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In the era of advancing transcatheter aortic valve replacement (TAVR) technology, traditional open surgery remains a valuable intervention for patients who are not TAVR candidates. We sought to compare perioperative variables and... more
In the era of advancing transcatheter aortic valve replacement (TAVR) technology, traditional open surgery remains a valuable intervention for patients who are not TAVR candidates. We sought to compare perioperative variables and postoperative outcomes of minimally invasive and full sternotomy surgical aortic valve replacement (SAVR) at a single institution. A retrospective analysis of 113 patients who underwent isolated SAVR via full sternotomy or upper hemi-sternotomy between January 2015 and December 2019 at the University of Utah Hospital was performed. Preoperative comorbidities and demographic information were not different among groups, with the exception of diabetes, which was significantly more common in the full sternotomy group (p = 0.01). Median procedure length was numerically shorter in the minimally invasive group but was not significant following the Bonferroni correction (p = 0.047). Other perioperative variables were not significantly different. The two groups show...
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In this study, we provide a comprehensive analysis of the genomic features of the phage CL31 and the infection dynamics with the biotechnologically relevant host strain Corynebacterium glutamicum ATCC 13032. Genome sequencing and... more
In this study, we provide a comprehensive analysis of the genomic features of the phage CL31 and the infection dynamics with the biotechnologically relevant host strain Corynebacterium glutamicum ATCC 13032. Genome sequencing and annotation of CL31 revealed a 45-kbp genome composed of 72 open reading frames, mimicking the GC content of its host strain (54.4%). An ANI-based distance matrix showed the highest similarity of CL31 to the temperate corynephage Φ16. While the C. glutamicum ATCC 13032 wild type strain showed only mild propagation of CL31, a strain lacking the cglIR-cglIIR-cglIM restriction-modification system was efficiently infected by this phage. Interestingly, the prophage-free strain C. glutamicum MB001 featured an even accelerated amplification of CL31 compared to the ∆resmod strain suggesting a role of cryptic prophage elements in phage defense. Proteome analysis of purified phage particles and transcriptome analysis provide important insights into structural componen...
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Background Stem bark of Anogeissus latifolia Roxb (family: Combretaceae) is used traditionally and ethnomedicinally to alleviate pain, inflammation and fever conditions. The current study investigates the analgesic, anti-inflammatory and... more
Background Stem bark of Anogeissus latifolia Roxb (family: Combretaceae) is used traditionally and ethnomedicinally to alleviate pain, inflammation and fever conditions. The current study investigates the analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of stem bark of Anogeissus latifolia Roxb. Method The HPLC studies were carried out to standardize the stem bark ethanolic extract of Anogeissus latifolia (ALEE) using ellagic acid as a marker. ALEE was screened for analgesic (formalin-induced pain and acetic acid induced writhing) and anti-inflammatory (formalin and carrageenan-induced paw oedema) activities in Wistar rats. Before 1 h of acetic acid or formalin or carrageenan injection, rats were orally fed with ALEE (100, 200 and 400 mg/kg), Aspirin (100 mg/kg) or Indomethacin (10 mg/kg). Antipyretic effect was studied in brewer’s yeast-induced pyrexia model in rats using Paracetamol (100 mg/kg) as a standard drug. Results HPLC analysis of ALEE revealed ...
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... V3 Naveen. 1981: H 5 days before bud initiation; H at bud initiation; U 5 days after bud initiation. 1982: _ 5 days before bud initiation; _ at bud initiation; ffl 5 days after bud initiation. ... Maydica, 28, 1 : 53-76. SARUP, P.,... more
... V3 Naveen. 1981: H 5 days before bud initiation; H at bud initiation; U 5 days after bud initiation. 1982: _ 5 days before bud initiation; _ at bud initiation; ffl 5 days after bud initiation. ... Maydica, 28, 1 : 53-76. SARUP, P., PANWAR, VPS. MARWAHA, KK and SIDDIQUI, KH 1979. ...
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Aloe vera (Liliaceae) is well known for its medicinal properties. It contains flavonoids, saponins, tannins, alkaloids and other compounds which exhibit medicinal, cosmetic and pharmacological properties. There is a lack of production of... more
Aloe vera (Liliaceae) is well known for its medicinal properties. It contains flavonoids, saponins, tannins, alkaloids and other compounds which exhibit medicinal, cosmetic and pharmacological properties. There is a lack of production of aloe leaf to meet the industry demand and therefore the means to facilitate large-scale aloe cultivation schemes need to be developed. Because sexual reproduction by seeds is almost ineffective in Aloe vera due to male sterility and vegetative propagation by offshoots is only possible during the growing seasons, there is a need to develop a propagation method to facilitate large-scale cultivation. In vitro regeneration of medicinal plants is important and there is the potential for the production of high-quality plant-based medicine. In the present study, an attempt has been made to enhance in vitro caulogenesis and aloin content in plants in the presence of a precursor (tryptophan) in the nutrient media. For in vitro culture establishment and shoot...
Research Interests: Plant Biology and Biology
This paper presents how wavelet family, level of decomposition i.e. Wavelet Transform and Step size of LMS algorithm affect the speech signal de-noising. Here Discrete-wavelet transform (DWT) based Least Mean Square (LMS) algorithm is... more
This paper presents how wavelet family, level of decomposition i.e. Wavelet Transform and Step size of LMS algorithm affect the speech signal de-noising. Here Discrete-wavelet transform (DWT) based Least Mean Square (LMS) algorithm is used for elimination of noise from the speech signal. This paper is focused on the analysis and performance of wavelet domain Least Mean Squared (LMS) an adaptive filtering algorithm. Analysis is done on noisy speech signal corrupted by white noise at different dB SNR. The results are performed/obtained in MATLAB 7.10.0 (R2010a). Output SNR (Signal to Noise Ratio) and MSE (Mean Square Error) is calculated & compared for different parameters like types of Wavelet and distinct value of step size. Results are shown for same input signal which is wave (.wav) file sampled at 16 kHz.
Ebstein anomaly (EA) is commonly associated with atrial flutter or fibrillation (AFl/F), which adversely affects outcome. Surgical ablation of AFl/F during surgery for EA has been shown to be effective, but the optimal lesion set remains... more
Ebstein anomaly (EA) is commonly associated with atrial flutter or fibrillation (AFl/F), which adversely affects outcome. Surgical ablation of AFl/F during surgery for EA has been shown to be effective, but the optimal lesion set remains unknown. Between 1995 and 2010, 86 patients had corrective surgery for EA and concomitant maze procedure for associated AFl/F. Median age at operation was 40 years (range, 1 to 72 years), and 49 patients (60%) were male. Preoperative AFl/F was paroxysmal in 43 patients (50%). All patients who had diagnosis of or treatment for accessory pathways and reentrant tachycardia were excluded from this analysis. All patients underwent tricuspid valve surgery for EA and concomitant maze procedure, including right-sided maze (RSM) in 62 patients (72%) and biatrial maze (BAM) in 24 patients (28%). Early mortality occurred in 3 patients (3.5%). During median follow-up of 52 months (range, 3 months to 17 years), overall freedom from AFl/F without antiarrhythmic m...
Research Interests: Treatment Outcome, Adolescent, Humans, Child, Female, and 15 moreMale, Atrial Fibrillation, Young Adult, Infant, Follow-up studies, Clinical Sciences, Aged, Middle Aged, Adult, Retrospective Studies, Catheter ablation, Atrial Flutter, Child preschool, Disease Free Survival, and Cardiovascular medicine and haematology
Research Interests: Dermatology, Adolescent, Esthetics, Prospective studies, Humans, and 15 moreFemale, Male, Patient Satisfaction, Psoriasis, Calcitriol, Recurrence, Clinical Sciences, Middle Aged, Topical Drug Administration, Adult, Public health systems and services research, Time Factors, Coal Tar, Severity of Illness Index, and Dermatologic agents
Research Interests: Chemistry, Ayurvedic Medicine, Medicine, Biological Sciences, Phytotherapy, and 15 moreAnimals, Male, Androgens, Prostate, Asteraceae, Plant Roots, CHEMICAL SCIENCES, Plant extracts, Amides, Rats, Body Weight, Luteinizing Hormone, Follicle stimulating hormone, Seminal Vesicles, and Medical and Health Sciences
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In vitroflowering and effective micropropagation protocol were studied inSwertia chirayita, an important medicinal plant using axillary bud explants. The Murashige and Skoog's medium (MS) supplemented with benzyl amino purine (BAP)... more
In vitroflowering and effective micropropagation protocol were studied inSwertia chirayita, an important medicinal plant using axillary bud explants. The Murashige and Skoog's medium (MS) supplemented with benzyl amino purine (BAP) 1.0 mg L-1and adenine sulfate 70.0 mg L-1was found optimum for production of multiple shoots. In the present study, incubation of flowering cultures on BAP supplemented medium (during shoot multiplication) was found necessary for flowering (6 weeks). However, concentrations of auxins-like IBA (0–2.0 mg/L) were ineffective to form reproductive buds. Subculture duration, photoperiod, and carbon source type do have influence on thein vitroflowering. The mature purple flowers were observed when the cultures were maintained in the same medium. This is the very first report that describesin vitroflowering system to overcome problems associated with flower growth and development as well as lay foundation for fruit and seed productionin vitroinSwertia chirayita.
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Stone matrix asphalt (SMA) is a gap-graded mix that contains a high concentration of coarse aggregate, thereby maximizing stone-to-stone contact in the mixture and providing an efficient network for load distribution. Coarse aggregate... more
Stone matrix asphalt (SMA) is a gap-graded mix that contains a high concentration of coarse aggregate, thereby maximizing stone-to-stone contact in the mixture and providing an efficient network for load distribution. Coarse aggregate particles are held together by a rich matrix of mineral filler and stabilizer in the thick asphalt film. This paper presents details on the laboratory studies carried out on stone matrix asphalt (SMA) mixtures with natural fibres and crumb rubber modified bitumen (CRMB). Indirect tensile strength, retained stability, resistance to moisture susceptibility, resistance to rutting, resistance to creep, and resistance to permeability and aging were found to improve with SMA mixtures with CRMB when compared with SMA mixtures with fibres as stabilizers.Key words: natural fibres, CRMB, SMA mixtures, draindown, moisture damage, creep, rutting, permeability, aging.
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THIOMABs are recombinant antibodies engineered with reactive cysteines, which can be covalently conjugated to drugs of interest to generate targeted therapeutics. During the analysis of THIOMABs secreted by stably transfected Chinese... more
THIOMABs are recombinant antibodies engineered with reactive cysteines, which can be covalently conjugated to drugs of interest to generate targeted therapeutics. During the analysis of THIOMABs secreted by stably transfected Chinese Hamster Ovary (CHO) cells, we discovered the existence of a new species--Triple Light Chain Antibody (3LC). This 3LC species is the product of a disulfide bond formed between an extra light chain and one of the engineered cysteines on the THIOMAB. We characterized the 3LC by size exclusion chromatography, mass spectrometry, and microchip electrophoresis. We also investigated the potential causes of 3LC formation during cell culture, focusing on the effects of free light chain (LC) polypeptide concentration, THIOMAB amino acid sequence, and glutathione (GSH) production. In studies covering 12 THIOMABs produced by 66 stable cell lines, increased free LC polypeptide expression--evaluated as the ratio of mRNA encoding for LC to the mRNA encoding for heavy chain (HC)--correlated with increased 3LC levels. The amino acid sequence of the THIOMAB molecule also impacted its susceptibility to 3LC formation: hydrophilic LC polypeptides showed elevated 3LC levels. Finally, increased GSH production--evaluated as the ratio of the cell-specific production rate of GSH (q(GSH)) to the cell-specific production rate of THIOMAB (q(p))--corresponded to decreased 3LC levels. In time-lapse studies, changes in extracellular 3LC levels during cell culture corresponded to changes in mRNA LC/HC ratio and q(GSH)/q(p) ratio. In summary, we found that cell lines with low mRNA LC/HC ratio and high q(GSH)/q(p) ratio yielded the lowest levels of 3LC. These findings provide us with factors to consider in selecting a cell line to produce THIOMABs with minimal levels of the 3LC impurity.
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Conjugation of an antibody to a drug can produce heterogeneous species that may have different physical stabilities and safety profiles. We explored the effect of thermal stress on the physical stability, specifically aggregation, of an... more
Conjugation of an antibody to a drug can produce heterogeneous species that may have different physical stabilities and safety profiles. We explored the effect of thermal stress on the physical stability, specifically aggregation, of an antibody drug conjugate (ADC), ADC 1, wherein the antibody was linked to the val-cit-Monomethyl Auristatin E (vc-MMAE) linker drug through the reduction of interchain disulfides. We also explored the effects of conjugation on the secondary and tertiary structures of ADC 1. Circular dichroism, intrinsic tryptophan fluorescence, and differential scanning calorimetry showed that for species with high drug loading, conjugation does not measurably alter the secondary structure, but it does render the CH2 domain less stable to thermal stress such that ADC 1 rapidly forms high molecular weight species (HMWS) at 40 °C. Characterization of the HMWS using chromatographic and electrophoretic methods showed that it is an irreversible, noncovalent, and structurally altered form of ADC 1 primarily composed of molecules with six or eight drugs. Furthermore, the variable domain of the antibody may contribute to the extent of aggregation, since eight ADCs with over 90% sequence homology exhibited monthly rates of HMWS formation that differ by up to a factor of 2.
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The management of the zone of apposition (ZOA) in patients with atrioventricular septal defect (AVSD) and parachute left atrioventricular valve (LAVV) is controversial. Between 1977 and 2010, 28 patients with parachute LAVV associated... more
The management of the zone of apposition (ZOA) in patients with atrioventricular septal defect (AVSD) and parachute left atrioventricular valve (LAVV) is controversial. Between 1977 and 2010, 28 patients with parachute LAVV associated with AVSD were reviewed. The median age at operation was 10 months (range, 36 days to 14 years). Sixteen (57%) patients had complete AVSD and 12 (43%) had partial AVSD. Thirteen (46%) patients had moderate to severe LAVV regurgitation. The ZOA was managed with complete closure in 6 (22%), partial closure in 10 (36%), and no closure in 11 (39%) patients One patient underwent LAVV replacement for dysplastic leaflets. Dismissal echocardiogram demonstrated moderate LAVV regurgitation in 10 (36%) patients; 7 patients had no closure of ZOA, and 3 had partial closure. Mild or moderate LAVV stenosis was present in all 6 patients with complete closure of ZOA and 1 patient with partial closure. Median follow-up was 9 years (maximum, 22 years). Eight patients had progression of LAVV regurgitation through the unsutured ZOA; 6 patients subsequently underwent LAVV replacement. Of the 7 patients who had LAVV stenosis, 1 patient required opening of ZOA 1 month after surgery. The other 6 patients had a decrease in mean gradient. There was 1 late death after the fourth redo LAVV replacement. Progression of LAVV regurgitation from the unsutured ZOA was the main indication for reoperation in parachute LAVV with AVSD. The ZOA in parachute LAVV should be partially or completely closed at the time of AVSD repair. Although mild LAVV stenosis appeared to improve with time, life-long surveillance is essential.
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The surface of implantable biomaterials is in direct contact with the host tissue and plays a critical role in determining biocompatibility. In order to improve the integration of implants, it is desirable to control interfacial reactions... more
The surface of implantable biomaterials is in direct contact with the host tissue and plays a critical role in determining biocompatibility. In order to improve the integration of implants, it is desirable to control interfacial reactions such that nonspecific adsorption of proteins is minimized and tissue-healing phenomena can be controlled. In this regard, our goal has been do develop a method to functionalize oxidized titanium surfaces by the covalent immobilization of bioactive organic molecules. Titanium first was chemically treated with a mixture of sulfuric acid and hydrogen peroxide to eliminate surface contaminants and to produce a consistent and reproducible titanium oxide surface layer. An intermediary aminoalkylsilane spacer molecule was then covalently linked to the oxide layer, followed by the covalent binding of either alkaline phosphatase or albumin to the free terminal NH2 groups using glutaraldehyde as a coupling agent. Surface analyses following coating procedures consisted of X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and atomic force microscopy (AFM). Enzymatic activity of coupled alkaline phosphatase was assayed colorimetrically, and surface coverage by bound albumin was evaluated by SEM visualization of colloidal gold immunolabeling. Our results indicate that the linkage of the aminoalkylsilane to the oxidized surface is stable and that bound proteins such alkaline phosphatase and albumin retain their enzymatic activity and antigenicity, respectively. The density of immunolabeling for albumin suggests that the binding and surface coverage obtained is in excess of what would be expected for inducing biological activity. In conclusion, this method offers the possibility of covalently linking selected molecules with known biological activity to oxidized titanium surfaces in order to guide and promote the tissue healing that occurs during implant integration in bone and soft tissues.
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Glioblastoma multiforme (GBM) is the most common malignant central nervous system neoplasm. Loss of heterozygosity (LOH) on chromosome 10q in these tumors has been found to show variable association with prognosis. To evaluate LOH 10q... more
Glioblastoma multiforme (GBM) is the most common malignant central nervous system neoplasm. Loss of heterozygosity (LOH) on chromosome 10q in these tumors has been found to show variable association with prognosis. To evaluate LOH 10q status in cases of GBM, and to correlate these results with patient characteristics, other genetic alterations, and survival. Fresh tumor tissue and blood samples were obtained for 25 cases of GBM diagnosed over a 2-year period. LOH 10q assay was performed on blood and tumor DNA by a PCR-based method using four microsatellite markers. TP53 mutation analysis and fluorescence in situ hybridization for epidermal growth factor receptor (EGFR) were performed. Histopathology was reviewed and clinical data were analyzed. LOH 10q was identified in 17 of 25 cases (68%). Losses were frequent with markers D10S1765 (12/20 informative cases; 60%) and D10S587 (12/17 informative cases; 70.5%) in the regions of 10q23.3 and 10q26.1, respectively. D10S540 for 10q25.1 sh...
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To evaluate age-related differences in histopathologic and molecular profile of glioblastomas (GBMs) at various age groups, with special reference to TP53 mutation, epidermal growth factor receptor (EGFR) amplification, EGFR vIII mutant,... more
To evaluate age-related differences in histopathologic and molecular profile of glioblastomas (GBMs) at various age groups, with special reference to TP53 mutation, epidermal growth factor receptor (EGFR) amplification, EGFR vIII mutant, PTEN deletion, and IDH1 mutation. Agewise GBM incidence was calculated over a period of 5 years (2005 to 2009). Seventy-five GBMs were selected for molecular analysis. Majority of cases were in the age group of 41 to 60 years, and mean age was 43.6 years. Histology of all 75 cases selected for molecular profiling was identical. Primary adult GBMs showed EGFR amplification and PTEN deletion in majority (37.3% and 54.9%, respectively). TP53 and IDH1 mutations were rare (11.8% cases each). In secondary GBMs, TP53 (66.7%) and IDH1 mutations (44.4%) were most frequent. PTEN deletion was seen in 33.3% and none had EGFR amplification. Pediatric GBMs (<18 y) harbored frequent TP53 mutations (46.7%) and PTEN deletion in 40%. IDH1 mutations and EGFR amplif...
Research Interests: Aging, Biology, Adolescent, Medicine, Molecular Pathology, and 15 moreHumans, Child, Mutation, Glioblastoma, Female, Male, Clinical Sciences, Middle Aged, Adult, Genetic variation, Molecular Diagnostic Methods, Brain Neoplasms, Gene expression profiling, gene amplification, and Chromosome aberrations
Page 1. JOURNAL OF RAMAN SPECTROSCOPY J. Raman Spectrosc. 2002; 33: 6770 Short Communication Lattice dynamic investigation of Raman and infrared wavenumbers at the zone center of orthorhombic RFeO3 (R = Tb, Dy, Ho, Er, Tm) perovskites ...
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Coronary bypass operation with cardiopulmonary bypass has provided disappointing results for the treatment of cardiac allograft vasculopathy (CAV). We describe a 61-year-old man who underwent heart transplantation for secondary dilated... more
Coronary bypass operation with cardiopulmonary bypass has provided disappointing results for the treatment of cardiac allograft vasculopathy (CAV). We describe a 61-year-old man who underwent heart transplantation for secondary dilated cardiomyopathy in 1995. ...
The availability of expressed sequence data derived from gene discovery programs became an alter-native source of mining simple sequence repeat (SSR) and developing inexpensive genetic markers for the crop improvements. In present study,... more
The availability of expressed sequence data derived from gene discovery programs became an alter-native source of mining simple sequence repeat (SSR) and developing inexpensive genetic markers for the crop improvements. In present study, 10 express sequence tags ( ...
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Quantity–intensity relations of potassium (K) were worked out for guava orchard soils. Equilibrium activity ratio of potassium (ARe ) ranged from 0.46 × 10 to 21.30 × 10 (mol L). The majority of the samples had less than 1 × 10 (mol L),... more
Quantity–intensity relations of potassium (K) were worked out for guava orchard soils. Equilibrium activity ratio of potassium (ARe ) ranged from 0.46 × 10 to 21.30 × 10 (mol L). The majority of the samples had less than 1 × 10 (mol L), indicating K depletion in these soils due to continuous K mining. ARe was significantly and positively correlated with available forms of K, K
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The aim of the present study was to study the effect of seeds of Asteracantha longifolia on the sexual behaviour of male albino rats. The ethanolic extract of seeds of A. longifolia was administered to groups of rats in 100, 150 and 200... more
The aim of the present study was to study the effect of seeds of Asteracantha longifolia on the sexual behaviour of male albino rats. The ethanolic extract of seeds of A. longifolia was administered to groups of rats in 100, 150 and 200 mg kg⁻¹ doses for a period of 28 days, and the action compared with control rats. The changes in body and organ weight, sexual behaviour, histo-architecture and fructose levels of seminal vesicles were observed. The sexual behaviour was assessed by determining parameters such as mount frequency (MF), intromission latency, mount latency (ML) and post-ejaculatory latency. The ethanolic extract exhibited pronounced anabolic effects in treated animals, as evidenced by gains in the body and reproductive organ weights. Increased spermatogenesis due to treatment with extracts was also witnessed in transverse section. The treatment further markedly affected sexual behaviour of the animals, as reflected by the reduction of ML, increase in MF and enhanced attr...
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In 1982-1983 a random sample of 1486 people aged 65 years and above was generated from general practitioner lists; 1070 were interviewed in the community using the Geriatric Mental State and a Social History questionnaire. The cohort was... more
In 1982-1983 a random sample of 1486 people aged 65 years and above was generated from general practitioner lists; 1070 were interviewed in the community using the Geriatric Mental State and a Social History questionnaire. The cohort was followed up by interview 3 years later. At year 3 the diagnostic computer program AGECAT diagnosed 44 incident cases of depression. Information from the depressed group&amp;amp;amp;amp;amp;amp;#39;s initial and further interviews was compared with a control group (which excluded cases of affective or organic mental illness). Univariate analysis yielded three factors that were significantly associated with the development of depression 3 years later: a lack of satisfaction with life; feelings of loneliness; and smoking. Multivariate analysis confirmed their independent effects and revealed 2 further factors attaining significance: female gender and a trigger factor, bereavement of a close figure within 6 months of the third-year diagnosis. Some other factors traditionally associated with depression, such as poor housing, marital status and living alone, failed to attain significance as risk factors.
Research Interests: Psychology, Epidemiology, Depression, Bereavement, Medicine, and 15 moreEngland, Prospective studies, Humans, Elderly People, Female, Loneliness, Depressive Disorder, Incidence, Aged, Cross Sectional Studies, Personal Satisfaction, Prospective Study, Life Change Events, Psychology and Cognitive Sciences, and Medical and Health Sciences
Trained raters from the Liverpool Continuing Health in the Community study interviewed 1070 people over the age of 65 in 1982-1983 using the Geriatric Mental State (GMS) examination. Three years later the cohort was re-interviewed, this... more
Trained raters from the Liverpool Continuing Health in the Community study interviewed 1070 people over the age of 65 in 1982-1983 using the Geriatric Mental State (GMS) examination. Three years later the cohort was re-interviewed, this time by psychiatrists trained in the GMS, who used the GMS and the History and Aetiology Schedule (HAS). The cohort had fallen in size to 875, because of mortality; 701 were re-interviewed. The cohort was followed up again 6 years after the first interview by trained nurse raters using the GMS (A3) and the Mini-Mental State Examination. Cases of mental disorder identified by the computer diagnostic program AGECAT were re-interviewed by psychiatrists along with a number of controls using the GMS and the HAS on the remaining 450 individuals. Observational behavioural ratings from the GMS and summary sheets were analysed along with AGECAT diagnoses and data on medication gained at the 3 assessments. The community prevalence of tardive dyskinesia and other movement disorders in elderly people over a 6-year follow-up appears to be very low (the community prevalence of tardive dyskinesia being 0.22% and akathisia 1.57%), is usually associated with organic mental disorder (and consequently higher mortality) and is furthermore not usually associated with antipsychotic medication.
Research Interests: Epidemiology, Dementia, England, Movement disorders, Prospective studies, and 15 moreHumans, Female, Male, Mental Disorders, Incidence, Aged, Prevalence, Patient Care Team, Cross Sectional Studies, Chorea, Cohort Studies, Antipsychotic agents, Psychology and Cognitive Sciences, Athetosis, and Medical and Health Sciences
A total of 1070 men and women aged 65 years and over living in the community in Liverpool were interviewed using the Geriatric Mental State. Diagnoses of depression at case and subcase level were made using the GMS-AGECAT package from an... more
A total of 1070 men and women aged 65 years and over living in the community in Liverpool were interviewed using the Geriatric Mental State. Diagnoses of depression at case and subcase level were made using the GMS-AGECAT package from an initial interview and at follow-up three years later. Data relating to blood pressure at year 0 was available on 748 subjects. Men not taking anti-hypertensives or antidepressants with diastolic blood pressure greater than 85 mmHg were significantly less likely to be subcases than men with low or normal diastolic pressure. People in this group were also significantly less likely to be cases 3 years later. There were no other significant findings. These results do not support an association between low blood pressure and coincidental or future subcase- or case-level depressive illness.
Research Interests: Epidemiology, Depression, Risk, Prospective studies, Humans, and 15 moreBlood Pressure, Elderly People, Female, Male, Depressive Disorder, Aged, Great Britain, Longitudinal Studies, Prognosis, Hypotension, Prospective Study, Cohort Studies, Psychiatric Status Rating Scales, Psychology and Cognitive Sciences, and Medical and Health Sciences
The prevention and treatment of psychiatric illness would be facilitated by its early recognition, and by a knowledge of the prevalence and incidence of the condition. Accurate methods for determining the latter are important steps in the... more
The prevention and treatment of psychiatric illness would be facilitated by its early recognition, and by a knowledge of the prevalence and incidence of the condition. Accurate methods for determining the latter are important steps in the search for risk factors; such ...
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ObjectMutations of the gene encoding isocitrate dehydrogenase (IDH) have been shown in a significant proportion of diffuse gliomas. These mutations are specific to gliomas and their utility for diagnosis and prognostication of these... more
ObjectMutations of the gene encoding isocitrate dehydrogenase (IDH) have been shown in a significant proportion of diffuse gliomas. These mutations are specific to gliomas and their utility for diagnosis and prognostication of these tumors is being proclaimed. The present study was conducted with the aim of assessing frequency of IDH1 mutations in gliomas, their correlation with other molecular alterations along
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Elbow joints are the second most common joints to dislocate, second only to shoulder joints with most of the dislocations occurring in the posterolateral direction. The dislocations can be simple involving capsuloligamentous structures... more
Elbow joints are the second most common joints to dislocate, second only to shoulder joints with most of the dislocations occurring in the posterolateral direction. The dislocations can be simple involving capsuloligamentous structures around the joint or complex involving associated bony injuries. The dislocations can be disabling for the patients with the sequelae involving decreased range of movement, valgus instability
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Oxidation by photo-Fenton like reaction is an economically feasible process for degradation of a variety of hazardous pollutants in wastewater from dyeing and printing industries. In present study, the progress of the reaction has been... more
Oxidation by photo-Fenton like reaction is an economically feasible process for degradation of a variety of hazardous pollutants in wastewater from dyeing and printing industries. In present study, the progress of the reaction has been monitored spectrophotometrically. An effort has been made to observe the effect of various inorganic additives like sodium thiosulfate and potassium bromate. The effect of variation
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A capacitated two-stage time minimization transportation problem is considered in this paper, in which the total availability of a homogeneous product at various sources is more than the total requirement of the same at destinations.... more
A capacitated two-stage time minimization transportation problem is considered in this paper, in which the total availability of a homogeneous product at various sources is more than the total requirement of the same at destinations. Unlike the conventional imbalanced time minimization transportation problem, in the current problem, transportation takes place in two stages such that the minimum requirement of the
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This paper addresses the heterogeneous redundancy allocation problem in multi-state series-parallel reliability structures with the objective to minimize the total cost of system design satisfying the given reliability constraint and the... more
This paper addresses the heterogeneous redundancy allocation problem in multi-state series-parallel reliability structures with the objective to minimize the total cost of system design satisfying the given reliability constraint and the consumer load demand. The demand distribution is presented as a piecewise cumulative load curve and each subsystem is allowed to consist of parallel redundant components of not more than