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Cementoblastoma, a benign mesenchymal odontogenic neoplasm is derived from ectomesenchymal cells of the periodontium. Cementoblastomas associated with primary teeth are extremely rare as permanent mandibular first molars are mostly... more
Cementoblastoma, a benign mesenchymal odontogenic neoplasm is derived from ectomesenchymal cells of the periodontium. Cementoblastomas associated with primary teeth are extremely rare as permanent mandibular first molars are mostly affected. Only 17 cases of those associated with deciduous dentition have been reported so far. The present case report describes a true cementoblastoma of an 8-year-old male child in relation to the left first primary mandibular molar along with emphasis on differential diagnosis.
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Ameloblastoma is a benign odontogenic tumor which undergoes malignant transformation to ameloblastic carcinoma. However, rarely it metastasizes without undergoing cytological malignant changes, an entity referred to as Metastasizing... more
Ameloblastoma is a benign odontogenic tumor which undergoes malignant transformation to ameloblastic carcinoma. However, rarely it metastasizes without undergoing cytological malignant changes, an entity referred to as Metastasizing Ameloblastoma (MA). Through this study we aimed to review cases of MA reported since 2000 to explore the impact of clinico-demographic variables on its prognosis. Based on PRISMA guidelines, a review of relevant literature from PubMed/Medline, Science Direct and Cochrane database was performed from January 2000 to March 2019. A total of 65 cases were considered for further evaluation as per predefined inclusion and exclusion criteria. Results showed that lungs followed by lymph nodes were the most common sites for benign metastatic deposits. Multiple recurrences and inadequate surgical removal increase the probability of distant metastatic spread. Despite having benign cytological features, tumor recurrence and metastasis were associated with an unfavorable clinical outcome in MA.
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Fibrous dysplasia (FD) is a benign skeletal lesion occurring due to mutation of Gs α gene and involves one or multiple bones. We present a case of a 30-year-old female patient, with a 1-year history of swelling under her right eye that... more
Fibrous dysplasia (FD) is a benign skeletal lesion occurring due to mutation of Gs α gene and involves one or multiple bones. We present a case of a 30-year-old female patient, with a 1-year history of swelling under her right eye that had gradually increased in size. Extraoral examination revealed a diffuse swelling extending anteroposteriorly from preauricular region to nasolabial fold, frontonasal region and superoinferiorly from zygoma to body of mandible, causing ipsilateral proptosis and contralateral deviation of nose. Intraoral examination showed obliteration of right upper and lower buccal vestibule. CT disclosed expansile lytic lesions involving multiple skull bones, jaws, sternum, rib and thoracic vertebrae. Histopathology displayed broad and interconnected trabeculae connected to the host bone exhibiting reversal lines resembling the mosaic pattern of Paget's disease. These features suggested pagetoid polyostotic FD. The patient underwent cosmetic recontouring and is...
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Dyskeratosis congenita (DC) is a multisystem inherited syndrome exhibiting marked clinical and genetic heterogeneity. In its classic form, it is characterised by a triad of dystrophic nails, reticular skin pigmentation andmucosal... more
Dyskeratosis congenita (DC) is a multisystem inherited syndrome exhibiting marked clinical and genetic heterogeneity. In its classic form, it is characterised by a triad of dystrophic nails, reticular skin pigmentation andmucosal leukoplakia. The affected patients often present with haematological, ophthal-mological, dermatological and neurological features with a marked tendency for spontaneous malignant transformation.Dyskeratosis congenita presents three modes of inheritance; X-linked recessive, autosomal recessive and autosomal dominant of which, X-linked recessive is the most common and thus results in a striking male predilection. However, a sufficient number of sporadic cases due to unidentified mutations have also been reported.
Odontogenic myxoma (OM) is a locally aggressive, benign, slowgrowing tumor arising from mesenchyme and/or odontogenic epithelium. It is the third most common odontogenic tumor predominantly affecting females and posterior mandible.... more
Odontogenic myxoma (OM) is a locally aggressive, benign, slowgrowing tumor arising from mesenchyme and/or odontogenic epithelium. It is the third most common odontogenic tumor predominantly affecting females and posterior mandible. Radiographically, OM demonstrates unilocular or multilocular, well or ill-defined radiolucency showing ‘honeycomb’, ‘soap-bubble’ or ‘tennis-racket’ pattern with cortical expansion and tooth displacement. Histologically, OM shows loosely arranged stellate or spindle-shaped cells interspersed in myxoid matrix. Various treatment modalities, such as wide excision, enucleation and curettage, curettage with/without electrical or chemical cautery, enbloc resection and wide resection with/without immediate grafting can be considered based on the extent of the lesion. Here, we present a case of a 17-year-old female, with OM in the left maxilla and the maxillary sinus. How to cite this article Hosalkar RM, Patel S, Pathak J, Swain N. Odontogenic Myxoma of Maxilla....
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ABSTRACTThe odontogenic epithelial remnants, i.e. cell rests of Serre and Malassez, are formed from dental lamina and Hertwig's epithelial root sheath respectively, may proliferate and have role in pathogenesis of odontogenic cysts... more
ABSTRACTThe odontogenic epithelial remnants, i.e. cell rests of Serre and Malassez, are formed from dental lamina and Hertwig's epithelial root sheath respectively, may proliferate and have role in pathogenesis of odontogenic cysts and tumors. Odontogenic keratocyst (OKC) is the most common and aggressive cyst of the dental lamina origin. Ameloblastoma, the second most common odontogenic tumor (OT), is a clinically benign and locally invasive polymorphic neoplasia. Differentiation of OKC from ameloblastoma sometimes poses a diagnostic dilemma, thus necessitating the need to differentiate between the two (especially unicystic ameloblastoma and OKC). Calretinin, a calcium binding protein, functions as a calcium buffer and a regulator of apoptosis. Some studies have shown its expression in parakeratinized OKC, unicystic and solid ameloblastoma, but not in other OTs. Calretinin may thus provide a better understanding of the biological behavior and tumorogenesis of ameloblastoma. cyt...
The term “vascular anomalies” represent a spectrum of vascular disorders that require a multidisciplinary approach for proper diagnosis, evaluation and management. Understanding the nuances and complexities of these vascular anomalies are... more
The term “vascular anomalies” represent a spectrum of vascular disorders that require a multidisciplinary approach for proper diagnosis, evaluation and management. Understanding the nuances and complexities of these vascular anomalies are essential for the most comprehensive care and optimal clinical outcomes. The idea of the book was born through realization that most dental healthcare professionals lacked adequate information on different clinical and histopathological types of vascular anomalies that could present in a dental practice. Most of the textbooks are typically intended for experts and not for general dental practice. In this book we focus on providing the general dentist and consultant oral pathologists with most common vascular tumors, vascular malformations and their associated syndromes. For each lesion we present information about its etiopathogenesis, clinical features, its clinical and oral manifestations, histopathology, immunohistochemistry differential diagnos...
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Candida albicans is the most common fungal pathogen in humans, although other Candida species can also cause candidiasis. Patients with symptomatic or erythematous oral lichen planus (OLP) have commonly been associated with these. In... more
Candida albicans is the most common fungal pathogen in humans, although other Candida species can also cause candidiasis. Patients with symptomatic or erythematous oral lichen planus (OLP) have commonly been associated with these. In recent times, however, there has been a notable shift in the incidence of non-Candida albicans (NCA) species which is gaining prominence due to significant differences in their susceptibility to antimycotic drugs. Studies showed that C. glabrata and C. tropicalis were the most common NCA species isolated in OLP. Treatment failure is common among NCA species in OLP due to its intrinsic resistant or low susceptibility to commonly used antifungal agents. This article reviews the role of Candida species in etiology, pathogenesis, clinical features, diagnosis, and management of OLP. How to cite this article: Sarkate PR, Pathak J, Patel S, et al. Role of Candida Species in Oral Lichen Planus. J Contemp Dent 2019;9(3):124–129.
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BACKGROUND Mortality and Morbidity rates in the patients diagnosed with oral cancers remain static despite availability of advanced diagnostic and treatment modalities. For improving the survival status of the patients, a thorough... more
BACKGROUND Mortality and Morbidity rates in the patients diagnosed with oral cancers remain static despite availability of advanced diagnostic and treatment modalities. For improving the survival status of the patients, a thorough understanding of the factors that predicts the progression of oral cancer is necessary to determine appropriate line of treatment. To do so in practise, critical knowledge regarding the prognostic factors that has high sensitivity holds immense importance. For determination of prognosis in oral cancer patients, clinical and histopathological parameters are widely used for assessment of treatment strategies. The primary objective of this study was to determine the clinical and histopathological prognostic factors in patients of oral squamous cell carcinoma of gingivobuccal sulcus (GBSSCC) treated by surgical intervention (neck dissection). METHODS Histopathological evaluation of archived samples of 60 GBSSCC patients which were treated by surgical intervent...
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Cementoblastoma, a benign mesenchymal odontogenic neoplasm is derived from ectomesenchymal cells of the periodontium. Cementoblastomas associated with primary teeth are extremely rare as permanent mandibular first molars are mostly... more
Cementoblastoma, a benign mesenchymal odontogenic neoplasm is derived from ectomesenchymal cells of the periodontium. Cementoblastomas associated with primary teeth are extremely rare as permanent mandibular first molars are mostly affected. Only 17 cases of those associated with deciduous dentition have been reported so far. The present case report describes a true cementoblastoma of an 8-year-old male child in relation to the left first primary mandibular molar along with emphasis on differential diagnosis.
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Carotid body paraganglioma (CBP) is a type neuroendocrine tumour arising from paraganglial chief cells of carotid body. Situated at the bifurcation of the common carotid artery, it constitutes 0.5% of all body tumours. Though CBP's is... more
Carotid body paraganglioma (CBP) is a type neuroendocrine tumour arising from paraganglial chief cells of carotid body. Situated at the bifurcation of the common carotid artery, it constitutes 0.5% of all body tumours. Though CBP's is most common paraganglioma of head and neck it is a rare neoplasm and requires a thorough examination for a proper diagnosis and therapeutic management. Here, we present a case of 36 year old female patient with CBP in left side of the neck.
Ethnologic identification is one of the major demanding subjects to facilitate human has been encountered with. The forensic magnitude of the dental tissue has been well predictable since teeth are hardest of all human tissues and they... more
Ethnologic identification is one of the major demanding subjects to facilitate human has been encountered with. The forensic magnitude of the dental tissue has been well predictable since teeth are hardest of all human tissues and they can be conserved undamaged for an extensive episode of instance following fatality. They are constant chemically and they retain their characteristics, which becomes a consistent source for determination of human identification. The study of the dental hard and soft tissue for the rationale of establishing the individuality of a victim is called dental profiling. By using the dental profiling techniques, age, gender, and race of an individual can be determined, as well as the data about their socioeconomic status, personal habits, oral and systemic health, occupation, diet, familial relationship, and psychological characteristics. A dental profile is more detailed and reliable if more than one technique is applied. Each human being possesses a unique ...
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Background Detection of oral squamous cell carcinoma (OSCC) at an early stage would be a paramount for any successful clinical treatment, and thus better prognosis. Serum proteomics, a minimally invasive procedure being simple, safe and... more
Background Detection of oral squamous cell carcinoma (OSCC) at an early stage would be a paramount for any successful clinical treatment, and thus better prognosis. Serum proteomics, a minimally invasive procedure being simple, safe and accessible, is one of the methods that are used for detection of various biomarkers that could be of diagnostic and prognostic importance for diseases including OSCC. The aim of this prospective study was to determine the role of serum albumin, globulin levels and albumin/globulin (A/G) ratio as a reliable diagnostic and prognostic biomarker in OSCC. Materials and Methods The study was conducted on 30 clinically diagnosed OSCC patients and 10 normal healthy patients of the control group. Blood samples were collected from all patients under necessary precautions and processed further to obtain serum. Biopsies were obtained from OSCC patients and were histopathologically graded into well, moderate and poorly differentiated OSCC. Serum sample from both ...