Hyperuricemia is present in
about 5% of the population, and allopurinol is
frequently used to tre... more Hyperuricemia is present in about 5% of the population, and allopurinol is frequently used to treat it. The use of this drug can be associated with a number of side effects, indicating allergic reactions, such as skin rash, reversible after its withdrawal. In some casesmore severe hypersensitivity reactions may be seen, such as erythema multiforme exudativum, or Steven-Johnson Syndrome (SJS). Reversible clinical hepatotoxicity, as well as acute renal failure, may also develop after allopurinol therapy.We describe here the case of a 74-year-old woman with chronic renal failure who was admitted to hospital after 1week of sore throat and fever, presenting mucous membrane lesions, widespread blistering of the skin, evolving to flaccid vesicles and bullae, and extensive epidermal detachment associated with acute renal failure and cholestatic jaundice.Adiagnosis of allopurinol-induced toxic epidermal necrolysis (TEN) was established. Allopurinol was discontinued, and intensive care management was required: the patient was successfully treated by using intravenous immunoglobulin (IVIg), standard hemodialysis, and albumin dialysis (Molecular Adsorbents Recirculating System – MARS, Teraklin AG, Rostock, Germany). Allopurinol-induced TEN is extremely rare, however, the survival rate is extremely low. Clinicians should be aware of this potentially severe adverse effect. This report emphasizes the importance of an aggressive pharmacological and dialysis treatment in the case of TEN.
... HCV Infection:'Six Years after' in a Dialysis Unit Rachele Brugnano a , Man... more ... HCV Infection:'Six Years after' in a Dialysis Unit Rachele Brugnano a , Manuela Gaburri a , Daniela Francisci b , Giuseppe Quintaliani a , Umberto Buoncristiani a a Nephrology-Dialysis Unit, R.Silvestrini Hospital, and b Department of Infectious Diseases, University of Perugia ...
Hyperuricemia is present in
about 5% of the population, and allopurinol is
frequently used to tre... more Hyperuricemia is present in about 5% of the population, and allopurinol is frequently used to treat it. The use of this drug can be associated with a number of side effects, indicating allergic reactions, such as skin rash, reversible after its withdrawal. In some casesmore severe hypersensitivity reactions may be seen, such as erythema multiforme exudativum, or Steven-Johnson Syndrome (SJS). Reversible clinical hepatotoxicity, as well as acute renal failure, may also develop after allopurinol therapy.We describe here the case of a 74-year-old woman with chronic renal failure who was admitted to hospital after 1week of sore throat and fever, presenting mucous membrane lesions, widespread blistering of the skin, evolving to flaccid vesicles and bullae, and extensive epidermal detachment associated with acute renal failure and cholestatic jaundice.Adiagnosis of allopurinol-induced toxic epidermal necrolysis (TEN) was established. Allopurinol was discontinued, and intensive care management was required: the patient was successfully treated by using intravenous immunoglobulin (IVIg), standard hemodialysis, and albumin dialysis (Molecular Adsorbents Recirculating System – MARS, Teraklin AG, Rostock, Germany). Allopurinol-induced TEN is extremely rare, however, the survival rate is extremely low. Clinicians should be aware of this potentially severe adverse effect. This report emphasizes the importance of an aggressive pharmacological and dialysis treatment in the case of TEN.
... HCV Infection:'Six Years after' in a Dialysis Unit Rachele Brugnano a , Man... more ... HCV Infection:'Six Years after' in a Dialysis Unit Rachele Brugnano a , Manuela Gaburri a , Daniela Francisci b , Giuseppe Quintaliani a , Umberto Buoncristiani a a Nephrology-Dialysis Unit, R.Silvestrini Hospital, and b Department of Infectious Diseases, University of Perugia ...
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about 5% of the population, and allopurinol is
frequently used to treat it. The use of this drug
can be associated with a number of side effects,
indicating allergic reactions, such as
skin rash, reversible after its withdrawal. In
some casesmore severe hypersensitivity reactions
may be seen, such as erythema
multiforme exudativum, or Steven-Johnson
Syndrome (SJS). Reversible clinical hepatotoxicity,
as well as acute renal failure, may
also develop after allopurinol therapy.We describe
here the case of a 74-year-old woman
with chronic renal failure who was admitted
to hospital after 1week of sore throat and fever,
presenting mucous membrane lesions,
widespread blistering of the skin, evolving to
flaccid vesicles and bullae, and extensive epidermal
detachment associated with acute renal
failure and cholestatic jaundice.Adiagnosis
of allopurinol-induced toxic epidermal
necrolysis (TEN) was established. Allopurinol
was discontinued, and intensive care
management was required: the patient was
successfully treated by using intravenous immunoglobulin
(IVIg), standard hemodialysis,
and albumin dialysis (Molecular Adsorbents
Recirculating System – MARS, Teraklin AG,
Rostock, Germany). Allopurinol-induced
TEN is extremely rare, however, the survival
rate is extremely low. Clinicians should be
aware of this potentially severe adverse effect.
This report emphasizes the importance of an
aggressive pharmacological and dialysis
treatment in the case of TEN.
about 5% of the population, and allopurinol is
frequently used to treat it. The use of this drug
can be associated with a number of side effects,
indicating allergic reactions, such as
skin rash, reversible after its withdrawal. In
some casesmore severe hypersensitivity reactions
may be seen, such as erythema
multiforme exudativum, or Steven-Johnson
Syndrome (SJS). Reversible clinical hepatotoxicity,
as well as acute renal failure, may
also develop after allopurinol therapy.We describe
here the case of a 74-year-old woman
with chronic renal failure who was admitted
to hospital after 1week of sore throat and fever,
presenting mucous membrane lesions,
widespread blistering of the skin, evolving to
flaccid vesicles and bullae, and extensive epidermal
detachment associated with acute renal
failure and cholestatic jaundice.Adiagnosis
of allopurinol-induced toxic epidermal
necrolysis (TEN) was established. Allopurinol
was discontinued, and intensive care
management was required: the patient was
successfully treated by using intravenous immunoglobulin
(IVIg), standard hemodialysis,
and albumin dialysis (Molecular Adsorbents
Recirculating System – MARS, Teraklin AG,
Rostock, Germany). Allopurinol-induced
TEN is extremely rare, however, the survival
rate is extremely low. Clinicians should be
aware of this potentially severe adverse effect.
This report emphasizes the importance of an
aggressive pharmacological and dialysis
treatment in the case of TEN.