Journal of Pediatric Ophthalmology & Strabismus, Nov 1, 1979
The clinical course is described of two genuine cases of the disease of Leber's miliary a... more The clinical course is described of two genuine cases of the disease of Leber's miliary aneurysms that developed into Coats' disease. Following the issue of the disease in a painful and blind eye, the cases were examined histopathologically. In the first case the transformation into Coats' disease, and subsequently into a painful eye, took six years, in the second case four years. This histopathological examination revealed vascular formations of the superficial corneal stroma of the periphery in the second case. In respect of the retina the presence of neovascularization was observed. Pathological vessels of varying width were also found in the deeper retinal layers. The presence of cholesterol clefts should be regarded rather as a consequence of the chronicity of the case than as being a characteristic feature of the condition.
Journal of Radioanalytical and Nuclear Chemistry Articles, 1989
Cataract is a very common disease of the eye lens known since ancient times. Different mechanisms... more Cataract is a very common disease of the eye lens known since ancient times. Different mechanisms are responsible for the biogenesis of cataract but most scientists agree with the theory that cataract formation can be attributed to metabolism disorders in the lens. Instrumental neutron activation analysis has been applied in this work for the determination of the following trace elements: antimony, cobalt, iron, rubidium, selenium and zinc in human lenses with mature cataract. The results are statistically treated and correlated with age and sex of patients. Based on these findings, the concentration of elements studied does not have any correlation with the age and/or sex of the patients, i.e. when the lens becomes totally opaque.
Journal of Pediatric Ophthalmology & Strabismus, 1979
The clinical course is described of two genuine cases of the disease of Leber's miliary a... more The clinical course is described of two genuine cases of the disease of Leber's miliary aneurysms that developed into Coats' disease. Following the issue of the disease in a painful and blind eye, the cases were examined histopathologically. In the first case the transformation into Coats' disease, and subsequently into a painful eye, took six years, in the second case four years. This histopathological examination revealed vascular formations of the superficial corneal stroma of the periphery in the second case. In respect of the retina the presence of neovascularization was observed. Pathological vessels of varying width were also found in the deeper retinal layers. The presence of cholesterol clefts should be regarded rather as a consequence of the chronicity of the case than as being a characteristic feature of the condition.
For the detection and determination of the trace elements Ag and Sc in mature human cataractous l... more For the detection and determination of the trace elements Ag and Sc in mature human cataractous lenses, the methods of neutron activation analysis was used. As regards Ag, attempts made in the past to establish its presence in the cataractous lens had failed, while Sc has not so far been thoroughly investigated. Our study of the two elements was also correlated to the age and sex of the patients with senile cataract. It was found that once senile cataract has fully matured, the determined trace-element concentrations no longer appear to be related to age and/or sex of the patients.
To investigate the diagnostic value and to establish threshold criteria for the ice pack test as ... more To investigate the diagnostic value and to establish threshold criteria for the ice pack test as an office preliminary test in the differential diagnosis of myasthenic diplopia in comparison with blepharoptosis. Prospective, comparative cohort study. Eighty-nine patients with a recent onset of diplopia, blepharoptosis, or both were evaluated with orbital cooling in a prospective manner. Forty-eight patients presented with diplopia, 25 patients with both blepharoptosis and ophthalmoplegia and 16 patients with blepharoptosis. All patients had the ice pack applied for 5 minutes on both eyelids at the initial orthoptic evaluation. Increasing the duration of cooling to 10 minutes was investigated in 36 diplopic patients. A complete diagnostic work-up was ordered and patients were followed up for a minimum of 6 months before diagnosis of myasthenia gravis was ascertained. Difference in cover test measurements in primary position or marginal reflex distance before and after the application of the ice pack, specific cause for diplopia and blepharoptosis. Fifteen patients were diagnosed as myasthenic. The optimal cutoff point for a positive response to the ice pack test proved to be a reduction in ocular deviation in primary position by 50% or by 10 prism diopters (PD) or more for presenting deviations larger than 20 PD. By this criterion, sensitivity for the detection of myasthenic diplopia was 76.9% (95% confidence interval [CI], 49.06%-92.50%) for the 5-minute application, compared with 92.3% (95% CI, 63.5%-98.9%) sensitivity demonstrated for blepharoptosis. Increasing the time of application to 10 minutes did not improve the diagnostic value of the test. Specificity was high (98.3%; 95% CI, 90.3%-99.9%) and was demonstrated even in patients with coexisting myasthenic and dysthyroid ophthalmopathy. Patients with oculomotor nerve paresis and Horner syndrome invariably were nonresponsive to the test. The ice pack test demonstrated high specificity and an acceptable sensitivity in the differential diagnosis of myasthenic diplopia. Data from this series suggest that a partial rather than a complete response to the ice pack test may be expected for myasthenic diplopia. Standardization of the method of application of the ice pack is critical for the interpretation of its effect.
Search by Subject Search using Medical Subject Headings (< b> MeSH</b>), a controlled... more Search by Subject Search using Medical Subject Headings (< b> MeSH</b>), a controlled vocabulary for indexing life sciences content.< br/> Note that some records do not have MeSH. These include Patents and the latest PubMed and PubMed Central records.
Journal of Pediatric Ophthalmology & Strabismus, Nov 1, 1979
The clinical course is described of two genuine cases of the disease of Leber&#39;s miliary a... more The clinical course is described of two genuine cases of the disease of Leber&#39;s miliary aneurysms that developed into Coats&#39; disease. Following the issue of the disease in a painful and blind eye, the cases were examined histopathologically. In the first case the transformation into Coats&#39; disease, and subsequently into a painful eye, took six years, in the second case four years. This histopathological examination revealed vascular formations of the superficial corneal stroma of the periphery in the second case. In respect of the retina the presence of neovascularization was observed. Pathological vessels of varying width were also found in the deeper retinal layers. The presence of cholesterol clefts should be regarded rather as a consequence of the chronicity of the case than as being a characteristic feature of the condition.
Journal of Radioanalytical and Nuclear Chemistry Articles, 1989
Cataract is a very common disease of the eye lens known since ancient times. Different mechanisms... more Cataract is a very common disease of the eye lens known since ancient times. Different mechanisms are responsible for the biogenesis of cataract but most scientists agree with the theory that cataract formation can be attributed to metabolism disorders in the lens. Instrumental neutron activation analysis has been applied in this work for the determination of the following trace elements: antimony, cobalt, iron, rubidium, selenium and zinc in human lenses with mature cataract. The results are statistically treated and correlated with age and sex of patients. Based on these findings, the concentration of elements studied does not have any correlation with the age and/or sex of the patients, i.e. when the lens becomes totally opaque.
Journal of Pediatric Ophthalmology & Strabismus, 1979
The clinical course is described of two genuine cases of the disease of Leber&#39;s miliary a... more The clinical course is described of two genuine cases of the disease of Leber&#39;s miliary aneurysms that developed into Coats&#39; disease. Following the issue of the disease in a painful and blind eye, the cases were examined histopathologically. In the first case the transformation into Coats&#39; disease, and subsequently into a painful eye, took six years, in the second case four years. This histopathological examination revealed vascular formations of the superficial corneal stroma of the periphery in the second case. In respect of the retina the presence of neovascularization was observed. Pathological vessels of varying width were also found in the deeper retinal layers. The presence of cholesterol clefts should be regarded rather as a consequence of the chronicity of the case than as being a characteristic feature of the condition.
For the detection and determination of the trace elements Ag and Sc in mature human cataractous l... more For the detection and determination of the trace elements Ag and Sc in mature human cataractous lenses, the methods of neutron activation analysis was used. As regards Ag, attempts made in the past to establish its presence in the cataractous lens had failed, while Sc has not so far been thoroughly investigated. Our study of the two elements was also correlated to the age and sex of the patients with senile cataract. It was found that once senile cataract has fully matured, the determined trace-element concentrations no longer appear to be related to age and/or sex of the patients.
To investigate the diagnostic value and to establish threshold criteria for the ice pack test as ... more To investigate the diagnostic value and to establish threshold criteria for the ice pack test as an office preliminary test in the differential diagnosis of myasthenic diplopia in comparison with blepharoptosis. Prospective, comparative cohort study. Eighty-nine patients with a recent onset of diplopia, blepharoptosis, or both were evaluated with orbital cooling in a prospective manner. Forty-eight patients presented with diplopia, 25 patients with both blepharoptosis and ophthalmoplegia and 16 patients with blepharoptosis. All patients had the ice pack applied for 5 minutes on both eyelids at the initial orthoptic evaluation. Increasing the duration of cooling to 10 minutes was investigated in 36 diplopic patients. A complete diagnostic work-up was ordered and patients were followed up for a minimum of 6 months before diagnosis of myasthenia gravis was ascertained. Difference in cover test measurements in primary position or marginal reflex distance before and after the application of the ice pack, specific cause for diplopia and blepharoptosis. Fifteen patients were diagnosed as myasthenic. The optimal cutoff point for a positive response to the ice pack test proved to be a reduction in ocular deviation in primary position by 50% or by 10 prism diopters (PD) or more for presenting deviations larger than 20 PD. By this criterion, sensitivity for the detection of myasthenic diplopia was 76.9% (95% confidence interval [CI], 49.06%-92.50%) for the 5-minute application, compared with 92.3% (95% CI, 63.5%-98.9%) sensitivity demonstrated for blepharoptosis. Increasing the time of application to 10 minutes did not improve the diagnostic value of the test. Specificity was high (98.3%; 95% CI, 90.3%-99.9%) and was demonstrated even in patients with coexisting myasthenic and dysthyroid ophthalmopathy. Patients with oculomotor nerve paresis and Horner syndrome invariably were nonresponsive to the test. The ice pack test demonstrated high specificity and an acceptable sensitivity in the differential diagnosis of myasthenic diplopia. Data from this series suggest that a partial rather than a complete response to the ice pack test may be expected for myasthenic diplopia. Standardization of the method of application of the ice pack is critical for the interpretation of its effect.
Search by Subject Search using Medical Subject Headings (< b> MeSH</b>), a controlled... more Search by Subject Search using Medical Subject Headings (< b> MeSH</b>), a controlled vocabulary for indexing life sciences content.< br/> Note that some records do not have MeSH. These include Patents and the latest PubMed and PubMed Central records.
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