A controlled release preparation of levodopa-carbidopa, CR III, given every 4 hours to 17 Parkinsonian patients for up to 10 months reduced plasma drug variations and improved motor response fluctuations compared with standard... more
A controlled release preparation of levodopa-carbidopa, CR III, given every 4 hours to 17 Parkinsonian patients for up to 10 months reduced plasma drug variations and improved motor response fluctuations compared with standard levodopa-carbidopa given every 2 hours. The results support the value of pharmaceutical approaches to the stabilisation of circulating levodopa levels in the treatment of Parkinson's disease.
Research Interests: Medicine, Humans, Controlled release, Female, Male, and 13 moreLevodopa, Aged, Middle Aged, Adult, Combination drug therapy, Parkinson´s Disease, Delayed-Action Preparations, Parkinson Disease, Carbidopa, Psychomotor Performance, Psychology and Cognitive Sciences, Medical and Health Sciences, and Drug combinations
We report on a patient affected by ICF syndrome (immunodeficiency, centromeric instability of chromosomes 1, 9 and 16 and facial dysmorphism), who presented with slowing in mentation, mild right hemiparesis and focal motor seizures. MRI... more
We report on a patient affected by ICF syndrome (immunodeficiency, centromeric instability of chromosomes 1, 9 and 16 and facial dysmorphism), who presented with slowing in mentation, mild right hemiparesis and focal motor seizures. MRI study of the brain suggested a diagnosis of progressive multifocal leukoencephalopathy (PML), which was confirmed by JC virus DNA detection on CSF by polymerase chain reaction (PCR). This is a unique case of adult infective neurological complication described in ICF Syndrome.
Research Interests:
Research Interests: Magnetic Resonance Imaging, Medicine, Humans, Thalamus, Neuroradiology, and 14 moreFemale, Atrial Fibrillation, Clinical Sciences, Aged, Basilar Artery, Ophthalmoplegia, Midbrain, Neurosciences, Ptosis, Vertebral artery, Cerebral Infarction, Internuclear Ophthalmoplegia, Mesencephalon, and Vertebrobasilar insufficiency
Research Interests: Cardiology, Computed Tomography, Cardiovascular disease, Medicine, Humans, and 15 moreInternal Medicine, Female, Male, Central Nervous System, Brain Ischemia, Lancet, Aged, Middle Aged, Blood Flow, Computerized tomography, Cerebral Blood Flow, Cerebrovascular Disorders, Acute Ischemic Stroke, Middle Cerebral Artery, and Medical and Health Sciences
Research Interests:
Research Interests:
Research Interests:
Research Interests: Cardiology, Medicine, Brain, Humans, Female, and 15 moreMale, Perfusion, Brain Ischemia, Aged, Middle Aged, Single Photon Emission Computed Tomography, Time Factors, Prognosis, Cerebral Blood Flow, Blood Flow Velocity, Cerebrovascular Disorders, Middle Cerebral Artery, Infarction, Psychology and Cognitive Sciences, and Medical and Health Sciences
The contribution of the peripheral and central pharmacokinetic mechanisms of levodopa to the pathogenesis of the motor fluctuations that complicate its long‐term administration was studied in 28 parkinsonian patients. The rate of levodopa... more
The contribution of the peripheral and central pharmacokinetic mechanisms of levodopa to the pathogenesis of the motor fluctuations that complicate its long‐term administration was studied in 28 parkinsonian patients. The rate of levodopa clearance from the general circulation, its plasma half‐life, and apparent volume of distribution were indistinguishable between patients with the on‐off or the wearing‐off phenomenon and those with a stable response to levodopa or those who had not been previously treated with levodopa. Peripheral pharmacokinetic factors are thus unlikely to account for the development of these response fluctuations. Conversely, the efficacy half‐time of levodopa differed markedly among the four response groups studied and may provide a quantitative index of central mechanisms that favor the development of the wearing‐off and on‐off phemonena. Although symptom duration was the best predictor of the severity of untreated parkinsonism, levodopa dose correlated best ...