Alzheimer's & Dementia: The Journal of the Alzheimer's Association, Volume 5, Issue... more Alzheimer's & Dementia: The Journal of the Alzheimer's Association, Volume 5, Issue 5, Pages e13, September 2009, Authors:J. Lui; Q. Li; K. De Ruyck; V. Gupta; K. Taddei; J. Foster; T. Taddei; B. Brown; V. Ward; M. Rodrigues; M. Rimajova; K. Ellis; C. Rowe; V. Villemagne; P. Hudson ...
We evaluated the impact of age and remission status on 242 consecutive patients who underwent all... more We evaluated the impact of age and remission status on 242 consecutive patients who underwent allogeneic hematopoietic cell transplantation for acute myeloid leukemia (AML) in our program between 1999 and 2011. Median age of all patients was 48 years (range, 18 to 71). Based on age and remission status, patients were divided into 4 groups: first complete remission (CR1) age <60 years (n = 116), second complete remission (CR2) age <60 years (n = 78), CR1 age ≥60 years (n = 32), and CR2 age ≥60 years (n = 16). Donors were matched related (n = 155, 64%) or matched unrelated (n = 87, 36%). Median follow-up of survivors was 65 months (range, 12 to 145). In a univariate analysis, 3-year overall survival rates of the 4 groups were 57%, 43%, 39%, and 16% (P = .003), respectively. In a multivariable analysis, hazard ratios of nonrelapse mortality and survival were 2.08 (P = .06) and 1.52 (P = .23), respectively, in patients ≥60 years in CR2 compared with ≥ 60 years in CR1. Although a plateau in survival was observed for patients ≥60 years in CR1 similar to those <60 years in CR1 and CR2, no long-term survivors were seen in patients ≥60 years in CR2. Our data suggest disappointing outcomes in AML patients ≥60 years of age transplanted in CR2. Therefore, if a transplant is indicated, early referral is recommended in patients ≥60 years with AML.
... Expl. Botany 30, 187. 8. Stobart, AK, Griffiths, WT, Ameen-Bukhair, I. and Sherwood, RP (1985... more ... Expl. Botany 30, 187. 8. Stobart, AK, Griffiths, WT, Ameen-Bukhair, I. and Sherwood, RP (1985) Physiol. Plant. 63, 293. ... Abstract | PDF (1230 K) | View Record in Scopus | Cited By in Scopus (19). 8.AK Stobart, WT Griffiths, I. Ameen-Bukhair and RP Sherwood, Physiol. Plant. ...
Delivery of next-generation intelligent optical networks requires a new breed of multiservice tra... more Delivery of next-generation intelligent optical networks requires a new breed of multiservice transport platforms, which seam-lessly bridge the gap between long-haul transport and broad-band access networks. These new platforms require development of multiservice interconnect ...
The self-biased LNPN operation is analyzed and the re-quirements to support high injection curren... more The self-biased LNPN operation is analyzed and the re-quirements to support high injection currents are deter-mined. The effects of process design and scaling on the LNPN behavior are investigated using analytical methods as well as device simulations and experimental ...
A 6.25 Gb/s serial receiver with a 4-tap adaptive DFE is implemented in a 0.13 μm 7LM CMOS proces... more A 6.25 Gb/s serial receiver with a 4-tap adaptive DFE is implemented in a 0.13 μm 7LM CMOS process. Direct cancellation of the first post-cursor ISI is achieved, enabling recovery of a data eye fully closed from channel losses and crosstalk. A BER-15 is measured over legacy backplane channels.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, Volume 5, Issue... more Alzheimer's & Dementia: The Journal of the Alzheimer's Association, Volume 5, Issue 5, Pages e13, September 2009, Authors:J. Lui; Q. Li; K. De Ruyck; V. Gupta; K. Taddei; J. Foster; T. Taddei; B. Brown; V. Ward; M. Rodrigues; M. Rimajova; K. Ellis; C. Rowe; V. Villemagne; P. Hudson ...
We evaluated the impact of age and remission status on 242 consecutive patients who underwent all... more We evaluated the impact of age and remission status on 242 consecutive patients who underwent allogeneic hematopoietic cell transplantation for acute myeloid leukemia (AML) in our program between 1999 and 2011. Median age of all patients was 48 years (range, 18 to 71). Based on age and remission status, patients were divided into 4 groups: first complete remission (CR1) age <60 years (n = 116), second complete remission (CR2) age <60 years (n = 78), CR1 age ≥60 years (n = 32), and CR2 age ≥60 years (n = 16). Donors were matched related (n = 155, 64%) or matched unrelated (n = 87, 36%). Median follow-up of survivors was 65 months (range, 12 to 145). In a univariate analysis, 3-year overall survival rates of the 4 groups were 57%, 43%, 39%, and 16% (P = .003), respectively. In a multivariable analysis, hazard ratios of nonrelapse mortality and survival were 2.08 (P = .06) and 1.52 (P = .23), respectively, in patients ≥60 years in CR2 compared with ≥ 60 years in CR1. Although a plateau in survival was observed for patients ≥60 years in CR1 similar to those <60 years in CR1 and CR2, no long-term survivors were seen in patients ≥60 years in CR2. Our data suggest disappointing outcomes in AML patients ≥60 years of age transplanted in CR2. Therefore, if a transplant is indicated, early referral is recommended in patients ≥60 years with AML.
... Expl. Botany 30, 187. 8. Stobart, AK, Griffiths, WT, Ameen-Bukhair, I. and Sherwood, RP (1985... more ... Expl. Botany 30, 187. 8. Stobart, AK, Griffiths, WT, Ameen-Bukhair, I. and Sherwood, RP (1985) Physiol. Plant. 63, 293. ... Abstract | PDF (1230 K) | View Record in Scopus | Cited By in Scopus (19). 8.AK Stobart, WT Griffiths, I. Ameen-Bukhair and RP Sherwood, Physiol. Plant. ...
Delivery of next-generation intelligent optical networks requires a new breed of multiservice tra... more Delivery of next-generation intelligent optical networks requires a new breed of multiservice transport platforms, which seam-lessly bridge the gap between long-haul transport and broad-band access networks. These new platforms require development of multiservice interconnect ...
The self-biased LNPN operation is analyzed and the re-quirements to support high injection curren... more The self-biased LNPN operation is analyzed and the re-quirements to support high injection currents are deter-mined. The effects of process design and scaling on the LNPN behavior are investigated using analytical methods as well as device simulations and experimental ...
A 6.25 Gb/s serial receiver with a 4-tap adaptive DFE is implemented in a 0.13 μm 7LM CMOS proces... more A 6.25 Gb/s serial receiver with a 4-tap adaptive DFE is implemented in a 0.13 μm 7LM CMOS process. Direct cancellation of the first post-cursor ISI is achieved, enabling recovery of a data eye fully closed from channel losses and crosstalk. A BER-15 is measured over legacy backplane channels.
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