DOAJ (DOAJ: Directory of Open Access Journals), Oct 1, 2000
The effects of some histaminergic agents were evaluated on stress- induced immunosuppression in i... more The effects of some histaminergic agents were evaluated on stress- induced immunosuppression in immunized nale rats. In rat immunized with sheep red blood cells ( SRBCs). Restraint stress (RS) prevented the booster-induced rise in anti-SRBC antibody titre and cell immunity response. Intracerebroventicular (I.C>V) injection of histamine (150 µg/rat) induced a similar effect with RS. Pretreatment with chlorpheniramine (50 µg/rat) reduced the inhibitory effect of Ras on immune function. Also histamine could inhibit the effect of RS on immune function. Also histamine could inhibitory the effect of chlorpheniramine when injected simultaneously. Pretreatment with ranidine (10 µg/rat) had not a significant effect. Serotonin (3 µg/rat) and dopamine (0.2 µg/rat) could reverse the effects of chlorpheniromine when injected with chlorpheniramine (P<0.05). Epinephrine (0.2 µg/rat) had not a significant effect. The results indicate that histamine mediates the immunosuppression of restraint stress by influencing the histamine H1 receptor in the brain and this effects of histamine may be modulated by serotoninergic and dopaminergic system.
Avicenna Journal of Clinical Medicine, Dec 15, 2003
ABSTRACT In comparison of effects of various drugs with the same indications produced by differen... more ABSTRACT In comparison of effects of various drugs with the same indications produced by different companies or comparing drugs manufactured in Iran with their foreign counterparts may result in producing drugs with higher qualities in our country. In this study the spasmolithic effect of two herbal drugs , gripe mixture and caraway mixture , that are prescribed as spasmolithic and carminative in infants were compared. 2 cm of rat jejunum was placed in a organ bath containing tyrode solution (37 C° , 100% O2) . The jejunum was contracted because of acetylcholine (1 mml). when the muscle contraction reached the plateau the different volumes of drug were added to the organ bath. The inhibitory effect of drug indicated by physiograph , the intestine was washed two times. When the intestine reached the basal tonicity , the different volumes of second drug were tested. The results were compared using paired t.test . The results show that both drugs inhibit the spasm induced by acetylcholine in rat jejunum . This inhibitory effect was dose dependent. The caraway mixture showed a higher effect in comparison with gripe mixture (P&lt;0.05). The caraway mixture has a higher inhibitory effect on acetylcholine induced spasm in rat jejunum . It seems that it has the same effect on human
Objective: Chemoprevention of cancer by application of natural phytochemical compounds has been u... more Objective: Chemoprevention of cancer by application of natural phytochemical compounds has been used to prevent, delay or suppress cancer progression. Cuscuta chinensis a traditional Iranian medicinal herb, has biological properties including anticancer, anti-aging, immuno-stimulatory and antioxidant effects. In this study, anti-proliferative effects of hydroalcoholic extract of C. chinensis on prostate (PC3) and breast (MCF7) cancer cell lines were investigated. Materials and methods: In the current study, we investigated treatment of PC3 cells with different concentrations of C. chinensis (0, 100, 200, 300, 400, and 500 µg/ml) for 24 and 48 hr; also, MCF7 cells were treated with various concentrations (0-600 µg/ml) of C. chinensis for 48 and 72 hr and cell viability was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. mRNA expression of BCL2 Associated X (Bax), B-cell lymphoma 2 (Bcl2), Cysteine-aspartic proteases (Caspase3) and Phosphatase and tensin homolog (PTEN) were analyzed by quantitative real-time PCR. Annexin V/PI staining and lactate dehydrogenase (LDH) cytotoxicity assay were used to detect apoptosis. Results: C. chinensis decreased PC3 and MCF7 cells viability in a dose- and time-dependent manner (p<0.01 to p<0.001). The gene expression of BAX/Bcl2 ratio, Caspase3 and PTEN increased in C. chinensis-treated cells compared to the control group. C. chinensis induced apoptosis (p<0.001) and LDH activity (p<0.01 to p<0.001). Conclusion: Our findings suggest that C. chinensis extract is able to inhibit proliferation and induce apoptosis in PC3 and MCF7 cell lines. Therefore, C. chinensis extract exerts antitumor activity against cancer cells.
ABSTRACT Introduction &amp; Objective: Most women in the course of their lives will experienc... more ABSTRACT Introduction &amp; Objective: Most women in the course of their lives will experience menstrual bleeding. Some have bleeding almost all the time. Different approaches have been proposed and drugs with fewer side effects are preferred. The aim of this study was to compare the effects of herbal medicines (fennelin &amp; vitagnus) and mefenamic acid in the treatment of severity of menstrual bleeding. Materials &amp; Methods: This double blind clinical trial was carried out in one hundred and five students with severe menstrual bleeding at Hamadan University of medical sciences in 2010. The students were randomly grouped in four groups and herbal medicines of fennelin &amp; vitagnus, mefenamic acid and placebo. The severity of menstrual bleeding was detected by the Higham table during one cycle before and two cycles after the intervention. The data analyzed by SPSS/16 and P&lt;0.05 was considered significant. Results: Demographic characteristics of the students were similar in the four groups. There was not a significant difference in the mean of severity of menstrual bleeding during the one cycle before intervention between the four groups, but the difference was significant during the two cycles after the intervention. Mefenamic acid reduces menstrual bleeding compared with vitagnus &amp; fennelin and showed no statistically significant difference. Conclusion: All three drugs; mefenamic acid, fennelin and vitagnus have been effective in reducing menstrual bleeding. The two herbal medicines (vitagnus and fennelin) can be used as effective and safe drugs to reduce menstrual bleeding. (Sci J Hamadan Univ Med Sci 2014; 21 (3):171-176 ) Keywords: Fennelin / Mefenamic Acid / Menstrual / Vitagnus
In comparison of effects of various drugs with the same indications produced by different compani... more In comparison of effects of various drugs with the same indications produced by different companies or comparing drugs manufactured in Iran with their foreign counterparts may result in producing drugs with higher qualities in our country. In this study the spasmolithic effect of two herbal drugs , gripe mixture and caraway mixture , that are prescribed as spasmolithic and carminative in infants were compared. 2 cm of rat jejunum was placed in a organ bath containing tyrode solution (37 C° , 100% O2) . The jejunum was contracted because of acetylcholine (1 mml). when the muscle contraction reached the plateau the different volumes of drug were added to the organ bath. The inhibitory effect of drug indicated by physiograph , the intestine was washed two times. When the intestine reached the basal tonicity , the different volumes of second drug were tested. The results were compared using paired t.test . The results show that both drugs inhibit the spasm induced by acetylcholine in ra...
The survey of the depression prevalence in hypertensive patients referents to medical and health ... more The survey of the depression prevalence in hypertensive patients referents to medical and health centers in Hamadan city Introduction: Despite of the high prevalence of depression and hypertension, the relationship between the two diseases has received little attention. Some prospective studies indicate that depression poses a risk factor for hypertension. In man ,depression has been found to be associated with an increased risk of developing cardiovascular diseases. The present study was conducted to examine the prevalence of depression in hypertensive patients referents to medical and health centers in Hamadan city. Material and methods: In a descriptive cross-sectional study 525 hypertensive patients who referents to medical and health centers of Hamadan in 1387 were studied. Depression status was evaluated by Beck Depression Inventory. Depression was defined as a score of more than 18.The data were analyzed with the use of the SPSS software ,version 10 , Mannwhitney and chi-squa...
Diabetes mellitus is one of the most common diseases in the world that imposes a tremendous healt... more Diabetes mellitus is one of the most common diseases in the world that imposes a tremendous health and social burden whether that burden is measured in terms of sickness, use of health systems resources or costs. Hyperglycemia is the most important clinical sign of diabetes leading to glycation of the various proteins in the body that leading to change in nature , structure and biochemical activity of them. One of the prevention method in the treatment of diabetes mellitus is decreased or inhibited this reaction, it seems that food additives are useful for this purpose. The main goal of this research is to determine the effect of some food additives such as: Somaq, Cinnamomum and Black Pepper on in vitro albumin glycation. In the presence of various concentration of food additives albumin was glycated and evaluated using TBA method. Results showed that these food additives have inhibitory effects on albumin glycation reaction with the concentration of 1g/dl, 0.2g/dl and 0.1g/dl. Amo...
Hospitalization can significantly disrupt sleeping patterns. In consideration of the previous rep... more Hospitalization can significantly disrupt sleeping patterns. In consideration of the previous reports of insomnia and apparent widespread use of benzodiazepines and other hypnotics in hospitalized patients, we conducted a study to assess quality of sleep and hypnotic drug use in our acute care adult patient population. The primary objectives of this study were to assess sleep disturbance and its determinants including the use of drugs with sedating properties. This single-centre prospective study involved an assessment of sleep quality for consenting patients admitted to the general medicine and family practice units of an acute care Canadian hospital. A validated Verran and Snyder-Halpern (VSH) Sleep Scale measuring sleep disturbance, sleep effectiveness, and sleep supplementation was completed daily by patients and scores were compared to population statistics. Patients were also asked to identify factors influencing sleep while in hospital, and sedating drug use prior to and duri...
Introduction & Objective: Most women in the course of their lives will experience menstrual bleed... more Introduction & Objective: Most women in the course of their lives will experience menstrual bleeding. Some have bleeding almost all the time. Different approaches have been proposed and drugs with fewer side effects are preferred. The aim of this study was to compare the effects of herbal medicines (fennelin & vitagnus) and mefenamic acid in the treatment of severity of menstrual bleeding. Materials & Methods: This double blind clinical trial was carried out in one hundred and five students with severe menstrual bleeding at Hamadan University of medical sciences in 2010. The students were randomly grouped in four groups and herbal medicines of fennelin & vitagnus, mefenamic acid and placebo. The severity of menstrual bleeding was detected by the Higham table during one cycle before and two cycles after the intervention. The data analyzed by SPSS/16 and P<0.05 was considered significant. Results: Demographic characteristics of the students were similar in the four groups. There wa...
Introduction & Objective: The observance of prescribing principles has the likelihood of correct ... more Introduction & Objective: The observance of prescribing principles has the likelihood of correct medication and consequently patient's recovery and also reduces the amount of unnecessary costs. In this context, we tried to examine the rate of observance of prescription principles in Hamadan University of Medical Sciences teaching staff including attendees, assistants and interns and compared it with non-teaching staff including general physicians and doctors’ prescription. Materials & Methods: The present study is a descriptive-analytical research with two-stage random sampling on the prescriptions presented to hospitals pharmacies and city pharmacies of Hamadan. A total of 800 prescriptions were collected from 15 pharmacies and the data were analyzed by t test, ANOVA and post hoc statistical tests. Results: According to the analyses of the examined prescriptions, average score of the observance of prescribing principles in non-teaching staff was more significant (10.1 vs. 9.6) ...
Oxidative stress mediated by reactive oxygen species is known to contribute to the inflammatory p... more Oxidative stress mediated by reactive oxygen species is known to contribute to the inflammatory process of bronchial asthma. Reactive oxygen species are released into the bronchial tree by activated inflammatory cells. In this study, we aimed to determine the effect of vitamin C administration on leukocyte vitamin C level as well as severity of asthma. In this double blind clinical trial study we evaluated 60 patients with chronic stable asthma. The patients were divided into two groups (A and B) including 30 patients in each group. Patients in these groups were matched according to their age, weight, height, gender, BMI and drug consumption. In addition to standard asthma treatment (according to stepwise therapy in 4 th step of bronchial asthma) in which the patients were controlled appropriately, group A received 1000 mg vitamin C daily and group B received placebo. At the baseline and after one month treatment, non-fasting blood samples were drawn for laboratory evaluations. Asth...
Scientific Journal of Hamadan University of Medical Sciences, 2010
Introduction & Objective: Despite the high prevalence of depression and hypertension, the rel... more Introduction & Objective: Despite the high prevalence of depression and hypertension, the relationship between these disorders has received little attention. Some prospective studies indicate that depression poses a risk factor for hypertension. Depression has been found to be associated with an increased risk of developing cardiovascular diseases. The present study was conducted to examine the prevalence of depression in hypertensive patients' refering to medical and health centers in Hamadan city. Materials & Methods: In a descriptive cross-sectional study 525 hypertensive patients who referred to the medical and health centers of Hamadan city in 2008 were studied. Depression status was evaluated by Beck depression inventory. Obtaining a score higher than 18 indicated depression. The data were analyzed with SPSS software(version 10) , chi-square and parson regression coefficient tests. Results: Depression prevalence in the hypertensive patients was 48.6%. Positive correlation was detected between age and score of depression(r=0.56 P.V=0.000). The rate of depression was significantly higher in the females than the males (c2=34 P.V=<0.5). Depression prevalence in the lower socioeconomic classes and the widows were higher than in the married and high class patients (P.V<0.05). Conclusion: Hypertensive patients are prone to depression. The lifetime co- morbidity of two diseases is significantly higher in females than males. The presence of a positive correlation between hypertension and depression indicates that hypertension is a risk factor for developing depression .High prevalence of depression suggests the need for depression screening and neurological consultation in hypertensive patients.
DOAJ (DOAJ: Directory of Open Access Journals), Oct 1, 2000
The effects of some histaminergic agents were evaluated on stress- induced immunosuppression in i... more The effects of some histaminergic agents were evaluated on stress- induced immunosuppression in immunized nale rats. In rat immunized with sheep red blood cells ( SRBCs). Restraint stress (RS) prevented the booster-induced rise in anti-SRBC antibody titre and cell immunity response. Intracerebroventicular (I.C>V) injection of histamine (150 µg/rat) induced a similar effect with RS. Pretreatment with chlorpheniramine (50 µg/rat) reduced the inhibitory effect of Ras on immune function. Also histamine could inhibit the effect of RS on immune function. Also histamine could inhibitory the effect of chlorpheniramine when injected simultaneously. Pretreatment with ranidine (10 µg/rat) had not a significant effect. Serotonin (3 µg/rat) and dopamine (0.2 µg/rat) could reverse the effects of chlorpheniromine when injected with chlorpheniramine (P<0.05). Epinephrine (0.2 µg/rat) had not a significant effect. The results indicate that histamine mediates the immunosuppression of restraint stress by influencing the histamine H1 receptor in the brain and this effects of histamine may be modulated by serotoninergic and dopaminergic system.
Avicenna Journal of Clinical Medicine, Dec 15, 2003
ABSTRACT In comparison of effects of various drugs with the same indications produced by differen... more ABSTRACT In comparison of effects of various drugs with the same indications produced by different companies or comparing drugs manufactured in Iran with their foreign counterparts may result in producing drugs with higher qualities in our country. In this study the spasmolithic effect of two herbal drugs , gripe mixture and caraway mixture , that are prescribed as spasmolithic and carminative in infants were compared. 2 cm of rat jejunum was placed in a organ bath containing tyrode solution (37 C° , 100% O2) . The jejunum was contracted because of acetylcholine (1 mml). when the muscle contraction reached the plateau the different volumes of drug were added to the organ bath. The inhibitory effect of drug indicated by physiograph , the intestine was washed two times. When the intestine reached the basal tonicity , the different volumes of second drug were tested. The results were compared using paired t.test . The results show that both drugs inhibit the spasm induced by acetylcholine in rat jejunum . This inhibitory effect was dose dependent. The caraway mixture showed a higher effect in comparison with gripe mixture (P&lt;0.05). The caraway mixture has a higher inhibitory effect on acetylcholine induced spasm in rat jejunum . It seems that it has the same effect on human
Objective: Chemoprevention of cancer by application of natural phytochemical compounds has been u... more Objective: Chemoprevention of cancer by application of natural phytochemical compounds has been used to prevent, delay or suppress cancer progression. Cuscuta chinensis a traditional Iranian medicinal herb, has biological properties including anticancer, anti-aging, immuno-stimulatory and antioxidant effects. In this study, anti-proliferative effects of hydroalcoholic extract of C. chinensis on prostate (PC3) and breast (MCF7) cancer cell lines were investigated. Materials and methods: In the current study, we investigated treatment of PC3 cells with different concentrations of C. chinensis (0, 100, 200, 300, 400, and 500 µg/ml) for 24 and 48 hr; also, MCF7 cells were treated with various concentrations (0-600 µg/ml) of C. chinensis for 48 and 72 hr and cell viability was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. mRNA expression of BCL2 Associated X (Bax), B-cell lymphoma 2 (Bcl2), Cysteine-aspartic proteases (Caspase3) and Phosphatase and tensin homolog (PTEN) were analyzed by quantitative real-time PCR. Annexin V/PI staining and lactate dehydrogenase (LDH) cytotoxicity assay were used to detect apoptosis. Results: C. chinensis decreased PC3 and MCF7 cells viability in a dose- and time-dependent manner (p<0.01 to p<0.001). The gene expression of BAX/Bcl2 ratio, Caspase3 and PTEN increased in C. chinensis-treated cells compared to the control group. C. chinensis induced apoptosis (p<0.001) and LDH activity (p<0.01 to p<0.001). Conclusion: Our findings suggest that C. chinensis extract is able to inhibit proliferation and induce apoptosis in PC3 and MCF7 cell lines. Therefore, C. chinensis extract exerts antitumor activity against cancer cells.
ABSTRACT Introduction &amp; Objective: Most women in the course of their lives will experienc... more ABSTRACT Introduction &amp; Objective: Most women in the course of their lives will experience menstrual bleeding. Some have bleeding almost all the time. Different approaches have been proposed and drugs with fewer side effects are preferred. The aim of this study was to compare the effects of herbal medicines (fennelin &amp; vitagnus) and mefenamic acid in the treatment of severity of menstrual bleeding. Materials &amp; Methods: This double blind clinical trial was carried out in one hundred and five students with severe menstrual bleeding at Hamadan University of medical sciences in 2010. The students were randomly grouped in four groups and herbal medicines of fennelin &amp; vitagnus, mefenamic acid and placebo. The severity of menstrual bleeding was detected by the Higham table during one cycle before and two cycles after the intervention. The data analyzed by SPSS/16 and P&lt;0.05 was considered significant. Results: Demographic characteristics of the students were similar in the four groups. There was not a significant difference in the mean of severity of menstrual bleeding during the one cycle before intervention between the four groups, but the difference was significant during the two cycles after the intervention. Mefenamic acid reduces menstrual bleeding compared with vitagnus &amp; fennelin and showed no statistically significant difference. Conclusion: All three drugs; mefenamic acid, fennelin and vitagnus have been effective in reducing menstrual bleeding. The two herbal medicines (vitagnus and fennelin) can be used as effective and safe drugs to reduce menstrual bleeding. (Sci J Hamadan Univ Med Sci 2014; 21 (3):171-176 ) Keywords: Fennelin / Mefenamic Acid / Menstrual / Vitagnus
In comparison of effects of various drugs with the same indications produced by different compani... more In comparison of effects of various drugs with the same indications produced by different companies or comparing drugs manufactured in Iran with their foreign counterparts may result in producing drugs with higher qualities in our country. In this study the spasmolithic effect of two herbal drugs , gripe mixture and caraway mixture , that are prescribed as spasmolithic and carminative in infants were compared. 2 cm of rat jejunum was placed in a organ bath containing tyrode solution (37 C° , 100% O2) . The jejunum was contracted because of acetylcholine (1 mml). when the muscle contraction reached the plateau the different volumes of drug were added to the organ bath. The inhibitory effect of drug indicated by physiograph , the intestine was washed two times. When the intestine reached the basal tonicity , the different volumes of second drug were tested. The results were compared using paired t.test . The results show that both drugs inhibit the spasm induced by acetylcholine in ra...
The survey of the depression prevalence in hypertensive patients referents to medical and health ... more The survey of the depression prevalence in hypertensive patients referents to medical and health centers in Hamadan city Introduction: Despite of the high prevalence of depression and hypertension, the relationship between the two diseases has received little attention. Some prospective studies indicate that depression poses a risk factor for hypertension. In man ,depression has been found to be associated with an increased risk of developing cardiovascular diseases. The present study was conducted to examine the prevalence of depression in hypertensive patients referents to medical and health centers in Hamadan city. Material and methods: In a descriptive cross-sectional study 525 hypertensive patients who referents to medical and health centers of Hamadan in 1387 were studied. Depression status was evaluated by Beck Depression Inventory. Depression was defined as a score of more than 18.The data were analyzed with the use of the SPSS software ,version 10 , Mannwhitney and chi-squa...
Diabetes mellitus is one of the most common diseases in the world that imposes a tremendous healt... more Diabetes mellitus is one of the most common diseases in the world that imposes a tremendous health and social burden whether that burden is measured in terms of sickness, use of health systems resources or costs. Hyperglycemia is the most important clinical sign of diabetes leading to glycation of the various proteins in the body that leading to change in nature , structure and biochemical activity of them. One of the prevention method in the treatment of diabetes mellitus is decreased or inhibited this reaction, it seems that food additives are useful for this purpose. The main goal of this research is to determine the effect of some food additives such as: Somaq, Cinnamomum and Black Pepper on in vitro albumin glycation. In the presence of various concentration of food additives albumin was glycated and evaluated using TBA method. Results showed that these food additives have inhibitory effects on albumin glycation reaction with the concentration of 1g/dl, 0.2g/dl and 0.1g/dl. Amo...
Hospitalization can significantly disrupt sleeping patterns. In consideration of the previous rep... more Hospitalization can significantly disrupt sleeping patterns. In consideration of the previous reports of insomnia and apparent widespread use of benzodiazepines and other hypnotics in hospitalized patients, we conducted a study to assess quality of sleep and hypnotic drug use in our acute care adult patient population. The primary objectives of this study were to assess sleep disturbance and its determinants including the use of drugs with sedating properties. This single-centre prospective study involved an assessment of sleep quality for consenting patients admitted to the general medicine and family practice units of an acute care Canadian hospital. A validated Verran and Snyder-Halpern (VSH) Sleep Scale measuring sleep disturbance, sleep effectiveness, and sleep supplementation was completed daily by patients and scores were compared to population statistics. Patients were also asked to identify factors influencing sleep while in hospital, and sedating drug use prior to and duri...
Introduction & Objective: Most women in the course of their lives will experience menstrual bleed... more Introduction & Objective: Most women in the course of their lives will experience menstrual bleeding. Some have bleeding almost all the time. Different approaches have been proposed and drugs with fewer side effects are preferred. The aim of this study was to compare the effects of herbal medicines (fennelin & vitagnus) and mefenamic acid in the treatment of severity of menstrual bleeding. Materials & Methods: This double blind clinical trial was carried out in one hundred and five students with severe menstrual bleeding at Hamadan University of medical sciences in 2010. The students were randomly grouped in four groups and herbal medicines of fennelin & vitagnus, mefenamic acid and placebo. The severity of menstrual bleeding was detected by the Higham table during one cycle before and two cycles after the intervention. The data analyzed by SPSS/16 and P<0.05 was considered significant. Results: Demographic characteristics of the students were similar in the four groups. There wa...
Introduction & Objective: The observance of prescribing principles has the likelihood of correct ... more Introduction & Objective: The observance of prescribing principles has the likelihood of correct medication and consequently patient's recovery and also reduces the amount of unnecessary costs. In this context, we tried to examine the rate of observance of prescription principles in Hamadan University of Medical Sciences teaching staff including attendees, assistants and interns and compared it with non-teaching staff including general physicians and doctors’ prescription. Materials & Methods: The present study is a descriptive-analytical research with two-stage random sampling on the prescriptions presented to hospitals pharmacies and city pharmacies of Hamadan. A total of 800 prescriptions were collected from 15 pharmacies and the data were analyzed by t test, ANOVA and post hoc statistical tests. Results: According to the analyses of the examined prescriptions, average score of the observance of prescribing principles in non-teaching staff was more significant (10.1 vs. 9.6) ...
Oxidative stress mediated by reactive oxygen species is known to contribute to the inflammatory p... more Oxidative stress mediated by reactive oxygen species is known to contribute to the inflammatory process of bronchial asthma. Reactive oxygen species are released into the bronchial tree by activated inflammatory cells. In this study, we aimed to determine the effect of vitamin C administration on leukocyte vitamin C level as well as severity of asthma. In this double blind clinical trial study we evaluated 60 patients with chronic stable asthma. The patients were divided into two groups (A and B) including 30 patients in each group. Patients in these groups were matched according to their age, weight, height, gender, BMI and drug consumption. In addition to standard asthma treatment (according to stepwise therapy in 4 th step of bronchial asthma) in which the patients were controlled appropriately, group A received 1000 mg vitamin C daily and group B received placebo. At the baseline and after one month treatment, non-fasting blood samples were drawn for laboratory evaluations. Asth...
Scientific Journal of Hamadan University of Medical Sciences, 2010
Introduction & Objective: Despite the high prevalence of depression and hypertension, the rel... more Introduction & Objective: Despite the high prevalence of depression and hypertension, the relationship between these disorders has received little attention. Some prospective studies indicate that depression poses a risk factor for hypertension. Depression has been found to be associated with an increased risk of developing cardiovascular diseases. The present study was conducted to examine the prevalence of depression in hypertensive patients' refering to medical and health centers in Hamadan city. Materials & Methods: In a descriptive cross-sectional study 525 hypertensive patients who referred to the medical and health centers of Hamadan city in 2008 were studied. Depression status was evaluated by Beck depression inventory. Obtaining a score higher than 18 indicated depression. The data were analyzed with SPSS software(version 10) , chi-square and parson regression coefficient tests. Results: Depression prevalence in the hypertensive patients was 48.6%. Positive correlation was detected between age and score of depression(r=0.56 P.V=0.000). The rate of depression was significantly higher in the females than the males (c2=34 P.V=<0.5). Depression prevalence in the lower socioeconomic classes and the widows were higher than in the married and high class patients (P.V<0.05). Conclusion: Hypertensive patients are prone to depression. The lifetime co- morbidity of two diseases is significantly higher in females than males. The presence of a positive correlation between hypertension and depression indicates that hypertension is a risk factor for developing depression .High prevalence of depression suggests the need for depression screening and neurological consultation in hypertensive patients.
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