Langerhans cell histiocytosis (LCH) is a rare hematological disorder characterized by local or ge... more Langerhans cell histiocytosis (LCH) is a rare hematological disorder characterized by local or generalized, uncontrolled proliferation and infiltration of Langerhans type of histiocytic cells. It represents a spectrum of clinicopathologic disorders, ranging from a highly aggressive and frequently fatal multisystem disease to an easily cured solitary lesion of bone. Involvement of children and the younger age group is more common than the adults. Oral cavity involvement occurs early in LCH, but the initial symptoms are generally nonspecific, often causing misdiagnosis. This report describes a rare case of chronic localized LCH in an adult patient, with involvement of oral cavity. A 34-year-old male patient presented with multiple nodulo-papular, ulcerated lesions in gingiva involving both the jaws (primarily mandible) and the left buccal mucosa, in addition to regional teeth mobility. The most striking feature was that even after extraction of mobile teeth, the lesions persisted. After recording proper history, performing clinical and radiological evaluation, an incisional biopsy was performed followed by histopathology and immunohistochemistry to reach a confirmatory diagnosis of LCH, thereby implementing early and appropriate initiation of treatment.
Rhabdomyosarcoma (RMS) is a rare, rapidly growing, highly aggressive malignant neoplasm, originat... more Rhabdomyosarcoma (RMS) is a rare, rapidly growing, highly aggressive malignant neoplasm, originating from undifferentiated mesenchymal cells that retain their ability to differentiate into skeletal muscle. It mainly affects children, accounts for <1% of all adult malignancies and has varied clinical presentations. The head and neck region accounts for 35%–40% of all RMS cases, of which 10%–12% cases involve the oral cavity. This report deals with a case of RMS in a 40-year-old woman, primarily involving maxillary gingiva for which she underwent excision with subsequent recurrences. The uniqueness of this case is that it reminds us of the essential clinical dictum that ‘every growth we encounter, no matter how benign it appears clinically, should be looked upon with suspicion’. Hence, proper integration of history, clinical examination and investigation is required to reach a correct diagnosis enabling early treatment, thereby preventing functional and aesthetic loss and psycholog...
Langerhans cell histiocytosis (LCH) is a rare hematological disorder characterized by local or ge... more Langerhans cell histiocytosis (LCH) is a rare hematological disorder characterized by local or generalized, uncontrolled proliferation and infiltration of Langerhans type of histiocytic cells. It represents a spectrum of clinicopathologic disorders, ranging from a highly aggressive and frequently fatal multisystem disease to an easily cured solitary lesion of bone. Involvement of children and the younger age group is more common than the adults. Oral cavity involvement occurs early in LCH, but the initial symptoms are generally nonspecific, often causing misdiagnosis. This report describes a rare case of chronic localized LCH in an adult patient, with involvement of oral cavity. A 34-year-old male patient presented with multiple nodulo-papular, ulcerated lesions in gingiva involving both the jaws (primarily mandible) and the left buccal mucosa, in addition to regional teeth mobility. The most striking feature was that even after extraction of mobile teeth, the lesions persisted. After recording proper history, performing clinical and radiological evaluation, an incisional biopsy was performed followed by histopathology and immunohistochemistry to reach a confirmatory diagnosis of LCH, thereby implementing early and appropriate initiation of treatment.
Rhabdomyosarcoma (RMS) is a rare, rapidly growing, highly aggressive malignant neoplasm, originat... more Rhabdomyosarcoma (RMS) is a rare, rapidly growing, highly aggressive malignant neoplasm, originating from undifferentiated mesenchymal cells that retain their ability to differentiate into skeletal muscle. It mainly affects children, accounts for <1% of all adult malignancies and has varied clinical presentations. The head and neck region accounts for 35%–40% of all RMS cases, of which 10%–12% cases involve the oral cavity. This report deals with a case of RMS in a 40-year-old woman, primarily involving maxillary gingiva for which she underwent excision with subsequent recurrences. The uniqueness of this case is that it reminds us of the essential clinical dictum that ‘every growth we encounter, no matter how benign it appears clinically, should be looked upon with suspicion’. Hence, proper integration of history, clinical examination and investigation is required to reach a correct diagnosis enabling early treatment, thereby preventing functional and aesthetic loss and psycholog...
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Papers by Richa Nangalia