Double patterning technique using spacer which can avoid CD (Critical Dimension) uniformity probl... more Double patterning technique using spacer which can avoid CD (Critical Dimension) uniformity problem mainly caused by overlay issue is one of the methods that could be applied to apply to manufacturing of memory devices. Though double exposure and etch technology ...
ABSTRACT Ultrathin stoichiometric Ta2O5 layer, which was formed by thermal oxidation of Ta layer ... more ABSTRACT Ultrathin stoichiometric Ta2O5 layer, which was formed by thermal oxidation of Ta layer on ALD TiO2, exhibits excellent selector characteristics. To maximize the selector performance, we adopted various interface engineering techniques such as Ta2O5 thickness, control of oxygen profile in TaOx layer, top electrode materials, and band gap of bottom insulating oxide layer. By optimizing process conditions, we obtained outstanding selector performances such as high current density (>107A/cm2), high selectivity (~104), better off-current (
We present a distance measurement method based on stereo vision system while guaranteeing accurac... more We present a distance measurement method based on stereo vision system while guaranteeing accuracy and reliability. It has been considered as difficult problem to measure both long and short distance with a stereo vision system accurately due to sampling error and camera sensor error. To resolve these problems of the stereo vision system, we utilize an algorithm which is consisted
2007 IEEE International Solid-State Circuits Conference. Digest of Technical Papers, 2007
... KwiYoung Kim, WooSeok Kim, HaJun Jeon, GyeSoo Koo, of the current mirror. To improve the dyna... more ... KwiYoung Kim, WooSeok Kim, HaJun Jeon, GyeSoo Koo, of the current mirror. To improve the dynamic PSRR for the sup-JiHyun Kim, JinHo Seo, MyeongLyong Ko, JaeWhui Kim ply noise in the 1.0V supply voltage, this work uses the following ...
Excitotoxin induces neurodegeneration via glutamatergic activation or oxidative stress, which mea... more Excitotoxin induces neurodegeneration via glutamatergic activation or oxidative stress, which means that the blockade of glutamate receptors and the scavenging of free radicals are potential therapeutic targets in neurodegenerative diseases. Sinapic acid (SA) has a GABA(A) receptor agonistic property and free radical scavenging activity. We investigated the neuroprotective effects of SA on kainic acid (KA)-induced hippocampal brain damage in mice. SA (10 mg/kg) by oral administration has an anticonvulsant effect on KA-induced seizure-like behavior. Moreover, SA (10 mg/kg) significantly attenuated KA-induced neuronal cell death in the CA1 and CA3 hippocampal regions when administered as late as 6 h after KA. In addition, flumazenil, a GABA(A) antagonist, blocked the effect of SA administered immediately after KA but not the effect of SA administered 6 h after KA. This late protective effect of SA was accompanied by reduced levels of reactive gliosis, inducible nitric oxide synthase expression, and nitrotyrosine formation in the hippocampus. In the passive avoidance task, KA-induced memory impairments were ameliorated by SA. These results suggest that the potential therapeutic effect of SA is due to its attenuation of KA-induced neuronal damage in the brain via its anti-convulsive activity through GABA(A) receptor activation and radical scavenging activity.
Patients with neocortical temporal lobe epilepsy (NTLE) may have less favorable outcome with ante... more Patients with neocortical temporal lobe epilepsy (NTLE) may have less favorable outcome with anterior temporal lobectomy than those with mesial temporal foci. The authors analyzed ictal intracranial electroencephalograms (EEGs) in patients with NTLE to identify features that predict surgical outcome. The following intracranial ictal EEG features in 31 consecutive medically intractable NTLE patients were studied: Frequency (i.e., low-voltage fast [>20 Hz], recruiting ictal-onset spikes, ictal-onset rhythms less than 5 Hz, ictal-onset rhythms with repetitive sharp waves between 5 and 20 Hz); extent of ictal onset (focal, sublobar, and lobar); localization within the temporal lobe (anterior, posterior, or regional); and the time to seizure spread outside the temporal lobe (rapid, intermediate, and slow). The average follow-up period was 36.7 months (range, 18 to 60 months). Findings between two outcome groups were compared: class I group (seizure-free) and class II to IV group (persistent seizures). Twenty-one (66.7%) of 31 patients with NTLE were seizure-free. Intracranial EEG features which were significantly associated with seizure-free outcome were focal or sublobar onset, anterior temporal onset, and slow propagation time (P < 0.05). There was a trend for patients with ictal onset morphologies of slow ictal-onset rhythm and repetitive sharp waves to be seizure-free (P = 0.07). Intracranial EEG is helpful in predicting surgical outcome in NTLE patients.
Two uterine adenomyomas with unusual features are presented. Case 1 was a 43-year-old woman who h... more Two uterine adenomyomas with unusual features are presented. Case 1 was a 43-year-old woman who had a 1-year history of menorrhagia and dysmenorrhea. The uterus showed a 3-cm-sized mass attached to the posterior wall of the lower uterine segment. On section, there was a well-circumscribed, submucosal cystic mass with a thick muscular wall. Histologically, the cavities were lined by well-developed secretory-phase endometrium and surrounded by smooth muscle, likeya small uterus. Case 2 was a 52-year-old woman who visited the hospital because of itching sensation on the vulva. On physical examination, the mass was found on the left side of the pelvis. The enlarged uterus had an 8-cm-sized protruding mass from the left side of the lower uterine segment. On section, the mass was cystic and solid. Histologically, the cysts were lined by thin basalis-type endometrial glands and stroma, and the solid portion was composed of smooth muscle and fat cells.
The aim of this study was to determine the mechanism underlying the neuroprotective effects of th... more The aim of this study was to determine the mechanism underlying the neuroprotective effects of the ethanolic extract of the seeds of Cassia obtusifolia (COE) (10 or 50mg/kg/day, p.o) on transient cerebral global ischemia induced by bilateral common carotid artery occlusion (2VO) in mice. Immunohistochemical and western blot studies showed that levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hippocampal CA1 region at 1day post-2VO were attenuated by COE (50mg/kg/day, p.o), which was administered immediately after 2VO. Furthermore, OX-42 - and glial fibrillary acidic protein (GFAP)-positive cell numbers at 4 days post-2VO were markedly attenuated by COE (50mg/kg/day, p.o) treatment for 4 days in CA1. Viable neurons detected by Nissl at 7 days post-2VO were increased by administering COE (50mg/kg/day, p.o) for 7 days. In addition, COE increased the expressions of phosphorylated cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in CA1 in naïve-control within 1 and 6h, respectively, and these expressions were also profoundly increased in 2VO-treated mice by COE at immediately post-2VO. These results suggest that the neuroprotective effects of COE are due to its anti-inflammatory effects and to its upregulation of BDNF expression and CREB phosphorylation.
Double patterning technique using spacer which can avoid CD (Critical Dimension) uniformity probl... more Double patterning technique using spacer which can avoid CD (Critical Dimension) uniformity problem mainly caused by overlay issue is one of the methods that could be applied to apply to manufacturing of memory devices. Though double exposure and etch technology ...
ABSTRACT Ultrathin stoichiometric Ta2O5 layer, which was formed by thermal oxidation of Ta layer ... more ABSTRACT Ultrathin stoichiometric Ta2O5 layer, which was formed by thermal oxidation of Ta layer on ALD TiO2, exhibits excellent selector characteristics. To maximize the selector performance, we adopted various interface engineering techniques such as Ta2O5 thickness, control of oxygen profile in TaOx layer, top electrode materials, and band gap of bottom insulating oxide layer. By optimizing process conditions, we obtained outstanding selector performances such as high current density (>107A/cm2), high selectivity (~104), better off-current (
We present a distance measurement method based on stereo vision system while guaranteeing accurac... more We present a distance measurement method based on stereo vision system while guaranteeing accuracy and reliability. It has been considered as difficult problem to measure both long and short distance with a stereo vision system accurately due to sampling error and camera sensor error. To resolve these problems of the stereo vision system, we utilize an algorithm which is consisted
2007 IEEE International Solid-State Circuits Conference. Digest of Technical Papers, 2007
... KwiYoung Kim, WooSeok Kim, HaJun Jeon, GyeSoo Koo, of the current mirror. To improve the dyna... more ... KwiYoung Kim, WooSeok Kim, HaJun Jeon, GyeSoo Koo, of the current mirror. To improve the dynamic PSRR for the sup-JiHyun Kim, JinHo Seo, MyeongLyong Ko, JaeWhui Kim ply noise in the 1.0V supply voltage, this work uses the following ...
Excitotoxin induces neurodegeneration via glutamatergic activation or oxidative stress, which mea... more Excitotoxin induces neurodegeneration via glutamatergic activation or oxidative stress, which means that the blockade of glutamate receptors and the scavenging of free radicals are potential therapeutic targets in neurodegenerative diseases. Sinapic acid (SA) has a GABA(A) receptor agonistic property and free radical scavenging activity. We investigated the neuroprotective effects of SA on kainic acid (KA)-induced hippocampal brain damage in mice. SA (10 mg/kg) by oral administration has an anticonvulsant effect on KA-induced seizure-like behavior. Moreover, SA (10 mg/kg) significantly attenuated KA-induced neuronal cell death in the CA1 and CA3 hippocampal regions when administered as late as 6 h after KA. In addition, flumazenil, a GABA(A) antagonist, blocked the effect of SA administered immediately after KA but not the effect of SA administered 6 h after KA. This late protective effect of SA was accompanied by reduced levels of reactive gliosis, inducible nitric oxide synthase expression, and nitrotyrosine formation in the hippocampus. In the passive avoidance task, KA-induced memory impairments were ameliorated by SA. These results suggest that the potential therapeutic effect of SA is due to its attenuation of KA-induced neuronal damage in the brain via its anti-convulsive activity through GABA(A) receptor activation and radical scavenging activity.
Patients with neocortical temporal lobe epilepsy (NTLE) may have less favorable outcome with ante... more Patients with neocortical temporal lobe epilepsy (NTLE) may have less favorable outcome with anterior temporal lobectomy than those with mesial temporal foci. The authors analyzed ictal intracranial electroencephalograms (EEGs) in patients with NTLE to identify features that predict surgical outcome. The following intracranial ictal EEG features in 31 consecutive medically intractable NTLE patients were studied: Frequency (i.e., low-voltage fast [>20 Hz], recruiting ictal-onset spikes, ictal-onset rhythms less than 5 Hz, ictal-onset rhythms with repetitive sharp waves between 5 and 20 Hz); extent of ictal onset (focal, sublobar, and lobar); localization within the temporal lobe (anterior, posterior, or regional); and the time to seizure spread outside the temporal lobe (rapid, intermediate, and slow). The average follow-up period was 36.7 months (range, 18 to 60 months). Findings between two outcome groups were compared: class I group (seizure-free) and class II to IV group (persistent seizures). Twenty-one (66.7%) of 31 patients with NTLE were seizure-free. Intracranial EEG features which were significantly associated with seizure-free outcome were focal or sublobar onset, anterior temporal onset, and slow propagation time (P < 0.05). There was a trend for patients with ictal onset morphologies of slow ictal-onset rhythm and repetitive sharp waves to be seizure-free (P = 0.07). Intracranial EEG is helpful in predicting surgical outcome in NTLE patients.
Two uterine adenomyomas with unusual features are presented. Case 1 was a 43-year-old woman who h... more Two uterine adenomyomas with unusual features are presented. Case 1 was a 43-year-old woman who had a 1-year history of menorrhagia and dysmenorrhea. The uterus showed a 3-cm-sized mass attached to the posterior wall of the lower uterine segment. On section, there was a well-circumscribed, submucosal cystic mass with a thick muscular wall. Histologically, the cavities were lined by well-developed secretory-phase endometrium and surrounded by smooth muscle, likeya small uterus. Case 2 was a 52-year-old woman who visited the hospital because of itching sensation on the vulva. On physical examination, the mass was found on the left side of the pelvis. The enlarged uterus had an 8-cm-sized protruding mass from the left side of the lower uterine segment. On section, the mass was cystic and solid. Histologically, the cysts were lined by thin basalis-type endometrial glands and stroma, and the solid portion was composed of smooth muscle and fat cells.
The aim of this study was to determine the mechanism underlying the neuroprotective effects of th... more The aim of this study was to determine the mechanism underlying the neuroprotective effects of the ethanolic extract of the seeds of Cassia obtusifolia (COE) (10 or 50mg/kg/day, p.o) on transient cerebral global ischemia induced by bilateral common carotid artery occlusion (2VO) in mice. Immunohistochemical and western blot studies showed that levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hippocampal CA1 region at 1day post-2VO were attenuated by COE (50mg/kg/day, p.o), which was administered immediately after 2VO. Furthermore, OX-42 - and glial fibrillary acidic protein (GFAP)-positive cell numbers at 4 days post-2VO were markedly attenuated by COE (50mg/kg/day, p.o) treatment for 4 days in CA1. Viable neurons detected by Nissl at 7 days post-2VO were increased by administering COE (50mg/kg/day, p.o) for 7 days. In addition, COE increased the expressions of phosphorylated cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in CA1 in naïve-control within 1 and 6h, respectively, and these expressions were also profoundly increased in 2VO-treated mice by COE at immediately post-2VO. These results suggest that the neuroprotective effects of COE are due to its anti-inflammatory effects and to its upregulation of BDNF expression and CREB phosphorylation.
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