BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare service... more BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare services, forcing the reorganisation of traditional care pathways. We investigated how physicians taking care of severe asthma patients in Europe reorganised care, and how these changes affected patient satisfaction, asthma control and future care.MethodsIn this European-wide cross-sectional study, patient surveys were sent to patients with a physician-diagnosis of severe asthma, and physician surveys to severe asthma specialists between November 2020 and May 2021.Results1101 patients and 268 physicians from 16 European countries contributed to the study. Common physician-reported changes in severe asthma care included use of video/phone consultations (46%), reduced availability of physicians (43%) and change to home-administered biologics (38%). Change to phone/video consultations was reported in 45% of patients, of whom 79% were satisfied or very satisfied with this change. Of 709 patients on...
Background Owing to the nature of health data, their sharing and reuse for research are limited b... more Background Owing to the nature of health data, their sharing and reuse for research are limited by legal, technical, and ethical implications. In this sense, to address that challenge and facilitate and promote the discovery of scientific knowledge, the Findable, Accessible, Interoperable, and Reusable (FAIR) principles help organizations to share research data in a secure, appropriate, and useful way for other researchers. Objective The objective of this study was the FAIRification of existing health research data sets and applying a federated machine learning architecture on top of the FAIRified data sets of different health research performing organizations. The entire FAIR4Health solution was validated through the assessment of a federated model for real-time prediction of 30-day readmission risk in patients with chronic obstructive pulmonary disease (COPD). Methods The application of the FAIR principles on health research data sets in 3 different health care settings enabled a ...
Due to the nature of health data, its sharing and reuse for research are limited by ethical, lega... more Due to the nature of health data, its sharing and reuse for research are limited by ethical, legal and technical barriers. The FAIR4Health project facilitated and promoted the application of FAIR principles in health research data, derived from the publicly funded health research initiatives to make them Findable, Accessible, Interoperable, and Reusable (FAIR). To confirm the feasibility of the FAIR4Health solution, we performed two pathfinder case studies to carry out federated machine learning algorithms on FAIRified datasets from five health research organizations. The case studies demonstrated the potential impact of the developed FAIR4Health solution on health outcomes and social care research. Finally, we promoted the FAIRified data to share and reuse in the European Union Health Research community, defining an effective EU-wide strategy for the use of FAIR principles in health research and preparing the ground for a roadmap for health research institutions to offer access to ...
Non-invasive ventilation is a form of mechanical ventilatory support that doesn't require end... more Non-invasive ventilation is a form of mechanical ventilatory support that doesn't require endotracheal intubation of the patient. The interface (mask) is a connection between the device and the patient that allows the set pressure gradient supplied by the ventilator to be transmitted to the airways. Today, there are different types of interfaces, which differ in shape, size, mechanical properties, and comfort. Despite the wide of different mask, common reasons for poor patient adaptation to NIV are related to side effects of the interface such as air loss, skin damage, and mask discomfort. We can prevent these side effects with a basic knowledge of the principles of handling and selecting the optimal interface.
Asthma is one of major public health problems worldwide, regardless the level of development. Als... more Asthma is one of major public health problems worldwide, regardless the level of development. Also, it is one of the most prevalent diseases in Serbia. There are no accurate data on asthma morbidity and mortality, but on the basis of the Serbian Health Insurance Fund evidence, the prevalence has been estimated at around 3% (n=220,000 patients). In the recent 30-year period, asthma mortality rate has reduced about two times and a half (from 6.3/100,000 to 2.5/100,000 patients in 2007), due to a global advance in both the diagnosing and treatment of asthma. In our country, asthma treatment protocols comply with the European guidelines (GINA). It is estimated that an accurate diagnosis of the disease is established in 66% of asthmatics, while the rest are either undiagnosed or misdiagnosed. About 35% of diagnosed asthmatics are treated with fixed treatment combinations (ICS/LABA). A worrying fact is that a yearly consumption of fixed combinations amounts to 3-4 pumps per patient on the...
Introduction. Chilaiditi's syndrome is a rare condition manifested by gastrointestinal sympto... more Introduction. Chilaiditi's syndrome is a rare condition manifested by gastrointestinal symptoms, and radiologically verified by transposition of the large intestine loop. This radiological finding with no manifested symptoms is termed the Chilaiditi's sign. The aim of this case report was to remind the clinicians of the possibility of this rare syndrome, whose symptoms and signs may be misinterpreted and inadequately treated, with consequent diverse complications. Case report. We presented the theoretical facts and a patient in whom the diagnosis of Chilaiditi's syndrome was established incidentally, when hospitalized for an exacerbation of his chronic obstructive pulmonary disease. The Chilaiditi's sign was verified as an incidental finding on chest X-ray performed to evaluate the primary disease. Conclusion. Chilaiditi's syndrome is a benign condition which rarely requires surgery. Its clinical importance lies in adequate differential diagnostic approach and ti...
Introduction. Asthma and chronic obstructive pulmonary disease are often unrecognized and undertr... more Introduction. Asthma and chronic obstructive pulmonary disease are often unrecognized and undertreated. The aim of this study was to describe the frequency of chronic obstructive pulmonary disease and asthma in primary care patients in Serbia, and to examine the agreement between general practitioners and pulmonologists on the diagnosis of chronic obstructive pulmonary disease and asthma. Material and Methods. In this multicenter observational study, the general practitioners identified eligible patients from October 2009 to June 2010. The study included all adult patients with respiratory symptoms and/or smoking history based on structured interview. The patients were referred to a pulmonologist and underwent a diagnostic work-up, including spirometry. Results. There were 2074 patients, 38.4% men, their mean age being 54?15.5 years. The patients were mostly current (40.3%) or ex-smokers (27.4%). The common symptoms included shortness of breath (84.9%), cough (79.1%) and wheezing (6...
International Journal of Chronic Obstructive Pulmonary Disease, 2021
Background Establishing a regional/national/international registry of patients suffering from chr... more Background Establishing a regional/national/international registry of patients suffering from chronic obstructive pulmonary disease (COPD) is essential for both research and healthcare, because it enables collection of comprehensive real-life data from a large number of individuals. Objective The aim of this study was to describe characteristics of COPD patients from the Serbian patient registry, and to investigate actual differences of those characteristics among the COPD phenotypes. Methods The Serbian registry of patients with COPD was established in 2018 at University of Kragujevac, Faculty of Medical Sciences, based on an online platform. Entry in the Registry was allowed for patients who were diagnosed with COPD according to the following criteria: symptoms of dyspnea, chronic cough or sputum production, history of risk factors for COPD and any degree of persistent airflow limitation diagnosed at spirometry. Results In the Serbian COPD registry B and D GOLD group were dominant...
The Egyptian Journal of Chest Diseases and Tuberculosis, 2019
creations are licensed under the identical terms. Chronic obstructive pulmonary disease (COPD) is... more creations are licensed under the identical terms. Chronic obstructive pulmonary disease (COPD) is a major worldwide health problem and severe burden for all healthcare systems in the world. Despite the underrecognition in clinical practice, questionable accuracy of diagnostic codes in healthcare databases, and problematic recording of disease-related deaths, COPD was established as the third leading cause of death in the USA in 2011 [1]. When looking at composite scores of health burden such as Disability-Adjusted Life Year (DALY), in 2013 COPD was the fifth leading cause of DALY’s lost worldwide [2], and second in the USA which is behind the ischemic heart disease only [3]. In addition, the economic burden of COPD is enormous. Total costs of COPD exceeded 38 billion euros [4] in the European Union and 50 billion dollars in the USA [5].
BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare service... more BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has put pressure on healthcare services, forcing the reorganisation of traditional care pathways. We investigated how physicians taking care of severe asthma patients in Europe reorganised care, and how these changes affected patient satisfaction, asthma control and future care.MethodsIn this European-wide cross-sectional study, patient surveys were sent to patients with a physician-diagnosis of severe asthma, and physician surveys to severe asthma specialists between November 2020 and May 2021.Results1101 patients and 268 physicians from 16 European countries contributed to the study. Common physician-reported changes in severe asthma care included use of video/phone consultations (46%), reduced availability of physicians (43%) and change to home-administered biologics (38%). Change to phone/video consultations was reported in 45% of patients, of whom 79% were satisfied or very satisfied with this change. Of 709 patients on...
Background Owing to the nature of health data, their sharing and reuse for research are limited b... more Background Owing to the nature of health data, their sharing and reuse for research are limited by legal, technical, and ethical implications. In this sense, to address that challenge and facilitate and promote the discovery of scientific knowledge, the Findable, Accessible, Interoperable, and Reusable (FAIR) principles help organizations to share research data in a secure, appropriate, and useful way for other researchers. Objective The objective of this study was the FAIRification of existing health research data sets and applying a federated machine learning architecture on top of the FAIRified data sets of different health research performing organizations. The entire FAIR4Health solution was validated through the assessment of a federated model for real-time prediction of 30-day readmission risk in patients with chronic obstructive pulmonary disease (COPD). Methods The application of the FAIR principles on health research data sets in 3 different health care settings enabled a ...
Due to the nature of health data, its sharing and reuse for research are limited by ethical, lega... more Due to the nature of health data, its sharing and reuse for research are limited by ethical, legal and technical barriers. The FAIR4Health project facilitated and promoted the application of FAIR principles in health research data, derived from the publicly funded health research initiatives to make them Findable, Accessible, Interoperable, and Reusable (FAIR). To confirm the feasibility of the FAIR4Health solution, we performed two pathfinder case studies to carry out federated machine learning algorithms on FAIRified datasets from five health research organizations. The case studies demonstrated the potential impact of the developed FAIR4Health solution on health outcomes and social care research. Finally, we promoted the FAIRified data to share and reuse in the European Union Health Research community, defining an effective EU-wide strategy for the use of FAIR principles in health research and preparing the ground for a roadmap for health research institutions to offer access to ...
Non-invasive ventilation is a form of mechanical ventilatory support that doesn't require end... more Non-invasive ventilation is a form of mechanical ventilatory support that doesn't require endotracheal intubation of the patient. The interface (mask) is a connection between the device and the patient that allows the set pressure gradient supplied by the ventilator to be transmitted to the airways. Today, there are different types of interfaces, which differ in shape, size, mechanical properties, and comfort. Despite the wide of different mask, common reasons for poor patient adaptation to NIV are related to side effects of the interface such as air loss, skin damage, and mask discomfort. We can prevent these side effects with a basic knowledge of the principles of handling and selecting the optimal interface.
Asthma is one of major public health problems worldwide, regardless the level of development. Als... more Asthma is one of major public health problems worldwide, regardless the level of development. Also, it is one of the most prevalent diseases in Serbia. There are no accurate data on asthma morbidity and mortality, but on the basis of the Serbian Health Insurance Fund evidence, the prevalence has been estimated at around 3% (n=220,000 patients). In the recent 30-year period, asthma mortality rate has reduced about two times and a half (from 6.3/100,000 to 2.5/100,000 patients in 2007), due to a global advance in both the diagnosing and treatment of asthma. In our country, asthma treatment protocols comply with the European guidelines (GINA). It is estimated that an accurate diagnosis of the disease is established in 66% of asthmatics, while the rest are either undiagnosed or misdiagnosed. About 35% of diagnosed asthmatics are treated with fixed treatment combinations (ICS/LABA). A worrying fact is that a yearly consumption of fixed combinations amounts to 3-4 pumps per patient on the...
Introduction. Chilaiditi's syndrome is a rare condition manifested by gastrointestinal sympto... more Introduction. Chilaiditi's syndrome is a rare condition manifested by gastrointestinal symptoms, and radiologically verified by transposition of the large intestine loop. This radiological finding with no manifested symptoms is termed the Chilaiditi's sign. The aim of this case report was to remind the clinicians of the possibility of this rare syndrome, whose symptoms and signs may be misinterpreted and inadequately treated, with consequent diverse complications. Case report. We presented the theoretical facts and a patient in whom the diagnosis of Chilaiditi's syndrome was established incidentally, when hospitalized for an exacerbation of his chronic obstructive pulmonary disease. The Chilaiditi's sign was verified as an incidental finding on chest X-ray performed to evaluate the primary disease. Conclusion. Chilaiditi's syndrome is a benign condition which rarely requires surgery. Its clinical importance lies in adequate differential diagnostic approach and ti...
Introduction. Asthma and chronic obstructive pulmonary disease are often unrecognized and undertr... more Introduction. Asthma and chronic obstructive pulmonary disease are often unrecognized and undertreated. The aim of this study was to describe the frequency of chronic obstructive pulmonary disease and asthma in primary care patients in Serbia, and to examine the agreement between general practitioners and pulmonologists on the diagnosis of chronic obstructive pulmonary disease and asthma. Material and Methods. In this multicenter observational study, the general practitioners identified eligible patients from October 2009 to June 2010. The study included all adult patients with respiratory symptoms and/or smoking history based on structured interview. The patients were referred to a pulmonologist and underwent a diagnostic work-up, including spirometry. Results. There were 2074 patients, 38.4% men, their mean age being 54?15.5 years. The patients were mostly current (40.3%) or ex-smokers (27.4%). The common symptoms included shortness of breath (84.9%), cough (79.1%) and wheezing (6...
International Journal of Chronic Obstructive Pulmonary Disease, 2021
Background Establishing a regional/national/international registry of patients suffering from chr... more Background Establishing a regional/national/international registry of patients suffering from chronic obstructive pulmonary disease (COPD) is essential for both research and healthcare, because it enables collection of comprehensive real-life data from a large number of individuals. Objective The aim of this study was to describe characteristics of COPD patients from the Serbian patient registry, and to investigate actual differences of those characteristics among the COPD phenotypes. Methods The Serbian registry of patients with COPD was established in 2018 at University of Kragujevac, Faculty of Medical Sciences, based on an online platform. Entry in the Registry was allowed for patients who were diagnosed with COPD according to the following criteria: symptoms of dyspnea, chronic cough or sputum production, history of risk factors for COPD and any degree of persistent airflow limitation diagnosed at spirometry. Results In the Serbian COPD registry B and D GOLD group were dominant...
The Egyptian Journal of Chest Diseases and Tuberculosis, 2019
creations are licensed under the identical terms. Chronic obstructive pulmonary disease (COPD) is... more creations are licensed under the identical terms. Chronic obstructive pulmonary disease (COPD) is a major worldwide health problem and severe burden for all healthcare systems in the world. Despite the underrecognition in clinical practice, questionable accuracy of diagnostic codes in healthcare databases, and problematic recording of disease-related deaths, COPD was established as the third leading cause of death in the USA in 2011 [1]. When looking at composite scores of health burden such as Disability-Adjusted Life Year (DALY), in 2013 COPD was the fifth leading cause of DALY’s lost worldwide [2], and second in the USA which is behind the ischemic heart disease only [3]. In addition, the economic burden of COPD is enormous. Total costs of COPD exceeded 38 billion euros [4] in the European Union and 50 billion dollars in the USA [5].
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