manpreet walia

Periodontitis, a disease involving supportive structures of the teeth prevails in all groups, ethnicities, races and both genders. It is a localised inflammatory response caused by bacterial infection of a periodontal pocket associated with subgingival plaque. Periodontal diseases include conditions such as chronic periodontitis, aggressive periodontitis and necrotizing periodontitis. Aggressive forms of periodontitis can be localized or generalized. Antibacterial agents have been used effectively in the management of periodontal infection. The effectiveness of mechanical debridement of plaque and repeated topical and systemic administration of antibacterial agents are limited due to the lack of accessibility to periodontopathic organisms in the periodontal pocket. Systemic administration of drugs leads to therapeutic concentrations at the site of infection, but for short periods of time, forcing repeated dosing for longer periods. Local delivery of antimicrobials has been investiga...

Nanoemulsions have the potential in pharmaceutical industries because of the transparency at high droplet volume fraction, higher rate of bioavailability or diffusion and increased shelf life of the pharmaceuticals. Nanoemulsions are clear, thermodynamically stable, isotropic liquid mixtures of oil, water, surfactant and co-surfactant. These are oil-in-water (o/w) type of emulsions with the average droplet size ranging from 5nm to 100 nm. Reduction in droplet size to nanoscale leads to change in physical properties such as optical transparency & unusual elastic behavior. Nanoemulsions have widespread applications in different fields such as pharmaceutics, food technology. Nanoemulsion offers a promising vehicle for increasing the aqueous solubility of poorly water-soluble drugs. Nanoemulsions have many advantages; for instance, enhance drug solubility, perfect thermodynamic stability, ease of manufacturing and permeation over conventional formulations that convert them to important ...

The objective of the present study was to formulate and evaluate fast dissolving tablets of Rosuvastatin (BCS Class II drug) to enhance solubility, improve bioavailability and patient compliance especially for the paediatric and geriatric patients with sufficient therapeutic benefits. Rosuvastatin exhibits poor solubility in water and low bioavailability of approximately 20%. Four solid dispersions (1:1, 1:2, 1:4 and 1:6 w/w) were prepared by melting method using PEG 4000 as a polymer. Solid dispersions were characterized for drug content uniformity, XRD, DSC and in vitro dissolution studies.  It was then further compressed into tablets by direct compression method using different superdisintegrants like sodium starch glycolate, crospovidone and croscarmellose sodium. All the fast dissolving tablets were evaluated for pre compression parameters such as angle of repose (I¸), bulk and tapped density, percentage compressibility (%) and Hausner ratio. Post compression parameters like g...

Objective: The objective of the present investigation was to design and evaluate a gel containing lycopene loaded colloidal microparticles. Methods: The lycopene loaded colloidal microparticles were successfully prepared by Cloud point technique to form colloids using Tween 40 and Tween 60 surfactant solution and then incorporated into microparticles by solvent evaporation method using polymer like HPMC and ethyl cellulose. These colloidal microparticles were evaluated for particle size (PS), drug loading (DL), entrapment efficiency (EE), Scanning Electron Microscopy (SEM). Further, these colloidal microparticles were incorporated into a topical formulation i.e., gel. This topical formulation was then evaluated for macroscopic examination, viscosity, drug content, spreadability, antioxidant activity, in vitro permeation and release kinetics. Results: Colloidal microparticles were successfully prepared and the particle size, drug loading and entrapment efficiency were found to be 249...