Hypophysiotropic somatostatin (SRIF) and growth hormone-releasing hormone (GHRH) neurons are prim... more Hypophysiotropic somatostatin (SRIF) and growth hormone-releasing hormone (GHRH) neurons are primarily involved in the neurohormonal control of growth hormone (GH) secretion. They are located in periventricular (PEV) and arcuate (ARC) hypothalamic nuclei, respectively, but their connectivity is not well defined. To better understand the neuronal network involved in the control of GH secretion, connections from PEV to ARC neurons were reconstructed in vitro and neuronal phenotypes assessed by single-cell multiplex RT-PCR. Of 814 stimulated PEV neurons, monosynaptic responses were detected in only 45 ARC neurons. Monosynaptic excitatory currents were detected in 29 ARC neurons and inhibitory currents in 16, indicating a 2/1 ratio for excitatory versus inhibitory connections. Galanin (GAL), NPY, pro-opiomelanocortin (POMC), and SRIF mRNAs were detected in neurons from both nuclei but GHRH mRNA almost exclusively in ARC. Among the five SRIF receptors, only sst1 and sst2 were expressed, ...
How do microglia regulate synaptic function? In this issue of Neuron, Zhang et al. (2014) describ... more How do microglia regulate synaptic function? In this issue of Neuron, Zhang et al. (2014) describe a novel form of long-term depression of AMPA receptor-mediated synaptic transmission in the hippocampus involving the activation of microglia.
... Robert Gardette, Florence Petit, Stéphane Peineau, Christophe Lanneau and Jacques Epelbaum IN... more ... Robert Gardette, Florence Petit, Stéphane Peineau, Christophe Lanneau and Jacques Epelbaum INSERM U549, 75014 Paris, France ... Meyerhof, W., Wulfsen, I., Schonrock, C., Fehr, S., Richter, D. Molecular cloning of a somatostatin-28 receptor and comparison of its expression ...
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involve... more The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.
Hypophysiotropic somatostatin (SRIF) and growth hormone-releasing hormone (GHRH) neurons are prim... more Hypophysiotropic somatostatin (SRIF) and growth hormone-releasing hormone (GHRH) neurons are primarily involved in the neurohormonal control of growth hormone (GH) secretion. They are located in periventricular (PEV) and arcuate (ARC) hypothalamic nuclei, respectively, but their connectivity is not well defined. To better understand the neuronal network involved in the control of GH secretion, connections from PEV to ARC neurons were reconstructed in vitro and neuronal phenotypes assessed by single-cell multiplex RT-PCR. Of 814 stimulated PEV neurons, monosynaptic responses were detected in only 45 ARC neurons. Monosynaptic excitatory currents were detected in 29 ARC neurons and inhibitory currents in 16, indicating a 2/1 ratio for excitatory versus inhibitory connections. Galanin (GAL), NPY, pro-opiomelanocortin (POMC), and SRIF mRNAs were detected in neurons from both nuclei but GHRH mRNA almost exclusively in ARC. Among the five SRIF receptors, only sst1 and sst2 were expressed, ...
How do microglia regulate synaptic function? In this issue of Neuron, Zhang et al. (2014) describ... more How do microglia regulate synaptic function? In this issue of Neuron, Zhang et al. (2014) describe a novel form of long-term depression of AMPA receptor-mediated synaptic transmission in the hippocampus involving the activation of microglia.
... Robert Gardette, Florence Petit, Stéphane Peineau, Christophe Lanneau and Jacques Epelbaum IN... more ... Robert Gardette, Florence Petit, Stéphane Peineau, Christophe Lanneau and Jacques Epelbaum INSERM U549, 75014 Paris, France ... Meyerhof, W., Wulfsen, I., Schonrock, C., Fehr, S., Richter, D. Molecular cloning of a somatostatin-28 receptor and comparison of its expression ...
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involve... more The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.
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Papers by S. Peineau