These days, Mycobacterium tuberculosis (Mtb) bacil is estimated to have infected one third of the... more These days, Mycobacterium tuberculosis (Mtb) bacil is estimated to have infected one third of the world's population. World Health Organization (WHO) data shows that in 2011 there were 8.7 million case of tuberculosis (TB) or equivalent to 125 cases per 100.000 of the world’s population. Some studies have been done to understand the role of certain genes toward the susceptibility of TB patients, most of those studies focused on genes that are involved in signal pathway of interferon gamma (IFN-γ). Interferon gamma is one of the cytokine that has a role in pathogenesis of pulmonary tuberculosis. Single nucleotide polymorphism of IFN-γ at +874 T/A position in the first intron is reported to have association with pulmonary TB in different population. The aim of this study is to investigate the genetic variation of IFN-γ in +874 T/A and its relation with IFN-γ plasma level in pulmonary tuberculosis patients. The study’s method is cross sectional. Blood sample was taken from the vein...
Background: .Atopic Asthma is a chronic inflammatory disease of the airways that based on an alle... more Background: .Atopic Asthma is a chronic inflammatory disease of the airways that based on an allergic reaction involving many cells and IL-33. Activation of Th2 cells by IL-33 as a result inhalation of allergens will affect dendritic cells in the airways to activate Th0 cells which in turn would activate Th2 cells to release other cytokines. These cytokines further increase the IgE and stimulates the release of mediators such as histamine, leukotrienes, prostaglandins and quinine, which causes the onset of clinical symptoms of asthma. The degree of asthma control directly reflects the effectiveness of treatment Interventions. Objective: To assess the correlation between the degree of disease control and serum levels of IL-33 in atopic asthma. Methods: A cross sectional study of 40 patients with atopic asthma at Hasanuddin University Hospital Makassar, aged 18-55 year old; and 20 controls. Patients with atopic asthma was underwent bronchodilator and skin prick test, also assessed for ACT. All subjects were checked for serum level of IL-33. Results The mean ages was 31.7±9.0 years. The mean serum levels of IL-33 was 1735,1 and the mean ACT score was 20.6. The mean serum levels of IL-33 in atopic asthma (1864.6) was significantly higher than controls (1476.2; p Conclusion: There is correlation between atopic asthma and serum levels of IL-33, while degree of asthma control is not correlated with atopic asthma.
These days, Mycobacterium tuberculosis (Mtb) bacil is estimated to have infected one third of the... more These days, Mycobacterium tuberculosis (Mtb) bacil is estimated to have infected one third of the world's population. World Health Organization (WHO) data shows that in 2011 there were 8.7 million case of tuberculosis (TB) or equivalent to 125 cases per 100.000 of the world’s population. Some studies have been done to understand the role of certain genes toward the susceptibility of TB patients, most of those studies focused on genes that are involved in signal pathway of interferon gamma (IFN-γ). Interferon gamma is one of the cytokine that has a role in pathogenesis of pulmonary tuberculosis. Single nucleotide polymorphism of IFN-γ at +874 T/A position in the first intron is reported to have association with pulmonary TB in different population. The aim of this study is to investigate the genetic variation of IFN-γ in +874 T/A and its relation with IFN-γ plasma level in pulmonary tuberculosis patients. The study’s method is cross sectional. Blood sample was taken from the vein...
Background: .Atopic Asthma is a chronic inflammatory disease of the airways that based on an alle... more Background: .Atopic Asthma is a chronic inflammatory disease of the airways that based on an allergic reaction involving many cells and IL-33. Activation of Th2 cells by IL-33 as a result inhalation of allergens will affect dendritic cells in the airways to activate Th0 cells which in turn would activate Th2 cells to release other cytokines. These cytokines further increase the IgE and stimulates the release of mediators such as histamine, leukotrienes, prostaglandins and quinine, which causes the onset of clinical symptoms of asthma. The degree of asthma control directly reflects the effectiveness of treatment Interventions. Objective: To assess the correlation between the degree of disease control and serum levels of IL-33 in atopic asthma. Methods: A cross sectional study of 40 patients with atopic asthma at Hasanuddin University Hospital Makassar, aged 18-55 year old; and 20 controls. Patients with atopic asthma was underwent bronchodilator and skin prick test, also assessed for ACT. All subjects were checked for serum level of IL-33. Results The mean ages was 31.7±9.0 years. The mean serum levels of IL-33 was 1735,1 and the mean ACT score was 20.6. The mean serum levels of IL-33 in atopic asthma (1864.6) was significantly higher than controls (1476.2; p Conclusion: There is correlation between atopic asthma and serum levels of IL-33, while degree of asthma control is not correlated with atopic asthma.
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