An efficient strategy towards N-formylation of amides and oxidation of indolines to isatins is de... more An efficient strategy towards N-formylation of amides and oxidation of indolines to isatins is described.
Senecio graciliflorus DC root extract was studied for secondary metabolite composition following ... more Senecio graciliflorus DC root extract was studied for secondary metabolite composition following bioactivity guided isolation technique. The ethyl acetate extract of Senecio graciliflorus root yielded nine chemical constituents: 3,4-di-tert-butyl toluene, stigmasterol, β-sitosterol, 2β-(angeloyloxy)furanoeremophilane, gallic acid, 2β-{[(Z)-2-hydroxymethylbut-2-enoyl]oxy}furanoeremophilane,1-Hydroxypentan-2-yl-4-methylbenzoate, sarcinnic acid, and sitosterol 3-O-β-D-glucopyranoside. The structures of the chemical constituents were elucidated on the basis of spectral data analysis in the light of literature. All the compounds are being reported for the first time from this plant. The isolated constituents were screened for in-vitro neuroprotective effects against corticostereone induced impairment. Among various isolated compounds, three natural products (sarcinnic acid, gallic acid and β-sitosterol) displayed robust neurotropic activity. These three compounds increased neuronal cell ...
An efficient strategy towards N-formylation of amides and oxidation of indolines to isatins is de... more An efficient strategy towards N-formylation of amides and oxidation of indolines to isatins is described.
Senecio graciliflorus DC root extract was studied for secondary metabolite composition following ... more Senecio graciliflorus DC root extract was studied for secondary metabolite composition following bioactivity guided isolation technique. The ethyl acetate extract of Senecio graciliflorus root yielded nine chemical constituents: 3,4-di-tert-butyl toluene, stigmasterol, β-sitosterol, 2β-(angeloyloxy)furanoeremophilane, gallic acid, 2β-{[(Z)-2-hydroxymethylbut-2-enoyl]oxy}furanoeremophilane,1-Hydroxypentan-2-yl-4-methylbenzoate, sarcinnic acid, and sitosterol 3-O-β-D-glucopyranoside. The structures of the chemical constituents were elucidated on the basis of spectral data analysis in the light of literature. All the compounds are being reported for the first time from this plant. The isolated constituents were screened for in-vitro neuroprotective effects against corticostereone induced impairment. Among various isolated compounds, three natural products (sarcinnic acid, gallic acid and β-sitosterol) displayed robust neurotropic activity. These three compounds increased neuronal cell ...
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