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O desenvolvimento de novos materiais que possam substituir os splints de silicone, no pós-operatório de cirurgias de desvio de septo, tem sido considerado. O poli(ácido lático) (PLA), é um dos polímeros mais estudados como biomateriais,... more
O desenvolvimento de novos materiais que possam substituir os splints de silicone, no pós-operatório de cirurgias de desvio de septo, tem sido considerado. O poli(ácido lático) (PLA), é um dos polímeros mais estudados como biomateriais, para preparação de suturas cirúrgicas, scaffolds e sistemas de liberação de fármacos devido à sua biocompatibilidade e bioreabsorção. A atorvastatina (ATV) exibe efeitos secundários interessantes na cicatrização de feridas pois promove ação anti-inflamatória, antioxidante, vasodilatadora e imunossupressora, que podem auxiliar na regeneração do tecido ósseo e cartilaginoso, quando administrada em altas doses. O presente trabalho consiste na produção e caracterização de filmes de PLA/ATV, carreados com atorvastatina, para futura aplicação em engenharia de tecidos e em sistemas de liberação prolongada de fármacos. Para tal, foram produzidos filmes de PLA pela técnica de solvent casting. O polímero, fármaco e filmes foram caracterizados por microscopia...
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In recent years, tissue engineering has been developing methodologies to potentialize the regeneration of injured tissues, such as using biomaterials to obtain scaffolds performing the controlled release of drugs. The polymers polyhydroxy... more
In recent years, tissue engineering has been developing methodologies to potentialize the regeneration of injured tissues, such as using biomaterials to obtain scaffolds performing the controlled release of drugs. The polymers polyhydroxy butyrate (PHB) and chitosan (CHI) have been used in the production of matrices applied to scaffold production. This study aims to produce and evaluate matrices containing different proportions of PHB and CHI using the compression molding technique. These matrices can form scaffolds after drug incorporation of Hamamelis virginiana (HV). In order to predict the swelling of the matrices, the Thin Plate Spline Interpolation method (TPSIM) was used to generate three-dimensional data fitted, showing the influence of time and concentration variables on drug absorption. Results show that the percentage of CHI in the samples determines the swelling degree of the matrices. According to scanning electron microscopy analyses, increasing this polymer's qua...
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The majority of synthetic polymers used in 3 D printing are not designed to promote specific cellular interactions and hence possess limited bioactivity. Most of the strategies proposed to overcome this limitation demand multiple and... more
The majority of synthetic polymers used in 3 D printing are not designed to promote specific cellular interactions and hence possess limited bioactivity. Most of the strategies proposed to overcome this limitation demand multiple and expensive processing steps. This study aimed to evaluate the surface modification of 3D-printed poly(lactic acid) (PLA) scaffolds with polydopamine (PDA) coating as an alternative strategy to enhance their bioactivity and to facilitate the immobilization of type I collagen (COL I) onto the implant surface. Physical and chemical properties of PLA scaffolds coated with PDA, COL I or both were evaluated. The response of porcine bone marrow stem cells (MSCs) to the coatings was also investigated. The PDA layer improved COL immobilization onto the surface of the PLA scaffolds by 92%. The combination of PDA and COL functionalizations provided the best conditions for early-stage (<7 days) cell response. In addition, the PDA plus COL surface facilitated the ...
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This work aims to produce Polycapractone (PCL) and Chitosan (CTS) matrices in different mass proportions and to analyze the incorporation of Arnica's Tincture and Dr. Humphrey's Curative Wonder under different temperatures. The... more
This work aims to produce Polycapractone (PCL) and Chitosan (CTS) matrices in different mass proportions and to analyze the incorporation of Arnica's Tincture and Dr. Humphrey's Curative Wonder under different temperatures. The purpose of this analysis is to make viable the creation of biocompatible matrices capable of absorbing and releasing drugs for future use in the field of Tissue Engineering, more specifically, Bone Tissue Engineering, and in addition, to potentiating the absorption capacity of drugs. The matrices produced were immersed in the cited drugs and placed under conditions of different temperatures. The analyzes were done for Mass Variation and Spectroscopy in the Infrared Region by Fourier Transform (FTIR), and the results showed that, for both drugs, the hot incorporation was better than the room temperature incorporation.
The skin of several animals can be affected by bacterial infection, especially in the case of dogs and cats. Among the bacteria that can cause skin and soft tissue infections, Staphylococcus aureus (S. aureus) is one of the commonest.... more
The skin of several animals can be affected by bacterial infection, especially in the case of dogs and cats. Among the bacteria that can cause skin and soft tissue infections, Staphylococcus aureus (S. aureus) is one of the commonest. Neomycin (NEO) is one of the most used antibiotics to prevent bacterial infections. Due to this cochleotoxicity and nephrotoxicity, their use is topical. Animals infected by these bacteria can potentially contaminate healthy animals and humans. A possible alternative may be the development of surfaces with bactericidal properties where animals, during the treatment phase, can rest without favoring the local proliferation of the bacteria. This work aims to produce, by hot extrusion, filaments of acrylonitrile butadiene styrene (ABS) with neomycin. ABS is a thermoplastic polymer commonly used in fused deposition modeling (FDM). A mixture of ABS and NEO (1:6% w/w) was extruded, resulting in ABS/neomycin filament with a diameter of 2.4 mm. Scanning electro...
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Adsorption processes can be employed in the treatment of wastewater containing heavy metals to reduce environmental damage. However, the high cost of adsorbent materials justifies the application of alternative adsorbents, such as coconut... more
Adsorption processes can be employed in the treatment of wastewater containing heavy metals to reduce environmental damage. However, the high cost of adsorbent materials justifies the application of alternative adsorbents, such as coconut fiber (CF) and chitosan (C). Thus, this study aimed to develop porous composite adsorbents from the mixture of grafted maleic anhydride polyethylene/CF/C/NaCl, as porogen agent (PE-g-MA/CF/C/NaCl), and evaluate statistically adsorption capacity of chromium (III) solution, with the aid of software Statistica 5.0®. The results showed that the process efficiency was influenced by the size of the CF, the content of C and the pH of the solution containing Cr (III). The maximum removal capacity of Cr (III) per unit mass of the composite was 42.28 mg.g-1.
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RESUMO Os processos de adsorção podem ser empregados no tratamento de efluentes líquidos contendo metais pesados visando a reduzir os danos ambientais. Porém, o alto custo dos materiais adsorventes justifica a aplicação de adsorventes... more
RESUMO Os processos de adsorção podem ser empregados no tratamento de efluentes líquidos contendo metais pesados visando a reduzir os danos ambientais. Porém, o alto custo dos materiais adsorventes justifica a aplicação de adsorventes alternativos, como a fibra de coco (FC) e a quitosana (Q). Assim, este trabalho teve como objetivo desenvolver compósitos porosos adsorventes a partir da mistura de polietileno graftizado com anidrido maleico/FC/Q/NaCl, como agente porogênico (PE-g-MA/FC/Q/NaCl), e avaliar estatisticamente a capacidade de adsorção do cromo (III) em solução, com auxílio do software Statistica 5.0®. Os resultados mostraram que a eficiência do processo sofreu influência das dimensões da FC, do teor de Q e do pH da solução contendo Cr (III). A capacidade máxima de remoção de Cr (III) por unidade de massa do compósito foi de 42,28 mg.g-1.
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Important organic reactions require the use of catalysts in order to be industrially or academically applicable. Heterogeneous catalysts, in this context, show significant advantages over conventional homogeneous catalysts, especially... more
Important organic reactions require the use of catalysts in order to be industrially or academically applicable. Heterogeneous catalysts, in this context, show significant advantages over conventional homogeneous catalysts, especially with regard to separation of products from the reaction medium, recycling, and reuse. Ion-exchange resins are solid acid heterogeneous catalysts that play a key role in many useful reactions such as alkylation, esterification, etherification of olefins with alcohols, dehydration of alcohols to olefins or ethers, olefin hydration, and ester hydrolysis. Alkylation is the transfer of an alkyl group from one molecule to another, and is one of the most important catalytic processes of the chemical industries since it is widely applied in different areas such as fuels, cleaning products, and pharmacological products. This chapter presents a review of the use of ion-exchange resins in alkylation reactions on different substrates, highlighting the particularities of each case. First, definitions and classical industrial processes are discussed followed by an illustration of alkylation reactions in terms of mechanism, activity, and selectivity. Finally, the use of biomass derivatives in catalyzed alkylation reactions with ion-exchange resins is presented.
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Biomimetization of Poly(3-hydroxybutyrate) scaffolds by fibronectin immobilization to be applied in bone tissue engineering The revolution in the science of molecular cell biology, combined with advances in polymer science and... more
Biomimetization of Poly(3-hydroxybutyrate) scaffolds by fibronectin immobilization to be applied in bone tissue engineering The revolution in the science of molecular cell biology, combined with advances in polymer science and engineering, is pushing the field of biomaterials into an era of molecular design. Polymer surface engineering may potentially be used to create materials that elicit controlled cellular adhesion and maintain differentiated phenotypic expression. The microbial polyester poly(3-hydroxybutyrate) (P(3HB)) have been attracted attention as promising material for applications in bone engineering. To covalently immobilize protein molecules on a chemically inert polymer surface such as P(3-HB), it is necessary to introduce some reactive groups such as hydroxyl (–OH), carboxyl (–COOH) or amino groups on the polymer surface. Taking that on account, amino groups were introduced onto a (P(3-HB) scaffolds surface by the reaction between ethylenediamine and the ester groups...
... Às minhas amigas a começar pelas mais antigas: Geórgia, Gisele Delaia, Daniele, Vanessa, Cátia, Gisellinha, Gigi, Cláudia, Cinthya, Lívia, Tatiana, Ana Paula e Michele. Aos amigos: Carlos, Vítor, Cristiano, Rodrigo, Miguel, Charles,... more
... Às minhas amigas a começar pelas mais antigas: Geórgia, Gisele Delaia, Daniele, Vanessa, Cátia, Gisellinha, Gigi, Cláudia, Cinthya, Lívia, Tatiana, Ana Paula e Michele. Aos amigos: Carlos, Vítor, Cristiano, Rodrigo, Miguel, Charles, André, Pablo e Geovânio. ...