Abstract The reactions of 6-acetyl-3-amino-4-imino-7-methyl-5-phenyl-3,5-dihydro-4 H -pyrano[2,3-... more Abstract The reactions of 6-acetyl-3-amino-4-imino-7-methyl-5-phenyl-3,5-dihydro-4 H -pyrano[2,3- d ]pyrimidine with triethyl phosphite and some electrophilic reagents, namely 1,2-dibromoethane, oxalyl chloride, chloroacetyl chloride, and ethyl chloroacetate, were studied. These one-pot three-component reactions regioselectively afforded four new 11-acetyl-2-ethoxy-10-methyl-12-phenylpyrano[2′,3′:4,5]pyrimido[1,6- b ][1,2,4,5λ 5 ]triazaphosphepin-2-ones in 69–73% yields.
Abstract A simple one-pot method has been proposed for a series of novel [1,2,4]triazolo[5,1- e ]... more Abstract A simple one-pot method has been proposed for a series of novel [1,2,4]triazolo[5,1- e ][1,4,2]diazaphosphole derivatives by three-component condensation of the corresponding acid chlorides, triethyl phosphite, and 5-amino-1,2,4-triazoles. The isolated compounds were investigated for their antimicrobial activities, and 6-(4-chlorophenyl)-substituted derivatives showed good antimicrobial properties.
ABSTRACT Design of some novel functionalized thiophene, thieno[2,3-b]thiophene, thiopyran and thi... more ABSTRACT Design of some novel functionalized thiophene, thieno[2,3-b]thiophene, thiopyran and thiopyrano[2,3-b]thiopyran bearing phosphonate groups was described in one-pot through simple two steps. The methodology depended on the reaction of three-component of chloroacetyl chloride with triethyl phosphite in the presence of sodium 2,2-dicyanoethene-1,1-bis(thiolate) or sodium (2,2-dicyano-1-methylthioethen-1-yl)thiolate in a certain sequence. GRAPHICAL ABSTRACT
Fragmentation pathways of six isolated and fused heterocyclic rings with dibromoquinazolinone moi... more Fragmentation pathways of six isolated and fused heterocyclic rings with dibromoquinazolinone moiety, were investigated by electron impact mass spectrometry (EI-MS). The intensity of the molecular ion peaks were recorded as low intensities and in ratio 1:2:1 for M+4, M+2 and M + , respectively. Characteristic fragment ions were formed by successive loss of simple functional groups followed by decomposition of heterocycles connected to dibromoquinazoline rings.
Phosphorus Sulfur and Silicon and The Related Elements, Oct 2, 2018
Abstract The synthesis of some novel chromonyl and pyrazolyl α-aminophosphonates containing a qui... more Abstract The synthesis of some novel chromonyl and pyrazolyl α-aminophosphonates containing a quinazolinone ring was carried out by applying Pudovik and Kabachnik-Fields reactions under solvent- and catalyst-free conditions. The anticancer activities of these compounds were evaluated against five cancer cell lines. 3-{[(3-Phenyl/1,3-diphenyl-1H-pyrazol-4-yl)methylidene]amino}-2-phenyl-quinazolin-4(3H)-ones (3d,e) and diethyl {[3-phenyl/1,3-diphenyl-1H-pyrazol-4-yl][(4-oxo-2-phenyl-quinazolin-3(4H) yl)amino] methyl}phosphonates (4d,e) displayed the potent anticancer activities against HCT116, MCF-7 and HepG2 cell lines in comparison with the standard drug. Graphical Abstract
Abstract The reactions of 6-acetyl-3-amino-4-imino-7-methyl-5-phenyl-3,5-dihydro-4 H -pyrano[2,3-... more Abstract The reactions of 6-acetyl-3-amino-4-imino-7-methyl-5-phenyl-3,5-dihydro-4 H -pyrano[2,3- d ]pyrimidine with triethyl phosphite and some electrophilic reagents, namely 1,2-dibromoethane, oxalyl chloride, chloroacetyl chloride, and ethyl chloroacetate, were studied. These one-pot three-component reactions regioselectively afforded four new 11-acetyl-2-ethoxy-10-methyl-12-phenylpyrano[2′,3′:4,5]pyrimido[1,6- b ][1,2,4,5λ 5 ]triazaphosphepin-2-ones in 69–73% yields.
Abstract A simple one-pot method has been proposed for a series of novel [1,2,4]triazolo[5,1- e ]... more Abstract A simple one-pot method has been proposed for a series of novel [1,2,4]triazolo[5,1- e ][1,4,2]diazaphosphole derivatives by three-component condensation of the corresponding acid chlorides, triethyl phosphite, and 5-amino-1,2,4-triazoles. The isolated compounds were investigated for their antimicrobial activities, and 6-(4-chlorophenyl)-substituted derivatives showed good antimicrobial properties.
ABSTRACT Design of some novel functionalized thiophene, thieno[2,3-b]thiophene, thiopyran and thi... more ABSTRACT Design of some novel functionalized thiophene, thieno[2,3-b]thiophene, thiopyran and thiopyrano[2,3-b]thiopyran bearing phosphonate groups was described in one-pot through simple two steps. The methodology depended on the reaction of three-component of chloroacetyl chloride with triethyl phosphite in the presence of sodium 2,2-dicyanoethene-1,1-bis(thiolate) or sodium (2,2-dicyano-1-methylthioethen-1-yl)thiolate in a certain sequence. GRAPHICAL ABSTRACT
Fragmentation pathways of six isolated and fused heterocyclic rings with dibromoquinazolinone moi... more Fragmentation pathways of six isolated and fused heterocyclic rings with dibromoquinazolinone moiety, were investigated by electron impact mass spectrometry (EI-MS). The intensity of the molecular ion peaks were recorded as low intensities and in ratio 1:2:1 for M+4, M+2 and M + , respectively. Characteristic fragment ions were formed by successive loss of simple functional groups followed by decomposition of heterocycles connected to dibromoquinazoline rings.
Phosphorus Sulfur and Silicon and The Related Elements, Oct 2, 2018
Abstract The synthesis of some novel chromonyl and pyrazolyl α-aminophosphonates containing a qui... more Abstract The synthesis of some novel chromonyl and pyrazolyl α-aminophosphonates containing a quinazolinone ring was carried out by applying Pudovik and Kabachnik-Fields reactions under solvent- and catalyst-free conditions. The anticancer activities of these compounds were evaluated against five cancer cell lines. 3-{[(3-Phenyl/1,3-diphenyl-1H-pyrazol-4-yl)methylidene]amino}-2-phenyl-quinazolin-4(3H)-ones (3d,e) and diethyl {[3-phenyl/1,3-diphenyl-1H-pyrazol-4-yl][(4-oxo-2-phenyl-quinazolin-3(4H) yl)amino] methyl}phosphonates (4d,e) displayed the potent anticancer activities against HCT116, MCF-7 and HepG2 cell lines in comparison with the standard drug. Graphical Abstract
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Papers by Prof. Dr. Tarik E. Ali