• HiReSPECT imaging is used for biomedical research and molecular imaging. • The SIMIND Monte Car... more • HiReSPECT imaging is used for biomedical research and molecular imaging. • The SIMIND Monte Carlo program was used to simulate the HiReSPECT system. • Collimator geometry and material play critical roles in SPECT imaging. • Gold LEHR collimator with 0.3 mm hole diameter provide suitable image quality in HiReSPECT.
The collimator in single photon emission computed tomography (SPECT), is an important part of the... more The collimator in single photon emission computed tomography (SPECT), is an important part of the imaging chain. One of the most important collimators that used in research, preclinical study, small animal, and organ imaging is the pinhole collimator. Pinhole collimator can improve the tradeoff between sensitivity and resolution in comparison with conventional parallel-hole collimator and facilities diagnosis. However, a major problem with pinhole collimator is a small field of view (FOV). Multi-pinhole collimator has been investigated in order to increase the sensitivity and FOV with a preserved spatial resolution. The geometry of pinhole and multi-pinhole collimators is a critical factor in the image quality and plays a key role in SPECT imaging. The issue of the material and geometry for pinhole and multi-pinhole collimators have been a controversial and much disputed subject within the field of SPECT imaging. On the other hand, recent developments in collimator optimization have...
The detector in single-photon emission computed tomography has played a key role in the quality o... more The detector in single-photon emission computed tomography has played a key role in the quality of the images. Over the past few decades, developments in semiconductor detector technology provided an appropriate substitution for scintillation detectors in terms of high sensitivity, better energy resolution, and also high spatial resolution. One of the considered detectors is cadmium telluride (CdTe). The purpose of this paper is to review the CdTe semiconductor detector used in preclinical studies, small organ and small animal imaging, also research in nuclear medicine and other medical imaging modalities by a complete inspect on the material characteristics, irradiation principles, applications, and epitaxial growth method.
BACKGROUND: Acquiring a high quality image has assigned an important concern for obtaining accura... more BACKGROUND: Acquiring a high quality image has assigned an important concern for obtaining accurate diagnosis in nuclear medicine. Detector is a critical component of Single Photon Emission Computed Tomography (SPECT) imaging system for giving accurate information from exact pattern of radionuclide distribution in the target organ. The images are strongly affected by the attenuation, scattering, and response of the detector. The conventional detector is mainly made from sodium iodide activated by thallium [NaI(Tl)] in nuclear medicine imaging. The aim of the study. This study has planned to introduce a suitable for an optimized SPECT imaging. SIMIND Monte Carlo program was utilized for simulating a SPECT imaging system with a NaI(Tl) detector, and a low-energy high-resolution (LEHR) collimator. MATERIAL AND METHODS: The Planar and SPECT scans of a 99m Tc point source and also an extended Cardiac-Torso (XCAT) computerized phantom with the experiment and simulated systems were prepared. After verification and validation of the simulated system, the similar scans of the phantoms were compared from the point of view of image quality for 7 scintillator crystals including: NaI(Tl), BGO, YAG:Ce, YAP:Ce, LuAG:Ce, LaBr 3 and CZT. The parameters of energy and spatial resolution, and sensitivity of the systems were compared. Images were analyzed quantitatively by SSIM algorithm with Zhou Wang and Rouse/Hemami methods, and also qualitatively by two nuclear medicine specialists. RESULTS: Energy resolutions of the mentioned crystals obtained were
Purpose: Micro Single Photon Emission Computed Tomography (Micro-SPECT) system has recently been ... more Purpose: Micro Single Photon Emission Computed Tomography (Micro-SPECT) system has recently been introduced on nuclear medicine in the preclinical and research in which NaI (Tl) and Cadmium Telluride (CdTe) are used as the gamma-ray detectors with more generally use of NaI (Tl). The present study aimed to evaluate different thicknesses of the NaI (Tl) and (CdTe) detectors on functional parameters of a micro-SPECT system. Materials and Methods: A Micro-SPECT system with CdTe semiconductor detector and a hexagonal parallel hole collimator with a hole diameter of 0.11 mm, high of 24.05 mm, and septal thickness of 0.016 mm was simulated by Simulating Medical Imaging Nuclear Detectors (SIMIND) Monte Carlo program. The system performance was assessed by comparing the functional parameters, including system efficiency, sensitivity, energy and spatial resolution with the NaI (Tl) detector. The simulated scans of a 99mTc point source, a digital micro-Jacszack phantom, and a voxelized MOBY mo...
Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition that resu... more Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition that results from incomplete resolution of thromboemboli in pulmonary arteries. Symptomatic patients with chronic thromboembolic disease may have normal hemodynamic at rest. The aim of this study is to evaluate the outcome of pulmonary endarterectomy (PEA) in symptomatic patients with chronic thromboembolic pulmonary disease (CTEPD) in the absence of pulmonary hypertension as currently defined (mean pulmonary artery pressure [mPAP] < 20 mm Hg). Patients and Methods Here, we report four symptomatic patients with chronic thromboembolic and normal hemodynamic at rest (mPAP ≤20 mm Hg or 20 < mPAP < 25 mm Hg and pulmonary vascular resistance [PVR] < 240 dyn·s/cm5) who underwent PEA between September 2015 and September 2019. The main outcome measures were functional New York Heart Association class, 6-minute walk distance (6MWD), hemodynamic measures in right heart catheterization (RHC), mo...
Egyptian Journal of Radiology and Nuclear Medicine, 2021
Background Parkinson’s disease (PD) diagnosis is yet largely based on the related clinical aspect... more Background Parkinson’s disease (PD) diagnosis is yet largely based on the related clinical aspects. However, genetics, biomarkers, and neuroimaging studies have demonstrated a confirming role in the diagnosis, and future developments might be used in a pre-symptomatic phase of the disease. Main text This review provides an update on the current applications of neuroimaging modalities for PD diagnosis. A literature search was performed to find published studies that were involved on the application of different imaging modalities for PD diagnosis. An organized search of PubMed/MEDLINE, Embase, ProQuest, Scopus, Cochrane, and Google Scholar was performed based on MeSH keywords and suitable synonyms. Two researchers (TM and JPI) independently and separately performed the literature search. Our search strategy in each database was done by the following terms: ((Parkinson [Title/Abstract]) AND ((“Parkinsonian syndromes ”[Mesh]) OR Parkinsonism [Title/Abstract])) AND ((PET [Title/Abstract...
Abomasal hypomotility is one of the important causes of neonatal mortality in small ruminants. Va... more Abomasal hypomotility is one of the important causes of neonatal mortality in small ruminants. Various pharmaceutical agents have been studied to address this problem in large ruminants. The aim of this study was to determine the effect of parenteral administration of tylosin and ivermectin on abomasal emptying rate in neonatal suckling lambs. Abomasal emptying rate was assessed using nuclear scintigraphic method in 10 healthy female Iranian fat tailed Ghezel lambs. Each lamb was tested three times, once as a control (1 ml of saline 0.9%, IM) and twice after the injection of tylosin (17.6 mg/kg, IM) and ivermectin (200 μg/kg, SC) in a crossover study. Based on radiopharmaceutical counts, remnant activity in abomasums at 90 min were 48.3 ± 3.5, 45.6 ± 7.5 and 41.6 ± 2.9% in control, tylosin and ivermectin groups, respectively. Administration of tylosin (p = 0.049) and ivermectin (p = 0.045) to lambs, significantly caused faster abomasal emptying rate compared to control. Evaluating t...
The purpose of this study was count the white blood cells following injection of technetium-99m i... more The purpose of this study was count the white blood cells following injection of technetium-99m in the cat. Radioactive materials can be used in diagnostic and therapeutic procedures. Technetium is used in most labeling and nuclear medicine diagnostic studies because of its favorable conditions in the body. In this study, injection of technetium-99m was used to evaluate the possible changes in the number of white blood cells because these cells are used in labeling and tracing of radioactive materials in the body and their alterations are important in many operations. In the present study, technetium was milked from Molybdenum to technetium generator and it was rapidly injected in 1.5 mCi into six cats through the femoral vein. A group of four other cats were used as controls after injection of saline. At 0, 30, 60 minutes, 24 and 48 hours after injection, blood samples were collected from all cats and the number of white blood cells were counted. This study did not show any significant changes in the amount of white blood cells in the two groups. Thus, the results of this study outlines the advantage of using technetium-99m as a radio-drug in treatment and diagnostic procedures.
Introduction: Myocardial perfusion SPECTby 99mTc-Sestamibi and 99mTc-Tetrofosmin radiopharmaceuti... more Introduction: Myocardial perfusion SPECTby 99mTc-Sestamibi and 99mTc-Tetrofosmin radiopharmaceuticals usually presents a false significant increase in the radiotracer uptake in the inferior myocardium due to the uptake in organs such as liver, bowel, stomach and biliary system. The present study evaluated a suitable Slit angle for differentiating extra-cardiac activities by Slit Slat collimation. Methods: The Siemens E.CAM gamma camera equipped with a Low Energy High Resolution (LEHR) collimator was simulated with the Simulating Medical Imaging Nuclear Detectors (SIMIND) Monte Carlo program. Following the verification of the simulation, a Slit Slat collimator was simulated for SPECT imaging of a NURBS-based Cardiac Torso (NCAT) phantom with different Slit angels ranged from 0 to 30 degrees. The reconstructed images were qualitatively assessed with blinded observer method by three nuclear medicine specialists. Results:The improved differentiation of the bowel activity from the cardia...
Background Parkinsonism as a group of movement disorders, exhibit similar clinical presentation. ... more Background Parkinsonism as a group of movement disorders, exhibit similar clinical presentation. Therefore, clinically differentiating these diseases is difficult. We investigated the diagnostic value of 99m Tc-TRODAT-1 SPECT in this setting. Due to the fact that this modality has some limitations in imaging small organs like the sub-regions of basal ganglia, we also evaluated the use of anatomical MR imaging along with functional SPECT imaging in parkinsonism. Methods This follow-up diagnostic test evaluation study was performed with 40 patients with the clinical presentation of parkinsonism, and 10 healthy subjects as controls. After administration of the radiopharmaceutical, SPECT images were acquired, then co-registered on MRI. Uptake values were evaluated in basal ganglia semi-quantitatively. Results In this study, 99mTc-TRODAT-1 SPECT was able to differentiate essential tremor and healthy subjects from progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) with a se...
Thyroid nodules are a common clinical problem. Epidemiologic studies have shown the prevalence of... more Thyroid nodules are a common clinical problem. Epidemiologic studies have shown the prevalence of palpable thyroid nodules to be approximately 5% in women and 1% in men living in iodine-sufficient area but high resolution ultrasound can detect thyroid nodules in 19%-68% depending to age of patients. The patient is a 64 year old man who was presented to our medical center 7 year after a right hemithyroidectomy due to a large nodule. Fine needle aspiration of the thyroid nodule demonstrated Adenomatous goiter. Pathology of the nodule was follicular variant of papillary thyroid carcinoma with capsular invasion and the patient didn’t any follow up until 8 months ago who came to this center with pain in left Humerus. Lung and bone metastases are a relatively uncommon finding in patients with well differentiated thyroid cancer. Radio Iodine therapy of Iodine-avid bone metastases has been associated with improved survival and should be employed although Radioactive Iodine is rarely curativ...
The aim of this study was to evaluate the efficacy of Tc-ECD radiodrug in cat's brain scintig... more The aim of this study was to evaluate the efficacy of Tc-ECD radiodrug in cat's brain scintigraphy . In present study, 12 adult healthy cats were selected and brain scintigraphy was done with radiopharmaceutical TcECD in these cats. In this method, the administration of radioisotopes to the body and accumulation of these substances in the target tissues, specific imaging is obtained, which is based on distribution of gamma radiations exposed from these radioisotopes and recording of them. For scintigraphy, animals were taken under anesthetic condition and TC-ECD was injected from femoral vein as bolus at the 2 mCi. 20 minutes after intravenous injection of radioidrug scintigraphic operations were done. The ROIs can be drawn in all scans and radioactive counts were easily measured. Our results show that the radiopharmaceutical Tc-ECD has excellent evaluate the efficacy in cat's brain scintigraphy. [Gholamreza Assadnassab, Shahram Dabiri Oskoei, Babak Mahmoudian, Mohammadreza ...
Iranian fat tailed Ghezel lambs, 7-10 days of age, were fasted at least 12 h and then fed with 1 ... more Iranian fat tailed Ghezel lambs, 7-10 days of age, were fasted at least 12 h and then fed with 1 mCi of 99m Tc-DTPA added to 150 cc fresh ewe milk. Scintigraphic images were obtained in the standing position using a parallel hole, low-energy, triple head gamma camera. Images were stored digitally for 90 min and were analyzed using a nuclear medicine software program. The number of radionuclide counts from all three views during scintigraphic evaluations showed a time-dependent decrease in the number of radionuclide counts from the laterals (P<0.01) and the ventral view (P<0.001) of the abomasum. There was no significant difference in the number of radionuclide counts from all three views during scintigraphic evaluations. 51.70 ± 3.54 percent of the abomasum content was emptied after 90 min. Evaluating the ROI showed that half emptying time (T1/2) was 67.13 ± 8.64 min. This study was showed that nuclear scintigraphy can be used to evaluate the abomasal emptying rate in suckling...
• HiReSPECT imaging is used for biomedical research and molecular imaging. • The SIMIND Monte Car... more • HiReSPECT imaging is used for biomedical research and molecular imaging. • The SIMIND Monte Carlo program was used to simulate the HiReSPECT system. • Collimator geometry and material play critical roles in SPECT imaging. • Gold LEHR collimator with 0.3 mm hole diameter provide suitable image quality in HiReSPECT.
The collimator in single photon emission computed tomography (SPECT), is an important part of the... more The collimator in single photon emission computed tomography (SPECT), is an important part of the imaging chain. One of the most important collimators that used in research, preclinical study, small animal, and organ imaging is the pinhole collimator. Pinhole collimator can improve the tradeoff between sensitivity and resolution in comparison with conventional parallel-hole collimator and facilities diagnosis. However, a major problem with pinhole collimator is a small field of view (FOV). Multi-pinhole collimator has been investigated in order to increase the sensitivity and FOV with a preserved spatial resolution. The geometry of pinhole and multi-pinhole collimators is a critical factor in the image quality and plays a key role in SPECT imaging. The issue of the material and geometry for pinhole and multi-pinhole collimators have been a controversial and much disputed subject within the field of SPECT imaging. On the other hand, recent developments in collimator optimization have...
The detector in single-photon emission computed tomography has played a key role in the quality o... more The detector in single-photon emission computed tomography has played a key role in the quality of the images. Over the past few decades, developments in semiconductor detector technology provided an appropriate substitution for scintillation detectors in terms of high sensitivity, better energy resolution, and also high spatial resolution. One of the considered detectors is cadmium telluride (CdTe). The purpose of this paper is to review the CdTe semiconductor detector used in preclinical studies, small organ and small animal imaging, also research in nuclear medicine and other medical imaging modalities by a complete inspect on the material characteristics, irradiation principles, applications, and epitaxial growth method.
BACKGROUND: Acquiring a high quality image has assigned an important concern for obtaining accura... more BACKGROUND: Acquiring a high quality image has assigned an important concern for obtaining accurate diagnosis in nuclear medicine. Detector is a critical component of Single Photon Emission Computed Tomography (SPECT) imaging system for giving accurate information from exact pattern of radionuclide distribution in the target organ. The images are strongly affected by the attenuation, scattering, and response of the detector. The conventional detector is mainly made from sodium iodide activated by thallium [NaI(Tl)] in nuclear medicine imaging. The aim of the study. This study has planned to introduce a suitable for an optimized SPECT imaging. SIMIND Monte Carlo program was utilized for simulating a SPECT imaging system with a NaI(Tl) detector, and a low-energy high-resolution (LEHR) collimator. MATERIAL AND METHODS: The Planar and SPECT scans of a 99m Tc point source and also an extended Cardiac-Torso (XCAT) computerized phantom with the experiment and simulated systems were prepared. After verification and validation of the simulated system, the similar scans of the phantoms were compared from the point of view of image quality for 7 scintillator crystals including: NaI(Tl), BGO, YAG:Ce, YAP:Ce, LuAG:Ce, LaBr 3 and CZT. The parameters of energy and spatial resolution, and sensitivity of the systems were compared. Images were analyzed quantitatively by SSIM algorithm with Zhou Wang and Rouse/Hemami methods, and also qualitatively by two nuclear medicine specialists. RESULTS: Energy resolutions of the mentioned crystals obtained were
Purpose: Micro Single Photon Emission Computed Tomography (Micro-SPECT) system has recently been ... more Purpose: Micro Single Photon Emission Computed Tomography (Micro-SPECT) system has recently been introduced on nuclear medicine in the preclinical and research in which NaI (Tl) and Cadmium Telluride (CdTe) are used as the gamma-ray detectors with more generally use of NaI (Tl). The present study aimed to evaluate different thicknesses of the NaI (Tl) and (CdTe) detectors on functional parameters of a micro-SPECT system. Materials and Methods: A Micro-SPECT system with CdTe semiconductor detector and a hexagonal parallel hole collimator with a hole diameter of 0.11 mm, high of 24.05 mm, and septal thickness of 0.016 mm was simulated by Simulating Medical Imaging Nuclear Detectors (SIMIND) Monte Carlo program. The system performance was assessed by comparing the functional parameters, including system efficiency, sensitivity, energy and spatial resolution with the NaI (Tl) detector. The simulated scans of a 99mTc point source, a digital micro-Jacszack phantom, and a voxelized MOBY mo...
Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition that resu... more Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition that results from incomplete resolution of thromboemboli in pulmonary arteries. Symptomatic patients with chronic thromboembolic disease may have normal hemodynamic at rest. The aim of this study is to evaluate the outcome of pulmonary endarterectomy (PEA) in symptomatic patients with chronic thromboembolic pulmonary disease (CTEPD) in the absence of pulmonary hypertension as currently defined (mean pulmonary artery pressure [mPAP] < 20 mm Hg). Patients and Methods Here, we report four symptomatic patients with chronic thromboembolic and normal hemodynamic at rest (mPAP ≤20 mm Hg or 20 < mPAP < 25 mm Hg and pulmonary vascular resistance [PVR] < 240 dyn·s/cm5) who underwent PEA between September 2015 and September 2019. The main outcome measures were functional New York Heart Association class, 6-minute walk distance (6MWD), hemodynamic measures in right heart catheterization (RHC), mo...
Egyptian Journal of Radiology and Nuclear Medicine, 2021
Background Parkinson’s disease (PD) diagnosis is yet largely based on the related clinical aspect... more Background Parkinson’s disease (PD) diagnosis is yet largely based on the related clinical aspects. However, genetics, biomarkers, and neuroimaging studies have demonstrated a confirming role in the diagnosis, and future developments might be used in a pre-symptomatic phase of the disease. Main text This review provides an update on the current applications of neuroimaging modalities for PD diagnosis. A literature search was performed to find published studies that were involved on the application of different imaging modalities for PD diagnosis. An organized search of PubMed/MEDLINE, Embase, ProQuest, Scopus, Cochrane, and Google Scholar was performed based on MeSH keywords and suitable synonyms. Two researchers (TM and JPI) independently and separately performed the literature search. Our search strategy in each database was done by the following terms: ((Parkinson [Title/Abstract]) AND ((“Parkinsonian syndromes ”[Mesh]) OR Parkinsonism [Title/Abstract])) AND ((PET [Title/Abstract...
Abomasal hypomotility is one of the important causes of neonatal mortality in small ruminants. Va... more Abomasal hypomotility is one of the important causes of neonatal mortality in small ruminants. Various pharmaceutical agents have been studied to address this problem in large ruminants. The aim of this study was to determine the effect of parenteral administration of tylosin and ivermectin on abomasal emptying rate in neonatal suckling lambs. Abomasal emptying rate was assessed using nuclear scintigraphic method in 10 healthy female Iranian fat tailed Ghezel lambs. Each lamb was tested three times, once as a control (1 ml of saline 0.9%, IM) and twice after the injection of tylosin (17.6 mg/kg, IM) and ivermectin (200 μg/kg, SC) in a crossover study. Based on radiopharmaceutical counts, remnant activity in abomasums at 90 min were 48.3 ± 3.5, 45.6 ± 7.5 and 41.6 ± 2.9% in control, tylosin and ivermectin groups, respectively. Administration of tylosin (p = 0.049) and ivermectin (p = 0.045) to lambs, significantly caused faster abomasal emptying rate compared to control. Evaluating t...
The purpose of this study was count the white blood cells following injection of technetium-99m i... more The purpose of this study was count the white blood cells following injection of technetium-99m in the cat. Radioactive materials can be used in diagnostic and therapeutic procedures. Technetium is used in most labeling and nuclear medicine diagnostic studies because of its favorable conditions in the body. In this study, injection of technetium-99m was used to evaluate the possible changes in the number of white blood cells because these cells are used in labeling and tracing of radioactive materials in the body and their alterations are important in many operations. In the present study, technetium was milked from Molybdenum to technetium generator and it was rapidly injected in 1.5 mCi into six cats through the femoral vein. A group of four other cats were used as controls after injection of saline. At 0, 30, 60 minutes, 24 and 48 hours after injection, blood samples were collected from all cats and the number of white blood cells were counted. This study did not show any significant changes in the amount of white blood cells in the two groups. Thus, the results of this study outlines the advantage of using technetium-99m as a radio-drug in treatment and diagnostic procedures.
Introduction: Myocardial perfusion SPECTby 99mTc-Sestamibi and 99mTc-Tetrofosmin radiopharmaceuti... more Introduction: Myocardial perfusion SPECTby 99mTc-Sestamibi and 99mTc-Tetrofosmin radiopharmaceuticals usually presents a false significant increase in the radiotracer uptake in the inferior myocardium due to the uptake in organs such as liver, bowel, stomach and biliary system. The present study evaluated a suitable Slit angle for differentiating extra-cardiac activities by Slit Slat collimation. Methods: The Siemens E.CAM gamma camera equipped with a Low Energy High Resolution (LEHR) collimator was simulated with the Simulating Medical Imaging Nuclear Detectors (SIMIND) Monte Carlo program. Following the verification of the simulation, a Slit Slat collimator was simulated for SPECT imaging of a NURBS-based Cardiac Torso (NCAT) phantom with different Slit angels ranged from 0 to 30 degrees. The reconstructed images were qualitatively assessed with blinded observer method by three nuclear medicine specialists. Results:The improved differentiation of the bowel activity from the cardia...
Background Parkinsonism as a group of movement disorders, exhibit similar clinical presentation. ... more Background Parkinsonism as a group of movement disorders, exhibit similar clinical presentation. Therefore, clinically differentiating these diseases is difficult. We investigated the diagnostic value of 99m Tc-TRODAT-1 SPECT in this setting. Due to the fact that this modality has some limitations in imaging small organs like the sub-regions of basal ganglia, we also evaluated the use of anatomical MR imaging along with functional SPECT imaging in parkinsonism. Methods This follow-up diagnostic test evaluation study was performed with 40 patients with the clinical presentation of parkinsonism, and 10 healthy subjects as controls. After administration of the radiopharmaceutical, SPECT images were acquired, then co-registered on MRI. Uptake values were evaluated in basal ganglia semi-quantitatively. Results In this study, 99mTc-TRODAT-1 SPECT was able to differentiate essential tremor and healthy subjects from progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) with a se...
Thyroid nodules are a common clinical problem. Epidemiologic studies have shown the prevalence of... more Thyroid nodules are a common clinical problem. Epidemiologic studies have shown the prevalence of palpable thyroid nodules to be approximately 5% in women and 1% in men living in iodine-sufficient area but high resolution ultrasound can detect thyroid nodules in 19%-68% depending to age of patients. The patient is a 64 year old man who was presented to our medical center 7 year after a right hemithyroidectomy due to a large nodule. Fine needle aspiration of the thyroid nodule demonstrated Adenomatous goiter. Pathology of the nodule was follicular variant of papillary thyroid carcinoma with capsular invasion and the patient didn’t any follow up until 8 months ago who came to this center with pain in left Humerus. Lung and bone metastases are a relatively uncommon finding in patients with well differentiated thyroid cancer. Radio Iodine therapy of Iodine-avid bone metastases has been associated with improved survival and should be employed although Radioactive Iodine is rarely curativ...
The aim of this study was to evaluate the efficacy of Tc-ECD radiodrug in cat's brain scintig... more The aim of this study was to evaluate the efficacy of Tc-ECD radiodrug in cat's brain scintigraphy . In present study, 12 adult healthy cats were selected and brain scintigraphy was done with radiopharmaceutical TcECD in these cats. In this method, the administration of radioisotopes to the body and accumulation of these substances in the target tissues, specific imaging is obtained, which is based on distribution of gamma radiations exposed from these radioisotopes and recording of them. For scintigraphy, animals were taken under anesthetic condition and TC-ECD was injected from femoral vein as bolus at the 2 mCi. 20 minutes after intravenous injection of radioidrug scintigraphic operations were done. The ROIs can be drawn in all scans and radioactive counts were easily measured. Our results show that the radiopharmaceutical Tc-ECD has excellent evaluate the efficacy in cat's brain scintigraphy. [Gholamreza Assadnassab, Shahram Dabiri Oskoei, Babak Mahmoudian, Mohammadreza ...
Iranian fat tailed Ghezel lambs, 7-10 days of age, were fasted at least 12 h and then fed with 1 ... more Iranian fat tailed Ghezel lambs, 7-10 days of age, were fasted at least 12 h and then fed with 1 mCi of 99m Tc-DTPA added to 150 cc fresh ewe milk. Scintigraphic images were obtained in the standing position using a parallel hole, low-energy, triple head gamma camera. Images were stored digitally for 90 min and were analyzed using a nuclear medicine software program. The number of radionuclide counts from all three views during scintigraphic evaluations showed a time-dependent decrease in the number of radionuclide counts from the laterals (P<0.01) and the ventral view (P<0.001) of the abomasum. There was no significant difference in the number of radionuclide counts from all three views during scintigraphic evaluations. 51.70 ± 3.54 percent of the abomasum content was emptied after 90 min. Evaluating the ROI showed that half emptying time (T1/2) was 67.13 ± 8.64 min. This study was showed that nuclear scintigraphy can be used to evaluate the abomasal emptying rate in suckling...
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