Professor of physiology Univesity Paris VIIProfessor of biophysics University Paris XIProfessor of Institut National de Sciences et Techniques Nucléaires (INSTN-CEA)Ex- clinical expert at the European Evaluation Medivines Agency Nuclear medicine specialist
... of Clinical Physiology and Nuclear Medicine Aarhus University Hospital-Skejby DK-8230 Aarhus ... more ... of Clinical Physiology and Nuclear Medicine Aarhus University Hospital-Skejby DK-8230 Aarhus N Denmark Julie Ferzli Department ... Turkey), Jorgen Frokiaer (Aarhus, Denmark), Joseph V. Nally (Cleveland, USA), Patrick O'Reilly (Stockport, UK), Pilar Orellana (Santiago, Chile ...
... of Clinical Physiology and Nuclear Medicine Aarhus University Hospital-Skejby DK-8230 Aarhus ... more ... of Clinical Physiology and Nuclear Medicine Aarhus University Hospital-Skejby DK-8230 Aarhus N Denmark Julie Ferzli Department ... Turkey), Jorgen Frokiaer (Aarhus, Denmark), Joseph V. Nally (Cleveland, USA), Patrick O'Reilly (Stockport, UK), Pilar Orellana (Santiago, Chile ...
Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique, 1995
Les mesures du debit de filtration glomerulaire (DFG) participent a notre comprehension de la phy... more Les mesures du debit de filtration glomerulaire (DFG) participent a notre comprehension de la physiologie et de la physiopathologie renales. La connaissance de ce parametre est necessaire au diagnostic et au suivi de l'insuffisance renale. L'objectif de cette revue est de faire le point sur les differentes techniques de mesure du DFG, leurs performances et leurs resultats. Nous rappellerons les caracteristiques de la clairance renale de l'inuline, methode classique de reference, et les nouvelles techniques faisant appel a l'utilisation de radiopharmaceutiques comme traceurs de filtration glomerulaire, apres injection unique et sans catheterisme vesical. Des techniques simplifiees permettent de s'affranchir des difficultes de recueil des urines. L'utilisation des clairances renales des nouveaux traceurs, et, pour certaines indications, des clairances plasmatiques, fournit des mesures precises du DFG sans les contraintes de la clairance de l'inuline. Le rec...
Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique, 1995
Cet article examine la valeur des differentes methodes utilisees tant pour le depistage de la ste... more Cet article examine la valeur des differentes methodes utilisees tant pour le depistage de la stenose arterielle renale chez l'hypertendu que pour le diagnostic de l'hypertension renovasculaire, dans le but de proposer quelques conseils pour la demarche diagnostique.
European journal of nuclear medicine and molecular imaging, Nov 30, 2018
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and ... more The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote the science, technology, and practical application of nuclear medicine. The European Association of Nuclear Medicine (EANM) is a professional nonprofit medical association that facilitates communication worldwide between individuals pursuing clinical and research excellence in nuclear medicine. The EANM was founded in 1985. SNMMI and EANM members are physicians, technologists, and scientists specializing in the research and practice of nuclear medicine. The SNMMI and EANM will periodically define new guidelines for nuclear medicine practice to help advance the science of nuclear medicine and to improve the quality of service to patients throughout the world. Existing practice guidelines will be reviewed for revision or renewal, as appropriate, on their fifth anniversary, or sooner, if indicated. Each practice guideline, representing a ...
ABSTRACT Both Langerhans’ cell histiocytosis (LCH) or non-LCH histiocytosis represent rare inflam... more ABSTRACT Both Langerhans’ cell histiocytosis (LCH) or non-LCH histiocytosis represent rare inflammatory diseases characterized by histiocytic infiltration. The objectives of this study were to evaluate 18F FDG PET/CT contribution to the metabolic characterization of histiocytoses and to assess the metabolic response to different immunomodulatory treatments.
Neogalactosylated and neolactosylated albumins are currently used as radiopharmaceutical agents f... more Neogalactosylated and neolactosylated albumins are currently used as radiopharmaceutical agents for imaging the liver asialoglycoprotein receptors, which allows the quantification of hepatic liver function in various diseases and also in healthy liver transplant donors. We developed an original process for synthesizing a chelating neolactosylated human albumin using maleimidopropyl-lactose and maleimidopropyl-diethylene triamine pentaacetic acid (DTPA) derivatives. The lactosylated protein (LACTAL) conjugate showed excellent liver uptake compared to nonlactosylated protein and a very high signal-to-noise ratio, based on functional assessment of biodistribution in mice using (99m)Tc-scintigraphy.
To evaluate if measurement of split renal function ( SRF split renal function ) with dynamic cont... more To evaluate if measurement of split renal function ( SRF split renal function ) with dynamic contrast material-enhanced ( DCE dynamic contrast enhanced ) magnetic resonance (MR) urography is equivalent to that with renal scintigraphy ( RS renal scintigraphy ) in patients suspected of having chronic urinary obstruction. The study protocol was approved by the institutional ethics committee of the coordinating center on behalf of all participating centers. Informed consent was obtained from all adult patients or both parents of children. This prospective, comparative study included 369 pediatric and adult patients from 14 university hospitals who were suspected of having chronic or intermittent urinary obstruction, and data from 295 patients with complete data were used for analysis. SRF split renal function was measured by using the area under the curve and the Patlak-Rutland methods, including successive review by a senior and an expert reviewer and measurement of intra- and interobserver agreement for each technique. An equivalence test for mean SRF split renal function was conducted with an α of 5%. Reproducibility was substantial to almost perfect for both methods. Equivalence of DCE dynamic contrast enhanced MR urography and RS renal scintigraphy for measurement of SRF split renal function was shown in patients with moderately dilated kidneys (P < .001 with the Patlak-Rutland method). However, in severely dilated kidneys, the mean SRF split renal function measurement was underestimated by 4% when DCE dynamic contrast enhanced MR urography was used compared with that when RS renal scintigraphy was used. Age and type of MR imaging device had no significant effect. For moderately dilated kidneys, equivalence of DCE dynamic contrast enhanced MR urography to RS renal scintigraphy was shown, with a standard deviation of approximately 12% between the techniques, making substitution of DCE dynamic contrast enhanced MR urography for RS renal scintigraphy acceptable. For severely dilated kidneys, a mean underestimation of SRF split renal function of 4% should be expected with DCE dynamic contrast enhanced MR urography, making substitution questionable.
ABSTRACT Introduction. - The nuclear medicine physician is a member of a team responsible for the... more ABSTRACT Introduction. - The nuclear medicine physician is a member of a team responsible for the safe and correct implementation of radioactivity-based procedures. To ensure the consistent provision of high-quality services, sufficient education and training are necessary. The aim of this study was to provide a structured description of the present status of the education and training framework in 12 EANM member or affiliated member countries. Materials and methods. - The acquisition of data describing national education and training systems was based on a questionnaire prepared by the authors. It comprised 19 questiOns related to education and training, the different professional levels, the presence or not of a national register and its characteristics, and finally of other miscellaneous professional issues. Results. - In the majority of cases, being an accredited nuclear medicine physician is required to practice nuclear medicine. The specialty duration ranges from 4 to 6 years (or 5 to 7 years for dual accreditation). Successful completion of the specialty requires satisfaction of time-related as well as other threshold criteria. A national register is available in the majority of the countries. There can be a register renewal mechanism, based on a Continuing Professional Development system. Discussion. - In conclusion, a common policy is generally followed in the countries evaluated, notwithstanding the presence of a few noted differences. Certain suggestions have been made, including the proposed threshold criteria for successful specialty completion, standardization of radiology-related training, the adoption of Continuing Professional Development systems and national registers' renewal mechanisms.
... of Clinical Physiology and Nuclear Medicine Aarhus University Hospital-Skejby DK-8230 Aarhus ... more ... of Clinical Physiology and Nuclear Medicine Aarhus University Hospital-Skejby DK-8230 Aarhus N Denmark Julie Ferzli Department ... Turkey), Jorgen Frokiaer (Aarhus, Denmark), Joseph V. Nally (Cleveland, USA), Patrick O'Reilly (Stockport, UK), Pilar Orellana (Santiago, Chile ...
... of Clinical Physiology and Nuclear Medicine Aarhus University Hospital-Skejby DK-8230 Aarhus ... more ... of Clinical Physiology and Nuclear Medicine Aarhus University Hospital-Skejby DK-8230 Aarhus N Denmark Julie Ferzli Department ... Turkey), Jorgen Frokiaer (Aarhus, Denmark), Joseph V. Nally (Cleveland, USA), Patrick O'Reilly (Stockport, UK), Pilar Orellana (Santiago, Chile ...
Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique, 1995
Les mesures du debit de filtration glomerulaire (DFG) participent a notre comprehension de la phy... more Les mesures du debit de filtration glomerulaire (DFG) participent a notre comprehension de la physiologie et de la physiopathologie renales. La connaissance de ce parametre est necessaire au diagnostic et au suivi de l'insuffisance renale. L'objectif de cette revue est de faire le point sur les differentes techniques de mesure du DFG, leurs performances et leurs resultats. Nous rappellerons les caracteristiques de la clairance renale de l'inuline, methode classique de reference, et les nouvelles techniques faisant appel a l'utilisation de radiopharmaceutiques comme traceurs de filtration glomerulaire, apres injection unique et sans catheterisme vesical. Des techniques simplifiees permettent de s'affranchir des difficultes de recueil des urines. L'utilisation des clairances renales des nouveaux traceurs, et, pour certaines indications, des clairances plasmatiques, fournit des mesures precises du DFG sans les contraintes de la clairance de l'inuline. Le rec...
Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique, 1995
Cet article examine la valeur des differentes methodes utilisees tant pour le depistage de la ste... more Cet article examine la valeur des differentes methodes utilisees tant pour le depistage de la stenose arterielle renale chez l'hypertendu que pour le diagnostic de l'hypertension renovasculaire, dans le but de proposer quelques conseils pour la demarche diagnostique.
European journal of nuclear medicine and molecular imaging, Nov 30, 2018
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and ... more The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote the science, technology, and practical application of nuclear medicine. The European Association of Nuclear Medicine (EANM) is a professional nonprofit medical association that facilitates communication worldwide between individuals pursuing clinical and research excellence in nuclear medicine. The EANM was founded in 1985. SNMMI and EANM members are physicians, technologists, and scientists specializing in the research and practice of nuclear medicine. The SNMMI and EANM will periodically define new guidelines for nuclear medicine practice to help advance the science of nuclear medicine and to improve the quality of service to patients throughout the world. Existing practice guidelines will be reviewed for revision or renewal, as appropriate, on their fifth anniversary, or sooner, if indicated. Each practice guideline, representing a ...
ABSTRACT Both Langerhans’ cell histiocytosis (LCH) or non-LCH histiocytosis represent rare inflam... more ABSTRACT Both Langerhans’ cell histiocytosis (LCH) or non-LCH histiocytosis represent rare inflammatory diseases characterized by histiocytic infiltration. The objectives of this study were to evaluate 18F FDG PET/CT contribution to the metabolic characterization of histiocytoses and to assess the metabolic response to different immunomodulatory treatments.
Neogalactosylated and neolactosylated albumins are currently used as radiopharmaceutical agents f... more Neogalactosylated and neolactosylated albumins are currently used as radiopharmaceutical agents for imaging the liver asialoglycoprotein receptors, which allows the quantification of hepatic liver function in various diseases and also in healthy liver transplant donors. We developed an original process for synthesizing a chelating neolactosylated human albumin using maleimidopropyl-lactose and maleimidopropyl-diethylene triamine pentaacetic acid (DTPA) derivatives. The lactosylated protein (LACTAL) conjugate showed excellent liver uptake compared to nonlactosylated protein and a very high signal-to-noise ratio, based on functional assessment of biodistribution in mice using (99m)Tc-scintigraphy.
To evaluate if measurement of split renal function ( SRF split renal function ) with dynamic cont... more To evaluate if measurement of split renal function ( SRF split renal function ) with dynamic contrast material-enhanced ( DCE dynamic contrast enhanced ) magnetic resonance (MR) urography is equivalent to that with renal scintigraphy ( RS renal scintigraphy ) in patients suspected of having chronic urinary obstruction. The study protocol was approved by the institutional ethics committee of the coordinating center on behalf of all participating centers. Informed consent was obtained from all adult patients or both parents of children. This prospective, comparative study included 369 pediatric and adult patients from 14 university hospitals who were suspected of having chronic or intermittent urinary obstruction, and data from 295 patients with complete data were used for analysis. SRF split renal function was measured by using the area under the curve and the Patlak-Rutland methods, including successive review by a senior and an expert reviewer and measurement of intra- and interobserver agreement for each technique. An equivalence test for mean SRF split renal function was conducted with an α of 5%. Reproducibility was substantial to almost perfect for both methods. Equivalence of DCE dynamic contrast enhanced MR urography and RS renal scintigraphy for measurement of SRF split renal function was shown in patients with moderately dilated kidneys (P < .001 with the Patlak-Rutland method). However, in severely dilated kidneys, the mean SRF split renal function measurement was underestimated by 4% when DCE dynamic contrast enhanced MR urography was used compared with that when RS renal scintigraphy was used. Age and type of MR imaging device had no significant effect. For moderately dilated kidneys, equivalence of DCE dynamic contrast enhanced MR urography to RS renal scintigraphy was shown, with a standard deviation of approximately 12% between the techniques, making substitution of DCE dynamic contrast enhanced MR urography for RS renal scintigraphy acceptable. For severely dilated kidneys, a mean underestimation of SRF split renal function of 4% should be expected with DCE dynamic contrast enhanced MR urography, making substitution questionable.
ABSTRACT Introduction. - The nuclear medicine physician is a member of a team responsible for the... more ABSTRACT Introduction. - The nuclear medicine physician is a member of a team responsible for the safe and correct implementation of radioactivity-based procedures. To ensure the consistent provision of high-quality services, sufficient education and training are necessary. The aim of this study was to provide a structured description of the present status of the education and training framework in 12 EANM member or affiliated member countries. Materials and methods. - The acquisition of data describing national education and training systems was based on a questionnaire prepared by the authors. It comprised 19 questiOns related to education and training, the different professional levels, the presence or not of a national register and its characteristics, and finally of other miscellaneous professional issues. Results. - In the majority of cases, being an accredited nuclear medicine physician is required to practice nuclear medicine. The specialty duration ranges from 4 to 6 years (or 5 to 7 years for dual accreditation). Successful completion of the specialty requires satisfaction of time-related as well as other threshold criteria. A national register is available in the majority of the countries. There can be a register renewal mechanism, based on a Continuing Professional Development system. Discussion. - In conclusion, a common policy is generally followed in the countries evaluated, notwithstanding the presence of a few noted differences. Certain suggestions have been made, including the proposed threshold criteria for successful specialty completion, standardization of radiology-related training, the adoption of Continuing Professional Development systems and national registers' renewal mechanisms.
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