Journal of the Portuguese Society of Dermatology and Venereology
A insulina é um agente terapêutico indispensável para o controlo da diabetes mellitus. Os efeitos... more A insulina é um agente terapêutico indispensável para o controlo da diabetes mellitus. Os efeitos adversos da sua administração, em particular fenómenos de hipersensibilidade, são raros, particularmente após o desenvolvimento de preparações de insulina humana recombinante, no entanto podem originar reacções graves. Apresentamos o caso de um doente de 69 anos, diabético do tipo 2, referenciado por episódios recorrentes de lesões urticariformes nos locais de administração subcutânea de insulina Humalog® Mix 25, surgindo minutos após as injecções e regredindo espontaneamente ao fim de horas. Esta situação evoluía desde há um ano, após início de insulinoterapia. O doente não referia outra sintomatologia e negava alergias medicamentosas, à excepção de reacção generalizada não especificada na infância após administração de penicilina intramuscular. Foram realizados prick tests com diversos tipos de insulina humana e análogos, todos com reacções positivas. Os testes epicutâneos com as Séri...
A 5-month-old boy was observed in our department presenting with an ulcerated infantile hemangiom... more A 5-month-old boy was observed in our department presenting with an ulcerated infantile hemangioma on the right buttock. This lesion appeared during the first week of life and had been growing progressively, showing ulceration for 3 weeks. We started treatment with corticosteroids, first with the association of betametasone and fusidic acid topically, and then systemically. After 6 weeks of oral treatment as there was no significant improvement, corticosteroid therapy was slowly tapered and local application of imiquimod 5 percent cream, on alternate days, was started. After 12 weeks of therapy with imiquimod there was complete resolution of the ulceration. There were no side effects.
A syndrome associating Livedo Reticularis (LR) with Cerebrovascular disease (CVD) was described, ... more A syndrome associating Livedo Reticularis (LR) with Cerebrovascular disease (CVD) was described, in 1965, by Sneddon. It occurs sporadically, but a few familial cases of Sneddon's Syndrome (SS) have been reported, like these 3 cases that represent one of the largest number among siblings. We studied three male brothers, aged 28, 37 and 42 years, with CVD (ischaemic stroke in 2 patients and cerebral haemorrhages in the third) and their sister with no CVD. All patients presented with long lasting Livedo Reticularis, extending beyond the lower limbs. Skin biopsy on the centre of the reticular pattern showed, only in the second patient, partial endothelium detachment in dermo-hypodermic blood vessels. The males also had accesses of Livedoid Vasculitis (LV), in which a skin biopsy showed obliteration of several upper dermal vessels with hialin thrombi and a very scarce inflammatory infiltrate. Complementary studies, with an extensive investigation on pro-coagulation/pro-thrombotic fe...
In the last two years several cases of severe contact dermatitis related to newly acquired sofas ... more In the last two years several cases of severe contact dermatitis related to newly acquired sofas and armchairs originating from China have been published. The responsible allergen is dimethylfumarate (DMF), an extremely potent sensitizer and irritant found in sachets inside the furniture. Recently, cases of contact dermatitis related to shoes and riding helmets have also been described. We evaluated two patients with allergic contact dermatitis related to shoes manufactured in China that were contaminated by dimethylfumarate found in sachets placed inside the shoeboxes. Patch tests with DMF extracted from the sachets inside the shoeboxes showed positive reactions. Postitive reactions were also obtained using small fragments of the shoes and tissue of the "MouldProof" sachet. The patients were instructed to avoid the suspected shoes and were treated with topical corticosteroids. Contact dermatitis induced by dimethylfumarate should be suspected in appropriate cases. It is i...
... PCS.06 Establishment of safe exposure limits for the elicitation of allergy fragrancesJeann... more ... PCS.06 Establishment of safe exposure limits for the elicitation of allergy fragrancesJeanne Duus Johansen National Allergy Research Centre, Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark ...
Journal of the Portuguese Society of Dermatology and Venereology
A insulina é um agente terapêutico indispensável para o controlo da diabetes mellitus. Os efeitos... more A insulina é um agente terapêutico indispensável para o controlo da diabetes mellitus. Os efeitos adversos da sua administração, em particular fenómenos de hipersensibilidade, são raros, particularmente após o desenvolvimento de preparações de insulina humana recombinante, no entanto podem originar reacções graves. Apresentamos o caso de um doente de 69 anos, diabético do tipo 2, referenciado por episódios recorrentes de lesões urticariformes nos locais de administração subcutânea de insulina Humalog® Mix 25, surgindo minutos após as injecções e regredindo espontaneamente ao fim de horas. Esta situação evoluía desde há um ano, após início de insulinoterapia. O doente não referia outra sintomatologia e negava alergias medicamentosas, à excepção de reacção generalizada não especificada na infância após administração de penicilina intramuscular. Foram realizados prick tests com diversos tipos de insulina humana e análogos, todos com reacções positivas. Os testes epicutâneos com as Séri...
A 5-month-old boy was observed in our department presenting with an ulcerated infantile hemangiom... more A 5-month-old boy was observed in our department presenting with an ulcerated infantile hemangioma on the right buttock. This lesion appeared during the first week of life and had been growing progressively, showing ulceration for 3 weeks. We started treatment with corticosteroids, first with the association of betametasone and fusidic acid topically, and then systemically. After 6 weeks of oral treatment as there was no significant improvement, corticosteroid therapy was slowly tapered and local application of imiquimod 5 percent cream, on alternate days, was started. After 12 weeks of therapy with imiquimod there was complete resolution of the ulceration. There were no side effects.
A syndrome associating Livedo Reticularis (LR) with Cerebrovascular disease (CVD) was described, ... more A syndrome associating Livedo Reticularis (LR) with Cerebrovascular disease (CVD) was described, in 1965, by Sneddon. It occurs sporadically, but a few familial cases of Sneddon's Syndrome (SS) have been reported, like these 3 cases that represent one of the largest number among siblings. We studied three male brothers, aged 28, 37 and 42 years, with CVD (ischaemic stroke in 2 patients and cerebral haemorrhages in the third) and their sister with no CVD. All patients presented with long lasting Livedo Reticularis, extending beyond the lower limbs. Skin biopsy on the centre of the reticular pattern showed, only in the second patient, partial endothelium detachment in dermo-hypodermic blood vessels. The males also had accesses of Livedoid Vasculitis (LV), in which a skin biopsy showed obliteration of several upper dermal vessels with hialin thrombi and a very scarce inflammatory infiltrate. Complementary studies, with an extensive investigation on pro-coagulation/pro-thrombotic fe...
In the last two years several cases of severe contact dermatitis related to newly acquired sofas ... more In the last two years several cases of severe contact dermatitis related to newly acquired sofas and armchairs originating from China have been published. The responsible allergen is dimethylfumarate (DMF), an extremely potent sensitizer and irritant found in sachets inside the furniture. Recently, cases of contact dermatitis related to shoes and riding helmets have also been described. We evaluated two patients with allergic contact dermatitis related to shoes manufactured in China that were contaminated by dimethylfumarate found in sachets placed inside the shoeboxes. Patch tests with DMF extracted from the sachets inside the shoeboxes showed positive reactions. Postitive reactions were also obtained using small fragments of the shoes and tissue of the "MouldProof" sachet. The patients were instructed to avoid the suspected shoes and were treated with topical corticosteroids. Contact dermatitis induced by dimethylfumarate should be suspected in appropriate cases. It is i...
... PCS.06 Establishment of safe exposure limits for the elicitation of allergy fragrancesJeann... more ... PCS.06 Establishment of safe exposure limits for the elicitation of allergy fragrancesJeanne Duus Johansen National Allergy Research Centre, Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark ...
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