As the Ah receptor target gene products play a critical role in chemical carcinogenesis, antagoni... more As the Ah receptor target gene products play a critical role in chemical carcinogenesis, antagonists are considered as potential chemopreventive agents. It is demonstrated in this paper that the isothiocyanates R,S-sulforaphane and erucin are non-competitive antagonists of the aryl hydrocarbon (Ah) receptor. Both isothiocyanates were poor agonists for the receptor and elevated CYP1A1 mRNA levels only modestly when incubated with precision-cut rat liver slices. In contrast, the classical Ah receptor agonist benzo[a]pyrene was a potent inducer of CYP1A1 mRNA levels, with this effect being effectively antagonised by the two isothiocyanates. In further studies, it was demonstrated that R,S-sulforaphane could both prevent the interaction of and displace already bound benzo[a]pyrene from the Ah receptor, but no concentration dependency was observed with respect to the isothiocyanate. Both erucin and R,Ssulforaphane antagonised the benzo[a]pyrene-mediated increase in the CYP1A-mediated Odeethylation of ethoxyresorufin in rat precision-cut liver slices. Of the two isomers of R,Ssulforaphane, the naturally-occurring R-isomer was more effective than the S-isomer in antagonising the activation of the Ah receptor by benzo[a]pyrene. Antagonism of the Ah receptor may be a major contributor to the established chemoprevention of aliphatic isothiocyanates
The paper presents the concept of emotional and decisional forgiveness proposed by Worthington et... more The paper presents the concept of emotional and decisional forgiveness proposed by Worthington et al. (Journal of Behavioral Medicine, 30, 291–302, 2007) and employing the Polish versions of the Decision to Forgive Scale and Emotional Forgiveness Scale developed in line with this theory. Both scales are tools measuring episodic forgiveness is forgiveness for a specific transgression that is made once. Decisional forgiveness is a declaration to forgive, whereas emotional forgiveness is a “change of heart”. The results of exploratory factor analysis and confirmatory factor analysis showed that the structure of the Polish scales is exactly the same as of the original tools, i.e., in case of the DTFS, a one-factor solution (CFI = .998, GFI = .990, RMSEA = .042), and in case of the EFS, a two-factor solution (CFI = .987; GFI = .984; RMSEA = .051). The Polish versions of the DTFS and EFS were significantly correlated with other tools of forgiveness (TRIM-18 – episodic forgiveness and HFS–...
As the Ah receptor target gene products play a critical role in chemical carcinogenesis, antagoni... more As the Ah receptor target gene products play a critical role in chemical carcinogenesis, antagonists are considered as potential chemopreventive agents. It is demonstrated in this paper that the isothiocyanates R,S-sulforaphane and erucin are non-competitive antagonists of the aryl hydrocarbon (Ah) receptor. Both isothiocyanates were poor agonists for the receptor and elevated CYP1A1 mRNA levels only modestly when incubated with precision-cut rat liver slices. In contrast, the classical Ah receptor agonist benzo[a]pyrene was a potent inducer of CYP1A1 mRNA levels, with this effect being effectively antagonised by the two isothiocyanates. In further studies, it was demonstrated that R,S-sulforaphane could both prevent the interaction of and displace already bound benzo[a]pyrene from the Ah receptor, but no concentration dependency was observed with respect to the isothiocyanate. Both erucin and R,Ssulforaphane antagonised the benzo[a]pyrene-mediated increase in the CYP1A-mediated Odeethylation of ethoxyresorufin in rat precision-cut liver slices. Of the two isomers of R,Ssulforaphane, the naturally-occurring R-isomer was more effective than the S-isomer in antagonising the activation of the Ah receptor by benzo[a]pyrene. Antagonism of the Ah receptor may be a major contributor to the established chemoprevention of aliphatic isothiocyanates
The paper presents the concept of emotional and decisional forgiveness proposed by Worthington et... more The paper presents the concept of emotional and decisional forgiveness proposed by Worthington et al. (Journal of Behavioral Medicine, 30, 291–302, 2007) and employing the Polish versions of the Decision to Forgive Scale and Emotional Forgiveness Scale developed in line with this theory. Both scales are tools measuring episodic forgiveness is forgiveness for a specific transgression that is made once. Decisional forgiveness is a declaration to forgive, whereas emotional forgiveness is a “change of heart”. The results of exploratory factor analysis and confirmatory factor analysis showed that the structure of the Polish scales is exactly the same as of the original tools, i.e., in case of the DTFS, a one-factor solution (CFI = .998, GFI = .990, RMSEA = .042), and in case of the EFS, a two-factor solution (CFI = .987; GFI = .984; RMSEA = .051). The Polish versions of the DTFS and EFS were significantly correlated with other tools of forgiveness (TRIM-18 – episodic forgiveness and HFS–...
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Papers by Ewa Sołtys