Objectives/Interrogation: Elbow ankylosis is a predictable complication in severe complex trauma ... more Objectives/Interrogation: Elbow ankylosis is a predictable complication in severe complex trauma of the distal humerus or the proximal end of the ulna in which, in addition to stiffness, there is an important joint compromise but no prosthetic replacement is indicated. In young and motivated patients[for full text, please go to the a.m. URL]
Objectives/Interrogation: Over the years upper limb replantation of small and large segments has ... more Objectives/Interrogation: Over the years upper limb replantation of small and large segments has experienced a progressive widening of indications because of the improvements in reconstructive techniques. While there are clear indications for replantation or amputation (general and local conditions[for full text, please go to the a.m. URL]
As a consequence of trauma or surgical interventions on peripheral nerves, scar tissue can form, ... more As a consequence of trauma or surgical interventions on peripheral nerves, scar tissue can form, interfering with the capacity of the nerve to regenerate properly. Scar tissue may also lead to traction neuropathies, with functional dysfunction and pain for the patient. The search for effective antiadhesion products to prevent scar tissue formation has, therefore, become an important clinical challenge. In this review, we perform extensive research on the PubMed database, retrieving experimental papers on the prevention of peripheral nerve scarring. Different parameters have been considered and discussed, including the animal and nerve models used and the experimental methods employed to simulate and evaluate scar formation. An overview of the different types of antiadhesion devices and strategies investigated in experimental models is also provided. To successfully evaluate the efficacy of new antiscarring agents, it is necessary to have reliable animal models mimicking the complica...
Objectives/Interrogation: Elbow ankylosis is a predictable complication in severe complex trauma ... more Objectives/Interrogation: Elbow ankylosis is a predictable complication in severe complex trauma of the distal humerus or the proximal end of the ulna in which, in addition to stiffness, there is an important joint compromise but no prosthetic replacement is indicated. In young and motivated patients[for full text, please go to the a.m. URL]
Objectives/Interrogation: Over the years upper limb replantation of small and large segments has ... more Objectives/Interrogation: Over the years upper limb replantation of small and large segments has experienced a progressive widening of indications because of the improvements in reconstructive techniques. While there are clear indications for replantation or amputation (general and local conditions[for full text, please go to the a.m. URL]
As a consequence of trauma or surgical interventions on peripheral nerves, scar tissue can form, ... more As a consequence of trauma or surgical interventions on peripheral nerves, scar tissue can form, interfering with the capacity of the nerve to regenerate properly. Scar tissue may also lead to traction neuropathies, with functional dysfunction and pain for the patient. The search for effective antiadhesion products to prevent scar tissue formation has, therefore, become an important clinical challenge. In this review, we perform extensive research on the PubMed database, retrieving experimental papers on the prevention of peripheral nerve scarring. Different parameters have been considered and discussed, including the animal and nerve models used and the experimental methods employed to simulate and evaluate scar formation. An overview of the different types of antiadhesion devices and strategies investigated in experimental models is also provided. To successfully evaluate the efficacy of new antiscarring agents, it is necessary to have reliable animal models mimicking the complica...
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Papers by Simonetta Odella