Journal of Pharmaceutical and Biomedical Analysis, 2008
Inductively coupled plasma mass spectrometry (ICP-MS) technique was used to analyze the contamina... more Inductively coupled plasma mass spectrometry (ICP-MS) technique was used to analyze the contamination of selected 20 metals in 32 samples of honeybee venom and to demonstrate differences in the content of these elements. Among the analyzed metal microelements (Al, Co, Cu, Zn, Mn, Mo, B, V, Sr and Ni), macro-elements (Ca, Mg, K and Na) and toxic metals (As, Ba,
The aim of this study was to determine the monthly DTR mass load of amphetamine-type compounds in... more The aim of this study was to determine the monthly DTR mass load of amphetamine-type compounds in Poland as well as an investigation of cyclical behaviour by using time series analysis and especially trends analysis. Amphetamine, methamphetamine and MDMA (ecstasy) were detected in wastewater samples collected from the main Wastewater Treatment Plant in the city of Poznan using liquid chromatography / tandem mass spectrometry (LC-MS-MS). Back-calculations used in the sewage epidemiology approach were applied to estimate the DTR mass load level of the drugs analyzed. Trends analysis was performed by fitting the data to a simple linear regression and then by using smoothing by means of a moving average (Mat lab 2013a). Trend analysis displays a steady tendency of increase or decrease throughout time series. When we plot the observation against time, we may notice that a straight line can describe the increase or decrease in the series as time goes on. Simple linear regression and metho...
Annals of agricultural and environmental medicine : AAEM, 2013
Hymenoptera stings occur very frequently and usually are not dangerous. The normal reaction after... more Hymenoptera stings occur very frequently and usually are not dangerous. The normal reaction after sting includes such symptoms as: mild swelling, redness and pain lasting from several minutes to several hours. In contrast, in people with allergy to insect venom, severe local reactions and systemic symptoms, including anaphylactic shock, may occur. Diagnostic tests should be performed in persons who experience systemic symptoms after a sting. The basic tests used in the diagnosis of allergy to hymenoptera venom are skin tests and detection of venom-specific IgE antibodies. If it is not possible to make a diagnosis on the basis of these data, specialized diagnostic tests, such as cellular tests, inhibition test and determination of tryptase and carboxypeptidase, can be performed. The presented study provides an overview of currently used diagnostic methods, both those used in everyday practice and allergy tests, which are available only in selected specialized centres.
The aim of the study was to determine the profile of amphetamines consumed by a community in Pola... more The aim of the study was to determine the profile of amphetamines consumed by a community in Poland. Amphetamine, methamphetamine and MDMA (ecstasy) were detected in wastewater samples collected from the main Wastewater Treatment Plant in the city of Poznań (about 687 000 people) using liquid chromatography/tandem mass spectrometry (LC-MS-MS). Back-calculations used in the sewage epidemiology approach were applied to estimate the level of consumption of the drugs being analyzed. These types of studies were carried out for the first time in Poland for a considerable period--from June 2009 to December 2010. The analysis of variance (ANOVA) confirmed significant monthly differences in amphetamine consumption. The concentration of amphetamine, methamphetamine and MDMA in wastewater samples and the levels of their consumption were lower than reported in other European countries, but unexpectedly, the ratio of consumed methamphetamine to MDMA and the consumption level of methamphetamine w...
Combinatorial Chemistry & High Throughput Screening, 2014
The identification of endocrine-disrupting chemicals (EDCs) is one of the important goals of envi... more The identification of endocrine-disrupting chemicals (EDCs) is one of the important goals of environmental chemical hazard screening. The adverse health effects of EDCs in humans have been demonstrated to involve the developmental, reproductive, neurological, cardiovascular, metabolic, and immune systems. The present study reports QSAR classification studies on a large database comprising 8,212 compounds collected from the Estrogenic Activity Database and National Center for Biotechnology Information Database. In this study, four classification models (Bayesian Categorization Model with molecular fingerprints or molecular descriptors as an input and Neural Classification Models with and without Bayesian regularization) were used. Evaluation of these binomial classification methods indicated that the Bayesian method (Bayesian QSAR) works as an excellent method for prediction with fingerprints used as input. In the case of the multilayer perceptron with molecular descriptors as inputs, changing the training mode by introducing a Bayesian regularization algorithm significantly improved ANNs' predictive power. Our goal was to test two popular classification methods suitable for processing large data sets. Such datasets were required to ensure the prediction performances and applicability of the models as a virtual screening tool for an extensive database.
... and aluminum stock solutions were prepared by dissolving weighed amounts of salts in 0.1 ... ... more ... and aluminum stock solutions were prepared by dissolving weighed amounts of salts in 0.1 ... where Q is a molecule of fluoroquinolone, M is a metal ion and QM ... The equilibrium constants betweenfluoroquinolones and metal ions, disre-garding the difference between activities ...
Journal of Pharmaceutical and Biomedical Analysis, 2008
Inductively coupled plasma mass spectrometry (ICP-MS) technique was used to analyze the contamina... more Inductively coupled plasma mass spectrometry (ICP-MS) technique was used to analyze the contamination of selected 20 metals in 32 samples of honeybee venom and to demonstrate differences in the content of these elements. Among the analyzed metal microelements (Al, Co, Cu, Zn, Mn, Mo, B, V, Sr and Ni), macro-elements (Ca, Mg, K and Na) and toxic metals (As, Ba,
The aim of this study was to determine the monthly DTR mass load of amphetamine-type compounds in... more The aim of this study was to determine the monthly DTR mass load of amphetamine-type compounds in Poland as well as an investigation of cyclical behaviour by using time series analysis and especially trends analysis. Amphetamine, methamphetamine and MDMA (ecstasy) were detected in wastewater samples collected from the main Wastewater Treatment Plant in the city of Poznan using liquid chromatography / tandem mass spectrometry (LC-MS-MS). Back-calculations used in the sewage epidemiology approach were applied to estimate the DTR mass load level of the drugs analyzed. Trends analysis was performed by fitting the data to a simple linear regression and then by using smoothing by means of a moving average (Mat lab 2013a). Trend analysis displays a steady tendency of increase or decrease throughout time series. When we plot the observation against time, we may notice that a straight line can describe the increase or decrease in the series as time goes on. Simple linear regression and metho...
Annals of agricultural and environmental medicine : AAEM, 2013
Hymenoptera stings occur very frequently and usually are not dangerous. The normal reaction after... more Hymenoptera stings occur very frequently and usually are not dangerous. The normal reaction after sting includes such symptoms as: mild swelling, redness and pain lasting from several minutes to several hours. In contrast, in people with allergy to insect venom, severe local reactions and systemic symptoms, including anaphylactic shock, may occur. Diagnostic tests should be performed in persons who experience systemic symptoms after a sting. The basic tests used in the diagnosis of allergy to hymenoptera venom are skin tests and detection of venom-specific IgE antibodies. If it is not possible to make a diagnosis on the basis of these data, specialized diagnostic tests, such as cellular tests, inhibition test and determination of tryptase and carboxypeptidase, can be performed. The presented study provides an overview of currently used diagnostic methods, both those used in everyday practice and allergy tests, which are available only in selected specialized centres.
The aim of the study was to determine the profile of amphetamines consumed by a community in Pola... more The aim of the study was to determine the profile of amphetamines consumed by a community in Poland. Amphetamine, methamphetamine and MDMA (ecstasy) were detected in wastewater samples collected from the main Wastewater Treatment Plant in the city of Poznań (about 687 000 people) using liquid chromatography/tandem mass spectrometry (LC-MS-MS). Back-calculations used in the sewage epidemiology approach were applied to estimate the level of consumption of the drugs being analyzed. These types of studies were carried out for the first time in Poland for a considerable period--from June 2009 to December 2010. The analysis of variance (ANOVA) confirmed significant monthly differences in amphetamine consumption. The concentration of amphetamine, methamphetamine and MDMA in wastewater samples and the levels of their consumption were lower than reported in other European countries, but unexpectedly, the ratio of consumed methamphetamine to MDMA and the consumption level of methamphetamine w...
Combinatorial Chemistry & High Throughput Screening, 2014
The identification of endocrine-disrupting chemicals (EDCs) is one of the important goals of envi... more The identification of endocrine-disrupting chemicals (EDCs) is one of the important goals of environmental chemical hazard screening. The adverse health effects of EDCs in humans have been demonstrated to involve the developmental, reproductive, neurological, cardiovascular, metabolic, and immune systems. The present study reports QSAR classification studies on a large database comprising 8,212 compounds collected from the Estrogenic Activity Database and National Center for Biotechnology Information Database. In this study, four classification models (Bayesian Categorization Model with molecular fingerprints or molecular descriptors as an input and Neural Classification Models with and without Bayesian regularization) were used. Evaluation of these binomial classification methods indicated that the Bayesian method (Bayesian QSAR) works as an excellent method for prediction with fingerprints used as input. In the case of the multilayer perceptron with molecular descriptors as inputs, changing the training mode by introducing a Bayesian regularization algorithm significantly improved ANNs' predictive power. Our goal was to test two popular classification methods suitable for processing large data sets. Such datasets were required to ensure the prediction performances and applicability of the models as a virtual screening tool for an extensive database.
... and aluminum stock solutions were prepared by dissolving weighed amounts of salts in 0.1 ... ... more ... and aluminum stock solutions were prepared by dissolving weighed amounts of salts in 0.1 ... where Q is a molecule of fluoroquinolone, M is a metal ion and QM ... The equilibrium constants betweenfluoroquinolones and metal ions, disre-garding the difference between activities ...
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