The purpose of this study is to establish a modeling approach that can be used to predict bulk po... more The purpose of this study is to establish a modeling approach that can be used to predict bulk powder flowability of pharmaceutical materials from their particle size and shape distributions. To build and validate the model, 23 commonly used pharmaceutical excipients and 38 binary blends were fully characterized for their particle size and shape distributions. The particle size and shape of each sample was characterized by multiple descriptors to fully reflect their morphological characteristics. The flow properties of these materials were analyzed using the Schulze Ring Shear Tester at a fixed humidity condition. A partial least squares (PLS) approach was used to build the mathematical model. Several different modeling approaches were attempted and the best method was identified as using a combination of formulation composition and particle size and shape distributions of single-component powder systems. The PLS model was shown to provide excellent predictions of powder flow function coefficient (FFC) of up to approximately 20. The results also revealed that both particle size and shape play an important role in determining the powder flow behavior.
The capability of the newly developed dynamic image analysis instrument QicPic equipped with the ... more The capability of the newly developed dynamic image analysis instrument QicPic equipped with the high-speed dry-powder-dispersing device was investigated systematically using various MCC particles. Instrument cross-validation was conducted by comparing the particle size distribution of spherical particles obtained with the QicPic and with a conventional laser diffraction instrument (HELOS). While good agreement was observed with spherical particles, significant differences were found when analyzing rod-shaped Ceolus KG-1000 particles, revealing the intrinsic difference in operating principles between these two techniques. Particle shape distributions of several spherical and rod-shaped samples obtained with the QicPic were compared to scanning electron micrographs (SEMs), and semi-quantitative agreement was obtained. The particle size and particle shape of a series of binary particulate systems composed of both spherical (CP-102) and rod-shaped (KG-1000) particles of varying mass ra...
The purpose of this study is to establish a modeling approach that can be used to predict bulk po... more The purpose of this study is to establish a modeling approach that can be used to predict bulk powder flowability of pharmaceutical materials from their particle size and shape distributions. To build and validate the model, 23 commonly used pharmaceutical excipients and 38 binary blends were fully characterized for their particle size and shape distributions. The particle size and shape of each sample was characterized by multiple descriptors to fully reflect their morphological characteristics. The flow properties of these materials were analyzed using the Schulze Ring Shear Tester at a fixed humidity condition. A partial least squares (PLS) approach was used to build the mathematical model. Several different modeling approaches were attempted and the best method was identified as using a combination of formulation composition and particle size and shape distributions of single-component powder systems. The PLS model was shown to provide excellent predictions of powder flow function coefficient (FFC) of up to approximately 20. The results also revealed that both particle size and shape play an important role in determining the powder flow behavior.
The capability of the newly developed dynamic image analysis instrument QicPic equipped with the ... more The capability of the newly developed dynamic image analysis instrument QicPic equipped with the high-speed dry-powder-dispersing device was investigated systematically using various MCC particles. Instrument cross-validation was conducted by comparing the particle size distribution of spherical particles obtained with the QicPic and with a conventional laser diffraction instrument (HELOS). While good agreement was observed with spherical particles, significant differences were found when analyzing rod-shaped Ceolus KG-1000 particles, revealing the intrinsic difference in operating principles between these two techniques. Particle shape distributions of several spherical and rod-shaped samples obtained with the QicPic were compared to scanning electron micrographs (SEMs), and semi-quantitative agreement was obtained. The particle size and particle shape of a series of binary particulate systems composed of both spherical (CP-102) and rod-shaped (KG-1000) particles of varying mass ra...
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Papers by Weili Yu