International Journal of Medical Toxicology and Legal Medicine, 2005
Ancestorship of a person can be determined using mitochondriol DNA (maternal lineage) and/or Y ch... more Ancestorship of a person can be determined using mitochondriol DNA (maternal lineage) and/or Y chromosome DNA (paternal lineage). A phylogeny tree can be drawn using Neighbour-joining and/or Maximum Parsimony methods from the mitochondrial DNA and ...
The effects of ovariectomy and hormone replacement in control and carcinogen treated female rats ... more The effects of ovariectomy and hormone replacement in control and carcinogen treated female rats were investigated by measuring whole blood and liver glutathione (WGSH, HGSH), glutathione S-transferase (GST), glutathione peroxidase (GPx), and glutathione reductase (GRx) and histological evaluation. Hepatocarcinogenesis was induced by diethylnitrosamine and 2-acetylaminofluorene. In control rats not receiving carcinogen, ovariectomy significantly increased the GST and GRx activities. Replacement with either estrogen or progesterone reduced the GST activities to below intact female values whereas replacement of both hormones together brought the GST activities to that of intact females. GRx activities were brought to intact female values by replacement with estrogen or progesterone, either singly or in combination. Neither ovariectomy nor sex hormone/s replacement influenced the levels of WGSH, HGSH and GPx activities. Carcinogen administration to intact rats increased all the parameters measured. Ovariectomized rats treated with carcinogen showed lower GPx and GRx activities at 2 mths. However, replacement with either progesterone or combined estrogen and progesterone increased GPx and GRx activities to original values. On the other hand GST and GPx activities in ovariectomized rats which had carcinogen treatment were lower than intact rats after 5 mths. Replacement with hormones either singly or both brought GST and GPx activities up to intact rat levels receiving carcinogen. The levels of WGSH, HGSH and GRx activities (5 mths) in carcinogen treated rats were not influenced by ovariectomy and/or hormone/s replacement. The results from this study suggested that ovariectomy reduced the severity of hepatocarcinogenesis which was restored by sex hormone/s replacement.
Bone age assessment (BAA) is often used to evaluate the growth status of children as part of the ... more Bone age assessment (BAA) is often used to evaluate the growth status of children as part of the detection of hormonal problems and genetic disorders. The determination of skeletal maturity is done based on a radiological examination of the hand-wrist skeletal area. This paper introduces a novel approach for BAA that utilizes a histogram based comparison technique. This approach is executed as a web based system that uses an image repository and similarity measures based on content-based image retrieval. This ...
International Journal of Medical Toxicology & Legal Medicine, Jan 1, 2005
Ancestorship of a person can be determined using mitochondriol DNA (maternal lineage) and/or Y ch... more Ancestorship of a person can be determined using mitochondriol DNA (maternal lineage) and/or Y chromosome DNA (paternal lineage). A phylogeny tree can be drawn using Neighbour-joining and/or Maximum Parsimony methods from the mitochondrial DNA and Y chromosome DNA. A known “average face” for each group of ancestor is determined. The mitochondrial DNA of an unknown person is mapped onto the phylogeny tree. The face of the unknown person is reconstructed using “Mendelian Morphing” technique by combining the nearest average faces for each group ancestors on the phylogeny tree. The authors feel this technique can be used for forensic and archeological facial reconstruction/approximation when the skull of skeletal remains is not available. The approximated face is about 60.70% similar (subjective evaluation) to the expected face.
International Journal of Medical Toxicology and Legal Medicine, 2005
Ancestorship of a person can be determined using mitochondriol DNA (maternal lineage) and/or Y ch... more Ancestorship of a person can be determined using mitochondriol DNA (maternal lineage) and/or Y chromosome DNA (paternal lineage). A phylogeny tree can be drawn using Neighbour-joining and/or Maximum Parsimony methods from the mitochondrial DNA and ...
The effects of ovariectomy and hormone replacement in control and carcinogen treated female rats ... more The effects of ovariectomy and hormone replacement in control and carcinogen treated female rats were investigated by measuring whole blood and liver glutathione (WGSH, HGSH), glutathione S-transferase (GST), glutathione peroxidase (GPx), and glutathione reductase (GRx) and histological evaluation. Hepatocarcinogenesis was induced by diethylnitrosamine and 2-acetylaminofluorene. In control rats not receiving carcinogen, ovariectomy significantly increased the GST and GRx activities. Replacement with either estrogen or progesterone reduced the GST activities to below intact female values whereas replacement of both hormones together brought the GST activities to that of intact females. GRx activities were brought to intact female values by replacement with estrogen or progesterone, either singly or in combination. Neither ovariectomy nor sex hormone/s replacement influenced the levels of WGSH, HGSH and GPx activities. Carcinogen administration to intact rats increased all the parameters measured. Ovariectomized rats treated with carcinogen showed lower GPx and GRx activities at 2 mths. However, replacement with either progesterone or combined estrogen and progesterone increased GPx and GRx activities to original values. On the other hand GST and GPx activities in ovariectomized rats which had carcinogen treatment were lower than intact rats after 5 mths. Replacement with hormones either singly or both brought GST and GPx activities up to intact rat levels receiving carcinogen. The levels of WGSH, HGSH and GRx activities (5 mths) in carcinogen treated rats were not influenced by ovariectomy and/or hormone/s replacement. The results from this study suggested that ovariectomy reduced the severity of hepatocarcinogenesis which was restored by sex hormone/s replacement.
Bone age assessment (BAA) is often used to evaluate the growth status of children as part of the ... more Bone age assessment (BAA) is often used to evaluate the growth status of children as part of the detection of hormonal problems and genetic disorders. The determination of skeletal maturity is done based on a radiological examination of the hand-wrist skeletal area. This paper introduces a novel approach for BAA that utilizes a histogram based comparison technique. This approach is executed as a web based system that uses an image repository and similarity measures based on content-based image retrieval. This ...
International Journal of Medical Toxicology & Legal Medicine, Jan 1, 2005
Ancestorship of a person can be determined using mitochondriol DNA (maternal lineage) and/or Y ch... more Ancestorship of a person can be determined using mitochondriol DNA (maternal lineage) and/or Y chromosome DNA (paternal lineage). A phylogeny tree can be drawn using Neighbour-joining and/or Maximum Parsimony methods from the mitochondrial DNA and Y chromosome DNA. A known “average face” for each group of ancestor is determined. The mitochondrial DNA of an unknown person is mapped onto the phylogeny tree. The face of the unknown person is reconstructed using “Mendelian Morphing” technique by combining the nearest average faces for each group ancestors on the phylogeny tree. The authors feel this technique can be used for forensic and archeological facial reconstruction/approximation when the skull of skeletal remains is not available. The approximated face is about 60.70% similar (subjective evaluation) to the expected face.
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