I am an independent researcher in the areas of international relations-cum-international law. The focus of my research is based on promoting peace and soliciting for conflict resolution approaches in global affairs. Undeniably, today Palestine and Kashmir problems/ issues need to be resolved via UNSC's judicious and impartial role based on the principles of the UN's Charter. Address: -Pakistan
TABLE OF CONTENT
THE GROWING BREACH IN MUSLIM UNITY: CAUSES & EFFECTS 124
By Hakim Khatib & Syed ... more TABLE OF CONTENT THE GROWING BREACH IN MUSLIM UNITY: CAUSES & EFFECTS 124 By Hakim Khatib & Syed Qamar Afzal Rizvi IRAQ: MUQTADA AL-SADR FLEXES HIS POLITICAL MUSCLES 132 By Rick Francona TERRORISM: THEN AND NOW 134 By Conn M. Hallinan EUROPE’S REFUGEE CRISIS: GRAPPLE WITH COMPLEXITY WE MUST 137 By Richard Black OMAN IN DIVIDED REGION 140 By Fadi Elhusseini THE JIHADIST CIVIL WAR 143 By Neville Teller WHAT HAPPENS WHEN ARAB AUTOCRATS LEFT TO FEND FOR THEMSELVES? 146 By James M. Dorsey TRUMP’S DOCTRINE POSES THREAT TO HUMAN SPECIES 149 By Hakim Khatib & Syed Qamar Afzal Rizvi GLOBALISATION BETWEEN HOPE AND THREAT TO DEMOCRACY 153 By Burhan Ghalioun SOCIAL MEDIA IN SAUDI ARABIA IS TURNING PEOPLE GAY 156 By Hakim khatib
The aim of this study was to investigate the effect of targeted alpha therapy for the control of ... more The aim of this study was to investigate the effect of targeted alpha therapy for the control of in vitro pancreatic cancer cell clusters and micrometastatic cancer lesions in vivo. The expression of tumor-associated antigen MUC-1 on three pancreatic cancer cell clusters and animal xenografts was detected by indirect immmunostaining. Monoclonal antibodies C595 (test) and A2 (non-specific control) were labeled with 213Bi using the chelator CHX.A" to form the alpha-immunoconjugate (AIC). Cell clusters were incubated with AIC and examined at 48 h. Apoptosis was documented using the TUNEL assay. In vivo, an antiproliferative effect for tumors was tested at two days post-subcutaneous cell inoculation. Mice were injected with different concentrations of AIC by regional or systemic administration. Changes in tumor progression were assessed by tumor size. MUC-1 is strongly expressed on CFPAC-1, PANC-1 and moderate expression was found CAPAN-1 cell clusters and tumor xenografts. The AICs can target and kill cancer cell clusters (100 mm) in vitro. Some 73-81 % of cells were TUNEL positive cells in the clusters after incubation with AIC. At two days post- cell inoculation in mice, a single local injection of 74 and 148 MBq/kg of AIC causes complete inhibition of tumor growth. Systemic injections of 111, 222 and 333 MBq/kg of AIC cause significant tumor growth delay after 16 weeks, compared with the nonspecific control providing 333 MBq/kg after 16 weeks. CFPAC-1, PANC-1 and CAPAN-1 pancreatic cancer cell clusters and pancreatic tumor xenografts show high expression of the MUC-1 target antigen. 213Bi-C595 can specifically target and regress pancreatic cancer cell clusters in vitro, and delay and inhibit tumor growth in vivo. 213Bi-C595 may be a useful agent for the treatment of micrometastatic pancreatic cancer with overexpression of MUC 1 antigen in post-surgical patients with minimal residual disease.
TABLE OF CONTENT
THE GROWING BREACH IN MUSLIM UNITY: CAUSES & EFFECTS 124
By Hakim Khatib & Syed ... more TABLE OF CONTENT THE GROWING BREACH IN MUSLIM UNITY: CAUSES & EFFECTS 124 By Hakim Khatib & Syed Qamar Afzal Rizvi IRAQ: MUQTADA AL-SADR FLEXES HIS POLITICAL MUSCLES 132 By Rick Francona TERRORISM: THEN AND NOW 134 By Conn M. Hallinan EUROPE’S REFUGEE CRISIS: GRAPPLE WITH COMPLEXITY WE MUST 137 By Richard Black OMAN IN DIVIDED REGION 140 By Fadi Elhusseini THE JIHADIST CIVIL WAR 143 By Neville Teller WHAT HAPPENS WHEN ARAB AUTOCRATS LEFT TO FEND FOR THEMSELVES? 146 By James M. Dorsey TRUMP’S DOCTRINE POSES THREAT TO HUMAN SPECIES 149 By Hakim Khatib & Syed Qamar Afzal Rizvi GLOBALISATION BETWEEN HOPE AND THREAT TO DEMOCRACY 153 By Burhan Ghalioun SOCIAL MEDIA IN SAUDI ARABIA IS TURNING PEOPLE GAY 156 By Hakim khatib
The aim of this study was to investigate the effect of targeted alpha therapy for the control of ... more The aim of this study was to investigate the effect of targeted alpha therapy for the control of in vitro pancreatic cancer cell clusters and micrometastatic cancer lesions in vivo. The expression of tumor-associated antigen MUC-1 on three pancreatic cancer cell clusters and animal xenografts was detected by indirect immmunostaining. Monoclonal antibodies C595 (test) and A2 (non-specific control) were labeled with 213Bi using the chelator CHX.A" to form the alpha-immunoconjugate (AIC). Cell clusters were incubated with AIC and examined at 48 h. Apoptosis was documented using the TUNEL assay. In vivo, an antiproliferative effect for tumors was tested at two days post-subcutaneous cell inoculation. Mice were injected with different concentrations of AIC by regional or systemic administration. Changes in tumor progression were assessed by tumor size. MUC-1 is strongly expressed on CFPAC-1, PANC-1 and moderate expression was found CAPAN-1 cell clusters and tumor xenografts. The AICs can target and kill cancer cell clusters (100 mm) in vitro. Some 73-81 % of cells were TUNEL positive cells in the clusters after incubation with AIC. At two days post- cell inoculation in mice, a single local injection of 74 and 148 MBq/kg of AIC causes complete inhibition of tumor growth. Systemic injections of 111, 222 and 333 MBq/kg of AIC cause significant tumor growth delay after 16 weeks, compared with the nonspecific control providing 333 MBq/kg after 16 weeks. CFPAC-1, PANC-1 and CAPAN-1 pancreatic cancer cell clusters and pancreatic tumor xenografts show high expression of the MUC-1 target antigen. 213Bi-C595 can specifically target and regress pancreatic cancer cell clusters in vitro, and delay and inhibit tumor growth in vivo. 213Bi-C595 may be a useful agent for the treatment of micrometastatic pancreatic cancer with overexpression of MUC 1 antigen in post-surgical patients with minimal residual disease.
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THE GROWING BREACH IN MUSLIM UNITY: CAUSES & EFFECTS 124
By Hakim Khatib & Syed Qamar Afzal Rizvi
IRAQ: MUQTADA AL-SADR FLEXES HIS POLITICAL MUSCLES 132
By Rick Francona
TERRORISM: THEN AND NOW 134
By Conn M. Hallinan
EUROPE’S REFUGEE CRISIS: GRAPPLE WITH COMPLEXITY WE MUST 137
By Richard Black
OMAN IN DIVIDED REGION 140
By Fadi Elhusseini
THE JIHADIST CIVIL WAR 143
By Neville Teller
WHAT HAPPENS WHEN ARAB AUTOCRATS LEFT TO FEND FOR THEMSELVES? 146
By James M. Dorsey
TRUMP’S DOCTRINE POSES THREAT TO HUMAN SPECIES 149
By Hakim Khatib & Syed Qamar Afzal Rizvi
GLOBALISATION BETWEEN HOPE AND THREAT TO DEMOCRACY 153
By Burhan Ghalioun
SOCIAL MEDIA IN SAUDI ARABIA IS TURNING PEOPLE GAY 156
By Hakim khatib
THE GROWING BREACH IN MUSLIM UNITY: CAUSES & EFFECTS 124
By Hakim Khatib & Syed Qamar Afzal Rizvi
IRAQ: MUQTADA AL-SADR FLEXES HIS POLITICAL MUSCLES 132
By Rick Francona
TERRORISM: THEN AND NOW 134
By Conn M. Hallinan
EUROPE’S REFUGEE CRISIS: GRAPPLE WITH COMPLEXITY WE MUST 137
By Richard Black
OMAN IN DIVIDED REGION 140
By Fadi Elhusseini
THE JIHADIST CIVIL WAR 143
By Neville Teller
WHAT HAPPENS WHEN ARAB AUTOCRATS LEFT TO FEND FOR THEMSELVES? 146
By James M. Dorsey
TRUMP’S DOCTRINE POSES THREAT TO HUMAN SPECIES 149
By Hakim Khatib & Syed Qamar Afzal Rizvi
GLOBALISATION BETWEEN HOPE AND THREAT TO DEMOCRACY 153
By Burhan Ghalioun
SOCIAL MEDIA IN SAUDI ARABIA IS TURNING PEOPLE GAY 156
By Hakim khatib