Teodhora Teodhora

Diabetes mellitus (DM) is a degenerative disease characterized by abnormalities in carbohydrate, lipid, and protein metabolisms. This research was aimed at the gel’s pharmacological activity, the extract’s potential in treating diabetic wounds in male rats of Melastoma malabathricum L leaves (ML) and Psidium guajava L leaves (PL), as well as microbiological activity. Viscous extracts of ML and PL were prepared in gel dosage form with concentrations of 4% and 6%. Clindamycin was used as a positive control. This study was conducted using an experimental laboratory method, and the study population included white male rats. The pharmacological activity was tested in the form of a gel dosage formula, and the rats were made diabetic using alloxan. The potential of the extract was observed in healing diabetic wounds in male rats. ML and PL leaf extract gels affect wound healing in diabetic patients. This can be seen from the change in diameter. Wound swab examination revealed the presence ...

Penggunaan obat tradisional akan bermanfaat bagi kesehatan apabila digunakan secara tepat. Pengetahuan dan sikap merupakan faktor yang mempengaruhi tindakan pemilihan pengobatan seseorang. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan dan sikap terhadap penggunaan obat tradisional di Kelurahan Sukamaju Baru, Kecamatan Tapos, Kota Depok. Jenis penelitian yang digunakan yaitu observasional yang bersifat deskriptif analitik dengan rancangan penelitian potong lintang (cross sectional) menggunakan instrumen penelitian berupa kuesioner. Pengambilan sampel dilakukan dengan teknik purposive sampling terhadap 153 responden dan diperoleh 149 responden yang memenuhi kriteria inklusi dan kriteria eksklusi. Analisis data dilakukan menggunakan uji chi-square. Hasil penelitian menunjukkan bahwa masyarakat yang mempunyai tingkat pengetahuan baik (69,1%), cukup (23,5%), dan kurang (7,4%). Hasil penelitian sikap yaitu 84,6% mempunyai sikap positif dan 15,4% mempunyai sikap ne...

Diabetes mellitus and cholesterol disorders are a lethal combination that places patients with diabetes 2-4 times more at risk for developing macrovascular and microvascular complications. Risk factors for Diabetes with Hyperlipidemia include age, sex, lifestyle, metabolic conditions that affect the metabolism of plasma lipoproteins, insulin deficiency. This study aims to know determine demographic data (age, sex, and length of stay), to know results of the laboratory tests and to know description of the therapy. The study was conducted descriptive with a cross sectional design, retrospective data collection methods from patients medical records of diabetic with hyperlipidemia at the hospital inpatient installation in January-December 2019, with 130 sample patients medical record. Result presented as a percentage table. The mean results of the study based on the highest patients demographics were at age 51-60 years as 40%, the highest gender was females 56%, based on the highest len...

Diabetes Mellitus type 2(DMT2) is a disease that results from a chronic metabolic disorder with multi ethology characterized by high levels of blood glucose accompanied by carbohydrate, lipid and protein metabolic disorders. The purpose of this study is to find out the difference between drop in blood glucose  in outpatient DMT2 who education and  not education in RSUP Fatmawati, South Jakarta period January-May 2017 .The research was done retrospectively non experimental by looking at the medical record of  76 patients DMT2 who were education and not education. The data analysis of used a Mann Whitney statistic to saw how drop in blood glucose in DMT2. The results showed the characteristics of type 2 Diabetes Mellitus patients, namely age> 55 years 84.21%, the most gender was 63.18% female, most low-educated 78.95%, long patients suffering from T2DM more than 10 years 52.63%. Studies have shown a decrease in GDP between DMT2 patients who education as defined at 33,11 mg/dl, whil...

Maja ( Crescentia cujete L.) is a plants that have many pharmacology activity. The chemical content of flavonoids, alkaloids, saponins, and tannins has the potential to provide therapeutic activity such as analgesic. This research to determine the therapeutic potential, namely analgesic of Maja fruit flesh extracts based on the amount of twisted mice induced by glacial acetic acid 1% and the effective dose equivalent to Ibuprofen. This research used DDY male mice, the test animals used were 25 mice were divided into 5 groups with a simple random sampling technique. Negative control used 1% CMC-Na, positive control used a 400 mg/kg BW Ibuprofen suspension and Maja fruit flesh extract treatment group at a dose of 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW. Based on the One-Way ANOVA statistic test results, it was found to the p-value = 0.001 showed a significantly different mean of the amount of stretching in the five groups after being treated. Maja fruit flesh extract which has an...

Rumput laut merupakan salah satu jenis alga merah penghasil agar. Agar banyak digunakan sebagai makanan, obat-obatan, kosmetik, kertas, dan tekstil. Penelitian bertujuan untuk mengetahui aktivitas antimikroba dari ekstrak etanol 96% rumput laut terhadap Propionibacterium acnes dan Aspergillus niger. Rumput laut diperoleh dari Pantai Ekas, Lombok Timur dan dimaserasi selama 48 jam dengan pelarut etanol 96%. Kemudian dilakukan uji aktivitas antimikroba dengan  metode difusi padat untuk mengukur diameter daya hambat dan  metode dilusi padat untuk menentukan  konsentrasi hambat minimum. Hasil menunjukkan bahwa ekstrak etanol 96% rumput laut dapat menghambat bakteri propionibacterium acnes pada konsentrasi 25% sebesar 9,16 mm, 50% sebesar 10,32 mm, 75% sebesar 10,79 mm  dan 100%  sebesar 12,10 mm.  Pada Aspergillus niger menunjukkan bahwa ekstrak etanol 96% rumput laut tidak memiliki aktivitas antimikroba pada konsentrasi 25%, 50%, 75% dan 100%.

Diabetes Mellitus (DM) is an incurable disease that can be prevented clinically from worsening. This disease is based on classification related to pancreatic damage in total or partial so that the impact on insulin production. Glucose transporter is a protein that can glucose uptake from outside cell into cell and provides an important role in the body's glucose homeostasis. Glucose transporter-2 (GLUT-2) is found in the pancreas, liver, and kidney. Parameters used are the expression and amount of GLUT-2 density in pancreatic β cells and in hepatocyte cells in normal and diabetic Rat. Used Wistar strain male white rats. An immunohistochemistry (IHC) staining technique was performed to observe the expression of GLUT-2 and the macbiophotonics image J program to determine total density of GLUT-2. GLUT-2 is marked in brown in the cell nucleus surrounded by cytoplasm. The results showed an increased in GLUT-2 expression in hepatocyte cells with a total density of 25,447,052 and a dec...

Physalis angulata L. merupakan tanaman yang dapat digunakan untuk mengatasi infeksi yang disebabkan oleh bakteri Staphylococcus aureus dan Pseudomonas aeruginosa. Penelitian ini bertujuan untuk meneliti pengaruh penggunaan HPMC sebagai basis dalam beberapa variasi konsentrasi terhadap mutu fisik gel dan aktivitas sebagai antibakteri Staphylococcus aureus dan Pseudomonas aeruginosa. Hasil penelitian menunjukkan bahwa gel ekstrak daun Physalis angulata L. pada penggunaan variasi basis HPMC tidak mempengaruhi mutu fisik organoleptik, homogenitas, pH dan aktivitas antibakteri terhadap bakteri Pseudomonas aeruginosa dan mempengaruhi mutu fisik viskositas, dan aktivitas antibakteri terhadap bakteri Staphylococcus aureus. Gel ekstrak daun Physalis angulata L. dengan menggunakan konsentrasi HPMC 4% menghasilkan gel dengan mutu fisik dan aktivitas antibakteri yang optimal terhadap bakteri Staphylococcus aureus dan Pseudomonas aeruginosa, dengan daya hambat yang diperoleh yaitu sebesar 12,7 m...