To mitigate the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory s... more To mitigate the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), vaccines have been rapidly developed and introduced in many countries. In Colombia, the population was vaccinated with four vaccines. Therefore, this research aimed to determine the ability of the vaccines introduced in the National Vaccination Plan to prevent SARS-CoV-2 infection and induce seroconversion and sought to investigate the longevity of antibodies in the blood. We conducted a prospective, nonprobabilistic, consecutive cross-sectional cohort study in a population with access to vaccination with CoronaVac, Ad26.COV2.S, AZD1222, and BNT162b2 from March 2021 to March 2022. The study included 1327 vaccinated people. A plurality of participants were vaccinated with BNT162b2 (36.1%; n = 480), followed by Ad26.COV2.S (26.9%; n = 358), CoronaVac (24%; n = 331), and AZD1222 (11.9%; n = 158). The crude seroprevalence on day zero varied between 18.1% a...
La investigación titulada "Prevención y Abordaje de la Violencia Sexual en Personas con Disc... more La investigación titulada "Prevención y Abordaje de la Violencia Sexual en Personas con Discapacidad desde un Enfoque de Determinantes Sociales", además de ser un esfuerzo por encontrar respuesta a las preocupaciones de diversas organizaciones comprometidas con la garantía de los derechos de las personas con discapacidad, y en especial de los Derechos Sexuales y Derechos Reproductivos, expone a partir de las voces de las personas con discapacidad y sus familiares, la profundidad de la violencia sexual padecida, así como la complejidad de las causas estructurales, los significados y las consecuencias que deja sobre sus vidas.
While one out of 30 people in the world is displaced or a refugee, in Colombia one out of 46 peop... more While one out of 30 people in the world is displaced or a refugee, in Colombia one out of 46 people is a Venezuelan migrant. At the end of 2018, 1,032,016 Venezuelans had migrated to Colombia. During 2018, the migrant population in the states along the Venezuelan border increased by almost one million people (418%). Arauca, César, La Guajira and Norte de Santander received and hosted nearly two-thirds of the migrant population that has come to Colombia (Colombia Migration, 2018).
Journal of the European Academy of Dermatology and Venereology : JEADV, Jan 12, 2016
to determine survival of a cohort of patients with acral lentiginous melanoma (ALM), treated at t... more to determine survival of a cohort of patients with acral lentiginous melanoma (ALM), treated at the National Cancer Institute of Colombia, the largest referral hospital of the country. all patients diagnosed with an invasive ALM between 2003 and 2009 at the Colombian National Cancer Institute were included for analyses and followed for vital status and date of death. Using Kaplan-Meier methods, overall survival at 1, 3 and 5 years post diagnosis was determined, and Cox proportional hazards models were constructed for the variables showing a significant effect on survival in univariate analyses. Overall survival of this cohort of 90 patients was 77% at one year, 59% at three years and 54% at five years after diagnosis. Females had a better prognosis in univariate analyses but this advantage disappeared in multivariate models. Clinical stage was a strong predictor of survival, in univariate and multivariate models, particularly among elderly patients. prognosis of ALM in Colombia is r...
Colorectal cancer (CRC) is one of the prominent causes of cancer related deaths because, in part,... more Colorectal cancer (CRC) is one of the prominent causes of cancer related deaths because, in part, there is not an early, non-invasive, effective detection strategy. Circulating microRNAs (miRNAs) have been proposed as potential non-invasive biomarkers for CRC. In this study, we evaluated the miRNA profile in sixteen CRC tissues by Next-Generation-Sequencing and compared the circulating expression levels of 22 miRNAs among 45 CRC, 14 hyperplastic polyps, 11 advanced adenoma patients and 45 control subjects, by reverse transcription-quantitative PCR, to search for miRNAs which could be potential biomarkers. In total, nine of them represented 70% of total read counts (miR-10a-5p, miR-192-5p, miR-10b-5p, miR-22-3p, miR-26a-5p, miR-148a-3p, miR-181a-5p, miR-92a-3p and miR-143-5p). In silico analysis found eight candidates to mature miRNAs. With respect to circulating miRNA, we found higher serum expression levels of miR-143-3p, miR-141-3p and miR-200c-3p in the CRC and adenoma groups com...
Biomedica : revista del Instituto Nacional de Salud, 2016
There is hardly any information regarding years of life lost due to cancer in Colombia. To quanti... more There is hardly any information regarding years of life lost due to cancer in Colombia. To quantify total and average years of life lost due to cancer in Colombia, and to investigate changes in this burden between 1997 and 2012. We obtained sex-specific data on age distribution, remaining life expectancy, deaths due to specific cancers and total number of deaths from the Colombian Departamento Administrativo Nacional de Estadísticas. We calculated years of life lost based on each individual´s age at death and the remaining life expectancy at that age; as for average years of life, we divided these by the number of deaths due to specific cancers. The total number of cancer deaths increased by 33% between 1997 and 2012, comprising 15% of male and 20% of female deaths in the period 2010-2012. Total years of life lost due to cancer increased by 25.1% for males and 31.1% for females over the study period. The highest increases (>40%) were observed for colorectal, pancreas and kidney c...
To mitigate the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory s... more To mitigate the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), vaccines have been rapidly developed and introduced in many countries. In Colombia, the population was vaccinated with four vaccines. Therefore, this research aimed to determine the ability of the vaccines introduced in the National Vaccination Plan to prevent SARS-CoV-2 infection and induce seroconversion and sought to investigate the longevity of antibodies in the blood. We conducted a prospective, nonprobabilistic, consecutive cross-sectional cohort study in a population with access to vaccination with CoronaVac, Ad26.COV2.S, AZD1222, and BNT162b2 from March 2021 to March 2022. The study included 1327 vaccinated people. A plurality of participants were vaccinated with BNT162b2 (36.1%; n = 480), followed by Ad26.COV2.S (26.9%; n = 358), CoronaVac (24%; n = 331), and AZD1222 (11.9%; n = 158). The crude seroprevalence on day zero varied between 18.1% a...
La investigación titulada "Prevención y Abordaje de la Violencia Sexual en Personas con Disc... more La investigación titulada "Prevención y Abordaje de la Violencia Sexual en Personas con Discapacidad desde un Enfoque de Determinantes Sociales", además de ser un esfuerzo por encontrar respuesta a las preocupaciones de diversas organizaciones comprometidas con la garantía de los derechos de las personas con discapacidad, y en especial de los Derechos Sexuales y Derechos Reproductivos, expone a partir de las voces de las personas con discapacidad y sus familiares, la profundidad de la violencia sexual padecida, así como la complejidad de las causas estructurales, los significados y las consecuencias que deja sobre sus vidas.
While one out of 30 people in the world is displaced or a refugee, in Colombia one out of 46 peop... more While one out of 30 people in the world is displaced or a refugee, in Colombia one out of 46 people is a Venezuelan migrant. At the end of 2018, 1,032,016 Venezuelans had migrated to Colombia. During 2018, the migrant population in the states along the Venezuelan border increased by almost one million people (418%). Arauca, César, La Guajira and Norte de Santander received and hosted nearly two-thirds of the migrant population that has come to Colombia (Colombia Migration, 2018).
Journal of the European Academy of Dermatology and Venereology : JEADV, Jan 12, 2016
to determine survival of a cohort of patients with acral lentiginous melanoma (ALM), treated at t... more to determine survival of a cohort of patients with acral lentiginous melanoma (ALM), treated at the National Cancer Institute of Colombia, the largest referral hospital of the country. all patients diagnosed with an invasive ALM between 2003 and 2009 at the Colombian National Cancer Institute were included for analyses and followed for vital status and date of death. Using Kaplan-Meier methods, overall survival at 1, 3 and 5 years post diagnosis was determined, and Cox proportional hazards models were constructed for the variables showing a significant effect on survival in univariate analyses. Overall survival of this cohort of 90 patients was 77% at one year, 59% at three years and 54% at five years after diagnosis. Females had a better prognosis in univariate analyses but this advantage disappeared in multivariate models. Clinical stage was a strong predictor of survival, in univariate and multivariate models, particularly among elderly patients. prognosis of ALM in Colombia is r...
Colorectal cancer (CRC) is one of the prominent causes of cancer related deaths because, in part,... more Colorectal cancer (CRC) is one of the prominent causes of cancer related deaths because, in part, there is not an early, non-invasive, effective detection strategy. Circulating microRNAs (miRNAs) have been proposed as potential non-invasive biomarkers for CRC. In this study, we evaluated the miRNA profile in sixteen CRC tissues by Next-Generation-Sequencing and compared the circulating expression levels of 22 miRNAs among 45 CRC, 14 hyperplastic polyps, 11 advanced adenoma patients and 45 control subjects, by reverse transcription-quantitative PCR, to search for miRNAs which could be potential biomarkers. In total, nine of them represented 70% of total read counts (miR-10a-5p, miR-192-5p, miR-10b-5p, miR-22-3p, miR-26a-5p, miR-148a-3p, miR-181a-5p, miR-92a-3p and miR-143-5p). In silico analysis found eight candidates to mature miRNAs. With respect to circulating miRNA, we found higher serum expression levels of miR-143-3p, miR-141-3p and miR-200c-3p in the CRC and adenoma groups com...
Biomedica : revista del Instituto Nacional de Salud, 2016
There is hardly any information regarding years of life lost due to cancer in Colombia. To quanti... more There is hardly any information regarding years of life lost due to cancer in Colombia. To quantify total and average years of life lost due to cancer in Colombia, and to investigate changes in this burden between 1997 and 2012. We obtained sex-specific data on age distribution, remaining life expectancy, deaths due to specific cancers and total number of deaths from the Colombian Departamento Administrativo Nacional de Estadísticas. We calculated years of life lost based on each individual´s age at death and the remaining life expectancy at that age; as for average years of life, we divided these by the number of deaths due to specific cancers. The total number of cancer deaths increased by 33% between 1997 and 2012, comprising 15% of male and 20% of female deaths in the period 2010-2012. Total years of life lost due to cancer increased by 25.1% for males and 31.1% for females over the study period. The highest increases (>40%) were observed for colorectal, pancreas and kidney c...
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