Three triorganotin (IV) cyclopentane carboxylates were synthesized and structurally characterized... more Three triorganotin (IV) cyclopentane carboxylates were synthesized and structurally characterized by in solid state by Fourier‐transform infrared spectroscopy and single crystal diffraction, and in solution by NMR (1H, 13C, and 119Sn) spectroscopy. The complexes were tested for their anticancer activity against MCF‐7 and HeLa cells along with normal BHK‐21 cells. As revealed by MTT assay, complex 2 was identified as the most potent derivative with an IC50 value of 2.59 and 0.051 μM against HeLa and MCF‐7 cells, respectively. The results were compared with cisplatin as reference drug. Fluorescent microscopic studies using 4′,6‐diamidino‐2‐phenylindole (DAPI) and propidium iodide (PI) staining confirmed the occurrence of apoptosis in HeLa cells treated with the most active complex 2. The complex 2 also triggered the release of lactate dehydrogenase (LDH) in treated HeLa and MCF‐7 cells whereas a luminescence assay displayed a remarkable increase in the activity of caspase‐9 and ‐3. Mo...
The hydroboration of bis(trimethylsilyl)ethyne, Me3Si-C≡C-SiMe3 1, with 9-borabicyclo [3.3.1] non... more The hydroboration of bis(trimethylsilyl)ethyne, Me3Si-C≡C-SiMe3 1, with 9-borabicyclo [3.3.1] nonane (9-BBN) gives first the expected (Z)-alkene 5 which rearranges, without UV irradiation, after several days quantitatively into the (E)-alkene 6. Heating of 6 in the presence of a further equivalent of 1 leads, again almost quantitatively, to an allene, the 1,1,4,4-tetrakis(trimethylsilyl)-4-[9-(9- borabicyclo[3.3.1]nonyl)]buta-1,2-diene 8. Reactive structures arising from π-σ delocalisation involving the boryl group are proposed to be responsible both for the cis/trans-isomerisation and the allene formation. It is suggested that analogous structures may explain the previously observed formation of allenes 9 and 10, tin-analogues of 8. The structures of 5, 6 and 8 in solution follow from a consistent set of NMR data (1H, 11B, 13C, 29Si NMR), and the solid-state structure of 8 was confirmed by X-ray analysis.
journal published by Elsevier. The attached copy is furnished to the author for internal non-comm... more journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: a b s t r a c t This article describes the synthesis, characterization and bioactivity of dimethyl (1), diethyl (2), diphenyl (3), di-n-octyl (4), di-tert-butyl (5), n-butylchlorotin(IV) (6) derivatives of N 0 -(2-hydroxy-3-methoxybenzylidene)formohydrazide ligand. On the basis of presence or absence of steric factor, these compounds are eit...
Nine organotin esters, Me2SnL21, Me3SnL 2, n-Bu2SnL23, n-Bu3SnL 4, Ph3SnL 5, (PhCH2)2SnL26, [(Me2... more Nine organotin esters, Me2SnL21, Me3SnL 2, n-Bu2SnL23, n-Bu3SnL 4, Ph3SnL 5, (PhCH2)2SnL26, [(Me2SnL)2O]27, Et2SnL28 and n-Oct2SnL29, of (E)-3-(3-fluorophenyl)-2-(4-chlorophenyl)-2-propenoic acid, HL have been synthesized and characterized by elemental analysis, IR, Multinuclear NMR (1H, 13C and 119Sn) and mass spectrometry. The geometry around the tin atom has been deduced and compared both in solution and solid states. The crystal structure of compound 5 has been determined by X-ray single crystal analysis, which shows a tetrahedral geometry around the tin atom with space group P1¯. These compounds have also been screened for bactericidal, fungicidal activities and cytotoxicity data.Nine organotin(IV) compounds containing (E)-3-(3-fluorophenyl)-2-(4-chlorophenyl)-2-propenoate ligand were synthesized, screened for biological activity and characterized by spectroscopic and single crystal X-ray analysis.
ABSTRACT Xanthene intermediates 4a and 4b were obtained from the reduction of nitro xanthene deri... more ABSTRACT Xanthene intermediates 4a and 4b were obtained from the reduction of nitro xanthene derivatives 3a and 3b which were synthesized via condensation of dimedone with m-nitrobenzaldehyde and p-nitrobenzaldehyde, respectively. Then xanthene sulfonamide 6a-n, and xanthene carboxamide derivatives 8a-h were synthesized by reaction of amino xanthene 4a, 4b with sulfonyl chlorides 5a-g and acyl chlorides 7a-d. Structures of the novel amino xanthene compounds and xanthene sulfonamide/carboxamide derivatives were established by their spectral data and elemental analyses. Furthermore, all the synthesized compounds were tested in vitro for their antimicrobial activity. The results were compared with reference standard antibiotics, erythromycin and nystatin. 6c, 6f, 6m and 8b Compounds were found to display most effective antimicrobial activity against a series of bacteria and fungi.
Analytical Sciences X Ray Structure Analysis Online, 2007
The title compound, C14H11N3O, is an effect of catalyzing behavior of dibenzyltin dichloride. It ... more The title compound, C14H11N3O, is an effect of catalyzing behavior of dibenzyltin dichloride. It belongs to the space group P21/n with cell parameters a = 13.5510(12), b = 5.8720(13), c = 15.4890(12)Å and β = 109.912(3)˚. The intermolecular CH·O hydrogen ...
The crystal structure of the title compound, C(11)H(12)O(2), consists of dimers which are formed ... more The crystal structure of the title compound, C(11)H(12)O(2), consists of dimers which are formed due to inter-molecular O-H⋯O hydrogen bonding. The dimers are linked to each other by C-H⋯O hydrogen bonds, where C-H belongs to the benzene ring and the O atom is of a carbonyl group of an adjoining mol-ecule. There exist two inter-molecular C-H⋯O hydrogen bonds which form five-membered rings. There exist two π-π inter-actions between the benzene rings. The perpendicular distance in these inter-actions are 3.006 and 3.396 Å. There also exist C-H⋯π and C-O⋯π inter-actions.
Three triorganotin (IV) cyclopentane carboxylates were synthesized and structurally characterized... more Three triorganotin (IV) cyclopentane carboxylates were synthesized and structurally characterized by in solid state by Fourier‐transform infrared spectroscopy and single crystal diffraction, and in solution by NMR (1H, 13C, and 119Sn) spectroscopy. The complexes were tested for their anticancer activity against MCF‐7 and HeLa cells along with normal BHK‐21 cells. As revealed by MTT assay, complex 2 was identified as the most potent derivative with an IC50 value of 2.59 and 0.051 μM against HeLa and MCF‐7 cells, respectively. The results were compared with cisplatin as reference drug. Fluorescent microscopic studies using 4′,6‐diamidino‐2‐phenylindole (DAPI) and propidium iodide (PI) staining confirmed the occurrence of apoptosis in HeLa cells treated with the most active complex 2. The complex 2 also triggered the release of lactate dehydrogenase (LDH) in treated HeLa and MCF‐7 cells whereas a luminescence assay displayed a remarkable increase in the activity of caspase‐9 and ‐3. Mo...
The hydroboration of bis(trimethylsilyl)ethyne, Me3Si-C≡C-SiMe3 1, with 9-borabicyclo [3.3.1] non... more The hydroboration of bis(trimethylsilyl)ethyne, Me3Si-C≡C-SiMe3 1, with 9-borabicyclo [3.3.1] nonane (9-BBN) gives first the expected (Z)-alkene 5 which rearranges, without UV irradiation, after several days quantitatively into the (E)-alkene 6. Heating of 6 in the presence of a further equivalent of 1 leads, again almost quantitatively, to an allene, the 1,1,4,4-tetrakis(trimethylsilyl)-4-[9-(9- borabicyclo[3.3.1]nonyl)]buta-1,2-diene 8. Reactive structures arising from π-σ delocalisation involving the boryl group are proposed to be responsible both for the cis/trans-isomerisation and the allene formation. It is suggested that analogous structures may explain the previously observed formation of allenes 9 and 10, tin-analogues of 8. The structures of 5, 6 and 8 in solution follow from a consistent set of NMR data (1H, 11B, 13C, 29Si NMR), and the solid-state structure of 8 was confirmed by X-ray analysis.
journal published by Elsevier. The attached copy is furnished to the author for internal non-comm... more journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: a b s t r a c t This article describes the synthesis, characterization and bioactivity of dimethyl (1), diethyl (2), diphenyl (3), di-n-octyl (4), di-tert-butyl (5), n-butylchlorotin(IV) (6) derivatives of N 0 -(2-hydroxy-3-methoxybenzylidene)formohydrazide ligand. On the basis of presence or absence of steric factor, these compounds are eit...
Nine organotin esters, Me2SnL21, Me3SnL 2, n-Bu2SnL23, n-Bu3SnL 4, Ph3SnL 5, (PhCH2)2SnL26, [(Me2... more Nine organotin esters, Me2SnL21, Me3SnL 2, n-Bu2SnL23, n-Bu3SnL 4, Ph3SnL 5, (PhCH2)2SnL26, [(Me2SnL)2O]27, Et2SnL28 and n-Oct2SnL29, of (E)-3-(3-fluorophenyl)-2-(4-chlorophenyl)-2-propenoic acid, HL have been synthesized and characterized by elemental analysis, IR, Multinuclear NMR (1H, 13C and 119Sn) and mass spectrometry. The geometry around the tin atom has been deduced and compared both in solution and solid states. The crystal structure of compound 5 has been determined by X-ray single crystal analysis, which shows a tetrahedral geometry around the tin atom with space group P1¯. These compounds have also been screened for bactericidal, fungicidal activities and cytotoxicity data.Nine organotin(IV) compounds containing (E)-3-(3-fluorophenyl)-2-(4-chlorophenyl)-2-propenoate ligand were synthesized, screened for biological activity and characterized by spectroscopic and single crystal X-ray analysis.
ABSTRACT Xanthene intermediates 4a and 4b were obtained from the reduction of nitro xanthene deri... more ABSTRACT Xanthene intermediates 4a and 4b were obtained from the reduction of nitro xanthene derivatives 3a and 3b which were synthesized via condensation of dimedone with m-nitrobenzaldehyde and p-nitrobenzaldehyde, respectively. Then xanthene sulfonamide 6a-n, and xanthene carboxamide derivatives 8a-h were synthesized by reaction of amino xanthene 4a, 4b with sulfonyl chlorides 5a-g and acyl chlorides 7a-d. Structures of the novel amino xanthene compounds and xanthene sulfonamide/carboxamide derivatives were established by their spectral data and elemental analyses. Furthermore, all the synthesized compounds were tested in vitro for their antimicrobial activity. The results were compared with reference standard antibiotics, erythromycin and nystatin. 6c, 6f, 6m and 8b Compounds were found to display most effective antimicrobial activity against a series of bacteria and fungi.
Analytical Sciences X Ray Structure Analysis Online, 2007
The title compound, C14H11N3O, is an effect of catalyzing behavior of dibenzyltin dichloride. It ... more The title compound, C14H11N3O, is an effect of catalyzing behavior of dibenzyltin dichloride. It belongs to the space group P21/n with cell parameters a = 13.5510(12), b = 5.8720(13), c = 15.4890(12)Å and β = 109.912(3)˚. The intermolecular CH·O hydrogen ...
The crystal structure of the title compound, C(11)H(12)O(2), consists of dimers which are formed ... more The crystal structure of the title compound, C(11)H(12)O(2), consists of dimers which are formed due to inter-molecular O-H⋯O hydrogen bonding. The dimers are linked to each other by C-H⋯O hydrogen bonds, where C-H belongs to the benzene ring and the O atom is of a carbonyl group of an adjoining mol-ecule. There exist two inter-molecular C-H⋯O hydrogen bonds which form five-membered rings. There exist two π-π inter-actions between the benzene rings. The perpendicular distance in these inter-actions are 3.006 and 3.396 Å. There also exist C-H⋯π and C-O⋯π inter-actions.
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