The Annals of otology, rhinology, and laryngology, 2013
We assessed voice outcomes following unilateral vocal fold paralysis (UVFP). We performed a retro... more We assessed voice outcomes following unilateral vocal fold paralysis (UVFP). We performed a retrospective chart review of 72 patients with UVFP proven by laryngeal electromyography, including their Voice Handicap Index-10 (VHI-10) scores at presentation and at the study end point (at the return of vocal fold motion or before the decision regarding definitive treatment). The average VHI-10 score on presentation was 26.9 of 40 (27.2 for patients who recovered motion and 26.7 for those who did not; p = 0.847). A recovery of vocal fold motion was experienced by 35% of patients, and 76.4% of patients underwent temporary vocal fold injection. For the patients who recovered motion, the average changes in VHI-10 score were -22.3 for those with injection and -11.4 for those without (p = 0.027). For patients without motion recovery, the average changes in VHI-10 score were -9.5 for those with injection and -0.8 for those without (p = 0.027). At the study end point, 84% of patients with return...
Laryngeal stroboscopy is arguably the most important clinical tool for the evaluation and treatme... more Laryngeal stroboscopy is arguably the most important clinical tool for the evaluation and treatment of patients with voice disorders. Unfortunately, at present, laryngeal stroboscopy is strictly a clinical tool and has no definitive use in the area of voice research. The limitation with laryngeal stroboscopy is the subjective nature of the interpretation of the video examination. A video stroboscopy research tool was developed using 10 stroboscopic parameters selected from the literature and clinical practice. The stroboscopy research tool was validated with the results of 18 reviewers using the instrument to rate 21 unique "cases" and 6 repeated "cases." The results of this video perceptual analysis study identified which parameters were the most robust and reliable across a wide range of reviewers and validated power analysis curves for future similar research. Furthermore, findings from this study revealed that a greater than 80% intra-rater reliability is the...
The Journal of the Acoustical Society of America, 2013
ABSTRACT Mechanical stresses on the vocal folds surface during high pitch or amplitude phonation ... more ABSTRACT Mechanical stresses on the vocal folds surface during high pitch or amplitude phonation have been postulated to cause vocal fold damage. Models for the quantitative estimate of the contact pressure may be valuable for prevention and treatment. The objective of this study was to non-invasively estimate the contact pressure for different phonation types, amplitudes, and pitch in human subjects using concurrent high-speed videoendoscopy and eletroglottography. The edge velocities before and after contact were estimated from the analysis of consecutive digital images. Instantaneous contact areas were determined from electroglottography along with magnetic resonance image (MRI). The contact pressure was assessed using the impulse momentum form of Newton's second law. Quantitative verifications using silicone models were made. Investigations were then carried out in quantitative human subjects to compare contact pressures for three different voice types, pitches, and loudnesses. Contact pressures for breathy, normal, and pressed voice were obtained for fifteen female subjects. The results were verified through comparisons with values measured directly using a probe microphone. The proposed methods appear to be robust and accurate for contact pressure estimation.
Benign midmembranous vocal fold lesions (BMVFLs) are common voice disorders, but interpretation o... more Benign midmembranous vocal fold lesions (BMVFLs) are common voice disorders, but interpretation of outcomes following treatment is difficult due to the lack of a standardized nomenclature system for these lesions. Outcome results are increasingly important to third party payers. This study aimed to investigate the outcomes of patients with BMVFLs using a previously validated nomenclature, and to provide incidences and outcome results for each diagnosis. A retrospective chart review of BMVFL patients was performed. Treatment was individualized but typically involved implementation of nonsurgical therapy followed by phonomicrosurgery as needed. A previously reported BMVFL stratification system was used. A total of 224 patients with BMVFLs were studied. Sixty-seven percent of all patients with a BMVFL underwent phonomicrosurgery. The most common BMVFL types were polyp and nonspecific vocal fold lesion. Pseudocyst represented 0.9% of the cohort. The Voice Handicap Index-10 (VHI-10) and ...
1) Present phonatory aerodynamic data for healthy controls (HCs) in connected speech; 2) contrast... more 1) Present phonatory aerodynamic data for healthy controls (HCs) in connected speech; 2) contrast these findings between HCs and patients with nontreated unilateral vocal fold paralysis (UVFP); 3) present pre- and post-vocal fold augmentation outcomes for patients with UVFP; 4) contrast data from patients with post-operative laryngeal augmentation to HCs. Retrospective, single-blinded. For phase I, 20 HC participants were recruited. For phase II, 20 patients with UVFP were age- and gender-matched to the 20 HC participants used in phase I. For phase III, 20 patients with UVFP represented a pre- and posttreatment cohort. For phase IV, 20 of the HC participants from phase I and 20 of the postoperative UVFP patients from phase III were used for direct comparison. Aerodynamic measures captured from a sample of the Rainbow Passage included: number of breaths, mean phonatory airflow rate, total duration of passage, inspiratory airflow duration, and expiratory airflow duration. The VHI-10 was also obtained pre- and postoperative laryngeal augmentation. All phonatory aerodynamic measures were significantly increased in patients with preoperative UVFP than the HC group. Patients with laryngeal augmentation took significantly less breaths, had less mean phonatory airflow rate during voicing, and had shorter inspiratory airflow duration than the preoperative UVFP group. None of the postoperative measures returned to HC values. Significant improvement in the Voice Handicap Index-10 scores postlaryngeal augmentation was also found. Methodology described in this study improves upon existing aerodynamic voice assessment by capturing characteristics germane to UVFP patient complaints and measuring change before and after laryngeal augmentation in connected speech. 4. Laryngoscope, 2015.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, Jan 3, 2015
The terms used to describe vocal fold motion impairment are confusing and not standardized. This ... more The terms used to describe vocal fold motion impairment are confusing and not standardized. This results in a failure to communicate accurately and to major limitations of interpreting research studies involving vocal fold impairment. We propose standard nomenclature for reporting vocal fold impairment. Overarching terms of vocal fold immobility and hypomobility are rigorously defined. This includes assessment techniques and inclusion and exclusion criteria for determining vocal fold immobility and hypomobility. In addition, criteria for use of the following terms have been outlined in detail: vocal fold paralysis, vocal fold paresis, vocal fold immobility/hypomobility associated with mechanical impairment of the crico-arytenoid joint and vocal fold immobility/hypomobility related to laryngeal malignant disease. This represents the first rigorously defined vocal fold motion impairment nomenclature system. This provides detailed definitions to the terms vocal fold paralysis and vocal...
To characterize perceived voice handicap of patients diagnosed with vocal fold atrophy and review... more To characterize perceived voice handicap of patients diagnosed with vocal fold atrophy and review treatment success. Retrospective study. Two hundred seventy-five patients diagnosed with vocal fold atrophy (January 2007-January 2009) were reviewed from a preexisting clinical database. Outcome measures included pre/post-treatment Voice Handicap Index-10 and data from a voice therapy discharge survey. Five groups emerged from the data set. Group A: patients who had no follow-up (69%). After removing group A from the data set, the following groups emerged: group B: patients who had no treatment but some follow-up (31%); group C: patients who had voice therapy only (44%); group D: patients who had surgery only (15%); and group E: patients who had voice therapy first and subsequent surgery (9%). The perceived voice handicap severity was worse for groups C and D compared to groups A, B, and E. Treatment success outcomes showed that groups C (36%), D (56%), and E (17%) only improved margin...
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2010
The Clinical Practice Guideline (CPG) on hoarseness (dysphonia) has several shortcomings that und... more The Clinical Practice Guideline (CPG) on hoarseness (dysphonia) has several shortcomings that undermine its initial intent to improve the care of patients with dysphonia. The purpose of this document is to identify and comment on those shortcomings. The guideline authors made curious and unsupported policy recommendations in some areas, such as the recommendation for performance of laryngoscopy for hoarseness. For example, the guideline provides a three-month allowance for patients with voice change prior to examination of the larynx, which is a marked change from prior American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) documents suggesting laryngoscopy after two to four weeks of dysphonia and poses a health risk to patients with dysphonia without an established diagnosis. We believe the use of laryngoscopy for the evaluation is dysphonia is primal, plays a vital role in the care of our patients, and should be strongly advocated by the CPG. A significant challenge of...
Intrinsic laryngeal muscle investigations, especially those of the interarytenoid (IA) muscle, ha... more Intrinsic laryngeal muscle investigations, especially those of the interarytenoid (IA) muscle, have been primarily teleologically based. We determined IA muscle anatomy and histochemical and immunohistochemical classification of extrafusal and intrafusal (muscle spindle) fibers in 5 patients. Extrafusal fibers were oxidative type I and glycolytic types IIA and IIX. Intrafusal fibers of muscle spindles were identified by the presence of tonic and neonatal myosin. The results demonstrate that the IA muscle has a phenotype similar to that of limb skeletal muscle. Myosin coexpression, the absence of intrafusal fibers, and fiber type grouping were unusual features found previously in the thyroarytenoid and posterior cricoarytenoid muscles, but they were not present in the IA muscle. These findings lead to the conclusion that the IA muscle has functional significance beyond its assumed importance in maintaining vocal fold position during phonation. The presence of spindles demonstrates differences in motor control as compared to the thyroarytenoid and posterior cricoarytenoid muscles. Further, extrafusal fiber characteristics implicate IA muscle involvement in muscle tension dysphonia and adductor spasmodic dysphonia. Given the unique physiologic characteristics of the human IA muscle, further research into the role of the IA muscle in voice disorders is warranted.
Despite increased clinical utility of the 532-nm potassium titanyl phosphate (KTP) laser, no stud... more Despite increased clinical utility of the 532-nm potassium titanyl phosphate (KTP) laser, no studies have examined outcomes for Reinke's edema (RE) as a function of laser parameters and initial treatment effects. Variability in delivery parameters, fiber-to-tissue distance, and immediate end-tissue effects limits universal application of existing study outcomes. We examine voice outcomes using standardized treatment classification, providing justification for laser parameter selection and immediate tissue effect in clinical use. Retrospective review of 9 patients who underwent KTP laser treatment for RE. Demographics, RE severity, laser settings, total laser energy, and immediate tissue effects were correlated with quantified voice outcomes. An average of 157 joules (6-640 J) was delivered over a 0.369-second exposure time (0.1-0.9 seconds). Immediate tissue effects varied from nonablative treatment (type I and type II) to ablation without tissue removal (type III). Overall, Voice Handicap Index-10 (VHI-10) decreased by 8.23; improvement was most pronounced with type II treatments (delta VHI-10 = 12). No complications were encountered. Potassium titanyl phosphate laser can be safely and effectively used to improve voice in RE patients regardless of severity. This is the first study to provide detailed information on laser settings, energy delivery, and treatment effect in RE management; these results may guide clinical use of this modality, especially for novice laser surgeons.
Studies have established the role of behavioral therapy in treating voice problems. However, stud... more Studies have established the role of behavioral therapy in treating voice problems. However, studies have also identified patient adherence as a limitation in voice therapy effectiveness. Accordingly, an understanding of patient preferences may help to improve adherence and increase voice therapy success. The primary aim of this study was to understand patient-perceived facilitators and barriers influencing voice therapy effectiveness in a group of treatment-seeking individuals with voice disorders. A secondary aim was to examine the relationship between self-reported improvement from voice therapy and the Voice Handicap Index-10 (VHI-10). Retrospective, observational study design. One hundred ten patients enrolled in voice therapy at the University of Pittsburgh Voice Center completed a self-administered Patient Perception of Voice Therapy questionnaire on discharge. Data from 45 individuals who met study criteria were analyzed. Patient-reported improvement from voice therapy was correlated with changes in VHI-10 scores. A majority of patients identified specific voice therapy exercises and transfer of techniques to conversation as the most useful aspects of treatment. Few patients rated vocal hygiene education as most useful. Generalizing new vocal behaviors was also identified as a barrier to voice therapy success for many patients. In this study, patients valued direct voice therapy in which they worked on altering vocal behaviors more than indirect voice therapy that aimed to educate patients about their voice. Study findings suggest the importance of direct voice therapy and the need to incorporate carryover activities early on in the therapy process for greater treatment satisfaction and success.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2007
Evaluate the effectiveness of CaHA injection for patients with glottal incompetence. Multi-center... more Evaluate the effectiveness of CaHA injection for patients with glottal incompetence. Multi-center, open-label, prospective clinical study with each patient serving as his/her own control. Voice-related outcome measures were collected for pre-injection and 1, 3, and 6 months. Sixty-eight patients were available for evaluation. Fifty percent of the injection procedures were done in office. Fifty-seven percent were diagnosed with unilateral paralysis and 42% with glottal incompetence with mobile vocal folds. Patient satisfaction 6 months post showed 56% had significantly improved voice and 38% reported moderately improved voice. Paired t tests from baseline to 6 months showed significant improvements on the VHI and VAS (vocal effort), CAPE-V judgments of voice severity and videoendostroboscopy ratings of glottal closure, and objective voice measures of glottal closure (MPT and S:Z ratio). Preliminary results in this large cohort of patients demonstrate excellent clinical results.
Journal of voice : official journal of the Voice Foundation, 2014
To (1) develop and validate the Dyspnea Index (DI); (2) quantify severity of symptoms in upper ai... more To (1) develop and validate the Dyspnea Index (DI); (2) quantify severity of symptoms in upper airway dyspnea; and (3) validate the DI as an outcome measure. Survey development and validation. Three hundred sixty-nine participants were recruited for different phases of the study. Two hundred participants with chief complaints of dyspnea were given a 41-item questionnaire addressing common symptoms of dyspnea related to the upper airway. The questions were then reduced based on principal component analysis (PCA) and internal consistency resulting in a 10-item questionnaire. Cognitive interviews were conducted with 15 participants. Test-retest reliability and discriminant validity were measured from 51 participants. The DI was further validated by administering the index to 57 healthy controls (HC). Validation of the DI as a treatment outcome tool occurred with 46 participants' pre- and post-treatment scores. PCA revealed that only a single factor was being measured in both the or...
To apply ergonomic principles in analysis of three different operative positions used in laryngea... more To apply ergonomic principles in analysis of three different operative positions used in laryngeal microsurgery. Prospective case-control study. Laryngologists were studied in three different microlaryngeal operative positions: a supported position in a chair with articulated arm supports, a supported position with arms resting on a Mayo stand, and a position with arms unsupported. Operative positions were uniformly photographed in three dimensions. Full body postural data was collected and analyzed using the validated Rapid Upper Limb Assessment (RULA) tool to calculate a risk score indicative of potential musculoskeletal misuse in each position. Joint forces were calculated for the neck and shoulder, and compression forces were calculated for the L5/S1 disc space. Higher-risk postures were obtained with unfavorably adjusted eyepieces and lack of any arm support during microlaryngeal surgery. Support with a Mayo stand led to more neck flexion and strain. Using a chair with articulated arm supports leads to decreased neck strain, less shoulder torque, and decreased compressive forces on the L5/S1 disc space. Ideal postures during microlaryngoscopy place the surgeon with arms and feet supported, with shoulders in an unraised, neutral anatomic position, upper arms neutrally positioned 20 degrees to 45 degrees from torso, lower arms neutrally positioned 60 degrees to 100 degrees from torso, and wrists extended or flexed <15 degrees. RULA and biomechanical analyses have identified lower-risk surgeon positioning to be utilized during microlaryngeal surgery. Avoiding the identified high-risk operative postures and repetitive stress injury may lead to reduced occupationally related musculoskeletal pain and may improve microsurgical motor control.
Synkinesis, or misdirected reinnervation, is likely a confounder when predicting return of functi... more Synkinesis, or misdirected reinnervation, is likely a confounder when predicting return of function of an immobile vocal fold. Currently, no information exists on the incidence of synkinesis in unilateral vocal fold immobility (UVFI) or the effect synkinesis has on prognosis and treatment. Our objective was to examine a vocal fold adductor synkinesis screening protocol using diagnostic laryngeal electromyography (LEMG). We aim to determine the effect of synkinesis on prognosis of recovery of purposeful vocal fold motion. Retrospective review of LEMG data and patient charts from laryngology practice. A standardized LEMG analysis method to diagnose vocal fold adductory synkinesis was performed in 124 consecutive laryngeal electromyographic exams. Synkinesis testing was positive in 12/124 patients (9.7%). Post hoc quantitative analysis of electromyographic recordings to compare motor unit potential amplitude in the thyroarytenoid/lateral cricoarytenoid complex during sustained phonation to those in the same muscle during a "sniff" revealed a significant difference in motor unit potential amplitude ratio for control subjects (0.32), those who recovered purposeful vocal fold motion (0.40), and those with vocal fold paralysis (0.96) (P = .001). The presence of synkinesis in patients with UVFI improved the negative predictive value of LEMG from 53% to 100% and the sensitivity from 56% to 100%. Presence of laryngeal synkinesis using motor amplitude ratio criteria, in the setting of good voluntary motor unit recruitment and UVFI, downgrades a patient's prognosis to one that is poor for recovery. We propose this screening protocol as an adjunct to diagnostic LEMG.
The Annals of otology, rhinology, and laryngology, 2013
We assessed voice outcomes following unilateral vocal fold paralysis (UVFP). We performed a retro... more We assessed voice outcomes following unilateral vocal fold paralysis (UVFP). We performed a retrospective chart review of 72 patients with UVFP proven by laryngeal electromyography, including their Voice Handicap Index-10 (VHI-10) scores at presentation and at the study end point (at the return of vocal fold motion or before the decision regarding definitive treatment). The average VHI-10 score on presentation was 26.9 of 40 (27.2 for patients who recovered motion and 26.7 for those who did not; p = 0.847). A recovery of vocal fold motion was experienced by 35% of patients, and 76.4% of patients underwent temporary vocal fold injection. For the patients who recovered motion, the average changes in VHI-10 score were -22.3 for those with injection and -11.4 for those without (p = 0.027). For patients without motion recovery, the average changes in VHI-10 score were -9.5 for those with injection and -0.8 for those without (p = 0.027). At the study end point, 84% of patients with return...
Laryngeal stroboscopy is arguably the most important clinical tool for the evaluation and treatme... more Laryngeal stroboscopy is arguably the most important clinical tool for the evaluation and treatment of patients with voice disorders. Unfortunately, at present, laryngeal stroboscopy is strictly a clinical tool and has no definitive use in the area of voice research. The limitation with laryngeal stroboscopy is the subjective nature of the interpretation of the video examination. A video stroboscopy research tool was developed using 10 stroboscopic parameters selected from the literature and clinical practice. The stroboscopy research tool was validated with the results of 18 reviewers using the instrument to rate 21 unique "cases" and 6 repeated "cases." The results of this video perceptual analysis study identified which parameters were the most robust and reliable across a wide range of reviewers and validated power analysis curves for future similar research. Furthermore, findings from this study revealed that a greater than 80% intra-rater reliability is the...
The Journal of the Acoustical Society of America, 2013
ABSTRACT Mechanical stresses on the vocal folds surface during high pitch or amplitude phonation ... more ABSTRACT Mechanical stresses on the vocal folds surface during high pitch or amplitude phonation have been postulated to cause vocal fold damage. Models for the quantitative estimate of the contact pressure may be valuable for prevention and treatment. The objective of this study was to non-invasively estimate the contact pressure for different phonation types, amplitudes, and pitch in human subjects using concurrent high-speed videoendoscopy and eletroglottography. The edge velocities before and after contact were estimated from the analysis of consecutive digital images. Instantaneous contact areas were determined from electroglottography along with magnetic resonance image (MRI). The contact pressure was assessed using the impulse momentum form of Newton's second law. Quantitative verifications using silicone models were made. Investigations were then carried out in quantitative human subjects to compare contact pressures for three different voice types, pitches, and loudnesses. Contact pressures for breathy, normal, and pressed voice were obtained for fifteen female subjects. The results were verified through comparisons with values measured directly using a probe microphone. The proposed methods appear to be robust and accurate for contact pressure estimation.
Benign midmembranous vocal fold lesions (BMVFLs) are common voice disorders, but interpretation o... more Benign midmembranous vocal fold lesions (BMVFLs) are common voice disorders, but interpretation of outcomes following treatment is difficult due to the lack of a standardized nomenclature system for these lesions. Outcome results are increasingly important to third party payers. This study aimed to investigate the outcomes of patients with BMVFLs using a previously validated nomenclature, and to provide incidences and outcome results for each diagnosis. A retrospective chart review of BMVFL patients was performed. Treatment was individualized but typically involved implementation of nonsurgical therapy followed by phonomicrosurgery as needed. A previously reported BMVFL stratification system was used. A total of 224 patients with BMVFLs were studied. Sixty-seven percent of all patients with a BMVFL underwent phonomicrosurgery. The most common BMVFL types were polyp and nonspecific vocal fold lesion. Pseudocyst represented 0.9% of the cohort. The Voice Handicap Index-10 (VHI-10) and ...
1) Present phonatory aerodynamic data for healthy controls (HCs) in connected speech; 2) contrast... more 1) Present phonatory aerodynamic data for healthy controls (HCs) in connected speech; 2) contrast these findings between HCs and patients with nontreated unilateral vocal fold paralysis (UVFP); 3) present pre- and post-vocal fold augmentation outcomes for patients with UVFP; 4) contrast data from patients with post-operative laryngeal augmentation to HCs. Retrospective, single-blinded. For phase I, 20 HC participants were recruited. For phase II, 20 patients with UVFP were age- and gender-matched to the 20 HC participants used in phase I. For phase III, 20 patients with UVFP represented a pre- and posttreatment cohort. For phase IV, 20 of the HC participants from phase I and 20 of the postoperative UVFP patients from phase III were used for direct comparison. Aerodynamic measures captured from a sample of the Rainbow Passage included: number of breaths, mean phonatory airflow rate, total duration of passage, inspiratory airflow duration, and expiratory airflow duration. The VHI-10 was also obtained pre- and postoperative laryngeal augmentation. All phonatory aerodynamic measures were significantly increased in patients with preoperative UVFP than the HC group. Patients with laryngeal augmentation took significantly less breaths, had less mean phonatory airflow rate during voicing, and had shorter inspiratory airflow duration than the preoperative UVFP group. None of the postoperative measures returned to HC values. Significant improvement in the Voice Handicap Index-10 scores postlaryngeal augmentation was also found. Methodology described in this study improves upon existing aerodynamic voice assessment by capturing characteristics germane to UVFP patient complaints and measuring change before and after laryngeal augmentation in connected speech. 4. Laryngoscope, 2015.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, Jan 3, 2015
The terms used to describe vocal fold motion impairment are confusing and not standardized. This ... more The terms used to describe vocal fold motion impairment are confusing and not standardized. This results in a failure to communicate accurately and to major limitations of interpreting research studies involving vocal fold impairment. We propose standard nomenclature for reporting vocal fold impairment. Overarching terms of vocal fold immobility and hypomobility are rigorously defined. This includes assessment techniques and inclusion and exclusion criteria for determining vocal fold immobility and hypomobility. In addition, criteria for use of the following terms have been outlined in detail: vocal fold paralysis, vocal fold paresis, vocal fold immobility/hypomobility associated with mechanical impairment of the crico-arytenoid joint and vocal fold immobility/hypomobility related to laryngeal malignant disease. This represents the first rigorously defined vocal fold motion impairment nomenclature system. This provides detailed definitions to the terms vocal fold paralysis and vocal...
To characterize perceived voice handicap of patients diagnosed with vocal fold atrophy and review... more To characterize perceived voice handicap of patients diagnosed with vocal fold atrophy and review treatment success. Retrospective study. Two hundred seventy-five patients diagnosed with vocal fold atrophy (January 2007-January 2009) were reviewed from a preexisting clinical database. Outcome measures included pre/post-treatment Voice Handicap Index-10 and data from a voice therapy discharge survey. Five groups emerged from the data set. Group A: patients who had no follow-up (69%). After removing group A from the data set, the following groups emerged: group B: patients who had no treatment but some follow-up (31%); group C: patients who had voice therapy only (44%); group D: patients who had surgery only (15%); and group E: patients who had voice therapy first and subsequent surgery (9%). The perceived voice handicap severity was worse for groups C and D compared to groups A, B, and E. Treatment success outcomes showed that groups C (36%), D (56%), and E (17%) only improved margin...
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2010
The Clinical Practice Guideline (CPG) on hoarseness (dysphonia) has several shortcomings that und... more The Clinical Practice Guideline (CPG) on hoarseness (dysphonia) has several shortcomings that undermine its initial intent to improve the care of patients with dysphonia. The purpose of this document is to identify and comment on those shortcomings. The guideline authors made curious and unsupported policy recommendations in some areas, such as the recommendation for performance of laryngoscopy for hoarseness. For example, the guideline provides a three-month allowance for patients with voice change prior to examination of the larynx, which is a marked change from prior American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) documents suggesting laryngoscopy after two to four weeks of dysphonia and poses a health risk to patients with dysphonia without an established diagnosis. We believe the use of laryngoscopy for the evaluation is dysphonia is primal, plays a vital role in the care of our patients, and should be strongly advocated by the CPG. A significant challenge of...
Intrinsic laryngeal muscle investigations, especially those of the interarytenoid (IA) muscle, ha... more Intrinsic laryngeal muscle investigations, especially those of the interarytenoid (IA) muscle, have been primarily teleologically based. We determined IA muscle anatomy and histochemical and immunohistochemical classification of extrafusal and intrafusal (muscle spindle) fibers in 5 patients. Extrafusal fibers were oxidative type I and glycolytic types IIA and IIX. Intrafusal fibers of muscle spindles were identified by the presence of tonic and neonatal myosin. The results demonstrate that the IA muscle has a phenotype similar to that of limb skeletal muscle. Myosin coexpression, the absence of intrafusal fibers, and fiber type grouping were unusual features found previously in the thyroarytenoid and posterior cricoarytenoid muscles, but they were not present in the IA muscle. These findings lead to the conclusion that the IA muscle has functional significance beyond its assumed importance in maintaining vocal fold position during phonation. The presence of spindles demonstrates differences in motor control as compared to the thyroarytenoid and posterior cricoarytenoid muscles. Further, extrafusal fiber characteristics implicate IA muscle involvement in muscle tension dysphonia and adductor spasmodic dysphonia. Given the unique physiologic characteristics of the human IA muscle, further research into the role of the IA muscle in voice disorders is warranted.
Despite increased clinical utility of the 532-nm potassium titanyl phosphate (KTP) laser, no stud... more Despite increased clinical utility of the 532-nm potassium titanyl phosphate (KTP) laser, no studies have examined outcomes for Reinke's edema (RE) as a function of laser parameters and initial treatment effects. Variability in delivery parameters, fiber-to-tissue distance, and immediate end-tissue effects limits universal application of existing study outcomes. We examine voice outcomes using standardized treatment classification, providing justification for laser parameter selection and immediate tissue effect in clinical use. Retrospective review of 9 patients who underwent KTP laser treatment for RE. Demographics, RE severity, laser settings, total laser energy, and immediate tissue effects were correlated with quantified voice outcomes. An average of 157 joules (6-640 J) was delivered over a 0.369-second exposure time (0.1-0.9 seconds). Immediate tissue effects varied from nonablative treatment (type I and type II) to ablation without tissue removal (type III). Overall, Voice Handicap Index-10 (VHI-10) decreased by 8.23; improvement was most pronounced with type II treatments (delta VHI-10 = 12). No complications were encountered. Potassium titanyl phosphate laser can be safely and effectively used to improve voice in RE patients regardless of severity. This is the first study to provide detailed information on laser settings, energy delivery, and treatment effect in RE management; these results may guide clinical use of this modality, especially for novice laser surgeons.
Studies have established the role of behavioral therapy in treating voice problems. However, stud... more Studies have established the role of behavioral therapy in treating voice problems. However, studies have also identified patient adherence as a limitation in voice therapy effectiveness. Accordingly, an understanding of patient preferences may help to improve adherence and increase voice therapy success. The primary aim of this study was to understand patient-perceived facilitators and barriers influencing voice therapy effectiveness in a group of treatment-seeking individuals with voice disorders. A secondary aim was to examine the relationship between self-reported improvement from voice therapy and the Voice Handicap Index-10 (VHI-10). Retrospective, observational study design. One hundred ten patients enrolled in voice therapy at the University of Pittsburgh Voice Center completed a self-administered Patient Perception of Voice Therapy questionnaire on discharge. Data from 45 individuals who met study criteria were analyzed. Patient-reported improvement from voice therapy was correlated with changes in VHI-10 scores. A majority of patients identified specific voice therapy exercises and transfer of techniques to conversation as the most useful aspects of treatment. Few patients rated vocal hygiene education as most useful. Generalizing new vocal behaviors was also identified as a barrier to voice therapy success for many patients. In this study, patients valued direct voice therapy in which they worked on altering vocal behaviors more than indirect voice therapy that aimed to educate patients about their voice. Study findings suggest the importance of direct voice therapy and the need to incorporate carryover activities early on in the therapy process for greater treatment satisfaction and success.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2007
Evaluate the effectiveness of CaHA injection for patients with glottal incompetence. Multi-center... more Evaluate the effectiveness of CaHA injection for patients with glottal incompetence. Multi-center, open-label, prospective clinical study with each patient serving as his/her own control. Voice-related outcome measures were collected for pre-injection and 1, 3, and 6 months. Sixty-eight patients were available for evaluation. Fifty percent of the injection procedures were done in office. Fifty-seven percent were diagnosed with unilateral paralysis and 42% with glottal incompetence with mobile vocal folds. Patient satisfaction 6 months post showed 56% had significantly improved voice and 38% reported moderately improved voice. Paired t tests from baseline to 6 months showed significant improvements on the VHI and VAS (vocal effort), CAPE-V judgments of voice severity and videoendostroboscopy ratings of glottal closure, and objective voice measures of glottal closure (MPT and S:Z ratio). Preliminary results in this large cohort of patients demonstrate excellent clinical results.
Journal of voice : official journal of the Voice Foundation, 2014
To (1) develop and validate the Dyspnea Index (DI); (2) quantify severity of symptoms in upper ai... more To (1) develop and validate the Dyspnea Index (DI); (2) quantify severity of symptoms in upper airway dyspnea; and (3) validate the DI as an outcome measure. Survey development and validation. Three hundred sixty-nine participants were recruited for different phases of the study. Two hundred participants with chief complaints of dyspnea were given a 41-item questionnaire addressing common symptoms of dyspnea related to the upper airway. The questions were then reduced based on principal component analysis (PCA) and internal consistency resulting in a 10-item questionnaire. Cognitive interviews were conducted with 15 participants. Test-retest reliability and discriminant validity were measured from 51 participants. The DI was further validated by administering the index to 57 healthy controls (HC). Validation of the DI as a treatment outcome tool occurred with 46 participants' pre- and post-treatment scores. PCA revealed that only a single factor was being measured in both the or...
To apply ergonomic principles in analysis of three different operative positions used in laryngea... more To apply ergonomic principles in analysis of three different operative positions used in laryngeal microsurgery. Prospective case-control study. Laryngologists were studied in three different microlaryngeal operative positions: a supported position in a chair with articulated arm supports, a supported position with arms resting on a Mayo stand, and a position with arms unsupported. Operative positions were uniformly photographed in three dimensions. Full body postural data was collected and analyzed using the validated Rapid Upper Limb Assessment (RULA) tool to calculate a risk score indicative of potential musculoskeletal misuse in each position. Joint forces were calculated for the neck and shoulder, and compression forces were calculated for the L5/S1 disc space. Higher-risk postures were obtained with unfavorably adjusted eyepieces and lack of any arm support during microlaryngeal surgery. Support with a Mayo stand led to more neck flexion and strain. Using a chair with articulated arm supports leads to decreased neck strain, less shoulder torque, and decreased compressive forces on the L5/S1 disc space. Ideal postures during microlaryngoscopy place the surgeon with arms and feet supported, with shoulders in an unraised, neutral anatomic position, upper arms neutrally positioned 20 degrees to 45 degrees from torso, lower arms neutrally positioned 60 degrees to 100 degrees from torso, and wrists extended or flexed <15 degrees. RULA and biomechanical analyses have identified lower-risk surgeon positioning to be utilized during microlaryngeal surgery. Avoiding the identified high-risk operative postures and repetitive stress injury may lead to reduced occupationally related musculoskeletal pain and may improve microsurgical motor control.
Synkinesis, or misdirected reinnervation, is likely a confounder when predicting return of functi... more Synkinesis, or misdirected reinnervation, is likely a confounder when predicting return of function of an immobile vocal fold. Currently, no information exists on the incidence of synkinesis in unilateral vocal fold immobility (UVFI) or the effect synkinesis has on prognosis and treatment. Our objective was to examine a vocal fold adductor synkinesis screening protocol using diagnostic laryngeal electromyography (LEMG). We aim to determine the effect of synkinesis on prognosis of recovery of purposeful vocal fold motion. Retrospective review of LEMG data and patient charts from laryngology practice. A standardized LEMG analysis method to diagnose vocal fold adductory synkinesis was performed in 124 consecutive laryngeal electromyographic exams. Synkinesis testing was positive in 12/124 patients (9.7%). Post hoc quantitative analysis of electromyographic recordings to compare motor unit potential amplitude in the thyroarytenoid/lateral cricoarytenoid complex during sustained phonation to those in the same muscle during a "sniff" revealed a significant difference in motor unit potential amplitude ratio for control subjects (0.32), those who recovered purposeful vocal fold motion (0.40), and those with vocal fold paralysis (0.96) (P = .001). The presence of synkinesis in patients with UVFI improved the negative predictive value of LEMG from 53% to 100% and the sensitivity from 56% to 100%. Presence of laryngeal synkinesis using motor amplitude ratio criteria, in the setting of good voluntary motor unit recruitment and UVFI, downgrades a patient's prognosis to one that is poor for recovery. We propose this screening protocol as an adjunct to diagnostic LEMG.
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