Osteolytic lesions of C2 are challenging pathologies to manage. Vertebroplasty, a minimally invas... more Osteolytic lesions of C2 are challenging pathologies to manage. Vertebroplasty, a minimally invasive technique has been widely used in lytic lesions of thoracic and lumbar spine. However, there has been limited experience with percutaneous vertebroplasty at C2, and the procedure is technically difficult. We describe a safer alternative technique of open vertebroplasty for lytic lesions involving the axis. Methods: The procedure was performed in a 49-year-old male with a metastatic lytic lesion involving the body and dens of C2 using an anterior cervical approach. The patient had an immediate reduction in pain with complete pain relief at 2 weeks and good stability at 3-month follow-up. The patient did not have any perioperative or postoperative complications. The anterior cervical approach open C2 vertebroplasty is a safe and effective option in the management of C2 osteolytic lesions.
Pediatric glioblastoma multiforme (GBM) tumors, which have been established as ‘de novo’ neoplasm... more Pediatric glioblastoma multiforme (GBM) tumors, which have been established as ‘de novo’ neoplasms, are known to differ from their adult counterparts in terms of biology, genetics and ultimately survival of patients. In order to evaluate the utility of markers of tumor biology for refining prognostic assessment, we retrospectively analyzed 54 pediatric GBMs (age range 9 months to 15 years) occurring at different anatomical sites in the brain, operated at our institute between 1995 and 2001. The expression of p53, epidermal growth factor receptor (EGFR), bcl-2 and retinoblastoma proteins (pRb) was analyzed by immunohistochemistry and the results were compared with the clinical profile, MIB-1 labeling index (LI) and patient survival. p53 immunoreactivity was noted in 53.7% of cases, predominantly in thalamic (75%) and cerebral lobar (62.2%), followed by brainstem tumors (30%). It was absent in cerebellar tumors. p53-positive tumors had a higher MIB-1 LI, compared to p53-negative tumor...
Spinal hamartoma is an extremely rare, benign tumor, and 22 cases have been reported so far. Here... more Spinal hamartoma is an extremely rare, benign tumor, and 22 cases have been reported so far. Hereby, we report a midline conus hamartoma in a 22-year-old male with no associated systemic manifestations.
Spinal hamartoma is an extremely rare, benign tumor, and 22 cases have been reported so far. Here... more Spinal hamartoma is an extremely rare, benign tumor, and 22 cases have been reported so far. Hereby, we report a midline conus hamartoma in a 22-year-old male with no associated systemic manifestations.
Osteolytic lesions of C2 are challenging pathologies to manage. Vertebroplasty, a minimally invas... more Osteolytic lesions of C2 are challenging pathologies to manage. Vertebroplasty, a minimally invasive technique has been widely used in lytic lesions of thoracic and lumbar spine. However, there has been limited experience with percutaneous vertebroplasty at C2, and the procedure is technically difficult. We describe a safer alternative technique of open vertebroplasty for lytic lesions involving the axis. Methods: The procedure was performed in a 49-year-old male with a metastatic lytic lesion involving the body and dens of C2 using an anterior cervical approach. The patient had an immediate reduction in pain with complete pain relief at 2 weeks and good stability at 3-month follow-up. The patient did not have any perioperative or postoperative complications. The anterior cervical approach open C2 vertebroplasty is a safe and effective option in the management of C2 osteolytic lesions.
Pediatric glioblastoma multiforme (GBM) tumors, which have been established as ‘de novo’ neoplasm... more Pediatric glioblastoma multiforme (GBM) tumors, which have been established as ‘de novo’ neoplasms, are known to differ from their adult counterparts in terms of biology, genetics and ultimately survival of patients. In order to evaluate the utility of markers of tumor biology for refining prognostic assessment, we retrospectively analyzed 54 pediatric GBMs (age range 9 months to 15 years) occurring at different anatomical sites in the brain, operated at our institute between 1995 and 2001. The expression of p53, epidermal growth factor receptor (EGFR), bcl-2 and retinoblastoma proteins (pRb) was analyzed by immunohistochemistry and the results were compared with the clinical profile, MIB-1 labeling index (LI) and patient survival. p53 immunoreactivity was noted in 53.7% of cases, predominantly in thalamic (75%) and cerebral lobar (62.2%), followed by brainstem tumors (30%). It was absent in cerebellar tumors. p53-positive tumors had a higher MIB-1 LI, compared to p53-negative tumor...
Spinal hamartoma is an extremely rare, benign tumor, and 22 cases have been reported so far. Here... more Spinal hamartoma is an extremely rare, benign tumor, and 22 cases have been reported so far. Hereby, we report a midline conus hamartoma in a 22-year-old male with no associated systemic manifestations.
Spinal hamartoma is an extremely rare, benign tumor, and 22 cases have been reported so far. Here... more Spinal hamartoma is an extremely rare, benign tumor, and 22 cases have been reported so far. Hereby, we report a midline conus hamartoma in a 22-year-old male with no associated systemic manifestations.
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Papers by Praveen Ganigi