Serbian Journal of Experimental and Clinical Research
Healthcare professionals should serve as promoters of rational antibiotic use in attempt to decre... more Healthcare professionals should serve as promoters of rational antibiotic use in attempt to decrease antibiotics misuse within the process of self-medication. Current pilot study was undertaken with the aim to identify potential predictors of self-medication with antibiotics (SMA) and to describe SMA practice among nursing students in Serbia. Data have been collected during the period March-May, 2016 in Medical school of bachelor degree, in Belgrade. Self-reported questionnaire served as a data source. Descriptive statistic was used to analyse study sample characteristics. Chi-square test was used to test differences between groups. Study sample have included 138 participants. Almost half of them, 43.8%, practice SMA. Life style (smoking, alcohol consumption, sleeping habits and physical activity) and socio-demographic characteristics (excepted school grade) were not shown as SMA determinants. Time & money savings were stated as the most frequent reason for SMA, while common cold, s...
Serbian Journal of Experimental and Clinical Research
Venous thromboembolism, including pulmonary embolism and deep vein thrombosis, is a significant f... more Venous thromboembolism, including pulmonary embolism and deep vein thrombosis, is a significant factor in morbidity and mortality of patients. New oral anticoagulants, such as apixaban, dabigatran, and rivaroxaban, have recently demonstrated their safety and efficacy in patients undergoing major orthopaedic surgery. Selection of the appropriate drug should be adjusted according to patient needs. Major bleeding is rare with new oral anticoagulants and is comparable with the bleeding rate associated with low-molecular-weight heparins. Clinical data indicate that therapy with apixaban and rivaroxaban was more effective compared to enoxaparin, while dabigatran has a similar efficacy to enoxaparin. Cost-effectiveness studies of new oral anticoagulants showed that these medicines offer higher efficacy with acceptable costs for the healthcare system, even saving costs in certain cases. Clinical practice in Serbia reflects considerably more frequent use of traditional anticoagulant medicati...
The study aims to analyze the effects of induction treatment with cyclophosphamide (CYC) pulse th... more The study aims to analyze the effects of induction treatment with cyclophosphamide (CYC) pulse therapy followed by maintenance treatment with other mild immunosuppressive agents on lung function in scleroderma (SSc) patients. Thirty patients with SSc (mean age 52 years, mean disease duration < 2 years) with forced vital capacity (FVC) ≤ 80% and/or diffusing capacity of carbon monoxide (DLco) ≤ 70% were included. Monthly CYC pulses were given for 6 months (induction treatment), followed by 3-monthly maintenance pulses for the next 18 months, and during the next 5 years patients received other mild immunosupressive therapy brought by the competent rheumatologist. The efficacy was evaluated by comparing FVC% and DLco% after 6, 24, and 84 months from the baseline. All patients completed induction and maintenance treatment with CYC. Three patients were lost to follow-up. The rest of 27 patients, during the next 5 years, received other immunosupressive agents (14 azathioprine, 9 methot...
Background/Aim. Osteoporosis mainly affects women in the early years following menopause. The aim... more Background/Aim. Osteoporosis mainly affects women in the early years following menopause. The aim of this study was to determine the level of knowledge about osteoporosis and osteoporosis related risk factors in postmenopausal women in Serbia. Methods. The study included postmenopausal women regardless if suffering from osteoporosis or not. Assessment of knowledge was carried out by using the Osteoporosis Knowledge Assessment Tool - Shorter Version (OKAT-S) questionnaire that was validated for Serbian population. Answers to the 9 questions were coded as 1 -true, or 0 - false or ?do not know?. Also, the following risk factors data for osteoporosis were collected: age, the onset and duration of menopause, body mass index (BMI), data on fractures, the incidence of falls, smoking, lifestyle (active, sedentary), regular sunbathing, calcium and vitamin D supplementation, intake of milk and dairy products. Results. A total of 132 postmenopausal women responded to the questionnaire with the...
Background/Aim. Pharmacists' competence represents a dynamic framework of knowledge, skills a... more Background/Aim. Pharmacists' competence represents a dynamic framework of knowledge, skills and abilities to carry out tasks, and it reflects on improving the quality of life and on patients? health. One of the documents for the Evaluation and Competency Development of Pharmacists is the Global Competency Framework (GbCF). The aim of this study was to implement the GBCF document into Serbian pharmacies, to perform assessment and self assessment of the competencies. Methods. The assessment and self-assessment of pharmacists? competencies were performed during the period 2012?13 year in eight community pharmacy chains, in seven cities in Serbia. For assessment and self-assessment of pharmacists competencies the GbCF model was applied, which was adjusted to pharmaceutical practice and legislation in Serbia. External assessment was conducted by teams of pharmacists using the structured observation of the work of pharmacists during regular working hours. Evaluated pharmacists filled ...
Different types of labour need different resources. Subsequently, different costs should be expec... more Different types of labour need different resources. Subsequently, different costs should be expected. The aim of the study was to determine costs of planned Caesarean section (C-section) in relation to costs of spontaneous (SVD) and induced vaginal (IVD) delivery. Retrospective study was conducted for the period January 1st-December 31st, 2010. Database of Health Insurance Fund of Republic of Serbia was used as a data source. Direct medical costs of labor were estimated for mother/newborn pair. The sample was consisted of 99 women where 46.5% had SVD, 28.3% IVD and 25.2% C-section. The average costs of labor, regardless of method, were 417.02+284.14 EUR. Costs of C-section were higher compare to SVD (640.18 +/- 240.04 vs. 243.27 +/- 131.70 EUR, p < 0.05) and IVD (640.18 +/- 240.04 vs. 497.10 +/- 327.91 EUR, p < 0.05). Considering high costs of C-section, it is necessary to review such clinical practice for the purpose of optimizing the use of resources.
Serbian Journal of Experimental and Clinical Research
Healthcare professionals should serve as promoters of rational antibiotic use in attempt to decre... more Healthcare professionals should serve as promoters of rational antibiotic use in attempt to decrease antibiotics misuse within the process of self-medication. Current pilot study was undertaken with the aim to identify potential predictors of self-medication with antibiotics (SMA) and to describe SMA practice among nursing students in Serbia. Data have been collected during the period March-May, 2016 in Medical school of bachelor degree, in Belgrade. Self-reported questionnaire served as a data source. Descriptive statistic was used to analyse study sample characteristics. Chi-square test was used to test differences between groups. Study sample have included 138 participants. Almost half of them, 43.8%, practice SMA. Life style (smoking, alcohol consumption, sleeping habits and physical activity) and socio-demographic characteristics (excepted school grade) were not shown as SMA determinants. Time & money savings were stated as the most frequent reason for SMA, while common cold, s...
Serbian Journal of Experimental and Clinical Research
Venous thromboembolism, including pulmonary embolism and deep vein thrombosis, is a significant f... more Venous thromboembolism, including pulmonary embolism and deep vein thrombosis, is a significant factor in morbidity and mortality of patients. New oral anticoagulants, such as apixaban, dabigatran, and rivaroxaban, have recently demonstrated their safety and efficacy in patients undergoing major orthopaedic surgery. Selection of the appropriate drug should be adjusted according to patient needs. Major bleeding is rare with new oral anticoagulants and is comparable with the bleeding rate associated with low-molecular-weight heparins. Clinical data indicate that therapy with apixaban and rivaroxaban was more effective compared to enoxaparin, while dabigatran has a similar efficacy to enoxaparin. Cost-effectiveness studies of new oral anticoagulants showed that these medicines offer higher efficacy with acceptable costs for the healthcare system, even saving costs in certain cases. Clinical practice in Serbia reflects considerably more frequent use of traditional anticoagulant medicati...
The study aims to analyze the effects of induction treatment with cyclophosphamide (CYC) pulse th... more The study aims to analyze the effects of induction treatment with cyclophosphamide (CYC) pulse therapy followed by maintenance treatment with other mild immunosuppressive agents on lung function in scleroderma (SSc) patients. Thirty patients with SSc (mean age 52 years, mean disease duration < 2 years) with forced vital capacity (FVC) ≤ 80% and/or diffusing capacity of carbon monoxide (DLco) ≤ 70% were included. Monthly CYC pulses were given for 6 months (induction treatment), followed by 3-monthly maintenance pulses for the next 18 months, and during the next 5 years patients received other mild immunosupressive therapy brought by the competent rheumatologist. The efficacy was evaluated by comparing FVC% and DLco% after 6, 24, and 84 months from the baseline. All patients completed induction and maintenance treatment with CYC. Three patients were lost to follow-up. The rest of 27 patients, during the next 5 years, received other immunosupressive agents (14 azathioprine, 9 methot...
Background/Aim. Osteoporosis mainly affects women in the early years following menopause. The aim... more Background/Aim. Osteoporosis mainly affects women in the early years following menopause. The aim of this study was to determine the level of knowledge about osteoporosis and osteoporosis related risk factors in postmenopausal women in Serbia. Methods. The study included postmenopausal women regardless if suffering from osteoporosis or not. Assessment of knowledge was carried out by using the Osteoporosis Knowledge Assessment Tool - Shorter Version (OKAT-S) questionnaire that was validated for Serbian population. Answers to the 9 questions were coded as 1 -true, or 0 - false or ?do not know?. Also, the following risk factors data for osteoporosis were collected: age, the onset and duration of menopause, body mass index (BMI), data on fractures, the incidence of falls, smoking, lifestyle (active, sedentary), regular sunbathing, calcium and vitamin D supplementation, intake of milk and dairy products. Results. A total of 132 postmenopausal women responded to the questionnaire with the...
Background/Aim. Pharmacists' competence represents a dynamic framework of knowledge, skills a... more Background/Aim. Pharmacists' competence represents a dynamic framework of knowledge, skills and abilities to carry out tasks, and it reflects on improving the quality of life and on patients? health. One of the documents for the Evaluation and Competency Development of Pharmacists is the Global Competency Framework (GbCF). The aim of this study was to implement the GBCF document into Serbian pharmacies, to perform assessment and self assessment of the competencies. Methods. The assessment and self-assessment of pharmacists? competencies were performed during the period 2012?13 year in eight community pharmacy chains, in seven cities in Serbia. For assessment and self-assessment of pharmacists competencies the GbCF model was applied, which was adjusted to pharmaceutical practice and legislation in Serbia. External assessment was conducted by teams of pharmacists using the structured observation of the work of pharmacists during regular working hours. Evaluated pharmacists filled ...
Different types of labour need different resources. Subsequently, different costs should be expec... more Different types of labour need different resources. Subsequently, different costs should be expected. The aim of the study was to determine costs of planned Caesarean section (C-section) in relation to costs of spontaneous (SVD) and induced vaginal (IVD) delivery. Retrospective study was conducted for the period January 1st-December 31st, 2010. Database of Health Insurance Fund of Republic of Serbia was used as a data source. Direct medical costs of labor were estimated for mother/newborn pair. The sample was consisted of 99 women where 46.5% had SVD, 28.3% IVD and 25.2% C-section. The average costs of labor, regardless of method, were 417.02+284.14 EUR. Costs of C-section were higher compare to SVD (640.18 +/- 240.04 vs. 243.27 +/- 131.70 EUR, p < 0.05) and IVD (640.18 +/- 240.04 vs. 497.10 +/- 327.91 EUR, p < 0.05). Considering high costs of C-section, it is necessary to review such clinical practice for the purpose of optimizing the use of resources.
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Papers by Ivana Tadic