Isatin base Schiff bases (1–20) were synthesized, characterized by
1 H NMR and EI/MS and evaluate... more Isatin base Schiff bases (1–20) were synthesized, characterized by 1 H NMR and EI/MS and evaluated for a -glucosidase inhibitory potential. Out of these twenty (20) compounds only six analogs showed potent a -glucosidase inhibitory potential with IC 50 value ranging in between 2.2 ± 0.25 and 83.5 ± 1.0 l M when compared with the standard acarbose (IC 50 = 840 ± 1.73 l M). Among the series compound 2 having IC 50 value (18.3 ± 0.56 l M), 9 (83.5 ± 1.0 l M), 11 (3.3 ± 0.25 l M), 12 (2.2 ± 0.25 l M), 14 (11.8 ± 0.15 l M), and 20 (3.0 ± 0.15 l M) showed excellent inhibitory potential many fold better than the standard acarbose. The binding interactions of these active analogs were confirmed through molecular docking.
Isatin base Schiff bases (1–20) were synthesized, characterized by
1 H NMR and EI/MS and evaluate... more Isatin base Schiff bases (1–20) were synthesized, characterized by 1 H NMR and EI/MS and evaluated for a -glucosidase inhibitory potential. Out of these twenty (20) compounds only six analogs showed potent a -glucosidase inhibitory potential with IC 50 value ranging in between 2.2 ± 0.25 and 83.5 ± 1.0 l M when compared with the standard acarbose (IC 50 = 840 ± 1.73 l M). Among the series compound 2 having IC 50 value (18.3 ± 0.56 l M), 9 (83.5 ± 1.0 l M), 11 (3.3 ± 0.25 l M), 12 (2.2 ± 0.25 l M), 14 (11.8 ± 0.15 l M), and 20 (3.0 ± 0.15 l M) showed excellent inhibitory potential many fold better than the standard acarbose. The binding interactions of these active analogs were confirmed through molecular docking.
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Papers by Wajid Rehman
1 H NMR and EI/MS and evaluated for
a -glucosidase inhibitory potential. Out of these twenty (20) compounds only six analogs showed potent
a -glucosidase inhibitory potential with IC 50 value ranging in between 2.2 ± 0.25 and 83.5 ± 1.0 l M when
compared with the standard acarbose (IC 50 = 840 ± 1.73 l M). Among the series compound 2 having IC 50
value (18.3 ± 0.56 l M), 9 (83.5 ± 1.0 l M), 11 (3.3 ± 0.25 l M), 12 (2.2 ± 0.25 l M), 14 (11.8 ± 0.15 l M),
and 20 (3.0 ± 0.15 l M) showed excellent inhibitory potential many fold better than the standard acarbose.
The binding interactions of these active analogs were confirmed through molecular docking.
1 H NMR and EI/MS and evaluated for
a -glucosidase inhibitory potential. Out of these twenty (20) compounds only six analogs showed potent
a -glucosidase inhibitory potential with IC 50 value ranging in between 2.2 ± 0.25 and 83.5 ± 1.0 l M when
compared with the standard acarbose (IC 50 = 840 ± 1.73 l M). Among the series compound 2 having IC 50
value (18.3 ± 0.56 l M), 9 (83.5 ± 1.0 l M), 11 (3.3 ± 0.25 l M), 12 (2.2 ± 0.25 l M), 14 (11.8 ± 0.15 l M),
and 20 (3.0 ± 0.15 l M) showed excellent inhibitory potential many fold better than the standard acarbose.
The binding interactions of these active analogs were confirmed through molecular docking.