Muller Journal of Medical Sciences and Research, 2015
Purpose: Multiple methods of accelerating fracture healing have been proposed and some are approv... more Purpose: Multiple methods of accelerating fracture healing have been proposed and some are approved for use in the clinical settings. A low intensity (30 nW/cm 2 ) pulsed ultrasound (LIPUS) signal will promote fracture healing. This study is conducted to determine the effect of LIPUS on fresh fracture healing. Materials and Methods: Out of the 60 patients with diaphyseal fractures of the tibia and femur fixed with an interlocking nail, 33 received LIPUS and 27 were kept as control. Ultrasound treatment was started three days after surgery, 20 minute sessions each day, for 30 days. The rate of fracture healing in the LIPUS group was compared with that of the control group. Six orthopedic surgeons and two radiologists analyzed the follow-up x-rays. Results: Five out of the six surgeons interpreted that there was significantly more callus formation and union in the LIPUS group compared to the control group, especially in the initial stage of healing. The need for dynamization decreased by 50% in the LIPUS group. Both radiologists interpreted that there was significantly more callus in the case where ultrasound was administered, when they evaluated the same with an diagnostic ultrasound scan at the fracture site. Conclusion: The present study establishes the relation between low intensity pulsed ultrasound therapy and fresh fracture healing, especially in the early stages. We strongly recommend the use of LIPUS as an adjunct therapy where the surgeon anticipates delayed union of the fracture.
To evaluate the ability of the maxillary sinus membrane to produce bone after internal sinus lift... more To evaluate the ability of the maxillary sinus membrane to produce bone after internal sinus lifting and implant placement without adding exogenous bone graft, and to assess the quality of bone that has been produced 6 months postoperatively.In this retrospective study, 10 subjects who underwent maxillary sinus floor lifting and met the inclusion criteria were selected and then subdivided into: Group-A underwent internal sinus elevation and placement of implants without the use of bone graft and Group-B underwent classical internal sinus lifting and placement of bovine bone particles and then placement of the implant as a control group. Radiofrequency analysis (RFA) values for measuring the Implant Stability Quotient (ISQ) of all implants were measured by Osstell device. CBCT was performed involving linear measurements of the site of sinus lifting for both groups.High RFA values demonstrating excellent biomechanical stability were observed in Group-A compared to Group-B at 6 months postoperatively. Group-A showed a median of ISQ value;78 (8), 77(12), 79(3.5) and 77(4.50). Group-A was significantly higher in ISQ values than Group-B, which showed median and interquartile range (IQR) of ISQ value of [51(12.50), 54(14.50), 55(9), and 55(7.50)]. However, the amount of bone available in group B was significantly higher than group A; [3.5 mm (0.75) and 3.8 mm (0.69)].Internal sinus lifting without bone graft has the ability of bone formation by osteogenic potential of the sinus membrane. Nevertheless, the high quality of bone being produced is of high importance for the success of an implant without the need for an exogenous bone graft. The newly formed bone was significantly of a better quality in Group-A. Thus, it is recommended to perform internal sinus lifting, without adding bone graft material and allow the osteogenic potential of the maxillary sinus membrane to produce its own osteogenic cells.
Background Titanium dioxide dental implants have a controversial effect on reactive oxygen specie... more Background Titanium dioxide dental implants have a controversial effect on reactive oxygen species (ROS) production. ROS is necessary for cellular signal transmission and proper metabolism, but also has the ability to cause cell death as well as DNA, RNA, and proteins damage by excessive oxidative stress. This study aimed to systematically review the effect of titanium dioxide dental implant-induced oxidative stress and its role on the osteogenesis-angiogenesis coupling in bone remodeling. Methods This systematic review was performed conforming to preferred reporting items for systematic review and meta-analysis (PRISMA) model. Four different databases (PubMed, Science Direct, Scopus and Medline databases) as well as manual searching were adopted. Relevant studies from January 2000 till September 2021 were retrieved. Critical Appraisal Skills Programme (CASP) was used to assess the quality of the selected studies. Results Out of 755 articles, only 14 which met the eligibility criter...
AimsTo compare morning and evening salivary melatonin levels, sleep quality and chronotype betwee... more AimsTo compare morning and evening salivary melatonin levels, sleep quality and chronotype between nurses working fixed day shifts and those working rotating night shifts.BackgroundRotating night shift work is an inevitable part of nursing and is a major reason for disrupted sleep.DesignCross‐sectional comparative design.Participants and SettingsWe used cluster sampling to recruit 520 female nurses working fixed day and rotating night shifts in the United Arab Emirates.MethodsMorning and evening melatonin were measured from corresponding saliva samples. The Pittsburgh Sleep Quality Index used to evaluate sleep quality and self‐assessment of preferred circadian times was used to assess participants’ chronotypes. Data were collected between October 2017–December 2018.ResultsRotating night shift nurses had significantly lower evening melatonin compared with the fixed day shift group. No significant difference was found in sleep quality between the groups, although more participants in ...
There was a significant increased in Absolute Contact Length measurements of endosteal bone growt... more There was a significant increased in Absolute Contact Length measurements of endosteal bone growth along the Nickel-Titanium (NiTi) implant coated with the natural coral powder and Hydroxyapatite (HA) compared to the non-calcium coated implants. This study demonstrated that coated implants seemed to show earlier and higher osseointergration phenomena compared to non coated ones. Furthermore, there was significantly greater bone-to-implant contact at the apical 1/3rd of the coated implants.
Resuming regular clinical activities at dental premises after the COVID-19 lockdown period or pos... more Resuming regular clinical activities at dental premises after the COVID-19 lockdown period or post COVID-19 is likely to be a challenge for all dental institutes. When returning to the dental practice or training, staff and students alike should abide by the new rules and regulations. In the process of controlling viral spread, clinical dental facilities face a higher risk of disease transmission among patients as well as clinical and non-clinical staff. Aerosols formation and diffusion into the surrounding air can be a real concern of viral transmission, if no protective measures are established. We aim in this review to present the currently implemented measures and propose changes in clinical dental facilities to minimize the risk of transmission. Dental professionals should be prepared to treat every patient as a suspected COVID-19 carrier and be ready to receive and manage an overwhelming number of patients. We suggest that dental practices establish a sensible workforce shift ...
Photodiagnosis and Photodynamic Therapy, Dec 1, 2021
BACKGROUND The primary aim of this prospective study is to demonstrate the technical feasibility ... more BACKGROUND The primary aim of this prospective study is to demonstrate the technical feasibility of OCT to map real tumor margins and to monitor skin changes that occurred post- PDT. Moreover, to optimize PDT efficacy based on the relationship between measured OCT features and treatment outcome. MATERIAL AND METHODS A series of 12 patients with overall 18 facial skin lesions were investigated by OCT before surface illumination by PDT to determine tumor free margins. Monitoring of the healing process was undertaken at 3, 6 and 12 months post-PDT. Parameters measured by the in vivo OCT during healing phase were the organization of skin layer and the degree skin fibroses for the active center and peripheral transit zone of the treated lesion. Clinical and aesthetics assessment was carried out at 12-month post-PDT. RESULTS Distinct microstructural differences between normal skin, pre-cancer, cancer, and the transition zone between the two tissues were observed on OCT images. In the subsequent healing phase, OCT demonstrate marked delineation and organization of skin layer at late stage of healing. Early features showing bizarre non-homogenous disorganized layering (scab) but afterwards, OCT was able to differentiate between different histological layers. One lesion demonstrated clinical healing by fibrosis (scar) without sign of recurrence. Another lesion demonstrated skin erythema. Only one lesion did not response to treatment despite margins clearance. The CR rate was 95% at the end of the study. The cosmetic effect was "excellent" in 89% of the patients. CONCLUSIONS This feasibility study lays the groundwork for using OCT as a real-time, noninvasive monitoring device for PDT in patients with skin cancer.
Muller Journal of Medical Sciences and Research, 2015
Purpose: Multiple methods of accelerating fracture healing have been proposed and some are approv... more Purpose: Multiple methods of accelerating fracture healing have been proposed and some are approved for use in the clinical settings. A low intensity (30 nW/cm 2 ) pulsed ultrasound (LIPUS) signal will promote fracture healing. This study is conducted to determine the effect of LIPUS on fresh fracture healing. Materials and Methods: Out of the 60 patients with diaphyseal fractures of the tibia and femur fixed with an interlocking nail, 33 received LIPUS and 27 were kept as control. Ultrasound treatment was started three days after surgery, 20 minute sessions each day, for 30 days. The rate of fracture healing in the LIPUS group was compared with that of the control group. Six orthopedic surgeons and two radiologists analyzed the follow-up x-rays. Results: Five out of the six surgeons interpreted that there was significantly more callus formation and union in the LIPUS group compared to the control group, especially in the initial stage of healing. The need for dynamization decreased by 50% in the LIPUS group. Both radiologists interpreted that there was significantly more callus in the case where ultrasound was administered, when they evaluated the same with an diagnostic ultrasound scan at the fracture site. Conclusion: The present study establishes the relation between low intensity pulsed ultrasound therapy and fresh fracture healing, especially in the early stages. We strongly recommend the use of LIPUS as an adjunct therapy where the surgeon anticipates delayed union of the fracture.
To evaluate the ability of the maxillary sinus membrane to produce bone after internal sinus lift... more To evaluate the ability of the maxillary sinus membrane to produce bone after internal sinus lifting and implant placement without adding exogenous bone graft, and to assess the quality of bone that has been produced 6 months postoperatively.In this retrospective study, 10 subjects who underwent maxillary sinus floor lifting and met the inclusion criteria were selected and then subdivided into: Group-A underwent internal sinus elevation and placement of implants without the use of bone graft and Group-B underwent classical internal sinus lifting and placement of bovine bone particles and then placement of the implant as a control group. Radiofrequency analysis (RFA) values for measuring the Implant Stability Quotient (ISQ) of all implants were measured by Osstell device. CBCT was performed involving linear measurements of the site of sinus lifting for both groups.High RFA values demonstrating excellent biomechanical stability were observed in Group-A compared to Group-B at 6 months postoperatively. Group-A showed a median of ISQ value;78 (8), 77(12), 79(3.5) and 77(4.50). Group-A was significantly higher in ISQ values than Group-B, which showed median and interquartile range (IQR) of ISQ value of [51(12.50), 54(14.50), 55(9), and 55(7.50)]. However, the amount of bone available in group B was significantly higher than group A; [3.5 mm (0.75) and 3.8 mm (0.69)].Internal sinus lifting without bone graft has the ability of bone formation by osteogenic potential of the sinus membrane. Nevertheless, the high quality of bone being produced is of high importance for the success of an implant without the need for an exogenous bone graft. The newly formed bone was significantly of a better quality in Group-A. Thus, it is recommended to perform internal sinus lifting, without adding bone graft material and allow the osteogenic potential of the maxillary sinus membrane to produce its own osteogenic cells.
Background Titanium dioxide dental implants have a controversial effect on reactive oxygen specie... more Background Titanium dioxide dental implants have a controversial effect on reactive oxygen species (ROS) production. ROS is necessary for cellular signal transmission and proper metabolism, but also has the ability to cause cell death as well as DNA, RNA, and proteins damage by excessive oxidative stress. This study aimed to systematically review the effect of titanium dioxide dental implant-induced oxidative stress and its role on the osteogenesis-angiogenesis coupling in bone remodeling. Methods This systematic review was performed conforming to preferred reporting items for systematic review and meta-analysis (PRISMA) model. Four different databases (PubMed, Science Direct, Scopus and Medline databases) as well as manual searching were adopted. Relevant studies from January 2000 till September 2021 were retrieved. Critical Appraisal Skills Programme (CASP) was used to assess the quality of the selected studies. Results Out of 755 articles, only 14 which met the eligibility criter...
AimsTo compare morning and evening salivary melatonin levels, sleep quality and chronotype betwee... more AimsTo compare morning and evening salivary melatonin levels, sleep quality and chronotype between nurses working fixed day shifts and those working rotating night shifts.BackgroundRotating night shift work is an inevitable part of nursing and is a major reason for disrupted sleep.DesignCross‐sectional comparative design.Participants and SettingsWe used cluster sampling to recruit 520 female nurses working fixed day and rotating night shifts in the United Arab Emirates.MethodsMorning and evening melatonin were measured from corresponding saliva samples. The Pittsburgh Sleep Quality Index used to evaluate sleep quality and self‐assessment of preferred circadian times was used to assess participants’ chronotypes. Data were collected between October 2017–December 2018.ResultsRotating night shift nurses had significantly lower evening melatonin compared with the fixed day shift group. No significant difference was found in sleep quality between the groups, although more participants in ...
There was a significant increased in Absolute Contact Length measurements of endosteal bone growt... more There was a significant increased in Absolute Contact Length measurements of endosteal bone growth along the Nickel-Titanium (NiTi) implant coated with the natural coral powder and Hydroxyapatite (HA) compared to the non-calcium coated implants. This study demonstrated that coated implants seemed to show earlier and higher osseointergration phenomena compared to non coated ones. Furthermore, there was significantly greater bone-to-implant contact at the apical 1/3rd of the coated implants.
Resuming regular clinical activities at dental premises after the COVID-19 lockdown period or pos... more Resuming regular clinical activities at dental premises after the COVID-19 lockdown period or post COVID-19 is likely to be a challenge for all dental institutes. When returning to the dental practice or training, staff and students alike should abide by the new rules and regulations. In the process of controlling viral spread, clinical dental facilities face a higher risk of disease transmission among patients as well as clinical and non-clinical staff. Aerosols formation and diffusion into the surrounding air can be a real concern of viral transmission, if no protective measures are established. We aim in this review to present the currently implemented measures and propose changes in clinical dental facilities to minimize the risk of transmission. Dental professionals should be prepared to treat every patient as a suspected COVID-19 carrier and be ready to receive and manage an overwhelming number of patients. We suggest that dental practices establish a sensible workforce shift ...
Photodiagnosis and Photodynamic Therapy, Dec 1, 2021
BACKGROUND The primary aim of this prospective study is to demonstrate the technical feasibility ... more BACKGROUND The primary aim of this prospective study is to demonstrate the technical feasibility of OCT to map real tumor margins and to monitor skin changes that occurred post- PDT. Moreover, to optimize PDT efficacy based on the relationship between measured OCT features and treatment outcome. MATERIAL AND METHODS A series of 12 patients with overall 18 facial skin lesions were investigated by OCT before surface illumination by PDT to determine tumor free margins. Monitoring of the healing process was undertaken at 3, 6 and 12 months post-PDT. Parameters measured by the in vivo OCT during healing phase were the organization of skin layer and the degree skin fibroses for the active center and peripheral transit zone of the treated lesion. Clinical and aesthetics assessment was carried out at 12-month post-PDT. RESULTS Distinct microstructural differences between normal skin, pre-cancer, cancer, and the transition zone between the two tissues were observed on OCT images. In the subsequent healing phase, OCT demonstrate marked delineation and organization of skin layer at late stage of healing. Early features showing bizarre non-homogenous disorganized layering (scab) but afterwards, OCT was able to differentiate between different histological layers. One lesion demonstrated clinical healing by fibrosis (scar) without sign of recurrence. Another lesion demonstrated skin erythema. Only one lesion did not response to treatment despite margins clearance. The CR rate was 95% at the end of the study. The cosmetic effect was "excellent" in 89% of the patients. CONCLUSIONS This feasibility study lays the groundwork for using OCT as a real-time, noninvasive monitoring device for PDT in patients with skin cancer.
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