नियंत्रण और आश्वासन पैरामीटर, टीएलसी / एचपीटीएलसी फिंगरप्रिंटिंग और यूनानी यौगिक दवा।
Keywords / मूलशब्द (कीवर्ड): गुल-ए-साद बार्ग, टैगेट्स इरेक्टा एल. (मेरिगोल्ड), ड्रग मानकीकरण अनुसंधान, क्यूसी., और क्यूए, एचपीटीएलसी फिंगरप्रिंट, और जीसी-एमएस प्रोफाइल, गुणवत्ता, सुरक्षा और विषाक्तता अध्ययन।
Keywords: SOP, Microscopy, Pharmacopoeial parameters, Isqeel, Quality control.
control and quality assurance of drug leading to its reproducible
quality. Therefore we need to develop standard validation techniques
to standardize and validate of the herbal products and formulations
using QC. QA Screening Studies. The drug Woodfordia fruticosa
(Linn.) Kurz) is therapeutically useful in the treatment of Anti-pyretic,
Anti-pills, Anti-inflammatory, Anti-ulcer, Anti-diarrheal, Anti-Sinus,
Anti-Diabetes, Anti-Leukorrhea, Anti-Leprosy, Anti-hyperglycemic
activity, Anti-depressant activity, Anti-cancer activity, Antioxidant
activity. The single drug WF was Standardization, Quality Control
Screening studied in three different batches as per the guidelines of
WHO/ AYUSH Protocols basis. Present research study is aimed to
evaluate the Standardization and product quality acceptability using
physico-chemical parameters; HPTLC fingerprinting as per WHO
guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain Foreign matter, w/w- (0.08 %,0.07%,0.08%), LOD/ Moisture, w/w- (6.054%,6.010% 6.320%), Total ash, w/w-(5.79%,5.82%,6.93%), Acid in-soluble ash, w/w-(0.776%,0.770%,0.778%), Alcohol and water soluble extractive matter, w/v- (12.80%,12.46%, 12.38%) & (24.40%, 4.46%,24.50%), pH(10% solution) (4.8,4.9,4.8), the HPTLC finger prints showed various spots at 254nm, 366nm Iodine vapours and visible light (M-S reagent). The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. The QC. findings revealed that the test drug was free
from adulterations. The evaluated validated quality standards will be very useful for referential support, validation of the standards of WF, pharmaco-vigilance and providing the quality raw medicine to deprived human being.
KEYWORDS: (Woodfordia fruticosa (Linn) Kurz), Physico-chemical quality QC and QA HPTLC fingerprinting and Unani Compound drug.
KEYWORDS: Tagetes erecta L., DSR, QC., and QA., HPTLC, and GC-MS profiles, Toxicology studies.
मूल्य बिन्दु: उस्तुखुद्दुस (लेवेनन्डुला स्टोकस एल,),अनिद्रा, स्म्र्तिलोप, ग्लाइकोसाइड, फेनोल, स्टोराइड्स, ट्र्पीन ।
Keywords / मूलशब्द : धातकी / धाई फूल / गुल-ए-धावा वुडफोर्डिया फ्रुटिकोसा (लिनन) कुर्ज़), भौतिक-रासायनिक गुणवत्ता, गुणवत्ता नियंत्रण और आश्वासन पैरामीटर, टीएलसी / एचपीटीएलसी फिंगरप्रिंटिंग और यूनानी यौगिक दवा।
Keywords / मूलशब्द (कीवर्ड): गुल-ए-साद बार्ग, टैगेट्स इरेक्टा एल. (मेरिगोल्ड), ड्रग मानकीकरण अनुसंधान, क्यूसी., और क्यूए, एचपीटीएलसी फिंगरप्रिंट, और जीसी-एमएस प्रोफाइल, गुणवत्ता, सुरक्षा और विषाक्तता अध्ययन।
Keywords: SOP, Microscopy, Pharmacopoeial parameters, Isqeel, Quality control.
Introduction: DSR, QC., and QA. of herbal products remains a challenging task. There needs to be more than investigated screening parameters to validation, in order to authenticate and differentiate adulterants in medicinal plants. Tagetes erecta L. is one of the herbaceous plant which is used to treat various human ailments. This study aims to evaluate the DSR, QC, HPTLC, and GC-MS fingerprint profiles of the flower part of plant drug and extracts of T E. Methods: The QC and DSR with the toxicity studies as heavy metal, aflatoxins, pesticide residues analysis, HPTLC and GC-MS analysis of the chloroform and ethanolic extract of T E. were carried out and performed using standard methods. The antibacterial potential, antimicrobial & antitoxicity effects of the tested drug samples of different microbes, hazardous and toxins were also investigated.
Results: The DSR, QC. properties of T E. have shown that all the parameters were within the permissible limits. The HPTLC fingerprint profile of the chloroform and ethanolic extract exhibited various peaks under UV 254 nm, under UV 366 nm and V-S reagent, visible light region. The GC-MS analysis confirmed and illustrated the presence of various BAC. in the test sample. The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis.
Conclusions: The QC. findings revealed that the test drug was free from adulterations. Shown Antibacterial immense potential. The physicochemical constants, HPTLC, and GC-MS profiles of T E. can be essential data in the future. This herb's extracts may treat and cures in Scabies, Fever, Skin diseases.
Keywords: Tagetes erecta L., DSR, QC., and QA., HPTLC, and GC-MS profiles, Toxicology studies
Standardization and product acceptability is used to describe all measures under taken during the manufacturing process and quality control and quality assurance of drug leading to its reproducible quality. Therefore we need to develop standard validation techniques to standardize and validate of the herbal formulations using QC. QA Screening Studies. The drug Woodfordia fruticosa (Linn.) Kurz) is therapeutically useful in the treatment of Anti-pyretic, Anti-pills, Anti-inflammatory, Anti-ulcer, Anti-diarrheal, Anti-Sinus, Anti-Diabetes, Anti-Leukorrhea, Anti-Leprosy, Anti-hyperglycemic activity, Anti-depressant activity, Anti-cancer activity, Antioxidant activity. The single drug WF was Standardization, Quality Control Screening studied in three different batches as per the guidelines of WHO/ AYUSH Protocols basis. Present research study is aimed to evaluate the Standardization and product quality acceptability using physico-chemical parameters; HPTLC fingerprinting as per WHO guidelines of analyzed parameters. The physico-chemical average reading data’s of every III Batches of test samples showed that the drug contain Foreign matter, w/w- (0.08 %,0.07%,0.08%), LOD/ Moisture ,w/w- (6.054%,6.010% 6.320%), Total ash, w/w- (5.79%,5.82%,6.93%), Acid in-soluble ash, w/w-(0.776%,0.770%,0.778%), Alcohol and water soluble extractive matter, w/v- (12.80%,12.46%, 12.38%) & (24.40%,24.46%, 24.50%), pH(10% solution) (4.8,4.9,4.8), the HPTLC finger prints showed various spots at 254nm, 366nm Iodine vapours and visible light (M-S reagent). The tested drug samples showed significant Antibacterial potential and Toxicology studies against certain pathogens organisms and microbial load analysis. The QC. findings revealed that the test drug was free from adulterations. The evaluated validated quality standards will be very useful for referential support, validation of the standards of WF, pharmaco-vigilance and providing the quality raw medicine to deprived human being.
Keywords: (Woodfordia fruticosa (Linn) Kurz), Physico-chemical quality QC and QA HPTLC fingerprinting and Unani Compound drug.