Clerodendrum infortunatum (C.I.) Linn. (Lamiaceae), commonly known as Bhant in Hindi, is a small ... more Clerodendrum infortunatum (C.I.) Linn. (Lamiaceae), commonly known as Bhant in Hindi, is a small shrub occurring throughout the plains of India. This plant has been used in Indian folk medicine in the treatment of bronchitis, asthma, fever, burning sensation, diseases of the blood, inflammation, and epilepsy. Biophytum sensitivum linn. (Oxalidaceae), is an important and widely used medicinal plant. Biophytum sensitivum linn. is used as a traditional folk medicine in ailments such as inflammation, arthritis, wounds, tumors and burns, gonorrhea, stomach ache, asthma, cough, degenerative joint disease, urinary calculi, diabetes, snake bite, amenorrhea and dysmenorrheal. The total flavonoid content of methanolic root extract of C. infortunatum (MECI) and methanolic whole plant extract of Biophytum sensitivum (MEBS) were determined by using aluminium chloride colorimetric method. Flavonoid compounds were found to be 5.5 and 9.49 µg of quercetin equivalent [QE] per mg of MECI and MEBS res...
The EXCiPACT ™ scheme would introduce an independent Certification of manufacturers and Suppliers... more The EXCiPACT ™ scheme would introduce an independent Certification of manufacturers and Suppliers of excipients as a means of ensuring patient safety, improving assurance of Supplier quality, while minimizing the overall supply chain costs. The EXCiPACT ™ Project Global Steering Committee had set the principles and deliverables for the various project teams which would lead to “International” acceptance, anywhere in the world, “Inclusivity” for all excipients’ quality standard, “Accessibility” to & from approved 3 rd Party Audit organizations providing certification, “Evolution not revolution” by adapting existing best practices, guides and standards and overall “Simplicity” of the Scheme. In a nutshell, EXCiPACT ™ is an independent nonprofit legal entity, registered in Brussels, designed to help enhance patient safety and supplier quality as well as minimizing overall supply chain costs by way of sharing information about QMS.
International Journal of Pharmaceutical Sciences Review and Research, 2021
Zinc Oxide (ZnO) nanoparticle was synthesized using rhizome extracts of Zingiber officinale for i... more Zinc Oxide (ZnO) nanoparticle was synthesized using rhizome extracts of Zingiber officinale for in-vitro anti-cancer study. The characterization of nanoparticle was confirmed using ultraviolet spectroscopy and Fourier Transfer Infrared Spectroscopy (FTIR). The ZGNPE characterization also used the UV-Vis Spectrophotometer spectrum technique to measure the structural characterization of nanoparticles by determine the absorbance measurement. Cytotoxic activity of myelogenous leukemia cells (K562) and normal human embryonic Kidney (HEK293T) cells were performed by MTT assay. Treated with ZnO nanoparticle with Zingiber officinale extracts (ZGNPE) showed significant inhibition on the cancer cells whereas in normal cell showed insignificant toxicity. Thus, ZGNPE may be used as chemotherapy drug and an enormous medical application with less toxicity in future. Further mechanistic studies are in progress.
1. INTRODUCTION Recently, the medicinal plants have been escalating the awareness as natural prod... more 1. INTRODUCTION Recently, the medicinal plants have been escalating the awareness as natural products all over the World for the treatment of numerous ailments 1. Medicinal plants act as a fundamental division for primary health concern in different developed and developing countries in 21st century 2 , and now a day peptic ulcer is an extremely widespread and unsafe ailment not only in India but all over the World. It comprising of gastric and duodenal ulcers have been overlapping patho-physiological features, but they have momentous distinction. Duodenal ulcer patients have a younger age of onset and on average have increased parietal cell mass and acid secretion. Gastric ulcer patients have normal or decreased acid secretion, which is often associated with decreased mucosal defense. In the USA, about 10% of adults have peptic ulcer disease. From limited informative sources of hospitalization, morbidity and mortality rates arising from peptic ulcer diseases, these were found to be...
Plants produce a diverse array of secondary metabolites, many of which possess antimicrobial acti... more Plants produce a diverse array of secondary metabolites, many of which possess antimicrobial activity in their biologically active forms or inactive precursors that are relatively safer than synthetic antibacterial compounds, offering profound therapeutic benefits and more affordable treatment (Trease et al. 1972) [1]. The beneficial medicinal effects typically result from the combinations of such secondary metabolites present in the plant to prevent or cure infectious conditions. One approach might be the testing of plants traditionally used for their antibacterial activities as potential sources for drug development. One of such folklore medicinal herb, Biophytum sensitivum (L) DC. (Oxalidaceae) is a small annual plant, growing throughout in wet lands (mostly plains) of tropical Africa, Asia and India; normally in the shade of trees and shrubs, in grasslands, open thickets, at low and medium altitudes and in the foothills of Himalayas. The parts of the plant has been known to possesses a wide spectrum of medicinal properties namely antiseptic properties, including positive effects in variety of skin infections, bruises, wounds & ulcer, burns & contusions, inflammatory diseases, and diabetes [2,3]. In this present study, the antibacterial potency of herbal creams and gels formulated with methanolic extract of Biophytum sensitivum was evaluated. The preliminary in vitro antibacterial activity of the dry methanolic extracts of dried whole plant of Biophytum sensitivum was determined against four different bacterial strains (Salmonella typhi, Staphylococcus aureus, Escherichia coli and Bacillus subtillis) using the agar well diffusion method to find the zone of inhibition of bacterial growth. Herbal creams and gels were prepared by incorporating the dry methanolic extract of whole plant of Biophytum sensitivum of into emulsifying cream and aqueous washable gel base and evaluated for their in vitro antibacterial efficacy. This study shows that Biophytum sensitivum has high potential as antibacterial agent when formulated as cream and gel for topical use and could therefore explain the successes claimed in the folklore use of the plant in the treatment of common skin conditions.
Clerodendrum infortunatum (C.I.) Linn. (Lamiaceae), commonly known as Bhant in Hindi, is a small ... more Clerodendrum infortunatum (C.I.) Linn. (Lamiaceae), commonly known as Bhant in Hindi, is a small shrub occurring throughout the plains of India. This plant has been used in Indian folk medicine in the treatment of bronchitis, asthma, fever, burning sensation, diseases of the blood, inflammation, and epilepsy. Biophytum sensitivum linn. (Oxalidaceae), is an important and widely used medicinal plant. Biophytum sensitivum linn. is used as a traditional folk medicine in ailments such as inflammation, arthritis, wounds, tumors and burns, gonorrhea, stomach ache, asthma, cough, degenerative joint disease, urinary calculi, diabetes, snake bite, amenorrhea and dysmenorrheal. The total flavonoid content of methanolic root extract of C. infortunatum (MECI) and methanolic whole plant extract of Biophytum sensitivum (MEBS) were determined by using aluminium chloride colorimetric method. Flavonoid compounds were found to be 5.5 and 9.49 µg of quercetin equivalent [QE] per mg of MECI and MEBS res...
The EXCiPACT ™ scheme would introduce an independent Certification of manufacturers and Suppliers... more The EXCiPACT ™ scheme would introduce an independent Certification of manufacturers and Suppliers of excipients as a means of ensuring patient safety, improving assurance of Supplier quality, while minimizing the overall supply chain costs. The EXCiPACT ™ Project Global Steering Committee had set the principles and deliverables for the various project teams which would lead to “International” acceptance, anywhere in the world, “Inclusivity” for all excipients’ quality standard, “Accessibility” to & from approved 3 rd Party Audit organizations providing certification, “Evolution not revolution” by adapting existing best practices, guides and standards and overall “Simplicity” of the Scheme. In a nutshell, EXCiPACT ™ is an independent nonprofit legal entity, registered in Brussels, designed to help enhance patient safety and supplier quality as well as minimizing overall supply chain costs by way of sharing information about QMS.
International Journal of Pharmaceutical Sciences Review and Research, 2021
Zinc Oxide (ZnO) nanoparticle was synthesized using rhizome extracts of Zingiber officinale for i... more Zinc Oxide (ZnO) nanoparticle was synthesized using rhizome extracts of Zingiber officinale for in-vitro anti-cancer study. The characterization of nanoparticle was confirmed using ultraviolet spectroscopy and Fourier Transfer Infrared Spectroscopy (FTIR). The ZGNPE characterization also used the UV-Vis Spectrophotometer spectrum technique to measure the structural characterization of nanoparticles by determine the absorbance measurement. Cytotoxic activity of myelogenous leukemia cells (K562) and normal human embryonic Kidney (HEK293T) cells were performed by MTT assay. Treated with ZnO nanoparticle with Zingiber officinale extracts (ZGNPE) showed significant inhibition on the cancer cells whereas in normal cell showed insignificant toxicity. Thus, ZGNPE may be used as chemotherapy drug and an enormous medical application with less toxicity in future. Further mechanistic studies are in progress.
1. INTRODUCTION Recently, the medicinal plants have been escalating the awareness as natural prod... more 1. INTRODUCTION Recently, the medicinal plants have been escalating the awareness as natural products all over the World for the treatment of numerous ailments 1. Medicinal plants act as a fundamental division for primary health concern in different developed and developing countries in 21st century 2 , and now a day peptic ulcer is an extremely widespread and unsafe ailment not only in India but all over the World. It comprising of gastric and duodenal ulcers have been overlapping patho-physiological features, but they have momentous distinction. Duodenal ulcer patients have a younger age of onset and on average have increased parietal cell mass and acid secretion. Gastric ulcer patients have normal or decreased acid secretion, which is often associated with decreased mucosal defense. In the USA, about 10% of adults have peptic ulcer disease. From limited informative sources of hospitalization, morbidity and mortality rates arising from peptic ulcer diseases, these were found to be...
Plants produce a diverse array of secondary metabolites, many of which possess antimicrobial acti... more Plants produce a diverse array of secondary metabolites, many of which possess antimicrobial activity in their biologically active forms or inactive precursors that are relatively safer than synthetic antibacterial compounds, offering profound therapeutic benefits and more affordable treatment (Trease et al. 1972) [1]. The beneficial medicinal effects typically result from the combinations of such secondary metabolites present in the plant to prevent or cure infectious conditions. One approach might be the testing of plants traditionally used for their antibacterial activities as potential sources for drug development. One of such folklore medicinal herb, Biophytum sensitivum (L) DC. (Oxalidaceae) is a small annual plant, growing throughout in wet lands (mostly plains) of tropical Africa, Asia and India; normally in the shade of trees and shrubs, in grasslands, open thickets, at low and medium altitudes and in the foothills of Himalayas. The parts of the plant has been known to possesses a wide spectrum of medicinal properties namely antiseptic properties, including positive effects in variety of skin infections, bruises, wounds & ulcer, burns & contusions, inflammatory diseases, and diabetes [2,3]. In this present study, the antibacterial potency of herbal creams and gels formulated with methanolic extract of Biophytum sensitivum was evaluated. The preliminary in vitro antibacterial activity of the dry methanolic extracts of dried whole plant of Biophytum sensitivum was determined against four different bacterial strains (Salmonella typhi, Staphylococcus aureus, Escherichia coli and Bacillus subtillis) using the agar well diffusion method to find the zone of inhibition of bacterial growth. Herbal creams and gels were prepared by incorporating the dry methanolic extract of whole plant of Biophytum sensitivum of into emulsifying cream and aqueous washable gel base and evaluated for their in vitro antibacterial efficacy. This study shows that Biophytum sensitivum has high potential as antibacterial agent when formulated as cream and gel for topical use and could therefore explain the successes claimed in the folklore use of the plant in the treatment of common skin conditions.
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Papers by Tapas Kumar Pal