Bioactive peptide gels enhance the regeneration of peripheral nerve injuries, which affect 20 mil... more Bioactive peptide gels enhance the regeneration of peripheral nerve injuries, which affect 20 million patients in the USA.
Primary aim is to compare the diagnostic value of contrast-enhanced 3D GRE T1-weighted sequences ... more Primary aim is to compare the diagnostic value of contrast-enhanced 3D GRE T1-weighted sequences with unenhanced MR venography and conventional magnetic resonance imaging (MRI), in detection of dural venous sinus (DVS) and cortical venous thrombosis; secondary aim is to determine the relationship between DVS thrombosis/site and gender, age, infarction or hemorrhage. We retrospectively reviewed conventional MR images, unenhanced MR venography and immediate post-contrast 3D GRE T1-weighted MR images in 30 patients (17 male and 13 female, 21-70 years old, mean age 40.1) with clinically suspected DVS thrombosis. MR examinations had been performed with 1.5T or 3T MR Scanners. DVSs were evaluated in 10 sub-segments, including cortical veins. Each set of MR images were examined separately, blinded to the final diagnosis. Associated findings were also noted and sensitivity, specificity and accuracy of each MRI technique were calculated. Final diagnosis of cortical venous and/or dural sinus thrombosis was established in 24 (80%) of 30 cases and 67 (22.3%) out of 300 segments. For detection of the thrombotic segment, sensitivity, specificity, and accuracy were 83.6%, 95.3%, and 92.7% by conventional MR sequences, 89.6%, 91.8%, and 91.3% by unenhanced MR venography, and 92.5%, 100%, and 98.3% by contrast-enhanced 3D GRE T1-weighted sequence, respectively. Infarction and hemorrhage were more frequent in cases with cortical venous thrombosis, while gender and age had no significant relation with DVS thrombosis or its site. Conventional MR sequences and unenhanced MR venography were helpful due to additional information they provided in some cases with isolated cortical venous thrombosis, with hyperintense thrombus material and with associated hemorrhage or infarction. Contrast-enhanced 3D GRE T1-weighted MRI is the most accurate imaging method for the detection of DVS and/or cortical venous thrombosis. Infarction and hemorrhage were more frequent in cases with cortical venous thrombosis.
Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2013
To explore amplitude and latency-check size function in multiple sclerosis (MS) patients without ... more To explore amplitude and latency-check size function in multiple sclerosis (MS) patients without optic neuritis history. Thirty-six MS patients and 21 control subjects were included. Pattern visual evoked responses to ive check sizes (2°, 1°, 30', 15', and 7') were recorded. P100 amplitudes were significantly reduced in 2°, 1° and 7' checks and, P100 latencies were significantly delayed in all checks in MS patients (p < 0.05). Inter-ocular amplitude/ latency differences were significantly higher in MS patients than control group (p < 0.05). The P100 amplitudes for 2° check was somewhat higher than amplitudes for 1° check in MS and control groups. However, MS patients had latter amplitude-check size function curve in large checks. In small checks, the slope of the amplitude-check size curves were similar for MS and control groups. The flattening of amplitude-check size function curve in large checks increased in MS patients with reduced P100 amplitudes. The P100...
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2013
4. Terao T, Ishii T, Kawamura D, et al. Diagnosis of patients with thoracic outlet syndrome (TOS)... more 4. Terao T, Ishii T, Kawamura D, et al. Diagnosis of patients with thoracic outlet syndrome (TOS) using physiological measures of the medial antebrachial cutaneous nerve. No Shinkei Geka. 2012;40:685-694. 5. Caputo FJ, Wittenberg AM, Vemuri C, et al. Supraclavicular decompression for neurogenic thoracic outlet syndrome in adolescent and adult populations. J Vasc Surg. 2013;57:149-157. 6. Ward AS, Chand M. Venous complications of thoracic outlet syndrome. Br J Hosp Med (Lond). 2011;72:511-514. 7. Kuroki T, Kumano K, Hirabayashi S. Usefulness of MRI in the preoperative diagnosis of cervical disk herniation. Arch Orthop Trauma Surg. 1993;112:180-184. 8. Bennett AJ, Wastell DG, Barker GR, Blackburn CW, Rood JP. Trigeminal somatosensory evoked potentials. A review of the literature as applicable to oral dysaesthesias. Int J Oral Maxillofac Surg. 1987;16:408-415. 9. Barker GR, Bennett AJ, Wastell DG. Applications of trigeminal somatosensory evoked potentials (TSEPs) in oral and maxillofacial surgery. Br J Oral Maxillofac Surg. 1987;25:308-313.
The aim of this study was to investigate cutaneous-silent-period (CSP) parameters in patients wit... more The aim of this study was to investigate cutaneous-silent-period (CSP) parameters in patients with restless legs syndrome (RLS) and examine the effects of treatment on CSP which, to our knowledge, have not been investigated till date. A total of 25 patients with RLS and 25 healthy volunteers were studied. CSP latency and duration in the upper and lower extremities were examined in the two groups. In RLS patients, the variables were examined before and after pramipexole treatment. Lower-extremity CSP latency was longer (106.22±11.69 ms vs. 91.67±8.53 ms; p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) and CSP duration was shorter (35.50±10.91 ms vs. 49.47±6.43 ms; p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) in patients, compared with controls. In the patient group, CSP durations in the upper (40.88±7.95 ms vs. 46.84±10.22 ms; p=0.006) and lower extremities (35.50±10.91 ms vs. 44.91±6.43 ms; p=0.005) were prolonged after treatment, compared with pre-treatment values. Small-fibre neuropathy may exist in RLS. In addition, we suggest that pramipexole may regulate cortical and spinal inhibitory mechanisms. The use of CSP may aid in the diagnosis of RLS and may be used as a measure of treatment effectiveness.
Bioactive peptide gels enhance the regeneration of peripheral nerve injuries, which affect 20 mil... more Bioactive peptide gels enhance the regeneration of peripheral nerve injuries, which affect 20 million patients in the USA.
Primary aim is to compare the diagnostic value of contrast-enhanced 3D GRE T1-weighted sequences ... more Primary aim is to compare the diagnostic value of contrast-enhanced 3D GRE T1-weighted sequences with unenhanced MR venography and conventional magnetic resonance imaging (MRI), in detection of dural venous sinus (DVS) and cortical venous thrombosis; secondary aim is to determine the relationship between DVS thrombosis/site and gender, age, infarction or hemorrhage. We retrospectively reviewed conventional MR images, unenhanced MR venography and immediate post-contrast 3D GRE T1-weighted MR images in 30 patients (17 male and 13 female, 21-70 years old, mean age 40.1) with clinically suspected DVS thrombosis. MR examinations had been performed with 1.5T or 3T MR Scanners. DVSs were evaluated in 10 sub-segments, including cortical veins. Each set of MR images were examined separately, blinded to the final diagnosis. Associated findings were also noted and sensitivity, specificity and accuracy of each MRI technique were calculated. Final diagnosis of cortical venous and/or dural sinus thrombosis was established in 24 (80%) of 30 cases and 67 (22.3%) out of 300 segments. For detection of the thrombotic segment, sensitivity, specificity, and accuracy were 83.6%, 95.3%, and 92.7% by conventional MR sequences, 89.6%, 91.8%, and 91.3% by unenhanced MR venography, and 92.5%, 100%, and 98.3% by contrast-enhanced 3D GRE T1-weighted sequence, respectively. Infarction and hemorrhage were more frequent in cases with cortical venous thrombosis, while gender and age had no significant relation with DVS thrombosis or its site. Conventional MR sequences and unenhanced MR venography were helpful due to additional information they provided in some cases with isolated cortical venous thrombosis, with hyperintense thrombus material and with associated hemorrhage or infarction. Contrast-enhanced 3D GRE T1-weighted MRI is the most accurate imaging method for the detection of DVS and/or cortical venous thrombosis. Infarction and hemorrhage were more frequent in cases with cortical venous thrombosis.
Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2013
To explore amplitude and latency-check size function in multiple sclerosis (MS) patients without ... more To explore amplitude and latency-check size function in multiple sclerosis (MS) patients without optic neuritis history. Thirty-six MS patients and 21 control subjects were included. Pattern visual evoked responses to ive check sizes (2°, 1°, 30', 15', and 7') were recorded. P100 amplitudes were significantly reduced in 2°, 1° and 7' checks and, P100 latencies were significantly delayed in all checks in MS patients (p < 0.05). Inter-ocular amplitude/ latency differences were significantly higher in MS patients than control group (p < 0.05). The P100 amplitudes for 2° check was somewhat higher than amplitudes for 1° check in MS and control groups. However, MS patients had latter amplitude-check size function curve in large checks. In small checks, the slope of the amplitude-check size curves were similar for MS and control groups. The flattening of amplitude-check size function curve in large checks increased in MS patients with reduced P100 amplitudes. The P100...
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2013
4. Terao T, Ishii T, Kawamura D, et al. Diagnosis of patients with thoracic outlet syndrome (TOS)... more 4. Terao T, Ishii T, Kawamura D, et al. Diagnosis of patients with thoracic outlet syndrome (TOS) using physiological measures of the medial antebrachial cutaneous nerve. No Shinkei Geka. 2012;40:685-694. 5. Caputo FJ, Wittenberg AM, Vemuri C, et al. Supraclavicular decompression for neurogenic thoracic outlet syndrome in adolescent and adult populations. J Vasc Surg. 2013;57:149-157. 6. Ward AS, Chand M. Venous complications of thoracic outlet syndrome. Br J Hosp Med (Lond). 2011;72:511-514. 7. Kuroki T, Kumano K, Hirabayashi S. Usefulness of MRI in the preoperative diagnosis of cervical disk herniation. Arch Orthop Trauma Surg. 1993;112:180-184. 8. Bennett AJ, Wastell DG, Barker GR, Blackburn CW, Rood JP. Trigeminal somatosensory evoked potentials. A review of the literature as applicable to oral dysaesthesias. Int J Oral Maxillofac Surg. 1987;16:408-415. 9. Barker GR, Bennett AJ, Wastell DG. Applications of trigeminal somatosensory evoked potentials (TSEPs) in oral and maxillofacial surgery. Br J Oral Maxillofac Surg. 1987;25:308-313.
The aim of this study was to investigate cutaneous-silent-period (CSP) parameters in patients wit... more The aim of this study was to investigate cutaneous-silent-period (CSP) parameters in patients with restless legs syndrome (RLS) and examine the effects of treatment on CSP which, to our knowledge, have not been investigated till date. A total of 25 patients with RLS and 25 healthy volunteers were studied. CSP latency and duration in the upper and lower extremities were examined in the two groups. In RLS patients, the variables were examined before and after pramipexole treatment. Lower-extremity CSP latency was longer (106.22±11.69 ms vs. 91.67±8.53 ms; p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) and CSP duration was shorter (35.50±10.91 ms vs. 49.47±6.43 ms; p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) in patients, compared with controls. In the patient group, CSP durations in the upper (40.88±7.95 ms vs. 46.84±10.22 ms; p=0.006) and lower extremities (35.50±10.91 ms vs. 44.91±6.43 ms; p=0.005) were prolonged after treatment, compared with pre-treatment values. Small-fibre neuropathy may exist in RLS. In addition, we suggest that pramipexole may regulate cortical and spinal inhibitory mechanisms. The use of CSP may aid in the diagnosis of RLS and may be used as a measure of treatment effectiveness.
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