Receiver operating characteristic (ROC) methodology was used to compare the performance of differ... more Receiver operating characteristic (ROC) methodology was used to compare the performance of different statistics in the automatic detection of multiple auditory steady-state responses (MSSR) and click auditory brainstem responses (cABR). Thirty-five healthy newborns tested within the first two weeks of birth. In each case cABR and MSSR (0.5 and 2 kHz) were recorded with and without acoustic stimulation, using AUDIX equipment. With this test sample of recordings, ROC curves were evaluated separately for each statistic evaluated: (1) the standard deviation ratio (SDR) and the correlation coefficient ratio (CCR) for the cABR; (2) the Hotelling T2 (HT2) and circular T2 (CT2) for the MSSR. All objective detection methods performed well (areas under ROC (AUC) > 0.9). The MSSR statistics showed significantly larger AUCs at both frequencies (HT2: 0.98 and 1; CT2: 0.96 and 0.99) than the cABR measures (SDR: 0.91 and CCR: 0.92). The HT2 hits rate was the highest (97-100% at 0.5 and 2 kHz) for fixed false alarms rates of both 10 and 20%. This superiority of performance of T2-like statistics, reflecting inherent advantages of MSSR analysis for automation, warrants serious consideration for further development of newborn screening technology.
Receiver operating characteristic (ROC) methodology was used to compare the performance of differ... more Receiver operating characteristic (ROC) methodology was used to compare the performance of different statistics in the automatic detection of multiple auditory steady-state responses (MSSR) and click auditory brainstem responses (cABR). Thirty-five healthy newborns tested within the first two weeks of birth. In each case cABR and MSSR (0.5 and 2 kHz) were recorded with and without acoustic stimulation, using AUDIX equipment. With this test sample of recordings, ROC curves were evaluated separately for each statistic evaluated: (1) the standard deviation ratio (SDR) and the correlation coefficient ratio (CCR) for the cABR; (2) the Hotelling T2 (HT2) and circular T2 (CT2) for the MSSR. All objective detection methods performed well (areas under ROC (AUC) > 0.9). The MSSR statistics showed significantly larger AUCs at both frequencies (HT2: 0.98 and 1; CT2: 0.96 and 0.99) than the cABR measures (SDR: 0.91 and CCR: 0.92). The HT2 hits rate was the highest (97-100% at 0.5 and 2 kHz) for fixed false alarms rates of both 10 and 20%. This superiority of performance of T2-like statistics, reflecting inherent advantages of MSSR analysis for automation, warrants serious consideration for further development of newborn screening technology.
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