... Multi-variate procedures offer at first glance a more ade-quate approach to this problem. ...... more ... Multi-variate procedures offer at first glance a more ade-quate approach to this problem. ... cally, local distinctiveness is conceived as the sum of areas of plane figures in a Venn-diagram. ... it is distance and consequently area that matters rather than q. Thus, a hybrid procedure of ...
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, Jan 11, 2015
The RNA World scenario of prebiotic chemical evolution is among the most plausible conceptual fra... more The RNA World scenario of prebiotic chemical evolution is among the most plausible conceptual framework available today for modelling the origin of life. RNA offers genetic and catalytic (metabolic) functionality embodied in a single chemical entity, and a metabolically cooperating community of RNA molecules would constitute a viable infrabiological subsystem with a potential to evolve into proto-cellular life. Our Metabolically Coupled Replicator System (MCRS) model is a spatially explicit computer simulation implementation of the RNA-World scenario, in which replicable ribozymes cooperate in supplying each other with monomers for their own replication. MCRS has been repeatedly demonstrated to be viable and evolvable, with different versions of the model improved in depth (chemical detail of metabolism) or in extension (additional functions of RNA molecules). One of the dynamically relevant extensions of the MCRS approach to prebiotic RNA evolution is the explicit inclusion of temp...
RNA or RNA-like polymers are the most likely candidates for having played the lead roles on the s... more RNA or RNA-like polymers are the most likely candidates for having played the lead roles on the stage of the origin of life. RNA is known to feature two of the three essential functions of living entities (metabolism, heredity and membrane): it is capable of unlimited heredity and it has a proven capacity for catalysing very different chemical reactions which may form simple metabolic networks. The Metabolically Coupled Replicator System is a class of simulation models built on these two functions to show that an RNA World scenario for the origin of life is ecologically feasible, provided that it is played on mineral surfaces. The fact that RNA templates and their copies are of complementary base sequences has an obvious dynamical relevance: complementary strains may have very different structures and, consequently, functions - one may specialize for increasing enzymatic activity while the other takes the role of the gene of the enzyme. Incorporating the functional divergence of tem...
ABSTRACT A pályázat keretében végzett kutatásaink a következő elméleti témakörökben történtek: 1)... more ABSTRACT A pályázat keretében végzett kutatásaink a következő elméleti témakörökben történtek: 1) Párosodási típusok evolúciója térben explicit modellel 2) Korai evolúciós problémák vizsgálata 3) A diszperzió és a mutualizmus evolúciója 4) Metapopulációk erősen zajos környezetben 5) Az interferencia-kompetíció szerepe mikrobiális élet-közösségek diverzitásának fenntartásában 6) Táplálékhálózatok szerkezete és stabilitása. Ebben a hat témakörben összesen 38, a pályázat azonosító számának feltüntetésével megjelent publikáció született, melyek összesített impakt faktora 113.86. Mindegyik témában folytatjuk a kutatásokat. | We have accomplished research in the following theoretical topics with the support of the present grant: 1) The evolution of mating types in a spatially explicit model 2) Research on problems of early evolution 3) The evolution of dispersal and mutualism 4) The dynamics of metapopulations in very noisy environments 5) The role of interference competition in the maintenance of the diversity of microbial communities 6) The strucure and the stability of food webs We have published 38 papers on these six topics with the number of the grant mentioned in the Acknowledgements of the papers. The cumulative impact factor of these publications is 113.86. We are planning to continue research in all the six topics.
We have analyzed the dynamics of metabolically coupled replicators in open chaotic flows. Replica... more We have analyzed the dynamics of metabolically coupled replicators in open chaotic flows. Replicators contribute to a common metabolism producing energy-rich monomers necessary for replication. The flow and the biological processes take place on a rectangular grid. There can be at most one molecule on each grid cell, and replication can occur only at localities where all the necessary replicators
Proceedings of The Royal Society B: Biological Sciences, 2007
Populations in spatially structured environments may be divided into a number of (semi-) isolated... more Populations in spatially structured environments may be divided into a number of (semi-) isolated subpopulations due to limited offspring dispersal. Limited dispersal and, as a consequence, local competition could slow down the invasion offitter mutants, allowing the short-term coexistence of ancestral genotypes and mutants. We determined the rate of invasion of beneficial mutants of Escherichia coli, dispersed to different degrees
... Multi-variate procedures offer at first glance a more ade-quate approach to this problem. ...... more ... Multi-variate procedures offer at first glance a more ade-quate approach to this problem. ... cally, local distinctiveness is conceived as the sum of areas of plane figures in a Venn-diagram. ... it is distance and consequently area that matters rather than q. Thus, a hybrid procedure of ...
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, Jan 11, 2015
The RNA World scenario of prebiotic chemical evolution is among the most plausible conceptual fra... more The RNA World scenario of prebiotic chemical evolution is among the most plausible conceptual framework available today for modelling the origin of life. RNA offers genetic and catalytic (metabolic) functionality embodied in a single chemical entity, and a metabolically cooperating community of RNA molecules would constitute a viable infrabiological subsystem with a potential to evolve into proto-cellular life. Our Metabolically Coupled Replicator System (MCRS) model is a spatially explicit computer simulation implementation of the RNA-World scenario, in which replicable ribozymes cooperate in supplying each other with monomers for their own replication. MCRS has been repeatedly demonstrated to be viable and evolvable, with different versions of the model improved in depth (chemical detail of metabolism) or in extension (additional functions of RNA molecules). One of the dynamically relevant extensions of the MCRS approach to prebiotic RNA evolution is the explicit inclusion of temp...
RNA or RNA-like polymers are the most likely candidates for having played the lead roles on the s... more RNA or RNA-like polymers are the most likely candidates for having played the lead roles on the stage of the origin of life. RNA is known to feature two of the three essential functions of living entities (metabolism, heredity and membrane): it is capable of unlimited heredity and it has a proven capacity for catalysing very different chemical reactions which may form simple metabolic networks. The Metabolically Coupled Replicator System is a class of simulation models built on these two functions to show that an RNA World scenario for the origin of life is ecologically feasible, provided that it is played on mineral surfaces. The fact that RNA templates and their copies are of complementary base sequences has an obvious dynamical relevance: complementary strains may have very different structures and, consequently, functions - one may specialize for increasing enzymatic activity while the other takes the role of the gene of the enzyme. Incorporating the functional divergence of tem...
ABSTRACT A pályázat keretében végzett kutatásaink a következő elméleti témakörökben történtek: 1)... more ABSTRACT A pályázat keretében végzett kutatásaink a következő elméleti témakörökben történtek: 1) Párosodási típusok evolúciója térben explicit modellel 2) Korai evolúciós problémák vizsgálata 3) A diszperzió és a mutualizmus evolúciója 4) Metapopulációk erősen zajos környezetben 5) Az interferencia-kompetíció szerepe mikrobiális élet-közösségek diverzitásának fenntartásában 6) Táplálékhálózatok szerkezete és stabilitása. Ebben a hat témakörben összesen 38, a pályázat azonosító számának feltüntetésével megjelent publikáció született, melyek összesített impakt faktora 113.86. Mindegyik témában folytatjuk a kutatásokat. | We have accomplished research in the following theoretical topics with the support of the present grant: 1) The evolution of mating types in a spatially explicit model 2) Research on problems of early evolution 3) The evolution of dispersal and mutualism 4) The dynamics of metapopulations in very noisy environments 5) The role of interference competition in the maintenance of the diversity of microbial communities 6) The strucure and the stability of food webs We have published 38 papers on these six topics with the number of the grant mentioned in the Acknowledgements of the papers. The cumulative impact factor of these publications is 113.86. We are planning to continue research in all the six topics.
We have analyzed the dynamics of metabolically coupled replicators in open chaotic flows. Replica... more We have analyzed the dynamics of metabolically coupled replicators in open chaotic flows. Replicators contribute to a common metabolism producing energy-rich monomers necessary for replication. The flow and the biological processes take place on a rectangular grid. There can be at most one molecule on each grid cell, and replication can occur only at localities where all the necessary replicators
Proceedings of The Royal Society B: Biological Sciences, 2007
Populations in spatially structured environments may be divided into a number of (semi-) isolated... more Populations in spatially structured environments may be divided into a number of (semi-) isolated subpopulations due to limited offspring dispersal. Limited dispersal and, as a consequence, local competition could slow down the invasion offitter mutants, allowing the short-term coexistence of ancestral genotypes and mutants. We determined the rate of invasion of beneficial mutants of Escherichia coli, dispersed to different degrees
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Papers by Tamás L Czárán