Journal of Pharmacy & Pharmacognosy Research, 2020
Context: Cordia sebestena fruits are traditionally used to treat wounds, boils, tumors, gout, ulc... more Context: Cordia sebestena fruits are traditionally used to treat wounds, boils, tumors, gout, ulcer, flu, fever, asthma, menstrual cramps, dysentery, diarrhea, headache, snakebite and liver disorders. However, information on hepatoprotective potential of Cordia sebestena fruit has not been reported in the research. Aims: To evaluate the hepatoprotective effect of the ethanolic extract of Cordia sebestena fruit (CSFE) against simvastatin-induced hepatotoxicity in rats. Methods: After authentication of fruit, its ethanolic extract was collected. Hepatotoxicity was induced by simvastatin in rodents. Hepatoprotective potential of CSFE was evaluated at 200 and 400 mg/kg, body weight by determining the altered levels of biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), cholesterol, bilirubin, urea, albumin, total protein and hematological indices including red blood cells (RBC), white blood cells (WBC), hemoglobin (Hb),...
Honeypot is a supplemented active defence system for network security. It traps attacks, records ... more Honeypot is a supplemented active defence system for network security. It traps attacks, records intrusion information about tools and activities of the hacking process, and prevents attacks outbound the compromised system. Integrated with other security solutions, Honeypot can solve many traditional dilemmas. It has emerged as a prominent technology that helps learn new hacking techniques from attackers and intruders. Honeypots can initiatively lure hackers to attack the internet, take the record of the ways and means of their invasion, and then analyze and study them.
Additional file 4: Table S4. Sarcoidosis, TB and CM top common dysregulated genes. Common DEGs in... more Additional file 4: Table S4. Sarcoidosis, TB and CM top common dysregulated genes. Common DEGs in granulomas derived this oncopanel in lung sarcoidosis and CM and in granulomas derived from lymph nodes from TB and Sarcoidosis.
The control of visceral leishmaniasis caused by Leishmania donovani still remains a challenging p... more The control of visceral leishmaniasis caused by Leishmania donovani still remains a challenging problem. Due to limitations of available therapies, search for new antileishmanial agents becomes necessary. India, being rich in traditional medicinal plant species, provides good opportunity for exploration of new, effective and safe antileishmanials. The seeds of Abutilon indicum, a herbaceous plant commonly known as Thuthi and used as a remedy for jaundice, piles, ulcer and leprosy, were evaluated for the first time for its antileishmanial activity. The crude methanolic extract and two of its four fractions- n-hexane and n-butanol were found to be highly active against Leishmania promastigotes and intracellular amastigotes. When administered orally to L. donovani infected hamsters the extract and its two fractions at a dose of 500 mg/kg x5 days exhibited ~75 % efficacy. The results suggested towards the potentiality of this plant’s seeds as a source of new antileishmanial leads for fu...
A Mobile Ad-Hoc Network (MANET) in which mobile nodes can access the Internet via a stationary ga... more A Mobile Ad-Hoc Network (MANET) in which mobile nodes can access the Internet via a stationary gateway node or access point. Ad-Hoc On Demand Distance Vector Routing (AODV) protocol has been studied to provide the connectivity to the wired network (internet and other resources) via gateway. An Attempt has been made to enable Mobile nodes to always have the fresher routes to the Gateway. All the traffic from the mobile node to the wired network will pass through the Gateway which understands the protocol of both wired networks and Mobile Ad-Hoc network. Three different approaches have been proposed to update the information with the mobile nodes about the wired Gateways. This Performance analysis has been done in a simulation environment. For the simulation purpose we have used the Network Simulator (NS-2), a widely available simulation tool. I. Introduction The term MANET (Mobile Ad-Hoc Network) refers to a set of wireless mobile nodes that can communicate and move at the same time....
Background Management of patients with interstitial lung disease (ILD) requires subspecialized, c... more Background Management of patients with interstitial lung disease (ILD) requires subspecialized, comprehensive, multidisciplinary care. The Pulmonary Fibrosis Foundation established the Care Center Network (CCN) in 2013 with identified criteria to become a designated CCN site. Despite these criteria, the essential components of an ILD clinic remain unknown. Research Questions How are ILD clinics within the CCN structured? What are the essential components of an ILD clinic according to ILD physician experts, patients, and caregivers? Study Design and Methods This study had 3 components. First, all 68 CCN sites were surveyed to determine the characteristics of their current ILD clinics. Second, an online, three-round modified Delphi survey was conducted between October and December 2019 with 48 ILD experts participating in total. Items for round one were generated using expert interviews. During rounds 1 and 2, experts rated the importance of each item on a 5-point Likert scale. The a priori threshold for consensus was greater than 75% of experts rating an item as important or very important. In round 3, experts graded items that met consensus and ranked items deemed essential for an ILD clinic. Third, ILD patient and caregiver focus groups were conducted and analyzed for content to determine their perspectives of an ideal ILD clinic. Results Forty items across four categories (members, infrastructure, resources and multidisciplinary conference) achieved consensus as essential to an ILD clinic. Patient and caregiver focus groups identified three major themes: comprehensive, patient-centered medical care; expanded access to care; and comprehensive support for living and coping with ILD. Interpretation The essential components of an ILD clinic are well-aligned between physician experts and patients. Future research can use these findings to evaluate the impact of these components on patient outcomes and inform best-practices for ILD clinics throughout the world.
ABSTRACTWe conducted an extensive serological study to quantify population-level exposure and def... more ABSTRACTWe conducted an extensive serological study to quantify population-level exposure and define correlates of immunity against SARS-CoV-2. We found that relative to mild COVID-19 cases, individuals with severe disease exhibited elevated authentic virus-neutralizing titers and antibody levels against nucleocapsid (N) and the receptor binding domain (RBD) and the S2 region of spike protein. Unlike disease severity, age and sex played lesser roles in serological responses. All cases, including asymptomatic individuals, seroconverted by 2 weeks post-PCR confirmation. RBD- and S2-specific and neutralizing antibody titers remained elevated and stable for at least 2-3 months post-onset, whereas those against N were more variable with rapid declines in many samples. Testing of 5882 self-recruited members of the local community demonstrated that 1.24% of individuals showed antibody reactivity to RBD. However, 18% (13/73) of these putative seropositive samples failed to neutralize authen...
Rationale: Despite the availability of multi-“omics” strategies, insights into the etiology and p... more Rationale: Despite the availability of multi-“omics” strategies, insights into the etiology and pathogenesis of sarcoidosis have been elusive. This is partly due to the lack of reliable preclinical models and a paucity of validated biomarkers. As granulomas are a key feature of sarcoidosis, we speculate that direct genomic interrogation of sarcoid tissues, may lead to identification of dysregulated gene pathways or biomarker signatures.Objective: To facilitate the development sarcoidosis genomic biomarkers by gene expression profiling of sarcoidosis granulomas in lung and lymph node tissues (most commonly affected organs) and comparison to infectious granulomas (coccidiodomycosis and tuberculosis). Methods: Transcriptomic profiles of immune-related gene from micro-dissected lungs and mediastinal lymph nodes sarcoidosis granulomas was compared to infectious granulomas. Differentially-expressed genes (DEGs) were profiled, compared among the three granulomatous diseases and analyzed fo...
Background: Monobactam antibiotics have been testified to demonstrate significant antibacterial a... more Background: Monobactam antibiotics have been testified to demonstrate significant antibacterial activity especially the treatment of infections by superbug microbes. Recently, research has been focused on the structural modifications, and new generation of this privileged natural scaffold. Objective: Efforts have been made to discover the structure-antibacterial relationship of monbactams in order to avoid the aimless work involving the ongoing generated analogues. This review aims to summarize the current knowledge and development of monobactams as a broad-spectrum antibacterial scaffolds. The recent structural modifications that expand the activity, especially in the infections by resistant-strains, combinational therapies and dosing, as well as the possibility of crosshypersensitivity/ reactivity/tolerability with penicillins and cephalosporins will also be summarized and inferred. Different approaches will be covered with emphasis on chemical methods and Structure- Activity Rela...
Communications in Computer and Information Science, 2011
The highly successful architecture and protocols of today's Internet may operate... more The highly successful architecture and protocols of today's Internet may operate poorly in environments characterized by very long delay paths and frequent network partitions. Delay Tolerant Networks (DTNs) are emerging solutions to networks that experience frequent ...
... With IO modeling, the product system that consists of supply chains is modeled using economi... more ... With IO modeling, the product system that consists of supply chains is modeled using economic flow databases (inputoutput tables). ... On the basis of Japan's IO table, Nansai [26] has developed database on embodied energy use and the emission of air pollutants. ...
After decades of research, two therapies for chronic fibrotic lung disease are now approved by th... more After decades of research, two therapies for chronic fibrotic lung disease are now approved by the FDA, with dozens more anti-fibrotic therapies in the pipeline. A great deal of enthusiasm has been generated for the use of these drugs, which are by no means curative but clearly have a favorable impact on lung function decline over time. Amidst a flurry of newly developed and repurposed drugs to treat the coronavirus disease 2019 (COVID-19) and its accompanying acute respiratory distress syndrome (ARDS), few have emerged as effective. Historically, survivors of severe viral pneumonia and related acute lung injury with ARDS often have near full recovery of lung function. While the pathological findings of the lungs of patients with COVID-19 can be diverse, current reports have shown significant lung fibrosis predominantly in autopsy studies. There is growing enthusiasm to study anti-fibrotic therapy for inevitable lung fibrosis, and clinical trials are underway using currently FDA-app...
Journal of Pharmacy & Pharmacognosy Research, 2020
Context: Cordia sebestena fruits are traditionally used to treat wounds, boils, tumors, gout, ulc... more Context: Cordia sebestena fruits are traditionally used to treat wounds, boils, tumors, gout, ulcer, flu, fever, asthma, menstrual cramps, dysentery, diarrhea, headache, snakebite and liver disorders. However, information on hepatoprotective potential of Cordia sebestena fruit has not been reported in the research. Aims: To evaluate the hepatoprotective effect of the ethanolic extract of Cordia sebestena fruit (CSFE) against simvastatin-induced hepatotoxicity in rats. Methods: After authentication of fruit, its ethanolic extract was collected. Hepatotoxicity was induced by simvastatin in rodents. Hepatoprotective potential of CSFE was evaluated at 200 and 400 mg/kg, body weight by determining the altered levels of biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), cholesterol, bilirubin, urea, albumin, total protein and hematological indices including red blood cells (RBC), white blood cells (WBC), hemoglobin (Hb),...
Honeypot is a supplemented active defence system for network security. It traps attacks, records ... more Honeypot is a supplemented active defence system for network security. It traps attacks, records intrusion information about tools and activities of the hacking process, and prevents attacks outbound the compromised system. Integrated with other security solutions, Honeypot can solve many traditional dilemmas. It has emerged as a prominent technology that helps learn new hacking techniques from attackers and intruders. Honeypots can initiatively lure hackers to attack the internet, take the record of the ways and means of their invasion, and then analyze and study them.
Additional file 4: Table S4. Sarcoidosis, TB and CM top common dysregulated genes. Common DEGs in... more Additional file 4: Table S4. Sarcoidosis, TB and CM top common dysregulated genes. Common DEGs in granulomas derived this oncopanel in lung sarcoidosis and CM and in granulomas derived from lymph nodes from TB and Sarcoidosis.
The control of visceral leishmaniasis caused by Leishmania donovani still remains a challenging p... more The control of visceral leishmaniasis caused by Leishmania donovani still remains a challenging problem. Due to limitations of available therapies, search for new antileishmanial agents becomes necessary. India, being rich in traditional medicinal plant species, provides good opportunity for exploration of new, effective and safe antileishmanials. The seeds of Abutilon indicum, a herbaceous plant commonly known as Thuthi and used as a remedy for jaundice, piles, ulcer and leprosy, were evaluated for the first time for its antileishmanial activity. The crude methanolic extract and two of its four fractions- n-hexane and n-butanol were found to be highly active against Leishmania promastigotes and intracellular amastigotes. When administered orally to L. donovani infected hamsters the extract and its two fractions at a dose of 500 mg/kg x5 days exhibited ~75 % efficacy. The results suggested towards the potentiality of this plant’s seeds as a source of new antileishmanial leads for fu...
A Mobile Ad-Hoc Network (MANET) in which mobile nodes can access the Internet via a stationary ga... more A Mobile Ad-Hoc Network (MANET) in which mobile nodes can access the Internet via a stationary gateway node or access point. Ad-Hoc On Demand Distance Vector Routing (AODV) protocol has been studied to provide the connectivity to the wired network (internet and other resources) via gateway. An Attempt has been made to enable Mobile nodes to always have the fresher routes to the Gateway. All the traffic from the mobile node to the wired network will pass through the Gateway which understands the protocol of both wired networks and Mobile Ad-Hoc network. Three different approaches have been proposed to update the information with the mobile nodes about the wired Gateways. This Performance analysis has been done in a simulation environment. For the simulation purpose we have used the Network Simulator (NS-2), a widely available simulation tool. I. Introduction The term MANET (Mobile Ad-Hoc Network) refers to a set of wireless mobile nodes that can communicate and move at the same time....
Background Management of patients with interstitial lung disease (ILD) requires subspecialized, c... more Background Management of patients with interstitial lung disease (ILD) requires subspecialized, comprehensive, multidisciplinary care. The Pulmonary Fibrosis Foundation established the Care Center Network (CCN) in 2013 with identified criteria to become a designated CCN site. Despite these criteria, the essential components of an ILD clinic remain unknown. Research Questions How are ILD clinics within the CCN structured? What are the essential components of an ILD clinic according to ILD physician experts, patients, and caregivers? Study Design and Methods This study had 3 components. First, all 68 CCN sites were surveyed to determine the characteristics of their current ILD clinics. Second, an online, three-round modified Delphi survey was conducted between October and December 2019 with 48 ILD experts participating in total. Items for round one were generated using expert interviews. During rounds 1 and 2, experts rated the importance of each item on a 5-point Likert scale. The a priori threshold for consensus was greater than 75% of experts rating an item as important or very important. In round 3, experts graded items that met consensus and ranked items deemed essential for an ILD clinic. Third, ILD patient and caregiver focus groups were conducted and analyzed for content to determine their perspectives of an ideal ILD clinic. Results Forty items across four categories (members, infrastructure, resources and multidisciplinary conference) achieved consensus as essential to an ILD clinic. Patient and caregiver focus groups identified three major themes: comprehensive, patient-centered medical care; expanded access to care; and comprehensive support for living and coping with ILD. Interpretation The essential components of an ILD clinic are well-aligned between physician experts and patients. Future research can use these findings to evaluate the impact of these components on patient outcomes and inform best-practices for ILD clinics throughout the world.
ABSTRACTWe conducted an extensive serological study to quantify population-level exposure and def... more ABSTRACTWe conducted an extensive serological study to quantify population-level exposure and define correlates of immunity against SARS-CoV-2. We found that relative to mild COVID-19 cases, individuals with severe disease exhibited elevated authentic virus-neutralizing titers and antibody levels against nucleocapsid (N) and the receptor binding domain (RBD) and the S2 region of spike protein. Unlike disease severity, age and sex played lesser roles in serological responses. All cases, including asymptomatic individuals, seroconverted by 2 weeks post-PCR confirmation. RBD- and S2-specific and neutralizing antibody titers remained elevated and stable for at least 2-3 months post-onset, whereas those against N were more variable with rapid declines in many samples. Testing of 5882 self-recruited members of the local community demonstrated that 1.24% of individuals showed antibody reactivity to RBD. However, 18% (13/73) of these putative seropositive samples failed to neutralize authen...
Rationale: Despite the availability of multi-“omics” strategies, insights into the etiology and p... more Rationale: Despite the availability of multi-“omics” strategies, insights into the etiology and pathogenesis of sarcoidosis have been elusive. This is partly due to the lack of reliable preclinical models and a paucity of validated biomarkers. As granulomas are a key feature of sarcoidosis, we speculate that direct genomic interrogation of sarcoid tissues, may lead to identification of dysregulated gene pathways or biomarker signatures.Objective: To facilitate the development sarcoidosis genomic biomarkers by gene expression profiling of sarcoidosis granulomas in lung and lymph node tissues (most commonly affected organs) and comparison to infectious granulomas (coccidiodomycosis and tuberculosis). Methods: Transcriptomic profiles of immune-related gene from micro-dissected lungs and mediastinal lymph nodes sarcoidosis granulomas was compared to infectious granulomas. Differentially-expressed genes (DEGs) were profiled, compared among the three granulomatous diseases and analyzed fo...
Background: Monobactam antibiotics have been testified to demonstrate significant antibacterial a... more Background: Monobactam antibiotics have been testified to demonstrate significant antibacterial activity especially the treatment of infections by superbug microbes. Recently, research has been focused on the structural modifications, and new generation of this privileged natural scaffold. Objective: Efforts have been made to discover the structure-antibacterial relationship of monbactams in order to avoid the aimless work involving the ongoing generated analogues. This review aims to summarize the current knowledge and development of monobactams as a broad-spectrum antibacterial scaffolds. The recent structural modifications that expand the activity, especially in the infections by resistant-strains, combinational therapies and dosing, as well as the possibility of crosshypersensitivity/ reactivity/tolerability with penicillins and cephalosporins will also be summarized and inferred. Different approaches will be covered with emphasis on chemical methods and Structure- Activity Rela...
Communications in Computer and Information Science, 2011
The highly successful architecture and protocols of today's Internet may operate... more The highly successful architecture and protocols of today's Internet may operate poorly in environments characterized by very long delay paths and frequent network partitions. Delay Tolerant Networks (DTNs) are emerging solutions to networks that experience frequent ...
... With IO modeling, the product system that consists of supply chains is modeled using economi... more ... With IO modeling, the product system that consists of supply chains is modeled using economic flow databases (inputoutput tables). ... On the basis of Japan's IO table, Nansai [26] has developed database on embodied energy use and the emission of air pollutants. ...
After decades of research, two therapies for chronic fibrotic lung disease are now approved by th... more After decades of research, two therapies for chronic fibrotic lung disease are now approved by the FDA, with dozens more anti-fibrotic therapies in the pipeline. A great deal of enthusiasm has been generated for the use of these drugs, which are by no means curative but clearly have a favorable impact on lung function decline over time. Amidst a flurry of newly developed and repurposed drugs to treat the coronavirus disease 2019 (COVID-19) and its accompanying acute respiratory distress syndrome (ARDS), few have emerged as effective. Historically, survivors of severe viral pneumonia and related acute lung injury with ARDS often have near full recovery of lung function. While the pathological findings of the lungs of patients with COVID-19 can be diverse, current reports have shown significant lung fibrosis predominantly in autopsy studies. There is growing enthusiasm to study anti-fibrotic therapy for inevitable lung fibrosis, and clinical trials are underway using currently FDA-app...
Uploads
Papers by Sachin Chaudhary